1. A pharmaceutical cream formulated with 1-(2-methylpropyl)-1H imidazo4,5-cquinolin-4-amine (imiquimod) for topical application to a dermal or mucosal surface to treat a dermal andor mucosal associated condition, said pharmaceutical cream comprising:
a therapeutically effective amount of imiquimod;
a pharmaceutically acceptable vehicle including an oleic acid component, where said oleic acid component contains at least about 80% oleic acid by weight as a fatty acid and has a peroxide value of no more than about 5 milliequivalents of oxygen per kilogram and contains less than about 1% by weight polar impurities at or prior to formulation of said pharmaceutical cream; and
an amount of imiquimod-related impurities formed during storage of said pharmaceutical cream;
wherein the amount of imiquimod-related impurities formed in said pharmaceutical cream is less than an amount of imiquimod-related impurities formed in an identical pharmaceutical imiquimod cream but formulated with a compendial grade oleic acid component when said pharmaceutical cream and the identical pharmaceutical imiquimod cream are each stored under identical storage conditions for about two months.
2. The pharmaceutical cream of claim 1, wherein said pharmaceutical cream contains imiquimod-related impurities in an amount of about 0.07% wt.wt. or less after storage of said pharmaceutical cream for about two months, where absorbance of said pharmaceutical cream is analyzed at about 308 nm using a UV detector.
3. The pharmaceutical cream of claim 1, wherein said pharmaceutical cream contains imiquimod-related impurities in an amount of no more than about 0.15% wt.wt. after storage of said pharmaceutical cream for about two months, where absorbance of said pharmaceutical cream is analyzed at about 308 nm using a UV detector.
4. The pharmaceutical cream of claim 1, wherein said pharmaceutical cream contains imiquimod-related impurities in an amount of about 0.04% wt.wt. after storage of said pharmaceutical cream for about two months, where absorbance of said pharmaceutical cream is analyzed at about 308 nm using a UV detector.
5. The pharmaceutical cream of claim 1, wherein said pharmaceutical cream further comprises an antioxidant selected from the group consisting of butylated hydroxyl toluene (BHT) and butylated hydroxyanisole (BHA).
6. The pharmaceutical cream of claim 1, wherein the imiquimod is present in an amount of not more than 10% by weight based on the total weight of said pharmaceutical cream and wherein the oleic acid component is present in an amount of no more than about 40% by weight based on the total weight of said pharmaceutical cream.
7. The pharmaceutical cream of claim 1, wherein the imiquimod is present in an amount of about 5% by weight based on the total weight of said pharmaceutical cream and wherein the oleic acid component is present in an amount of about 28% by weight based on the total weight of said pharmaceutical cream.
8. The pharmaceutical cream of claim 1, wherein the imiquimod is present in an amount of about 5% by weight based on the total weight of said pharmaceutical cream and wherein the oleic acid component is present in an amount of about 25% by weight based on the total weight of said pharmaceutical cream.
9. The pharmaceutical cream of claim 1, wherein said oleic acid component is Super Refined oleic acid NF.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A management method, comprising:
storing, in a map-information storing unit, map information, the map information being created based on an instruction to place a graphic image of a device on a map;
storing, in a device-information storing unit, information about a device that operates on a network;
setting, in a creation-state setting unit, a creation state of the map,
retaining, in a creation-state retaining unit, the map in association with the creation state of the map;
storing, in a storage unit, the information about the device in association with the creation state;
acquiring, in an acquiring unit and from the device that operates on the network, information about the device when the set creation state of the map indicates creation of the map is completed;
when the set creation state of the map indicates that creation of the map is completed,
determining, in a control unit, whether the acquired information about the device is in accordance with the map information stored in the map-information storing unit, and if the acquired information about the device is in accordance with the map information, allowing disclosure of the map, and if the acquired information about the device is not in accordance with the map information, not allowing disclosure of the map;
when a creation state is selected, displaying devices corresponding to information about the device associated with the creation state selected on the map; and
causing the control unit to prohibit disclosure of the map when the creation state that is set by the creation-state setting unit indicates creation of the map is in progress.
2. The management method according to claim 1, wherein the creation state that is set by the creation-state setting unit indicates either creation of the map is in progress or creation of the map is completed.
3. The management method according to claim 1 further comprising:
causing the control unit to prohibit disclosure of the map when the creation state that is set by the creation-state setting unit indicates creation of the map is in progress.
4. The management method according to claim 1 further comprising:
notifying the device that creation of the map is in progress when the creation state that is set by the creation-state setting unit indicates creation of the map is in progress.
5. A management device comprising:
a map-information storing unit that stores therein map information, the map information being created based on an instruction to place a graphic image of a device on a map;
a device-information storing unit that stores therein information about a device that operates on a network;
a creation-state setting unit that sets a creation state of the map,
a creation-state retaining unit that retains the map in association with the creation state of the map;
a storage unit that stores the information about the device in association with the creation state;
an acquiring unit that acquires, from the device that operates on the network, information about the device when the set creation state of the map indicates creation of the map is completed;
a control unit, wherein when the set creation state of the map indicates that creation of the map is completed,
the control unit determines whether the acquired information about the device is in accordance with the map information stored in the map-information storing unit, and if the acquired information about the device is in accordance with the map information, the control unit allows disclosure of the map, and if the acquired information about the device is not in accordance with the map information, the control unit does not allow disclosure of the map; and
an instructing unit that causes the control unit to prohibit disclosure of the map when the creation state that is set by the creation-state setting unit indicates creation of the map is in progress,
wherein when a creation state is selected, devices corresponding to information about a device associated with the creation state selected are displayed on the map.
6. The management device according to claim 5, wherein the creation state that is set by the creation-state setting unit indicates either creation of the map is in progress or creation of the map is completed.
7. The management device according to claim 5 further comprising a notifying unit that notifies the device that creation of the map is in progress when the creation state that is set by the creation-state setting unit indicates creation of the map is in progress.
8. A management system, comprising:
a device that operates on a network; and
a management device that includes
a map-information storing unit that stores therein map information, the map information being created based on an instruction to place a graphic image of a device on a map;
a device-information storing unit that stores therein information about the device that operates on a network;
a creation-state setting unit that sets a creation state of the map,
a creation-state retaining unit that retains the map in association with the creation state of the map;
a storage unit that stores the information about the device in association with the creation state;
an acquiring unit that acquires, from the device that operates on the network, information about the device when the set creation state of the map indicates creation of the map is completed; and
a control unit, wherein when the set creation state of the map indicates that creation of the map is completed,
the control unit determines whether the acquired information about the device is in accordance with the map information stored in the map-information storing unit, and if the acquired information about the device is in accordance with the map information, the control unit allows disclosure of the map, and if the acquired information about the device is not in accordance with the map information, the control unit does not allow disclosure of the map; and an instructing unit that causes the control unit to prohibit disclosure of the map when the creation state that is set by the creation-state setting unit indicates creation of the map is in progress,
wherein when a creation state is selected, devices corresponding to information about a device associated with the creation state selected are displayed on the map.
9. The management system according to claim 8, wherein the creation state that is set by the creation-state setting unit indicates either creation of the map is in progress or creation of the map is completed.
10. The management system according to claim 8, wherein the management device further includes a notifying unit that notifies the device that creation of the map is in progress when the creation state that is set by the creation-state setting unit indicates creation of the map is in progress.