What we claim is:
1. Compounds of the general formula
40
in which
A is the group NR7,
W is oxygen, sulphur, two hydrogen atoms or the group NR8,
Z is a bond or the group NR10 or N,
R1 is branched or unbranched C1-12-alkyl or C2-12-alkenyl which is optionally substituted once or many times by halogen, hydroxy, C1-6-alkyloxy, aralkyloxy, C1-6-alkyl andor NR11R12; or C3-10-cycloalkyl, or C3-10-cycloalkenyl which is optionally substituted once or many times by halogen, hydroxy, C1-6-alkyloxy, aralkyloxy, C1-6-alkyl andor NR11R12,
X is C1-6-alkyl;
R2 signifies monocyclic or bicyclic heteroaryl, which is unsubstituted or optionally substituted once or many times by halogen, C1-6-alkyl, C1-6-alkoxy andor hydroxy,
R3, R4, R5 and R6 are hydrogen, halogen; or C1-6-alkoxy, C1-6-alkyl, C1-6-carboxyalkyl either unsubstituted or
R3, R4, R5 and R6 are hydrogen, halogen; or C1-6-alkoxy, C1-6-alkyl, C1-6-carboxyalkyl either unsubstituted or optionally substituted once or many times by halogen,
R7 is hydrogen, C1-6-alkyl or C1-8-cycloalkyl,
R8, R9 and R10 are hydrogen or C1-6-alkyl and
R11 and R12 are hydrogen or C1-6-alkyl or form a ring which may contain a further hetero atom and may be optionally substituted by C1-6-alkyl,
except those compounds in which W is oxygen, Z is a bond, X is C2-alkyl, R2 signifies unsubstituted 4-pyridyl, R3, R4, R6, R7 and R9 are respectively hydrogen, R5 is hydrogen or chlorine and R1 signifies n-propyl, cyclopropyl or allyl, as well as the isomers and salts thereof.
2. Compounds of general formula I, according to claim 1, in which
A is the group NR7,
W is oxygen,
Z is a bond,
R1 is branched or unbranched C1-12-alkyl or C2-12-alkenyl which is optionally substituted once or many times by halogen, hydroxy, C1-6-alkyloxy, aralkyloxy, C1-6-alkyl andor NR11R12; or C3-10-cycloalkyl, or C3-10-cycloalkenyl which is optionally substituted once or many times by halogen, hydroxy, C1-6-alkyloxy, aralkyloxy, C1-6-alkyl andor NR11R12,
X is C1-6-alkyl;
R2 signifies monocyclic or bicyclic heteroaryl, which is unsubstituted or optionally substituted once or many times by halogen, C1-6-alkyl, C1-6-alkoxy andor hydroxy,
R3, R4, R5 and R6 are hydrogen, halogen; or C1-6-alkoxy, C1-6-alkyl, C1-6-carboxyalkyl either unsubstituted or optionally substituted once or many times by halogen,
R7 is hydrogen, C1-6-alkyl or C1-8-cycloalkyl,
R9 is hydrogen or C1-6-alkyl and
R11 and R12 are hydrogen or C1-6-alkyl or form a ring which may contain a further hetero atom and may be optionally substituted by C1-6-alkyl,
except those compounds in which W is oxygen, Z is a bond, X is C2-alkyl, R2 signifies unsubstituted 4-pyridyl, R3, R4, R6, R7 and R9 are respectively hydrogen, R5 is hydrogen or chlorine and R1 signifies n-propyl, cyclopropyl or allyl, as well as the isomers and salts thereof.
