1. A method to be executed at least in part in a computing device for managing alternate contact information, the method comprising:
receiving contact information associated with a subscriber from a plurality of sources;
determining an initial alternate contact list by aggregating the received contact information according to a predefined schema;
enabling the subscriber to modify the initial alternate contact list;
determining a presence status of the subscriber; and
publishing the modified alternate contact list as part of the subscriber’s contact card based on the subscriber’s presence status.
2. The method of claim 1, wherein enabling the subscriber to modify the initial alternate contact list includes:
enabling the subscriber to select and prioritize contacts from the initial alternate contact list; and
enabling the subscriber to modify information associated with the selected contacts according to the predefined schema.
3. The method of claim 1, further comprising:
enabling the subscriber to define access parameters associated with the published alternate contact list.
4. The method of claim 1, wherein received contact information includes information associated with at least one from a set of: an organizational directory, a personal directory, a custom directory.
5. The method of claim 1, wherein the received contact information is aggregated based on at least one from a set of: an organizational hierarchy, a functional hierarchy, an organization policy, and a category of contacts.
6. The method of claim 1, further comprising:
prioritizing the initial alternate contact list based on a presence status of individual contacts on the initial alternate contact list.
7. The method of claim 1, wherein dynamic information associated with each contact in the published alternate contact list is provided to recipients of the subscriber’s contact card through a presence channel.
8. The method of claim 1, further comprising:
enabling a recipient application to display the alternate contact list as part of the subscriber’s contact card, wherein the recipient application is further enabled to display a contact card of a selected alternate contact in response to selection of that alternate contact.
9. The method of claim 8, wherein contact card of the selected alternate contact includes another alternate contact list associated with the selected alternate contact.
10. The method of claim 1, wherein the presence status includes at least one from a set of: available, unavailable, temporarily unavailable, offline, away, busy, and out of office.
11. The method of claim 10, wherein a recipient application is enabled to one of:
display the alternate contact list as part of the subscriber’s contact card if the presence status is other than available;
direct calls for the subscriber to alternate contacts in a predefined order of availability of other communication modalities;
notify a caller that the subscriber’s communication is routed; and
define delegation information for the subscriber.
12. The method of claim 1, further comprising:
enabling the subscriber to generate a plurality of alternate contact lists each alternate contact list being associated with a distinct presence status; and
enabling a recipient application to display an alternate contact list corresponding to a current presence status of the subscriber as part of the subscriber’s contact card.
13. A communication system for managing alternate contact information, the system comprising:
a first server configured to:
receive contact information associated with a subscriber from a plurality of sources;
aggregate the received contact information to an initial alternate contact list according to a predefined schema;
enable the subscriber to modify the initial alternate contact list by at least one of:
selecting contacts from the initial alternate contact list,
prioritizing the selected contacts, and
modifying information associated with the prioritized contacts according to the predefined schema; and
a second server configured to:
determine a presence status of the subscriber and the prioritized contacts; and
publish the modified alternate contact list as part of the subscriber’s contact card based on the subscriber’s and the prioritized contacts’ presence status.
14. The system of claim 13, wherein the predefined schema includes at least one contact attribute from a set of: a name, an alias, a contact description, a contact role, and contact availability.
15. The system of claim 13, wherein the contact information includes at least one from a set of: an address, an organization, an email address, a phone number, an image associated with the contact; an organizational hierarchy; delegates information defined by the subscriber; and team information defined by an administrator.
16. The system of claim 13, wherein the received contact information is further aggregated based on organization level rules associated with at least one from a set of: access control, security, and update frequency.
17. A computer-readable storage medium with instructions stored thereon for managing alternate contact information, the instructions comprising:
receiving contact information associated with a subscriber from a plurality of servers managing at least one from a set of: an organizational directory, a personal directory, a custom directory;
determining a contact list by aggregating the received contact information according to a predefined schema based on organization level rules associated with at least one from a set of: access control, security, and update frequency;
generating an alternate contact list for the subscriber from the contact list by:
automatically selecting and prioritizing contacts from the contact list based on at least one of subscriber defined and system defined rules; and
enabling the subscriber to modify attributes associated with the selected contacts according to the predefined schema;
determining a presence status of the subscriber; and
publishing the alternate contact list as part of the subscriber’s contact card based on the subscriber’s presence status, wherein dynamic information associated with each contact in the published alternate contact list is provided to recipients of the subscriber’s contact card.
18. The computer-readable medium of claim 17, wherein the alternate contact list is presented to recipient applications even when the presence status of the subscriber is available.
19. The computer-readable medium of claim 17, wherein the alternate contact list is re-prioritized based on each contact’s presence status.
