1. A method to improve the fertility of a soil, to help detoxify hazardous chemicals in the soil, and to reduce erosion of the soil, comprising the steps of
(a) providing worm cocoon injection apparatus comprising
(i) a frame,
(ii) at least one coulter mounted on the frame to form an opening in soil,
(iii) a tank to hold water and earthworm cocoons,
(iv) a mixer in said tank to prevent the earthworm cocoons from settling to the bottom of said tank,
(v) a pump to dispense in the opening produced by said coulter a selected amount of water and cocoons,
(vi) motive power to operate said mixer and said pump;
(b) selecting a planting depth in the range of two to six inches;
(c) determining if
(i) the soil is sufficiently dry to inject worm cocoons,
(ii) the temperature of the soil at said planting depth is in the range of soil temperature is in the range of about forty-two to eighty degrees F., and
(iii) the ambient air temperature is in the range of thirty-three to one hundred degrees F.;
(d) if the soil is sufficiently dry to inject worm cocoons, if the temperature of the soil at said selected depth is in the range of soil temperature is in the range of about forty-two to eighty degrees F., and if the ambient air temperature is equal to or greater than forty two degrees F.,
(i) selecting a plurality of soil physical conditions;
(ii) evaluating the soil to determine said selected soil physical conditions for the soil;
(iii) selecting at least two species of worms to improve at least one of said selected soil conditions;
(iv) determining for each of said selected species of worm the quantity of worm cocoons desired per acre of soil;
(v) determining that pesticides, fertilizers, and other chemicals harmful to worms are not present in the soil in a concentration sufficient to kill said selected species of worms;
(vi) providing a selected quantity of worm cocoons of said selected species of worms;
(vii) providing a selected quantity of water having a temperature in the range of about forty-two to eighty degrees F.;
(vi) placing said quantity of worm cocoons and said quantity of water in said tank;
(vii) utilizing said motive power to activate said mixer to prevent the worm cocoons from settling to the bottom of the tank;
(viii) moving said worm cocoon injection apparatus over the soil such that said disc makes in the soil an opening having said selected depth;
(ix) operating said a pump to dispense at selected positions along the slit, before the slit closes, a selected amount of water and cocoons; and,
(e) avoiding use of pesticides, fertilizers, and other chemicals in a concentration sufficient to kill worms hatching from the cocoons.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. Benzenesulfonanilide compounds of formulae I and I\u2032:
wherein
R1 is hydrogen or methyl;
R2 is hydrogen or methyl;
R3 hydrogen, fluorine, C1-C2 alkoxy or fluorinated C1-C2 alkoxy;
R4 is hydrogen or C1-C4 alkyl or fluorinated C1-C4 alkyl;
R5 is hydrogen, fluorine, C1-C2 alkyl, fluorinated C1-C2 alkyl, C1-C2 alkoxy or fluorinated C1-C2 alkoxy; and
R6 is hydrogen, fluorine or chlorine;
and physiologically tolerated acid addition salts and the N-oxides thereof.
2. The compounds as claimed in claim 1, wherein R1 is hydrogen.
3. The compounds as claimed in claim 1, wherein R2 is hydrogen.
4. The compounds as claimed in claims 1 or 2, wherein R2 is methyl.
5. The compounds as claimed in claim 4, wherein the carbon atom that carries R2 has S-configuration.
6. The compounds as claimed in claim 4, wherein the carbon atom that carries R2 has R-configuration.
7. The compounds as claimed in claim 1, wherein R3 is methoxy.
8. The compounds as claimed in claim 1, wherein R3 is hydrogen or fluorine.
9. The compounds as claimed in claim 1, wherein R4 is hydrogen or C1-C2 alkyl.
10. The compounds as claimed in claim 9, wherein R4 is hydrogen.
11. The compounds as claimed in claim 1, wherein R5 is hydrogen.
12. The compounds as claimed in claim 1, wherein R5 is methoxy or difluoromethoxy.
13. The compounds as claimed in claim 1, wherein R6 is hydrogen.
14. The compounds as claimed in claim 1, wherein R5 and R6 are hydrogen, R3 is selected from the group consisting of C1-C2 alkoxy and fluorinated C1-C2 alkoxy and R4 is selected from the group consisting of hydrogen or C1-C2 alkyl.
15. The compounds as claimed in claim 1, wherein one or more of the following provisos a), b), c) or d) are met:
a) R5 is selected from the group consisting of fluorine, C1-C2 alkyl fluorinated C1-C2 alkyl, C1-C2 alkoxy or fluorinated C1-C2 alkoxy;
b) R6 is fluorine or chlorine;
c) R3 is hydrogen or fluorine; andor
d) R4 is C3-C4-alkyl or fluorinated C1-C4-alkyl;
16. The compounds as claimed in claim 15, wherein R6 is fluorine or chlorine, which is located in the 6-position of the benzene ring.
17. The compounds as claimed in claim 15, wherein R6 is fluorine or chlorine, which is located in the 5-position of the benzene ring.
18. The compounds as claimed in any of claims 15, 16 or 17, wherein R3 is hydrogen.
19. The compounds as claimed in any of claims 15, 16 or 17, wherein R5 is methoxy.
20. The compounds as claimed in claim 15, wherein R3 is hydrogen.
21. The compounds as claimed in claim 1, wherein the OCHF2-radical in formula I is located on the benzene ring in the ortho-position with respect to the sulfonyl group.
22. The compounds as claimed in claim 1, wherein the OCHF2-radical in formula I is located on the benzene ring in the meta-position with respect to the sulfonyl group.
23. The compounds as claimed in claim 1, wherein the OCHF2-radical in formula I is located on the benzene ring in the para-position with respect to the sulfonyl group.
24. A pharmaceutical composition comprising at least one compound as claimed in claim 1, optionally together with at least one physiologically acceptable carrier or auxiliary substance.
25. A method for treating a medical disorder selected from diseases of the central nervous system, addiction diseases or obesity, said method comprising administering an effective amount of at least one compound as claimed in any of claims 1 to 23 to a subject in need thereof.
26. The method as claimed in claim 25, wherein the medical disorder is a disease of the central nervous system.
27. The method as claimed in claim 26, for treating cognitive dysfunctions.
28. The method as claimed in claim 26, for treating cognitive dysfunctions associated with Alzheimer’s disease.
29. The method as claimed in claim 26, for treating cognitive dysfunctions associated with schizophrenia.
30. The method as claimed in claim 25, wherein the medical disorder is an addiction disease.
31. The method as claimed in claim 25, wherein the medical disorder is obesity.