1. A method of comparing nucleic acid sequences, comprising:
providing a nucleic acid sequence obtained from a sample and including at least one homopolymer region;
collapsing each of the homopolymer regions to a single nucleotide to form a representative sample sequence without homopolymer regions; and
comparing the representative sample sequence to at least one of a plurality of reference nucleic acid sequences without homopolymer regions to determine whether the representative sample sequence matches one of the plurality of reference nucleic acid sequences.
2. The method of claim 1, wherein the steps of collapsing and comparing include the use of indexes and a binary search to determine whether the representative sample sequence matches one of the plurality of reference nucleic acid sequences.
3. The method of claim 1, wherein the representative sample sequence and each of the plurality of reference nucleic acid sequences are of the same length.
4. The method of claim 1, wherein the representative sample sequence and each of the plurality of reference nucleic acid sequences are between about 15 and about 100 nucleotides in length.
5. The method of claim 1, wherein the plurality of reference nucleic acid sequences together are representative of substantially all genomic DNA in an organism.
6. The method of claim 1, wherein each of the plurality of reference nucleic acid sequences comprises a genomic DNA sequence.
7. The method of claim 1, wherein each of the plurality of reference nucleic acid sequences comprises a cDNA or RNA sequence.
8. A method of comparing nucleic acid sequences, comprising:
providing a nucleic acid sequence obtained from a sample and including at least one homopolymer region;
collapsing each of the homopolymer regions to a single nucleotide to form a representative sample sequence without homopolymer regions;
comparing the representative sample sequence to one or more members of a database of reference nucleic acid sequences without homopolymer regions to determine whether the representative sample sequence matches one of the reference nucleic acid sequences, at least one of the reference nucleic acid sequences created by collapsing at least one homopolymer region to a single nucleotide, the database comprising information that is related to the at least one reference nucleic acid sequence and that is indicative of one or more corresponding nucleic acid sequences in which no homopolymer region was collapsed;
identifying one of the reference nucleic acid sequences in the database that matches the representative sample sequence;
identifying, for the identified reference nucleic acid sequence and based on any related and indicative information for the identified reference nucleic acid sequence, any one or more corresponding nucleic acid sequences in which no homopolymer region was collapsed; and
determining which of the identified corresponding nucleic acid sequences matches the nucleic acid sequence obtained from the sample.
9. The method of claim 8, wherein:
the nucleic acid sequence obtained from the sample comprises an observed DNA sequencing output; and
the determining step comprises calculating a probability of obtaining the observed DNA sequencing output for each of the identified corresponding nucleic acid sequences.
10. A method of matching nucleic acid sequences, comprising:
sequencing a nucleic acid from a patient;
collapsing each homopolymer region of the patient nucleic acid sequence to a single nucleotide to form a representative sample sequence; and
determining whether the representative sample sequence matches a member of a database of reference nucleic acid sequences without homopolymer regions, at least one of the reference nucleic acid sequences created by collapsing at least one homopolymer region to a single nucleotide, at least some of the reference nucleic acid sequences being indicative of a diagnosis, prognosis, or indication for a course of treatment of the patient.
11. The method of claim 10, wherein the steps of collapsing and determining include the use of indexes and a binary search to determine whether the representative sample sequence matches a member of the database of reference nucleic acid sequences.
12. A computer-readable medium storing a plurality of sequence representations, each of the sequence representations comprising a unique nucleic acid sequence without a homopolymer region, at least one of the sequence representations created by collapsing at least one homopolymer region to a single nucleotide.
13. The computer-readable medium of claim 12, wherein each unique nucleic acid sequence comprises the same number of nucleotides.
14. The computer-readable medium of claim 12, wherein each nucleic acid sequence is between about 15 and about 100 nucleotides in length.
15. The computer-readable medium of claim 12, wherein the computer-readable medium stores more than one million sequence representations.
16. The computer-readable medium of claim 12, wherein the unique nucleic acid sequences are genomic DNA sequences.
17. The computer-readable medium of claim 12, wherein the unique nucleic acid sequences are cDNA or RNA sequences.
18. The computer-readable medium of claim 12, wherein a nucleic acid sequence obtained from a sample can be compared against at least some of the plurality of sequence representations.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A circuit for disconnecting a power source upon the detection of a leakage current from one of a first and a second wire connected to the power source, comprising:
a sensing conductor located adjacent to one of the first and second wires for sensing a leakage current from one of the first and second wires;
a disconnect switch interposed within the first and second wires connected to the power source;
said disconnect switch having a disconnect switch solenoid coil for opening said disconnect switch;
a threshold conduction device being conductive upon a threshold voltage applied to the threshold conduction device;
a connector connecting said disconnect switch solenoid coil in series with said threshold conduction device between one of the first and second wires and said sensing conductor; and
a threshold voltage generator comprising a capacitor connected in series with a diode between said sensing conductor and one of the first and second wires for charging said capacitor for generating said threshold voltage for said threshold conduction device upon a leakage current flow between said sensing conductor and one of the first and second wires and through said threshold voltage generator.
2. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 1, wherein said sensing conductor comprises a first and a second shield sensing conductor located about the first and second wires.
3. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 1, wherein said sensing conductor comprises a shield sensing conductor located about both of the first and second wires.
4. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 1, wherein said disconnect switch includes a normally open solenoid operated switch;
a mechanical latch mechanism for maintaining said disconnect switch in a closed condition and
said disconnect switch solenoid coil operating a plunger for disengaging said mechanical latch mechanism for opening said disconnect switch.
5. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 1, wherein said threshold conduction device includes a thyristor.
6. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 1, wherein said threshold conduction device includes a silicon, control rectifier (SCR).
7. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 1, wherein said threshold conduction device includes a silicon control rectifier (SCR) with a Zener diode connected to a gate of said silicon control rectifier (SCR).
8. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 1, wherein said threshold conduction device is a Diode For Alternating Current (DIAC).
9. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 1, wherein said threshold conduction device is a Silicon Diode For Alternating Current (SIDAC).
10. A circuit for disconnecting a power source upon the detection of a leakage current from one of a first and a second wire connected to the power source, comprising:
a sensing conductor located adjacent to one of the first and second wires for sensing a leakage current from one of the first and second wires;
a disconnect switch interposed within the first and second wires connected to the power source;
said disconnect switch having a disconnect switch solenoid coil for opening said disconnect switch;
a divider circuit interconnected between the first and second wires for providing a divider node;
a threshold conduction device being conductive upon a threshold voltage applied to the threshold conduction device;
a connector connecting said disconnect switch solenoid coil in series with said threshold conduction device between said divider node and said sensing conductor; and
a capacitor connected between said divider node and said sensing conductor to provide said threshold voltage to said threshold conduction device upon a leakage current flow between said sensing conductor and one of the first and second wires.
11. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 10, wherein said divider circuit includes a diode divider circuit.
12. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 11, wherein said divider circuit includes a resistive divider circuit.
13. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 10, wherein said divider circuit provides a voltage node.
14. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 10, wherein said capacitor is connected between said divider node and said sensing conductor and in parallel with said threshold conduction device.
15. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 10, wherein said threshold conduction device includes a silicon control rectifier (SCR).
16. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 10, wherein said threshold conduction device is a Diode For Alternating Current (DIAC).
17. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 10, wherein said threshold conduction device is a Silicon Diode For Alternating Current (SIDAC).
18. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 10, wherein said threshold conduction device comprises a thyristor connected in series with said disconnect switch solenoid coil between and said divider node and said sensing conductor; and
a breakdown voltage conduction device connected for actuating said thyristor upon said capacitor providing a breakdown voltage to said breakdown voltage conduction device.
19. A circuit for disconnecting a power source upon the detection of a leakage current as set forth in claim 10, wherein said threshold conduction device comprises a thyristor connected in series with said disconnect switch solenoid coil and said divider node and said sensing conductor; and
a Zener diode connected to a gate of said thyristor for actuating said thyristor upon said capacitor providing a breakdown voltage to said Zener diode.
20. A circuit for disconnecting a power source upon the detection of a leakage current from one of a first and a second wire connected to the power source, comprising:
a sensing conductor located adjacent to one of the first and second wires for sensing a leakage current from one of the first and second wires;
a disconnect switch interposed within the first and second wires connected to the power source;
said disconnect switch having a disconnect switch solenoid coil for opening said disconnect switch;
a threshold conduction device being conductive upon a threshold voltage applied to the threshold conduction device;
a connector connecting said disconnect switch solenoid coil in series with said threshold conduction device between said divider node and said sensing conductor; and
a capacitor connected between said sensing conductor and one of the first and second wires for charging said capacitor with a leakage current flow between said sensing conductor and one of the first and second wires to provide said threshold voltage generator to said threshold conduction device.
21. A circuit for disconnecting a power source upon the detection of a leakage current from a wire connected to the power source, comprising:
a sensing conductor located adjacent to the wire for sensing a leakage current from the wire;
a disconnect switch interposed within the wire connected to the power source; and
a disconnect switch control circuit comprising a capacitor connected to said sensing conductor for opening said disconnect switch upon said capacitor accumulating a predetermined amount of the leakage current from said sensing conductor.