We claim:
1. Apparatus for blow molding containers from a thermoplastic material, said apparatus comprising:
an extruder for continuously extruding at least one tube of the thermoplastic material downwardly along a vertical axis;
a first mold, said first mold having a first set of mold halves than open and close relative to each other to define, when closed, a first mold cavity;
a second mold, said second mold having a second set of mold halves that open and close relative to each other to define, when closed, a second mold cavity;
means for moving said first mold along a first closed path to present said first mold at a first position to engage, when open, a first finite length of the thermoplastic tube for blowing of the first finite length of the thermoplastic tube into a container as the first mold moves from the first position to a second position of the first closed path; and
means for moving said second mold along a second closed path to present said second mold at the first position to engage, while open, a second finite length of the thermoplastic tube into a container as the second mold moves along the second closed path to the second position;
the first position of the first closed path and the first position of the second closed path being the same, and the second position of the first closed path and the second position of the second closed path being the same, said apparatus comprising no more than two molds.
2. Apparatus for blow molding containers from a thermoplastic material, said apparatus comprising:
an extruder for continuously extruding at least one tube of the thermoplastic material downwardly along a vertical axis;
a first mold, said first mold having a first set of mold halves that open and close relative to each other to define, when closed, a first mold cavity;
a second mold, said second mold having a second set of mold halves that open and close relative to each other to define, when closed, a second mold cavity;
means for moving said first mold along a first closed path to present said first mold at a first position to engage, when open, a first finite length of the thermoplastic tube for blowing of the first finite length of the thermoplastic tube into a container as the first mold moves from the first position to a second position of the first closed path;
means for moving said second mold along a second closed path to present said second mold at the first position to engage, while open, a second finite length of the thermoplastic tube for blowing the second finite length of the thermoplastic tube into a container as the second mold moves along the second closed path to the second position;
the first position of the first closed path and the first position of the second closed path being the same, and the second position of the first closed path and the second position of the second closed path being the same; and
a single in-mold labelling device positioned beneath the extruder to introduce labels into the first and second molds as the first and second molds proceed along the first closed path and the second closed path, respectively.
3. Apparatus according to claim 1 and further comprising:
a single container take-out device for successively removing blown containers from the first mold and the second mold at the second position.
4. Apparatus according to claim 3 wherein:
the second position is horizontally spaced from the first position.
5. Apparatus according to claim 4 wherein:
the second position and the first position are at the same elevation.
6. Apparatus according to claim 1 wherein:
the first closed path includes a first leg extending outwardly in a first direction and downwardly from the first position; and
the second closed path includes a first leg extending outwardly in a direction opposed to the direction of the first leg of the first closed path and downwardly.
7. Apparatus according to claim 2 and further comprising:
a single container take-out device for successively removing blown containers from the first mold and the second mold at the second position.
8. Apparatus according to claim 7 wherein:
the second position is horizontally spaced from the first position.
9. Apparatus according to claim 8 wherein:
the second position and the first position are at the same elevation.
10. Apparatus according to claim 2 wherein:
the first closed path includes a first leg extending outwardly in a first direction and downwardly from the first position; and
the second closed path includes a first leg extending outwardly in a direction opposed to the direction of the first leg of the first closed path and downwardly.
11. A method of blow molding containers from a thermoplastic material, the method comprising:
substantially continuously extruding a thermoplastic material downwardly a vertical axis;
engaging a first finite length of the thermoplastic material in a first mold set at a first position of the first mold set;
moving the first mold set in a closed path having a first leg in which the first mold set is moved from the first position upwardly in a first direction and downwardly;
engaging a second finite length of the extruded thermoplastic material in a second mold at the position where the first finite length of the extruded thermoplastic material was engaged by the first mold set after the first mold set has moved along the first leg of its first closed path;
moving the second mold set along a second closed path having a first leg extending outwardly in a second direction from the first position and downwardly, the second direction being opposed to the first direction;
removing the blown containers from the first mold set at a second position of the second closed path, the second position being spaced horizontally away from the first position; and
thereafter removing the blown containers from the second mold set at a second position of the second mold set, the second position of the second mold set being the same as the second position of the first mold set;
the method comprising using no more than two molds.