3. Compounds of general formula I, according to claims 1 and 2, in which
A is the group NR7,
W is oxygen,
Z is a bond,
R1 is branched or unbranched C1-12-alkyl or C2-12-alkenyl which is optionally substituted once or many times by halogen, hydroxy, C1-6-alkyloxy, aralkyloxy, C1-6-alkyl andor NR11R12I; or C3-10-cycloalkyl, or C3-10-cycloalkenyl which is optionally substituted once or many times by halogen, hydroxy, C1-6-alkyloxy, aralkyloxy, C1-6-alkyl andor NR11R12,
X is C1-6-alkyl;
R2 is pyridyl,
R3, R4, R5 and R6 are hydrogen, halogen; or C1-6-alkoxy, C1-6-alkyl, C1-6-carboxyalkyl either unsubstituted or optionally substituted once or many times by halogen,
R7 is hydrogen, C1-6-alkyl or C1-8-cycloalkyl,
R9 is hydrogen or C1-6-alkyl and
R11 and R12 are hydrogen or C1-6-alkyl or form a ring which may contain a further hetero atom and may be optionally substituted by C, 6-alkyl, except those compounds in which W is oxygen, Z is a bond, X is C2-alkyl, R2 signifies unsubstituted 4-pyridyl, R3, R4, R6, R7 and R9 are respectively hydrogen, R5 is hydrogen or chlorine and R1 signifies n-propyl, cyclopropyl or allyl, as well as the isomers and salts thereof.
4. Compounds of general formula I, according to claims 1 to 3, in which
A is the group NR7,
W is oxygen,
Z is a bond,
R1 is branched or unbranched C1-12-alkyl or C2-12-alkenyl which is optionally substituted once or many times by halogen, hydroxy, C1-6-alkyloxy, aralkyloxy, C1-6-alkyl and or NR11R12 or C3-10-cycloalkyl, or C3-10-cycloalkenyl which is optionally substituted once or many times by halogen, hydroxy, C1-6-alkyloxy, aralkyloxy, C1-6-alkyl andor NR11R12,
X is C1-6-alkyl;
R2 is pyridyl,
R3, R4, R5 and R6 are hydrogen, halogen; or C1-6-alkoxy, C1-6-alkyl, C1-6-carboxyalkyl either unsubstituted or optionally substituted once or many times by halogen,
R7 is hydrogen, C1-6-alkyl or C1-8-cycloalkyl,
R9 is hydrogen or C1-6-alkyl and
R11 and R12 are hydrogen or C1-6-alkyl, or form a ring which may contain oxygen or nitrogen as a further hetero atom and may be optionally substituted by C1-6-alkyl,
except those compounds in which W is oxygen, Z is a bond, X is C2-alkyl, R2 signifies unsubstituted 4-pyridyl, R3, R4, R6, R7 and R9 are respectively hydrogen, R5 is hydrogen or chlorine and R1 signifies n-propyl, cyclopropyl or allyl, as well as the isomers and salts thereof.
5. Compounds of general formula I, according to claims 1 to 4, in which
A is the group NR7,
W is oxygen,
Z is a bond,
R1 is branched or unbranched C1-12-alkyl which is optionally substituted once or many times by halogen, C1-6-alkyloxy or NR11R12;or C3-10-cycloalkyl which is optionally substituted once or many times by hydroxy, C1-6-alkyloxy, C1-6-alkyl or benzyloxy,
X is C1-6-alkyl;
R2 is pyridyl,
R3, R4, R5 and R6 are hydrogen,
R7 and R9 are hydrogen,
R11 and R12 are hydrogen or C1-6-alkyl or form a morpholinyl, piperidinoyl or pyrrolidinoyl ring, which may be optionally substituted by C1-6-alkyl,
except those compounds in which W is oxygen, Z is a bond, X is C2-alkyl, R2 signifies unsubstituted 4-pyridyl, R3, R4, R6, R7 and R9 are respectively hydrogen, R5 is hydrogen or chlorine and R1 signifies n-propyl, cyclopropyl or allyl, as well as the isomers and salts thereof.
6. Use of the compounds of general formula I, according to claims 1 to 5, in the production of a medicament for treating tumours, psoriasis, arthritis, such as rheumatoid arthritis, haemangioma, angiofibroma, eye diseases such as diabetic retinopathy, neovascular glaucoma, kidney diseases such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplantation rejections and glomerulopathy, fibrotic diseases such as cirrhosis of the liver, mesangial cell proliferation diseases, artherioscierosis and injuries to nerve tissue, for stopping ascites formation and for suppressing VEGF-induced oedema.
