1. A method of assessing an individual for the presence or absence of a genetic polymorphism associated with hereditary spastic paraplegia (SPG), the method comprising assessing a test sample from the individual for the presence of at least one mutation in the receptor expression enhancing protein 1 (REEP1) gene, wherein the presence of at least one mutation is indicative of the presence of a genetic polymorphism associated with hereditary spastic paraplegia.
2. The method of claim 1, wherein the test sample from the individual comprises genomic DNA.
3. The method of claim 2, wherein the genomic DNA comprises chromosome 2 or a fragment thereof comprising 2p12.
4. The method of claim 1, wherein assessing the test sample comprises amplifying all or a fragment of the REEP1 gene.
5. The method of claim 1, wherein assessing the test sample comprises direct sequence analysis.
6. The method of claim 1, wherein the mutation is selected from the group consisting of: a single base transversion C\u2192G at nucleotide 56 (56 C\u2192G); a single base transition C\u2192A at nucleotide 59 (59C\u2192A); a transition at nucleotide 182-2G\u2192A (182-2G\u2192A); a single base deletion of nucleotide 193 (193delT); a single base deletion of nucleotide 223 (223delC); a single base deletion of nucleotide 507 (507delC); a single base deletion of nucleotide 526 (526delG); a single base transition C\u2192T in the 3\u2032-UTR at 606+14 (606+14C\u2192T); a single base transition G\u2192T in the 3\u2032-UTR at 606+43 (606+43G\u2192T); and a single base transition G\u2192A in the 3\u2032-UTR at 606+50 59C\u2192A (606+50G\u2192A)).
7. A method of diagnosing hereditary spastic paraplegia (SPG) in an individual, the method comprising assessing a test sample from the individual for the presence of at least one mutation in the receptor expression enhancing protein 1 (REEP1) gene, wherein the presence of at least one mutation is indicative of the presence of hereditary spastic paraplegia.
8. The method of claim 7, wherein the test sample from the individual comprises genomic DNA.
9. The method of claim 8, wherein the genomic DNA comprises chromosome 2 or a fragment thereof comprising 2p12.
10. The method of claim 7, wherein assessing the test sample comprises amplifying all or a fragment of the REEP1 gene.
11. The method of claim 7, wherein assessing the test sample comprises direct sequence analysis.
12. The method of claim 7, wherein the mutation is selected from the group consisting of: a single base transversion C\u2192G at nucleotide 56 (56 C\u2192G); a single base transition C\u2192A at nucleotide 59 (59C\u2192A); a transition at nucleotide 182-2G\u2192A (182-2G\u2192A); a single base deletion of nucleotide 193 (193delT); a single base deletion of nucleotide 223 (223delC); a single base deletion of nucleotide 507 (507delC); a single base deletion of nucleotide 526 (526delG); a single base transition C\u2192T in the 3\u2032-UTR at 606+14 (606+14C\u2192T); a single base transition G\u2192T in the 3\u2032-UTR at 606+43 (606+43G\u2192T); and a single base transition G\u2192A in the 3\u2032-UTR at 606+50 59C\u2192A (606+50G\u2192A)).
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of correcting deviation of a temperature sensor placed in a header having a plurality of nozzles in an inkjet printer, the method comprising the steps of:
spraying ink through the nozzles a predetermined number of times;
measuring a temperature of the temperature sensor corresponding to the number of sprayed times;
measuring a voltage output from the temperature sensor; and
determining a correction value of the temperature sensor using the measured temperature and the output voltage of the temperature sensor.
2. The method of claim 1, further comprising storing the correction value in a nonvolatile memory.
3. The method of claim 1, wherein the temperature sensor comprises a thermistor.
4. The method of claim 1, wherein the correction value is determined according to the following equation:
Temperature=Slope*Output voltage+Correction value, in which the Slope is the ratio of the measured temperature to the output voltage.
5. The method of claim 4, wherein the Slope is 100.
6. The method of claim 1, wherein the step of measuring the output voltage from the temperature sensor comprises:
amplifying the output voltage from the temperature sensor; and
converting the analog amplified output voltage into a digital form.
7. The method of claim 1, further comprising measuring deviation corrected temperature of the temperature sensor based on the output voltage of the temperature sensor using the determined correction value.
8. An apparatus for correcting deviation of a temperature sensor placed in a header having a plurality of nozzles in an inkjet printer, the apparatus comprising:
a header for spraying ink through the nozzles a predetermined number of times;
a temperature measuring unit for measuring a temperature of the temperature sensor corresponding to the number of sprayed times;
a voltage measuring unit for measuring a voltage output from the temperature sensor; and
a controller for determining a correction value of the temperature sensor using the measured temperature and the output voltage of the temperature sensor.
9. The apparatus of claim 8, further comprising a nonvolatile memory storing the correction value.
10. The apparatus of claim 8, wherein the temperature sensor comprises a thermistor.
11. The apparatus of claim 8, wherein the controller determines the correction value using the following equation:
Temperature=Slope*Output voltage+Correction value, in which the Slope is the ratio of the measured temperature to the output voltage.
12. The apparatus of claim 11, wherein the Slope is 100.
13. The apparatus of claim 8, wherein the voltage measuring unit comprises:
an amplifier for amplifying the output voltage from the temperature sensor; and
an analog to digital converter for converting the amplified output voltage into a digital form.
14. The apparatus of claim 13, wherein the amplifier comprises an operational amplifier.