1. A method of achieving increased systemic availability of methotrexate comprising:
(a) determining that a patient in need of methotrexate requires more systemically available methotrexate than can be obtained by an orally administered dose of methotrexate;
and,
(b) subcutaneously administering a dose of methotrexate which provides more systemically available methotrexate than could be obtained by the orally administered dose of methotrexate.
2. The method of claim 1, wherein the orally administered dose is 15 mg of methotrexate.
3. The method of claim 1, wherein the orally administered dose is 20 mg of methotrexate.
4. The method of claim 1, wherein the orally administered dose is 25 mg of methotrexate.
5. The method of claim 1, wherein the dose of methotrexate is administered weekly.
6. The method of claim 5, wherein the dose is 10 mg.
7. The method of claim 5, wherein the dose is 15 mg.
8. The method of claim 5, wherein the dose is 20 mg.
9. The method of claim 5, wherein the dose is 25 mg.
10. A kit for administration of a medicament to a subject in need thereof, the kit comprising:
(a) instructions for identifying a subject in need of an oral dose of methotrexate wherein the patient requires more systemically available methotrexate than can be obtained by an orally administered dose of methotrexate; and,
(b) an injector device for subcutaneous administration of methotrexate to the subject.
11. The kit of claim 10, wherein the injector device is a hand-powered syringe.
12. The kit of claim 10, wherein the injector device is a powered injector.
13. The kit of claim 10, wherein the injector device is a jet injector.
14. The kit of claim 10, wherein the oral dose is 10 mg.
15. The kit of claim 10, wherein the oral dose is 15 mg.
16. The kit of claim 10, wherein the oral dose is 20 mg.
17. The kit of claim 10, wherein the oral dose is 25 mg.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An intraluminal occlusion device having a longitudinal axis, comprising:
a tubular frame having a proximal end defining a proximal opening, a distal end defining a distal opening, and a circumferential surface extending from the proximal end to the distal end, the frame comprising two or more longitudinal struts and a plurality of interconnecting struts extending between adjacent longitudinal struts, each of the longitudinal struts having a proximal concave portion and a distal convex portion; and
a covering extending over the proximal opening and attached to the tubular frame.
2. The intraluminal occlusion device of claim 1, wherein the tubular frame comprises an expandable frame having radially compressed and radially expanded configurations.
3. The intraluminal occlusion device of claim 2, wherein the tubular frame comprises a self-expandable frame.
4. The intraluminal occlusion device of claim 2, wherein the tubular frame requires the input of an expansive force to transition from the radially compressed configuration to the radially expanded configuration.
5. The intraluminal occlusion device of claim 2, wherein the tubular frame is formed from one or more wires.
6. The intraluminal occlusion device of claim 2, wherein the tubular frame is cut from a tubular member.
7. The intraluminal occlusion device of claim 2, wherein the tubular frame comprises stainless steel.
8. The intraluminal occlusion device of claim 2, wherein the tubular frame comprises nitinol.
9. The intraluminal occlusion device of claim 1, wherein a first longitudinal strut has a first proximal concave portion and a first distal convex portion;
wherein the first proximal concave portion has a first length that extends along said longitudinal axis of said intraluminal occlusion device and the first distal convex portion has a second length that extends along said longitudinal axis of said intraluminal occlusion device; and
wherein the first length is greater than the second length.
10. The intraluminal occlusion device of claim 1, wherein a first longitudinal strut has a first proximal concave portion and a first distal convex portion;
wherein the first proximal concave portion has a first longitudinal midpoint and the first distal convex portion has a second longitudinal midpoint;
wherein a first transverse axis orthogonally intersects the first proximal concave portion at the first longitudinal midpoint;
wherein a second transverse axis orthogonally intersects the first distal convex portion at the second longitudinal midpoint;
wherein each of the first and second transverse axes orthogonally intersects said longitudinal axis of said intraluminal occlusion device.
11. The intraluminal occlusion device of claim 1, wherein the covering comprises a bioremodellable material.
12. The intraluminal occlusion device of claim 11, wherein the covering comprises an extracellular matrix material.
13. The intraluminal occlusion device of claim 12, wherein the covering comprises small intestine submucosa.
14. The intraluminal occlusion device of claim 1, wherein the covering extends over the circumferential surface defined by the tubular frame.
15. The intraluminal occlusion device of claim 14, wherein the covering extends over the distal opening.
16. The intraluminal occlusion device of claim 1, wherein the tubular frame includes one or more barbs disposed on a concave portion of at least one of the longitudinal struts.
17. The intraluminal occlusion device of claim 1, wherein the proximal concave portion of each of the longitudinal struts has a concave portion proximal end and a concave portion distal end;
further comprising first and second series of barbs, each barb of the first series of barbs disposed on the concave portion proximal end of one of the longitudinal attachment struts and each barb of the second series of barbs disposed on the concave portion distal end of one of the longitudinal attachment struts;
wherein each barb of the first and second series of barbs extends away from the one of the longitudinal attachment struts and radially outward with respect to said longitudinal axis of said intraluminal occlusion device.
18. An intraluminal occlusion device having a longitudinal axis, comprising:
a tubular frame having a proximal end defining a proximal opening, a distal end defining a distal opening, and a circumferential surface extending from the proximal end to the distal end, the frame comprising two or more longitudinal struts and a plurality of interconnecting struts extending between adjacent longitudinal struts, each of the longitudinal struts having a proximal concave portion and a distal convex portion; and
a covering extending over the proximal opening and attached to the tubular frame;
wherein a first longitudinal strut has a first proximal concave portion and a first distal convex portion;
wherein the first proximal concave portion has a first length that extends along said longitudinal axis of said intraluminal occlusion device and the first distal convex portion has a second length that extends along said longitudinal axis of said intraluminal occlusion device;
wherein the first length is greater than the second length; and
wherein the covering extends over the circumferential surface defined by the tubular frame.
19. The intraluminal occlusion device of claim 18, wherein the covering extends over the distal opening.
20. An intraluminal occlusion device having a longitudinal axis, comprising:
a tubular frame having a proximal end defining a proximal opening, a distal end defining a distal opening, and a circumferential surface extending from the proximal end to the distal end, the frame comprising two or more longitudinal struts and a plurality of interconnecting struts extending between adjacent longitudinal struts, each of the longitudinal struts having a proximal concave portion and a distal convex portion; and
a covering extending over the proximal opening and attached to the tubular frame;
wherein a first longitudinal strut has a first proximal concave portion and a first distal convex portion;
wherein the first proximal concave portion has a first longitudinal midpoint and the first distal convex portion has a second longitudinal midpoint;
wherein a first transverse axis orthogonally intersects the first proximal concave portion at the first longitudinal midpoint;
wherein a second transverse axis orthogonally intersects the first distal convex portion at the second longitudinal midpoint;
wherein each of the first and second transverse axes orthogonally intersects said longitudinal axis of said intraluminal occlusion device;
wherein the covering extends over the circumferential surface defined by the tubular frame; and
wherein the covering extends over the distal opening.