1. A method, comprising:
providing a signal associated with initiation of an analyte sensor, the analyte sensor for monitoring analyte level;
providing a count, wherein the count is temporally associated with the signal associated with the initiation of the analyte sensor;
periodically incrementing the count;
storing the count temporally associated with the signal associated with the initiation of the analyte sensor, wherein when sensor life of the initiated analyte sensor has not expired and a system failure is detected, continuing use of the initiated analyte sensor based at least in part on the stored count;
providing a new sensor count; and
incrementing the new sensor count only when a new sensor is first initiated.
2. The method of claim 1, wherein incrementing the count is associated with a measurement cycle.
3. The method of claim 2, wherein the measurement cycle comprises a periodic determination of the monitored analyte level.
4. The method of claim 1, including storing the count temporally associated with the initiation of the analyte sensor in a memory device.
5. The method of claim 4, wherein the memory device is a nonvolatile memory device, such that count information stored in the memory is not lost during the system failure.
6. The method of claim 1, wherein the system failure is a component failure.
7. The method of claim 1, wherein the system failure includes a battery drain, power shut-down, or reset.
8. The method of claim 1, including outputting a message or alarm when the system failure Occurs.
9. The method of claim 1, wherein incrementing the count is associated with communication of data packets.
10. The method of claim 1, wherein the analyte sensor comprises a working electrode that includes an analyte responsive enzyme and a mediator, wherein at least one of the analyte responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and wherein at least one of the analyte responsive enzyme and the mediator is crosslinked with the polymer.
11. A data processing device, comprising:
a first counter configured to incrementally count;
a data communication unit;
a data processing section coupled to the data communication unit and the first counter, the data processing section configured to determine an elapsed life of an analyte sensor;
wherein when a device failure is detected and the determined elapsed life indicates that analyte sensor life has not expired, continuing use of the analyte sensor based at least in part on the first counter configured to incrementally count; and
a new sensor counter coupled to the data processing section and configured to increment a new sensor count only when a new sensor is first initiated.
12. The data processing device of claim 11, wherein the analyte sensor is configured to generate a signal associated with a level of monitored analyte.
13. The data processing device of claim 11, further including a storage unit configured to store a count temporally associated with initiation of the analyte sensor.
14. The data processing device of claim 11, wherein the analyte sensor includes a glucose sensor.
15. The data processing device of claim 13, wherein the data processing device is configured to compare the stored count with an incremented count associated with the first counter to determine the elapsed life of the analyte sensor.
16. The data processing device of claim 15, wherein the data processing unit is configured to estimate the remaining sensor life based on the stored count and the incremented count.
17. The data processing device of claim 13, further including an output unit configured to output one or more signals associated with the count.
18. The data processing device of claim 13, wherein the analyte sensor comprises a working electrode that includes an analyte responsive enzyme and a mediator, wherein at least one of the analyte responsive enzyme and the mediator is chemically bonded to a polymer disposed on the working electrode, and wherein at least one of the analyte responsive enzyme and the mediator is crosslinked with the polymer.
19. A method of operating an analyte monitoring system comprising:
providing a signal associated with initiation of an analyte sensor;
providing a first counter to count incrementally; and
providing a second counter to incrementally count by one only when a new sensor is first initiated;
wherein when sensor life of the initiated analyte sensor has not expired and a system failure is detected, continuing use of the initiated analyte sensor based at least in part on the first counter and the second counter.
20. The method of claim 19, wherein the method further includes determining a number of sensors initiated by determining a count of the second counter.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound selected from those of formula (I):
wherein:
n represents an integer from 1 to 6 inclusive,
R1 and R2, which may be identical or different, each independently of the other represent a hydrogen atom, a linear or branched (C1-C6)alkyl group or an aryl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched,
R3 and R4, which may be identical or different, each independently of the other represent a hydrogen atom or a linear or branched (C1-C6)alkyl group, wherein at least one of the two groups R3 or R4 represents a linear or branched (C1-C6)alkyl group,
R5 and R6, which may be identical or different, each independently of the other represent a hydrogen atom or a linear or branched (C1-C6)alkyl, halogen, hydroxy, linear or branched (C1-C6)alkoxy, cyano, nitro, linear or branched (C2-C6)acyl, linear or branched (C1-C6)alkoxycarbonyl, linear or branched (C1-C6)trihaloalkyl or linear or branched (C1-C6)trihaloalkoxy group or an amino group optionally substituted by one or two linear or branched (C1-C6)alkyl groups,
it being understood that an aryl group means phenyl, biphenyl, naphthyl, dihydronaphthyl, tetrahydronaphthyl, indanyl or indenyl group, each of the groups being optionally substituted by one or more identical or different groups selected from halogen, linear or branched (C1-C6)alkyl, hydroxy, cyano, nitro, linear or branched (C1-C6)alkoxy, linear or branched (C2-C7)acyl, linear or branched (C1-C6)alkoxycarbonyl, linear or branched (C1-C6)trihaloalkyl and linear or branched (C1-C6)trihaloalkoxy groups and amino groups optionally substituted by one or two linear or branched (C1-C6)alkyl groups,
its enantiomers, diastereoisomers and additional salts thereof with a pharmaceutically acceptable acid or base.