12. A method of blow molding containers from a thermoplastic material, the method comprising:
substantially continuously extruding a thermoplastic material downwardly a vertical axis;
engaging a first finite length of the thermoplastic material in a first mold set a first position of the first mold set;
moving the first mold set in a closed path having a first in which the first mold set is moved from the first position upwardly in a first direction and downwardly;
engaging a second finite length of the extruded thermoplastic material in a second mold at the position where the first finite length of the extruded thermoplastic material was engaged by the first mold set after the first mold set has moved along the first leg of its first closed path;
moving the second mold set along a second closed path having a first leg extending outwardly in a second direction from the first position and downwardly, the second direction being opposed to the first direction;
removing the blown containers from the first mold set at a second position of the second closed path, the second position being spaced horizontally away from the first position;
thereafter removing the blown containers from the second mold set at a second position of the second mold set, the second position of the second mold set being the same as the second position of the first mold set; and
applying labels, in sequence, to interiors of the first mold set and the second mold set, the labels being applied to the interiors of the first mold set at the first position of the first mold set and being applied to the interiors of the second mold set at the first position of the second mold set.
13. Apparatus for blow molding containers from a thermoplastic material, said apparatus comprising:
an extruder for continuously extruding at least one tube of the thermoplastic material downwardly along a vertical axis;
a first mold, said first mold having a first set of mold halves that open and close relative to each other to define, when closed, a first mold cavity;
a second mold, said second mold having a second set of mold halves that open and close relative to each other to define, when closed, a second mold cavity;
means for moving said first mold along a first closed path to present said first mold at a first position to engage, when open, a first finite length of the thermoplastic tube for blowing of the first finite length of the thermoplastic tube into a container as the first mold moves from the first position to a second position of the first closed path;
means for moving said second mold along a second closed path to present said second mold at the first position to engage, while open, a second finite length of the thermoplastic tube for blowing the second finite length of the thermoplastic tube into a container as the second mold moves along the second closed path to the second position;
the first position of the first closed path and the first position of the second closed path being the same, and the second position of the first closed path and the second position of the second closed path being the same; and
means separate from the first mold set and the second mold set for grasping the extruded tube and for moving downwardly before a finite length of the extruded thermoplastic tube is grasped by the first mold set or the second mold set, the means for grasping releasing the extruded thermoplastic tube and withdrawing from the thermoplastic tube after the finite length of the thermoplastic tube has been grasped by the first mold set or the second mold set.
14. A method of blow molding containers from a thermoplastic material, the method comprising;
substantially continuously extruding a thermoplastic material downwardly a vertical axis;
engaging a first finite length of the thermoplastic material in a first mold set at a first position of the first mold set;
moving the first mold set in a closed path having a first leg in which the first mold set is moved from the first position upwardly in a first direction and downwardly;
engaging a second finite length of the extruded thermoplastic material in a second mold at the position where the first finite length of the extruded thermoplastic material was engaged by the first mold set after the first mold set has moved along the first leg of its first closed path;
moving the second mold set along a second closed path having a first leg extending outwardly in a second direction from the first position and downwardly, the second direction being opposed to the first direction;
removing the blown containers from the first mold set at a second position of the second closed path, the second position being spaced horizontally away from the first position; and
thereafter removing the blown containers from the second mold set at a second position of the second mold set, the second position of the second mold set being the same as the second position of the first mold set;
grasping the extruded thermoplastic tube by a device separate from the first mold means and the second mold means and before the first finite length of the thermoplastic tube or the second finite lengths of thermoplastic tube is grasped by the first mold means or the second mold means;
moving the device downwardly;
grasping the first finite length of the thermoplastic tube or the second finite lengths of the thermoplastic tube while it is engaged by the device;
releasing the thermoplastic tube by the device; and
withdrawing the device from the thermoplastic tube to permit the first finite length of the thermoplastic tube in the first mold means or the second finite length of thermoplastic tube in the second mold means, as the case may be, to move along the first closed path or the second closed path.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1-12. (canceled)
13. A salt selected from the anhydrous and hydrated forms of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo3.2.1octane tartrate.
14. The salt of claim 13 being selected from the anhydrous and hydrated forms of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo3.2.1octane L-tartrate.
15. The salt of claim 13, being (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo3.2.1octane L-tartrate monohydrate.
16. The salt of claim 13, being an anhydrous form of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo3.2.1octane L-tartrate.
17. The salt of claim 16, being the polymorphic form (form II) of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo3.2.1octane L-tartrate anhydrate characterized by the following principal peaks in its X-ray powder diffraction pattern:
Peak No.
1
2
3
4
5
6
7
8
9
10
2 Theta \xb0 (Cu K\u03b1)
10.35
11.68
12.53
14.81
15
15.77
16.82
17.41
17.77
18.87
d space (\u212b)
8.5
7.6
7.1
6.0
5.9
5.6
5.3
5.1
5.0
4.7
Peak
11
12
13
14
15
16
17
18
19
2 Theta \xb0 (Cu K\u03b1)
20.29
21.26
21.66
23.44
23.73
25.44
25.99
27.58
28.14
d space (\u212b)
4.4
4.2
4.1
3.8
3.7
3.5
3.4
3.2
3.2
18. The salt of claim 16, being the polymorphic form (form III) of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo3.2.1octane L-tartrate anhydrate characterized by the following principal peaks in its X-ray powder diffraction pattern:
Peak No.