7. Medicament, containing at least one compound according to claims 1 to 5.
8. Medicament according to claim 7 for treating tumours, psoriasis, arthritis, such as rheumatoid arthritis, haemangioma, angiofibroma, eye diseases such as diabetic retinopathy, neovascular glaucoma, kidney diseases such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplantation rejections and glomerulopathy, fibrotic diseases such as cirrhosis of the liver, mesangial cell proliferation diseases, artheriosclerosis and injuries to nerve tissue, for stopping ascites formation and for suppressing VEGF-induced oedema.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A facility management system comprising:
a work order system configured for:
receiving a request for service;
retrieving, from a contract database, one or more pieces of key data extracted from a contract in response to the request; and
preparing a work order ordering corrective work based on the request and the retrieved pieces of key data.
2. The facility management system of claim 1, further comprising a contract database configured for storing key data extracted from one or more contracts.
3. The facility management system of claim 1, wherein the work order system is further configured for outputting the work order to a vendor for completion of the corrective work.
4. The facility management system of claim 1, wherein the work order system is further configured for initiating billing for recovery of some or all the cost of the vendor completing the corrective work.
5. The facility management system of claim 1, wherein the corrective work is associated with a site and wherein the work order system is further configured for:
determining whether preventive maintenance or recurring service has been scheduled for the site; and wherein:
preparing the work order ordering corrective work based on the request for service and the retrieved pieces of key data comprises:
bundling the corrective work with the preventative maintenance or recurring service, thereby minimizing a number of necessary work orders.
6. The facility management system of claim 1, wherein the contract is associated with a vendor, the facility management system further comprising:
a billing system configured for:
receiving terms extracted from an invoice submitted by the vendor for performing the corrective work; and
determining whether to approve payment of the invoice.
7. The facility management system of claim 6, wherein determining whether to approve payment of the invoice comprises:
retrieving, from the contract database, one or more second pieces of key data extracted from the contract; and
comparing the terms extracted from the invoice to the one or more second pieces of key data extracted from the contract, thereby determining whether the terms match the one or more second pieces of key data; and wherein determining whether to approve payment of the invoice is based on whether the terms match the one or more second pieces of key data.
8. The facility management system of claim 1, wherein the request for service is associated with a type of service and wherein retrieving one or more pieces of key data extracted from a contract comprises:
searching the contract database for a contract associated with the type of service of the request for service, thereby resulting in a relevant contract and
retrieving, from the contract database, one or more pieces of key data extracted from the relevant contract.
9. The facility management system of claim 1, wherein receiving a request for service comprises receiving one or more pieces of request data.
10. The facility management system of claim 9, wherein the one or more pieces of request data comprise type of service data or site of service data.
11. The facility management system of claim 10, wherein retrieving one or more pieces of key data extracted from a contract comprises:
searching the contract database for a contract associated with one or more of the pieces of request data, thereby resulting in a relevant contract; and
retrieving, from the contract database, one or more pieces of key data extracted from the relevant contract.
12. The facility management system of claim 1, wherein the request for service comprises a request for a type of service, and wherein the one or more pieces of key data retrieved from the contract comprise a contract price for performing the type of service.
13. The facility management system of claim 12, wherein preparing the work order comprises preparing the work order ordering corrective work corresponding with the type of service and based on the contract price for performing the type of service.
14. The facility management system of claim 13, wherein the work order system is further configured for outputting the work order to a vendor for completion of the corrective work, and wherein the facility management system further comprises:
a billing system configured for:
receiving terms extracted from an invoice submitted by the vendor for performing the corrective work, the terms comprising an invoice price for performing the corrective work; and
determining whether to approve payment of the invoice.
