1. A system comprising:
an illumination source, the illumination source including a light emitting device; and
a driver circuit coupled to the light emitting device, the driver circuit including:
a current sensing circuit coupled to the light emitting device, the current sensing circuit adapted to sense driving current being supplied to the light emitting device, the current sensing circuit including an operational amplifier and a collection of resistors configured to sense a ripple in the driving current;
an error amplifier circuit coupled to the current sensing circuit, and the current sensing circuit is adapted to supply a first voltage to the error amplifier circuit, the first voltage being related to the driving current and the ripple being supplied to the one or more light emitting devices;
a pulse width modulation circuit coupled to the error amplifier circuit and adapted to modulate a pulse width of a control signal based at least in part on an output of the error amplifier circuit to compensate for the ripple sensed by the current sensing circuit, the control signal to be employed to adjust the driving current being supplied to the light emitting device; and
a buck converter coupled to the light emitting devices the buck converter adapted to switch the driving current being supplied to the light emitting device by changing amplitude of the driving current based, at least in part, on the control signal.
2. The system of claim 1, further comprising
a controller, adapted to receive an image signal and to output a light valve control signal representing an image for a frame; and
a light valve, coupled to the controller and optically coupled to the illumination source, the light valve being adapted to modulate an incident light produced by the illumination source into image bearing light based on the light valve control signal.
3. The system of claim 2, further comprising
projection optics, optically coupled to the light valve to receive the image bearing light and to project the image.
4. The system of claim 3, wherein the controller is further adapted to receive and project a series of images as video.
5. The system of claim 1, further comprising
an image signal source, coupled to the controller, to output the image signal.
6. The system of claim 1, wherein the system comprises one of a group consisting of a projector and a projection television.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula (I)
or a salt, N-oxide, hydrate or solvate thereof,
wherein
R1, R2, R3 and R4 each independently are hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl, halo, \u2014S(O)nR10, \u2014SO2N(R10)2, \u2014N(R10)2, \u2014C(O)N(R10)2,
\u2014NR10C(O)R9, \u2014CO2R10, \u2014C(O)R9, \u2014NO2, \u2014CN or \u2014OR11;
wherein each R9 is independently C1-C6alkyl, aryl, or heteroaryl;
R10 is independently hydrogen, C1-C6alkyl, aryl, or heteroaryl;
R11 is hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl or a group \u2014SO2R9;
n is 0, 1 or 2;
R5 is C1-C6alkyl, fully or partially fluorinated C1-C6alkyl, C1-C6alkenyl, C1-C6alkynyl, optionally substituted aryl, or optionally substituted heteroaryl;
R6 is hydrogen, C1-C6alkyl or fully or partially fluorinated C1-C6alkyl;
R7 and R8 are independently hydrogen or C1-C6alkyl, or R7 and R8 together with the atom to which they are attached form a cycloalkyl group; and
X is \u2014CHR6\u2014, \u2014S(O)n\u2014, \u2014NR6SO2\u2014 or \u2014SO2NR6\u2014 wherein n is 0, 1 or 2.
2. The compound as claimed in claim 1, independent of use, with the proviso that, when X is \u2014CH2\u2014, R6 is methyl and R5 is 4-chlorophenyl, then R1, R2, R3, R4, R7 and R8 are not all hydrogen.
3. The compound as claimed in claim 1, wherein R1, R2, R3 and R4 are independently selected from hydrogen, methyl, ethyl, trifluoromethyl, fluoro, chloro, bromo, \u2014NO2, \u2014CN, \u2014SO2R9, \u2014SO2N(R10)2, \u2014C(O)N(R10)2, \u2014NR10C(O)R9, \u2014CO2R10, and \u2014C(O)R9, wherein each R9 is independently C1-C6alkyl, aryl, or heteroaryl; R10 is independently hydrogen, C1-C6alkyl, aryl, or heteroaryl; and R11 is hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl or a group S are as defined in claim 4.