1
2
3
4
5
6
7
8
9
10
2 Theta \xb0 (Cu K\u03b1)
5.37
10.6
10.82
11.58
11.88
12.79
14.78
16.27
16.5
17.03
d space (\u212b)
16.4
8.3
8.2
7.6
7.4
6.9
6.0
5.4
5.4
5.2
Peak
11
12
13
14
15
16
17
18
19
2 Theta \xb0 (Cu K\u03b1)
17.84
19.29
20.01
21.2
22.99
23.46
24.54
25.15
26.59
d space (\u212b)
5.0
4.6
4.4
4.2
3.9
3.8
3.6
3.5
3.3
19. The salt of claim 16, being the polymorphic form (form IV) of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo3.2.1octane L-tartrate anhydrate characterized by the following principal peaks in its X-ray powder diffraction pattern:
Peak No.
1
2
3
4
5
6
7
8
9
10
2 Theta \xb0 (Cu K\u03b1)
5.31
10.19
11.23
12.13
12.35
12.69
14.31
14.55
14.77
16.43
d space (\u212b)
16.6
8.7
7.9
7.3
7.2
7.0
6.2
6.1
6.0
5.4
Peak
11
12
13
14
15
16
17
18
19
20
2 Theta \xb0 (Cu K\u03b1)
17.48
18.21
18.43
18.81
19.36
19.61
20.26
20.5
21.29
21.46
d space (\u212b)
5.1
4.9
4.8
4.7
4.6
4.5
4.4
4.3
4.2
4.1
Peak
21
22
23
24
25
26
27
28
29
30
31
32
2 Theta \xb0 (Cu K\u03b1)
21.95
22.53
22.77
23.38
23.59
23.9
24.45
25.02
25.56
26.19
26.83
27.21
d space (\u212b)
4.0
3.9
3.9
3.8
3.8
3.7
3.6
3.6
3.5
3.4
3.3
3.3
20. A pharmaceutical composition, comprising a therapeutically effective amount of a salt of claim 13, together with at least one pharmaceutically acceptable carrier, excipient or diluent.
21. Use of a salt of claim 13 for the manufacture of a medicament.
22. A method for treatment, prevention or alleviation of a disease or a disorder or a condition of a living animal body, including a human, which disorder, disease or condition is responsive to inhibition of monoamine neurotransmitter re-uptake in the central nervous system, which method comprises the step of administering to such a living animal body in need thereof a therapeutically effective amount of a salt according to claim 13.
23. The method according to claim 22, wherein the disease, disorder or condition ismood disorder, depression, atypical depression, depression secondary to pain, major depressive disorder, dysthymic disorder, bipolar disorder, bipolar I disorder, bipolar II disorder, cyclothymic disorder, mood disorder due to a general medical condition, substance-induced mood disorder, pseudodementia, Ganser’s syndrome, obsessive compulsive disorder, panic disorder, panic disorder without agoraphobia, panic disorder with agoraphobia, agoraphobia without history of panic disorder, panic attack, memory deficits, memory loss, attention deficit hyperactivity disorder, obesity, anxiety, generalized anxiety disorder, eating disorder, Parkinson’s disease, parkinsonism, dementia, dementia of ageing, senile dementia, Alzheimer’s disease, acquired immunodeficiency syndrome dementia complex, memory dysfunction in ageing, specific phobia, social phobia, post-traumatic stress disorder, acute stress disorder, drug addiction, drug abuse, cocaine abuse, nicotine abuse, tobacco abuse, alcohol addiction, alcoholism, pain, chronic pain, inflammatory pain, neuropathic pain, migraine pain, tension-type headache, chronic tension-type headache, pain associated with depression, fibromyalgia, arthritis, osteoarthritis, rheumatoid arthritis, back pain, cancer pain, irritable bowel pain, irritable bowel syndrome, post-operative pain, post-stroke pain, drug-induced neuropathy, diabetic neuropathy, sympathetically-maintained pain, trigeminal neuralgia, dental pain, myofacial pain, phantom-limb pain, bulimia, premenstrual syndrome, late luteal phase syndrome, post-traumatic syndrome, chronic fatigue syndrome, urinary incontinence, stress incontinence, urge incontinence, nocturnal incontinence, sexual dysfunction, premature ejaculation, erectile difficulty, erectile dysfunction, eating disorders, anorexia nervosa, sleep disorders, autism, mutism, trichotillomania, narcolepsy, post-stroke depression, stroke-induced brain damage, stroke-induced neuronal damage or Gilles de la Tourettes disease.