1. A manufacturing method of thermal module, comprising steps of:
providing a base seat with a raised section and a heat dissipation unit with a recess;
heating the heat dissipation unit and fitting the raised section of the base seat into the recess of the heat dissipation unit to connect the heat dissipation unit with the base seat; and
tightly connecting the heat dissipation unit with the base seat to form an integrated body after the heat dissipation unit is cooled.
2. The manufacturing method of thermal module as claimed in claim 1, wherein an inner side of the recess is formed with at least one protrusion and at least one side of the raised section is formed with a groove corresponding to the protrusion, the protrusion being connected to the groove.
3. A thermal module made by means of the manufacturing method as claimed in claim 1, the thermal module comprising:
a base seat having a raised section raised from a middle section of the base seat; and
a heat dissipation unit including multiple radiating fins and a recess corresponding to the raised section, the recess being formed on one side of the heat dissipation unit, which side faces the base seat, the raised section being connected to the recess.
4. The thermal module as claimed in claim 3, wherein an inner side of the recess is formed with at least one protrusion and at least one side of the raised section is formed with a groove corresponding to the protrusion, the protrusion being connected to the groove.
5. The thermal module as claimed in claim 3, wherein the raised section has a first side, a second side and a third side, two ends of the second side being respectively connected with the first and third sides.
6. The thermal module as claimed in claim 3, wherein the second side has an arched shape.
7. The thermal module as claimed in claim 3, wherein the second side has a rectangular shape.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A platelet preservation package, comprising: a platelet preservation composition comprising:
a short-to-ultrashort acting antiplatelet agent, wherein said antiplatelet agent is a GPIIbIIIa inhibitor;
a short-to-ultrashort acting anticoagulant, wherein said anticoagulant is a compound that reversibly inhibits factor Xa, or factor IIa, or both; and
a bag for storing the platelet preservation composition,
wherein said antiplatelet agent and said anticoagulant are stored in said bag and wherein said composition is capable of extending the shelf-life of platelets when mixed with said platelets in said bag.
2. The platelet preservation package of claim 1, wherein said antiplatelet agent is capable of reversibly blocking platelet activation andor aggregation by blocking sites on the platelet surface.
3. The platelet preservation package of claim 1, wherein said antiplatelet agent is selected from the group consisting of eptifibatide, orbofiban, xemilofiban, lamifiban, tirofiban, and mixtures thereof.
4. The platelet preservation package of claim 1, wherein said antiplatelet agent is selected from the group consisting of linear and cyclic RGD-containing peptides.
5. The platelet preservation package of claim 4, wherein said linear and cyclic RGD-containing peptides are conjugated to a nitric oxide donor.
6. The platelet preservation package of claim 1, wherein said antiplatelet agent is a pharmaceutically acceptable antiplatelet agent and has a circulating half-life of inhibition of about less than 4 hours.
7. The platelet preservation package of claim 1, wherein said antiplatelet agent comprises about 0.001 mg to about 5 mg of a GPIIbIIIa inhibitor.
8. The platelet preservation package of claim 1, wherein said anticoagulant is a short-to-ultrashort acting Xa inhibitor with a circulating half-life of less than 4 hours.
9. The platelet preservation package of claim 1, wherein said anticoagulant is a short-to-ultrashort acting IIa inhibitor, and wherein said short-to-ultrashort acting IIa inhibitor is selected from the group consisting of hirudin, hirulog, melgatran, and combinations thereof.
10. The platelet preservation package of claim 1, wherein said anticoagulant is a pharmaceutically acceptable anticoagulant and is a combination of at least one short-to-ultrashort acting IIa inhibitor, and at least one short-to-ultrashort acting Xa inhibitor.
11. The platelet preservation package of claim 1, wherein the preserved platelet composition further comprises a short-to-ultrashort acting broad spectrum anti-microbial agent selected from the group consisting of: natural penicillins, semisynthetic penicillins, monobactam, cephalosporin, carbapenems, vancomycin, isoniazid, ethambutol, aminoglycoside, tetracycline, chloramphenicol, macrolide, rifamycin, quinolone, fluoroquinolone, sulfonamide, polyene antibiotic, imidazole, triazole, griseofulvin and combinations thereof.
12. A platelet preservation package, comprising: a platelet preservation composition comprising:
a short-to-ultrashort acting antiplatelet agent, wherein said antiplatelet agent is a GPIIbIIIa inhibitor;
a short-to-ultrashort acting anticoagulant, wherein said anticoagulant is a compound that reversibly inhibits factor Xa; and
a blood collection bag,
wherein said antiplatelet agent and said anticoagulant are stored in said blood collection bag and wherein said composition is capable of extending the shelf-life of platelets when mixed with said platelets in said blood collection bag.
13. A platelet preservation package, comprising: a platelet preservation composition comprising:
a short-to-ultrashort acting antiplatelet agent, wherein said antiplatelet agent is a GPIIbIIIa inhibitor;
a short-to-ultrashort acting anticoagulant, wherein said anticoagulant is a compound that reversibly inhibits factor IIa; and
a blood collection bag,
wherein said antiplatelet agent and said anticoagulant are stored in said blood collection bag and wherein said composition is capable of extending the shelf-life of platelets when mixed with said platelets in said blood collection bag.