4. The compound as claimed in claim 3, wherein any R9 is selected from methyl, ethyl and phenyl; any R10 is selected from hydrogen, methyl, ethyl and phenyl; and any R11 is selected from methyl, trifluoromethyl, ethyl, phenyl, \u2014SO2H and \u2014SO2CH3.
5. The compound as claimed in claim 1, wherein R1, R2, R3 and R4 are independently selected from hydrogen, chloro, fluoro, cyano, methyl and trifluoromethyl.
6. The compound as claimed in claim 1, wherein two of R1, R2, R3 and R4 are hydrogen, while the others are independently selected from hydrogen, chloro, fluoro, cyano, methyl and trifluoromethyl.
7. The compound as claimed in claim 1, wherein R5 is methyl, ethyl, n- or iso-propyl, trifluoromethyl, allyl, optionally substituted phenyl or naphthyl; or optionally substituted monocyclic heterooaryl having 5 or 6 ring atoms; or optionally substituted bicyclic heteroaryl having 8 to 10 ring atoms.
8. The compound as claimed in claim 1, wherein R6 is optionally substituted pyridyl, pyrimidinyl, furyl, thienyl, imidazolyl, oxazolyl, isoxazolyl, or pyrrolyl, quinolinyl, indolyl, or benzimidazolyl.
9. The compound as claimed in claim 1, wherein R5 is optionally substituted phenyl.
10. The compound as claimed in claim 1, wherein the said optional substituents are selected from chloro, fluoro, methylsulfonyl, ethylsulfonyl, carbamate, methylcarbamate, methylaminosulfonyl, ethylaminosulfonyl, methylsulfonylamino, ethylsulfonylamino, morpholin-1-ylsulfonyl, piperidin-1-ylsulfonyl, piperizin-1-ylsulfonyl, 4-methylpiperizin-1-ylsulfonyl, and tetrahydropyrrol-1ylsulfonyl.
11. The compound as claimed in claim 1, wherein the divalent radical \u2014X\u2014 is \u2014CH2\u2014, \u2014S(O)\u2014, \u2014NHSO2\u2014 or \u2014SO2NH\u2014.
12. The compound as claimed in claim 1, wherein the divalent radical \u2014X\u2014 is \u2014S\u2014 or \u2014SO2\u2014.
13. The compound as claimed in claim 1, wherein R6 is hydrogen, ethyl or trifluoromethyl.
14. The compound as claimed in claim 1, wherein R6 is methyl.
15. The compound as claimed in claim 1, wherein R7 and R8 are each hydrogen.
16. The compound as claimed in claim 1, wherein one of R7 and R8 is methyl and the other is hydrogen.
17. The compound as claimed in claim 1, wherein R7 and R8 taken together with the carbon atom to which they are attached form a cyclopropyl, cyclopentyl or cyclohexyl ring.
18. The compound as claimed in claim 1, wherein R1, R2, R3 and R4 are independently selected from hydrogen, chloro, fluoro, cyano, methyl trifluoromethyl, methoxy, and trifluoromethoxy; X is \u2014S\u2014 or \u2014SO2\u2014; R5 is optionally substituted phenyl, R6 is methyl, and R7 and R8 are hydrogen.
19. The compound as claimed in claim 18, wherein R5 is phenyl or phenyl substituted by one or two substituents selected from chloro, fluoro, trifluoromethyl, methylsulfonyl, ethylsulfonyl, carbamate, methylcarbamate, methylaminosulfonyl, ethylaminosulfonyl, methylsulfonylamino, ethylsulfonylamino, morpholin-1-ylsulfonyl, piperidin-1-ylsulfonyl, piperizin-1-ylsulfonyl, 4-methylpiperizin-1-ylsulfonyl, and tetrahydropyrrol-1 ylsulfonyl.
20. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of formula (I)
or a salt, N-oxide, hydrate or solvate thereof, wherein
R1, R2, R3 and R4 each independently are hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl, halo, \u2014S(O)2N(R10)2, \u2014C(O)N(R10)2, \u2014NR10C(O)R9, \u2014CO2R10, \u2014C(O)R9, \u2014NO2, \u2014CN or \u2014OR11;
wherein each R9 is independently C1-C6alkyl, aryl, or heteroaryl;
R10 is independently hydrogen, C1-C6alkyl, aryl, or heteroaryl;
R11 is hydrogen, C alkyl, fully or partially fluorinated C1-C6alkyl or a group \u2014SO2R9;
n is 0, 1 or 2;
R5 is C1-C6alkyl, fully or partially fluorinated C1-C6 alkyl C1-C6alkenyl, C1-C6 alkynyl, optionally substituted aryl, or optionally substituted heteroaryl;
R6 is hydrogen, C1-C6alkyl or fully or partially fluorinated C1-C6alkyl;
R7 and R8 are independently hydrogen or C1-C6alkyl, or R7 and R8 together with the atom to which they are attached form a cycloalkyl group; and
X is \u2014CHR6\u2014, \u2014S(O)n\u2014, \u2014NR6SO2\u2014 or \u2014SO2NR6\u2014 wherein n is 0, 1 or 2.
21. Use of a compound of formula (I)
or a salt, N-oxide, hydrate or solvate thereof, wherein
R1, R2, R3 and R4 each independently are hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6 alkyl, halo, \u2014S(O)nR10, \u2014N(R10)2, \u2014C(O)N(R10)11;
wherein each R9 is independently C1-C6alkyl, aryl, or heteroaryl;
R10 is independently hydrogen, C1-C6alkyl, aryl, or heteroaryl;
R11 is hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6 group \u2014SO2R9;
n is 0, 1 or 2;
R5 is C1-C6alkyl, full partially fluorinated C1-C6alkyl, C1-C6alkenyl, C1-C6alkynyl, optionally substituted aryl, or optionally substituted heteroaryl;
R6 is hydrogen, C1-C6alkyl or fully or partially fluorinated C1-C6 alkyl;
R7 and R8 are independently hydrogen or C1-C6alkyl, or R7 and R8 together with the atom to which they are attached form a cycloalkyl group; and
X is \u2014CHR6\u2014, \u2014S(O)n\u2014, \u2014NR6SO2\u2014 or \u2014SO2NR6\u2014 wherein n is 0, 1 or 2, for the manufacture of a composition for the treatment of asthma, chronic obstructive pulmonary disease, rhinitis, allergic airway syndrome or allergic rhinobronchitis.
22. A method of treatment of a disease selected from asthma, chronic obstructive pulmonary disease, rhinitis, allergic airway syndrome, and allergic rhinobronchitis, comprising administering to a patient suffering such disease an effective amount of a compound of formula (I)
or a salt, N-oxide, hydrate or solvate thereof, for therapeutic use
wherein
R1, R2, R3 and R4 each independently are hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl, halo, \u2014S(O)nR10, SO2N(R10)2, \u2014N(R10)2, \u2014C(O)N(R10)2, \u2014NR10C(O)R9, \u2014CO2R10, \u2014NO2, \u2014CN or \u2014OR11;
wherein each R9 is independently C1-C6alkyl, aryl, or heteroaryl;
R10 is independently hydrogen, C1-C6alkyl, aryl, or heteroaryl;
R11 is hydrogen, C1-C6alkyl, fully or partially fluorinated C1-C6alkyl or a group \u2014SO2R9;
n is 0, 1 or 2;
R5 is C1-C6alkyl, fully or partially fluorinated C1-C6alkenyl, C1-C6alkynyl, optionally substituted aryl, or optionally substituted heteroaryl;
R6 is hydrogen, C1-C6alkyl or fully or partially fluorinated C1-C6alkyl;
R7 and R8 are independently hydrogen or C1-C6alkyl, or R7 and R8 together with the atom to which they are attached form a cycloalkyl group; and
X is \u2014CHR6\u2014, \u2014S(O)n\u2014, NR6SO2\u2014 or \u2014SO2NR6\u2014 wherein n is 0, 1 or 2.