1-11. (canceled)
12. A process for producing a solid pharmaceutical powder, comprising the steps of:
(a) providing a feed mixture of microcrystalline cellulose and a solution of a water-soluble polymer and 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile or a pharmaceutically acceptable acid addition salt thereof, in a solvent;
(b) spray-drying the feed mixture from step (a) to form a solid dispersion of 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile or a pharmaceutically acceptable acid addition salt thereof, and the polymer by introducing the feed mixture as droplets into a spray-drying chamber via an atomizing means.
13. The process of claim 12, wherein 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile base is used.
14. The process of claim 12, wherein the microcrystalline cellulose has an average particle size of 5-50 \u03bcm.
15. The process of claim 12, wherein the microcrystalline cellulose has an average particle size of 10-30 \u03bcm.
16. The process of claim 12 wherein the microcrystalline cellulose has an average particle size of 20 \u03bcm.
17. The process of claim 12, wherein the water-soluble polymer is selected from hydroxypropylmethyl cellulose, polyvinyl pyrrolidone, and copolyvidone.
18. The process of claim 17, wherein the polymer is hydroxypropylmethyl cellulose.
19. The process of claim 12, wherein the weight ratio of the polymer to 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile or a pharmaceutically acceptable acid addition salt thereof is in the range of from 10:1 to 1:1.
20. The process of claim 19, wherein the weight ratio of the polymer to 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile or a pharmaceutically acceptable acid addition salt thereof is in the range of from 5:1 to 1:1.
21. The process of claim 20, wherein the weight ratio of the polymer to 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile or a pharmaceutically acceptable acid addition salt thereof is 3:1.
22. The process of claim 19, wherein the weight ratio of microcrystalline cellulose to 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile or a pharmaceutically acceptable acid addition salt thereof is in the range of from 1:1 to 1:3.
23. The process of claim 22, wherein the weight ratio of microcrystalline cellulose to 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile or a pharmaceutically acceptable acid addition salt thereof is 1:2.
24. The process of claim 12, wherein the solvent is selected from the group consisting of acetone, dichloromethane, ethanol, methanol and combinations thereof.
25. The process of claim 12, wherein the atomizing means comprises a high-pressure nozzle.
26. A solid dispersion of 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile or a pharmaceutically acceptable acid addition salt thereof in powder form prepared by the process of claim 12.
27. The dispersion of claim 26 comprising 4-6-amino-5-bromo-2-(4-cyanophenyl)amino-4-pyrimidinyloxy-3,5-dimethylbenzonitrile base.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A configuration management system comprising:
a plurality of databases that stores information about resources as configuration items;
a configuration management apparatus;
a plurality of proxy apparatuses; and
a proxy management apparatus,
wherein the proxy management apparatus receives configuration items from the plurality of databases, reconciles the receives configuration items, selects a destination proxy apparatus such that processing by the plurality of proxy apparatuses is distributed over the proxy apparatuses, and sends the reconciled configuration items to the selected proxy apparatus,
wherein the proxy apparatuses store configuration items sent from the proxy management apparatus,
and wherein the configuration management apparatus receives a query from a client, selects among the plurality of proxy apparatuses a proxy apparatus that stores a configuration item that is to serve as a query result, and receives the configuration item from the selected proxy apparatus.
2. The configuration management system as claimed in claim 1, wherein the proxy management apparatus selects a destination proxy apparatus such that the numbers of configuration items stored in the plurality of proxy apparatuses are substantially equal to each other, thereby selecting a destination proxy apparatus such that processing by the plurality of proxy apparatuses is distributed over the proxy apparatuses.
3. The configuration management system as claimed in claim 1, wherein the proxy management apparatus receives proxy-apparatus-specific load information from the plurality of proxy apparatuses, and, based on the received load information, sends the plurality of proxy apparatuses an instruction to move configuration items that are stored in the plurality of proxy apparatuses such that loads are evenly distributed over the plurality of proxy apparatuses,
and wherein the plurality of proxy apparatuses exchange stored configuration items with each other based on the instruction to move.
4. The configuration management system as claimed in claim 1, wherein the configuration management apparatus determines a version number of a backup to send information indicative of the version number to the proxy management apparatus and the plurality of proxy apparatuses, and uses the version number to back up data about the plurality of proxy apparatuses that are locally stored,
wherein the proxy management apparatus uses the version number to back up data about the plurality of proxy apparatuses that are locally stored,
and wherein the plurality of proxy apparatuses use the version number to back up the configuration items that are locally stored.
5. A proxy system comprising:
a plurality of proxy apparatuses; and
a proxy management apparatus,
wherein the proxy management apparatus receives configuration items from a plurality of databases that store information about resources as configuration items, reconciles the receives configuration items, selects a destination proxy apparatus such that processing by the plurality of proxy apparatuses is distributed over the proxy apparatuses, and sends the reconciled configuration items to the selected proxy apparatus,
wherein the proxy apparatuses store configuration items sent from the proxy management apparatus, and send the configuration management apparatus one or more configuration items responsive to a request from the configuration management apparatus that receives a query from a client.
6. The configuration management system as claimed in claim 5, wherein the proxy management apparatus selects a destination proxy apparatus such that the numbers of configuration items stored in the plurality of proxy apparatuses are substantially equal to each other, thereby selecting a destination proxy apparatus such that processing by the plurality of proxy apparatuses is distributed over the proxy apparatuses.
7. The configuration management system as claimed in claim 5, wherein the proxy management apparatus receives proxy-apparatus-specific load information from the plurality of proxy apparatuses, and, based on the received load information, sends the plurality of proxy apparatuses an instruction to move configuration items that are stored in the plurality of proxy apparatuses such that loads are evenly distributed over the plurality of proxy apparatuses,
and wherein the plurality of proxy apparatuses exchange stored configuration items with each other based on the instruction to move.
8. The configuration management system as claimed in claim 5, wherein the proxy management apparatus uses a version number sent from the configuration management apparatus to back up data about the plurality of proxy apparatuses that are locally stored,
and wherein the plurality of proxy apparatuses use the version number to back up the configuration items that are locally stored.
9. A configuration management method comprising:
receiving configuration items from a plurality of databases that store information about resources as configuration items;
reconciling the received configuration items;
selecting a destination proxy apparatus such that processing by the plurality of proxy apparatuses is distributed over the proxy apparatuses;
sending the reconciled configuration items to the selected proxy apparatus;
storing in the selected proxy apparatus the configuration items that are sent; and
receiving a query from a client, selecting among the plurality of proxy apparatuses a proxy apparatus that stores a configuration item that is to serve as a query result, and receiving the configuration item from the selected proxy apparatus.
10. The configuration management method as claimed in claim 9, wherein the selecting selects a destination proxy apparatus such that the numbers of configuration items stored in the plurality of proxy apparatuses are substantially equal to each other, thereby selecting a destination proxy apparatus such that processing by the plurality of proxy apparatuses is distributed over the proxy apparatuses.
11. The configuration management method as claimed in claim 9, further performing:
receiving proxy-apparatus-specific load information from the plurality of proxy apparatuses;
sending, to the plurality of proxy apparatuses based on the received load information, an instruction to move configuration items that are stored in the plurality of proxy apparatuses such that loads are evenly distributed over the plurality of proxy apparatuses; and
exchanging configuration items stored in the plurality of proxy apparatuses between plurality of proxy apparatuses based on the instruction to move.
12. The configuration management method as claimed in claim 9, further performing:
determining a version number for a backup; and
backing up data about the plurality of proxy apparatuses by use of the version number, and backing up configuration items stored in the plurality of proxy apparatuses by use of the version number.