15. The facility management system of claim 14, wherein determining whether to approve payment of the invoice comprises:
comparing the invoice price for performing the corrective work to the contract price for performing the type of service; and
approving payment of the invoice when the invoice price matches the contract price.
16. A method for facility management comprising:
receiving a request for service;
retrieving, by a processing device, from a contract database, one or more pieces of key data extracted from a contract in response to the request; and
preparing a work order ordering corrective work based on the request and the retrieved pieces of key data.
17. The method of claim 16, further comprising:
initiating storage, by a processing device, of key data extracted from one or more contracts.
18. The method of claim 16, further comprising:
outputting the work order to a vendor for completion of the corrective work.
19. The method of claim 16, further comprising:
initiating billing for recovery of some or all the cost of the vendor completing the corrective work.
20. The method of claim 16, wherein the corrective work is associated with a site and wherein the method further comprises:
determining whether preventive maintenance or recurring service has been scheduled for the site; and wherein:
preparing the work order ordering corrective work based on the request for service and the retrieved pieces of key data comprises:
bundling the corrective work with the preventative maintenance or recurring service, thereby minimizing a number of necessary work orders.
21. The method of claim 16, wherein the contract is associated with a vendor, the method further comprising:
receiving terms extracted from an invoice submitted by the vendor for performing the corrective work; and
determining whether to approve payment of the invoice.
22. The method of claim 21, wherein determining whether to approve payment of the invoice comprises:
retrieving, from the contract database, one or more second pieces of key data extracted from the contract; and
comparing the terms extracted from the invoice to the one or more second pieces of key data extracted from the contract, thereby determining whether the terms match the one or more second pieces of key data; and wherein determining whether to approve payment of the invoice is based on whether the terms match the one or more second pieces of key data.
23. The method of claim 16, wherein the request for service is associated with a type of service and wherein retrieving one or more pieces of key data extracted from a contract comprises:
searching the contract database for a contract associated with the type of service of the request for service, thereby resulting in a relevant contract and
retrieving, from the contract database, one or more pieces of key data extracted from the relevant contract.
24. The method of claim 16, wherein receiving a request for service comprises receiving one or more pieces of request data.
25. The method of claim 24, wherein the one or more pieces of request data comprise type of service data or site of service data.
26. The method of claim 25, wherein retrieving one or more pieces of key data extracted from a contract comprises:
searching the contract database for a contract associated with one or more of the pieces of request data, thereby resulting in a relevant contract and
retrieving, from the contract database, one or more pieces of key data extracted from the relevant contract.
27. The method of claim 16, wherein the request for service comprises a request for a type of service, and wherein the one or more pieces of key data retrieved from the contract comprise a contract price for performing the type of service.
28. The method of claim 27, wherein preparing the work order comprises preparing the work order ordering corrective work corresponding with the type of service and based on the contract price for performing the type of service.
29. The method of claim 28, further comprising:
outputting the work order to a vendor for completion of the corrective work;
receiving terms extracted from an invoice submitted by the vendor for performing the corrective work, the terms comprising an invoice price for performing the corrective work; and
determining whether to approve payment of the invoice.
30. The method of claim 29, wherein determining whether to approve payment of the invoice comprises:
comparing the invoice price for performing the corrective work to the contract price for performing the type of service; and
approving payment of the invoice when the invoice price matches the contract price.
31. A computer program product comprising a non-transient computer-readable medium comprising computer-executable instructions for facility management, the instructions comprising:
instructions for receiving a request for service;
instructions for retrieving from a contract database, one or more pieces of key data extracted from a contract in response to the request; and
instructions for preparing a work order ordering corrective work based on the request and the retrieved pieces of key data.
32. The computer program product of claim 31, wherein the instructions further comprise:
instructions for initiating storage of key data extracted from one or more contracts.
33. The computer program product of claim 31, wherein the instructions further comprise:
instructions for outputting the work order to a vendor for completion of the corrective work.
34. The computer program product of claim 31, wherein the instructions further comprise:
instructions for initiating billing for recovery of some or all the cost of the vendor completing the corrective work.