20. The computer-readable medium of claim 17, wherein the alternate contact list is configured so that another alternate contact list for a selected contact is presented to a recipient application depending on the contact’s presence status.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method for synthesizing crystalline form A of prasugrel, wherein the crystalline form A has the following X-ray powder diffraction pattern measured by copper cathode diffractometer, expressed as the interplanar spacing d, Bragg angle 2\u03b8, intensity and relative intensity, wherein the relative intensity is expressed as a percentage relative to the strongest ray:
interplanar spacing
relative
2\u03b8 angle (\xb0)
d(\u212b)
intensity
intensity (%)
7.639
11.56
1569
19
9.717
9.09
192
2.3
11.118
7.95
2838
34.4
13.340
6.63
8253
100
13.679
6.47
808
9.8
14.360
6.16
4184
50.7
14.639
6.05
5807
70.4
14.980
5.91
2125
25.7
17.737
5.00
720
8.7
18.480
4.80
2087
25.3
18.761
4.73
8089
98
19.221
4.61
6421
77.8
20.640
4.30
707
8.6
21.301
4.17
7910
95.8
22.298
3.98
1681
20.4
22.640
3.92
1743
21.1
23.300
3.81
7209
87.4
24.258
3.67
6855
83.1
24.682
3.60
649
7.9
26.221
3.40
1237
15
26.862
3.32
1947
23.6
28.320
3.15
501
6.1
29.422
3.03
548
6.6
30.179
2.96
323
3.9
31.280
2.86
2091
25.3
31.922
2.80
632
7.7
32.780
2.73
924
11.2
33.421
2.68
362
4.4
34.960
2.56
531
6.4
35.557
2.52
218
2.6
36.960
2.43
486
5.9
38.060
2.36
583
7.1
38.339
2.35
358
4.3
39.000
2.31
953
11.5
characterized in that the method comprises the following steps:
(1) o-fluorobenzyl cyclopropyl ketone as a raw material is reacted with 1,3-dibromo-5,5-dimethylhydantoin or 1,3-dichloro-5,5- dimethylhydantoin as a halogenating agent in acetic acid as a solvent to give \u03b1-cyclopropylcarbonyl-2-fluorobenzyl halide (compound 2);
(2) \u03b1-cyclopropylcarbonyl-2-fluorobenzyl halide is reacted with 2-oxo-4,5,6,7-tetrahydrothieno3,2-cpyridine toluenesulfonate (compound 3) in the concerted catalysis of a phase transfer catalyst and an inorganic salt using an inorganic base as an acid binding agent and DMF as a solvent under nitrogen atmosphere to get 5-(\u03b1-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7-tetrahydrothieno 3,2-cpyridine (compound 4);
(3) 5-(\u03b1-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7-tetrahydrothieno3,2-cpyridine is acylated in the presence of an acylating reagent using triethylamine as an acid binding agent and DMF as a solvent under nitrogen atmosphere at room temperature, and finally extracted, dried and filtrated to give the mother liquor of prasugrel, and the mother liquor is concentrated to get prasugrel as a gum;
(4) an alcoholic solvent is added to the prasugrel as a gum obtained in the above step, and crystal is precipitated after stirring at room temperature, then the crystal is filtrated to give prasugrel as solid;
the reaction scheme is as follows:
2. The synthesis method according to claim 1, characterized in that the reaction temperature in step (1) is 0\xb0 C. to 100\xb0 C.
3. The synthesis method according to claim 2, characterized in that the reaction temperature is 60\xb0 C. to 85\xb0 C.
4. The synthesis method according to claim 1, characterized in that the molar ratio of o-fluorobenzyl cyclopropyl ketone to the halogenating agent is 1:0.5-0.65.
5. The synthesis method according to claim 1, characterized in that the molar ratio of \u03b1-cyclopropylcarbonyl-2-fluorobenzyl bromide to 2-oxo-4,5,6,7-tetrahydrothieno3,2-cpyridine p-toluenesulfonate in step (2) is 1:1-1.5.
6. The synthesis method according to claim 1, characterized in that the molar ratio of \u03b1-cyclopropylcarbonyl-2-fluorobenzyl bromide to the inorganic base in step (2) is 1:2-8.
7. The synthesis method according to claim 1, characterized in that the inorganic base is one or more selected from the group consisting of sodium carbonate, potassium carbonate, sodium bicarbonate, and potassium bicarbonate.
8. The synthesis method according to claim 7, characterized in that the inorganic base is sodium bicarbonate.
9. The synthesis method according to claim 1, characterized in that the molar ratio of \u03b1-cyclopropylcarbonyl-2-fluorobenzyl bromide to the phase transfer catalyst in step (2) is 1:0.05-1.2.
10. The synthesis method according to claim 1, characterized in that the phase transfer catalyst comprises one or more selected from the group consisting of tetrabutylammonium bromide, tetraethyl ammonium bromide, tetrabutyl ammonium chloride and tetraethylammonium chloride.
11. The synthesis method according to claim 1, characterized in that the molar ratio of \u03b1-cyclopropylcarbonyl-2-fluorobenzyl bromide to the inorganic salt in step (2) is 1:0.02-1.2.
12. The synthesis method according to claim 1, characterized in that the inorganic salt comprises one or more selected from the group consisting of sodium bromide and potassium bromide.
13. The synthesis method according to claim 1, characterized in that the reaction temperature in step (2) is 0\xb0 C.-100\xb0 C.
14. The synthesis method according to claim 13, characterized in that the temperature of the reaction is 40\xb0 C.-50\xb0 C.
15. The synthesis method according to claim 1, characterized in that the molar ratio of 5-(\u03b1-cyclopropylcarbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7 -tetrahydrothieno 3 ,2-cpyridine to triethylamine in step (3) is 1:1-10.
16. The synthesis method according to claim 1, characterized in that the alcoholic solvent in step (4) comprises one or more selected from the group consisting of methanol, ethanol, isopropanol, n-butanol, tert-butanol, benzyl alcohol or benzoic alcohol.
17. The synthesis method according to claim 16, characterized in that the alcoholic solvent is methanol, ethanol or isopropanol.
18. The synthesis method according to claim 1, characterized in that the ratio of the volume of the alcoholic solvent to the weight of \u03b1-cyclopropylcarbonyl-2-fluorobenzyl halide is 2.5 mlg-6.5 mlg.
19. The synthesis method according to claim 18, characterized in that the ratio of the volume of the alcoholic solvent to the weight of \u03b1-cyclopropylcarbonyl-2-fluorobenzyl halide is 3.0 mlg.