2. The compound of claim 1, wherein n is an integer having the value 1, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.
3. The compound of claim 1, wherein R1 and R2, which may be identical or different, each represent a hydrogen atom or a linear or branched (C1-C6)alkyl group, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.
4. The compound of claim 1, wherein R3 and R4, which may be identical or different, each represent a hydrogen atom or methyl group, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.
5. The compound of claim 1, wherein R5 and R6, which may be identical or different, each represents a hydrogen atom or a halogen atom, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.
6. The compound of claim 1 which is selected from:
(1S,2S), (1R,2R)-N,2-dimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2S)- or (1R,2R)-(\u2212)-N,2-dimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2S)- or (1R,2R)-(+)-N,2-dimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2S), (1R,2R)-2-methyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2S)- or (1R,2R)-(\u2212)-2-methyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2S)- or (1R,2R)-(+)-2-methyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2S), (1R,2R)-N,N,2-trimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2S)- or (1R,2R)-(+)-N,N,2-trimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2S)- or (1R,2R)-(\u2212)-N,N,2-trimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2S), (1R,2R)-1-{(6-chloro-3-pyridinyl)oxymethyl}-N,2-dimethylcyclopropanamine,
(1S,2S)- or (1R,2R)-(\u2212)-1-{(6-chloro-3-pyridinyl)oxymethyl}-N,2-dimethylcyclopropanamine,
(1S,2S)- or (1R,2R)-(+)-1-{(6-chloro-3-pyridinyl)oxymethyl}-N,2-dimethylcyclopropanamine,
(1S,2S), (1R,2R)-1-{(6-chloro-3-pyridinyl)oxymethyl}-2-methylcyclopropanamine,
(1S,2S)- or (1R,2R)-(\u2212)-1-{(6-chloro-3-pyridinyl)oxymethyl}-2-methylcyclopropanamine,
(1S,2S)- or (1R,2R)-(+)-1-{(6-chloro-3-pyridinyl)oxymethyl}-2-methylcyclopropanamine,
(1S,2S), (1R,2R)-1-{(6-chloro-3-pyridinyl)oxymethyl}-N,N,2-trimethylcyclopropanamine,
(1S,2S)- or (1R,2R)-(+)-1-{(6-chloro-3-pyridinyl)oxymethyl}-N,N,2-trimethylcyclopropanamine,
(1S,2S)- or (1R,2R)-(\u2212)-1-{(6-chloro-3-pyridinyl)oxymethyl}-N,N,2-trimethylcyclopropanamine,
(1S,2R), (1R,2S)-N,2-dimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2R)- or (1R,2S)-(+)-N,2-dimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2R)- or (1R,2S)-(\u2212)-N,2-dimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2R), (1R,2S)-1-{(5-bromo-3-pyridinyl)oxymethyl}-N,2-dimethylcyclopropanamine,
(1S,2R), (1R,2S)-2-methyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(1S,2R), (1R,2S)-N,N,2-trimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(R,S)-N,2,2-trimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
(R or S)-(+)-N,2,2-trimethyl-1-(3-pyridinyloxy)methylcyclopropanamine, and
(R or S)-(\u2212)-N,2,2-trimethyl-1-(3-pyridinyloxy)methylcyclopropanamine,
its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.
7. A pharmaceutical composition comprising as active ingredient a compound according to claim 1, alone or in combination with one or more pharmaceutically acceptable, inert, non-toxic excipients or carriers.