35. The computer program product of claim 31, wherein the corrective work is associated with a site and wherein the instructions further comprise:
instructions for determining whether preventive maintenance or recurring service has been scheduled for the site; and wherein:
the instructions for preparing the work order ordering corrective work based on the request for service and the retrieved pieces of key data comprise:
instructions for bundling the corrective work with the preventative maintenance or recurring service, thereby minimizing a number of necessary work orders.
36. The computer program product of claim 31, wherein the contract is associated with a vendor, the instructions further comprising:
instructions for receiving terms extracted from an invoice submitted by the vendor for performing the corrective work; and
instructions for determining whether to approve payment of the invoice.
37. The computer program product of claim 36, wherein the instructions for determining whether to approve payment of the invoice comprise:
instructions for retrieving, from the contract database, one or more second pieces of key data extracted from the contract; and
instructions for comparing the terms extracted from the invoice to the one or more second pieces of key data extracted from the contract, thereby determining whether the terms match the one or more second pieces of key data; and wherein determining whether to approve payment of the invoice is based on whether the terms match the one or more second pieces of key data.
38. The computer program product of claim 31, wherein the request for service is associated with a type of service and wherein the instructions for retrieving one or more pieces of key data extracted from a contract comprise:
instructions for searching the contract database for a contract associated with the type of service of the request for service, thereby resulting in a relevant contract; and
instructions for retrieving, from the contract database, one or more pieces of key data extracted from the relevant contract.
39. The computer program product of claim 31, wherein the instructions for receiving a request for service comprise instructions for receiving one or more pieces of request data.
40. The computer program product of claim 39, wherein the one or more pieces of request data comprise type of service data or site of service data.
41. The computer program product of claim 40, wherein the instructions for retrieving one or more pieces of key data extracted from a contract comprise:
instructions for searching the contract database for a contract associated with one or more of the pieces of request data, thereby resulting in a relevant contract and
instructions for retrieving, from the contract database, one or more pieces of key data extracted from the relevant contract.
42. The computer program product of claim 31, wherein the request for service comprises a request for a type of service, and wherein the one or more pieces of key data retrieved from the contract comprise a contract price for performing the type of service.
43. The computer program product of claim 42, wherein the instructions for preparing the work order comprise instructions for preparing the work order ordering corrective work corresponding with the type of service and based on the contract price for performing the type of service.
44. The computer program product of claim 43, the instructions further comprising:
instructions for outputting the work order to a vendor for completion of the corrective work;
instructions for receiving terms extracted from an invoice submitted by the vendor for performing the corrective work, the terms comprising an invoice price for performing the corrective work; and
instructions for determining whether to approve payment of the invoice.
45. The computer program product of claim 44, wherein the instructions for determining whether to approve payment of the invoice comprise:
instructions for comparing the invoice price for performing the corrective work to the contract price for performing the type of service; and
instructions for approving payment of the invoice when the invoice price matches the contract price.
46. A facility management system comprising:
a work order system configured for:
receiving a request for service;
retrieving, from a contract database, one or more pieces of key data extracted from a contract in response to the request;
preparing a work order ordering corrective work based on the request and the retrieved pieces of key data; and
outputting the work order to a vendor for completion of the corrective work; and
a billing system configured for:
receiving terms extracted from an invoice submitted by the vendor for performing the corrective work, the terms comprising an invoice price for performing the corrective work; and
determining whether to approve payment of the invoice, comprising:
comparing the invoice price for performing the corrective work to the contract price for performing the type of service; and
approving payment of the invoice when the invoice price matches the contract price.
47. The facility management system of claim 46, wherein the corrective work is associated with a site and wherein the work order system is further configured for:
determining whether preventive maintenance or recurring service has been scheduled for the site; and wherein:
preparing the work order ordering corrective work based on the request for service and the retrieved pieces of key data comprises:
bundling the corrective work with the preventative maintenance or recurring service, thereby minimizing a number of necessary work orders.