1. A non-transitory computer readable storage medium having stored thereon computer executable instructions that, when executed on a computer, configure the computer to perform a method comprising:
identifying a plurality of items of electronic content that have been accessed by a plurality of individuals over a global communications network and on which an advertising serving entity has a capability of delivering at least one digital advertisement to each of the plurality of individuals on the global communications network, wherein the plurality of items of electronic content accessed by the plurality of individuals over the global communications network is a subset of items of electronic content that is less than an entire set of items of electronic content that is accessible by the plurality of individuals over the global communications network;
storing a set of content comprising the plurality of identified items of electronic content;
normalizing the set of content;
identifying each of a plurality of keywords contained in the set of content; and
measuring a semantic distance between each of the identified keywords using a total number of content items in the set, a number of at least one of the plurality of keywords in the set and a number of at least one other of the plurality of keywords in the set; and
upon an individual accessing an item of electronic content on the global communications network, selecting one or more digital advertisements to serve to the individual by the advertising serving entity in connection with an advertising campaign based on at least the measured semantic distance and content of the item of electronic content,
wherein measuring the semantic distance is calculated as 1\u2212\u03c4 wherein
Keyword i is one of the identified keywords;
Keyword j is another one of the identified keywords;
a semantic distance between Keyword i and Keyword j is to be measured;
n is a total number of content items in the set;
ni is a number of content items in the set that contain a keyword indexed by i;
nj is a number of content items in the set that contain a keyword indexed by j;
nij is a number of the content items containing both keywords indexed by i and j;
m11 is equal to nij;
m12 is equal to ni\u2212nij;
m21 is equal to nj\u2212nij;
m22 is equal to n\u2212ni\u2212nj+nij;
m+1 is equal to ni;
m+2 is equal to m12+m22;
mi+ is equal to ni;
m2+ is equal to m21+m22; and
\u03c4
=
m
11
2
n
\u2062
\u2062
m
1
+
+
m
12
2
n
\u2062
\u2062
m
1
+
+
m
21
2
n
\u2062
\u2062
m
2
+
+
m
22
2
n
\u2062
\u2062
m
2
+
–
(
m
+
1
n
)
2
–
(
m
+
2
n
)
2
1
–
(
m
+
1
n
)
2
–
(
m
+
2
n
)
2
.
2. The computer readable storage medium of claim 1, the method further comprising:
classifying each of the plurality of identified items of electronic content in the set using, at least in part, the measured semantic distance.
3. The computer readable storage medium of claim 1 wherein the normalization is performed using a capture-recapture methodology.
4. A system comprising:
memory operable to store at least one program; and
at least one processor communicatively coupled to the memory, in which the at least one program, when executed by the at least one processor, causes the at least one processor to perform a method comprising the steps of:
identifying a plurality of items of electronic content that have been accessed by a plurality of individuals over a global communications network and on which an advertising serving entity has a capability of delivering at least one digital advertisement to each of the plurality of individuals on the global communications network, wherein the plurality of items of electronic content accessed by the plurality of individuals over the global communications network is a subset of items of electronic content that is less than an entire set of items of electronic content that is accessible by the plurality of individuals over the global communications network;
storing a set of content comprising the plurality of identified items of electronic content;
normalizing the set of content;
identifying each of a plurality of keywords contained in the set of content; and
measuring a semantic distance between each of the identified keywords using a total number of content items in the set, a number of at least one of the plurality of keywords in the set and a number of at least one other of the plurality of keywords in the set; and
upon an individual accessing an item of electronic content on the global communications network, selecting one or more digital advertisements to serve to the individual by the advertising serving entity in connection with an advertising campaign based on at least the measured semantic distance and content of the item of electronic content, wherein measuring the semantic distance is calculated as 1\u2212\u03c4 wherein
Keyword i is one of the identified keywords;
Keyword j is another one of the identified keywords;
a semantic distance between Keyword i and Keyword j is to be measured;
n is a total number of content items in the set;
ni is a number of content items in the set that contain a keyword indexed by i;
nj is a number of content items in the set that contain a keyword indexed by j;
nij is a number of the content items containing both keywords indexed by i and j;
m11 is equal to nij;
m12 is equal to ni\u2212nij;
m21 is equal to nj\u2212nij;
m22 is equal to n\u2212ni\u2212nj+nij;
m+1 is equal to ni;
m+2 is equal to m12+m22;
m1+ is equal to ni;
m2+ is equal to m21+m22; and
\u03c4
=
m
11
2
n
\u2062
\u2062
m
1
+
+
m
12
2
n
\u2062
\u2062
m
1
+
+
m
21
2
n
\u2062
\u2062
m
2
+
+
m
22
2
n
\u2062
\u2062
m
2
+
–
(
m
+
1
n
)
2
–
(
m
+
2
n
)
2
1
–
(
m
+
1
n
)
2
–
(
m
+
2
n
)
2
.
5. The system of claim 4, the method further comprising:
classifying each of the plurality of identified items of electronic content in the set using, at least in part, the measured semantic distance.
6. The system of claim 4 wherein the normalization is performed using a capture-recapture methodology.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-23. (canceled)
24. A process for preparing a sustained release 4-aminopyridine composition comprising the steps of:
(a) dry blending said 4-aminopyridine with a rate-controlling polymer to form a blend comprising 4-aminopyridine dispersed in said rate-controlling polymer; and
(b) compressing the blend formed in step (a) to form one or more tablets, wherein the 4-aminopyridine content of each of the one or more tablets is 10 mg of 4-aminopyridine.
25. The process of claim 24 further comprising the step of milling the 4-aminopyridine to produce a particle size distribution such that 90% of the 4-aminopyridine particles are smaller than 1.5 mm, 50% of the 4-aminopyridine particles are smaller than 1 mm, and 10% of the 4-aminopyridine particles are smaller than 500 \u03bcm.
26. The process of claim 25, wherein the milling step is carried out prior to dispersing the 4-aminopyridine in the rate-controlling polymer.
27. The process of claim 24, wherein one or more excipients are added to the blend during the dry blending step.
28. The process of claim 27, wherein a diluent, a glidant andor a lubricant are added to the blend during the dry blending step.
29. The process of claim 24 further comprising the step of: (c) coating one or more tablets formed in step (b) with a film coating.
30. The process of claim 29, wherein the film coating is a light-protective andor cosmetic film coating.
31. The process of claim 28, wherein the blend is formed using 4-aminopyridine in an amount from about 0.5 to about 6.25% ww, the rate-controlling polymer in an amount from about 20 to about 96% ww, and the diluent in an amount from about 10 to about 80% ww of the sustained release composition.
32. The process of claim 28, wherein the blend is formed using 4-aminopyridine in an amount less than 4.75% ww, the rate-controlling polymer in an amount from 20 to 70% ww, and the diluent in an amount from 20 to 50% ww of the sustained release composition.
33. The process of claim 32, wherein the rate-controlling polymer is hydroxypropyl methylcellulose and the diluent is microcrystalline cellulose.
34. A sustained release 4-aminopyridine composition that is the product of the process of claim 24, 25, 32, or 33.