1. A compound of formula (I) or a pharmaceutically acceptable salt thereof, or any stereoisomer or mixture thereof,
wherein:
R1 is a (C1-C2) alkyl radical;
R2 and R3 are radicals independently selected from the group consisting of F, Cl and methyl;
R4 is H or OH;
A is a birradical selected from the group consisting of \u2014(CH2)n\u2014 and \u2014(CH2)-phenyl-(CH2)\u2014;
t is an integer from 0 to 1; and
n is an integer from 8 to 15.
2. The compound according to claim 1, wherein R1 is methyl, R2 is Cl, t is 0, and R4 is H.
3. The compound according to claim 1, wherein A is \u2014(CH2)n\u2014 and n is an integer from 8 to 12.
4. The compound according to claim 3, wherein n is an integer from 8 to 9.
5. The compound according to claim 1, wherein A is \u2014(CH2)\u2014 phenyl-(CH2)\u2014.
6. The compound according to claim 1, which is selected from the following list:
(\xb1)-N-{8-(3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocyclooctabquinolin-12-yl)aminooctyl}-9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxamide;
(\xb1)-N-{9-(3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocyclooctabquinolin-12-yl)aminononyl}-9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxamide;
(\u2212)-(7S,11S)\u2014N-{9-(3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocyclooctabquinolin-12-yl)aminononyl}-9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxamide;
(+)-(7R,11R)\u2014N-{9-(3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocyclooctabquinolin-12-yl)aminononyl}-9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxamide;
(\xb1)-N-{10-(3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocyclooctabquinolin-12-yl)aminodecyl}-9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxamide;
(\xb1)-N-{11-(3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocyclooctabquinolin-12-yl)aminoundecyl}-9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxamide; and
(\xb1)-N-{4-{(3-chloro-6,7,10,11-tetrahydro-9-methyl-7,11-methanocyclooctabquinolin-12-yl)aminomethyl}benzyl}-9,10-dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxamide.
7. The compound according to claim 1, wherein the pharmaceutically acceptable salt is a hydrochloride salt.
8. A process for the preparation of the compound of formula (I) as defined in claim 1, which comprises:
(a) reacting a compound of formula (II), a salt or a reactive derivative thereof,
with a compound of formula (III) or a salt thereof, or any stereoisomer or mixture thereof;
wherein R1, R2, R3, R4, A, t, and n are as defined in claim 1, respectively; and,
(b) optionally, converting the compound thus obtained into a pharmaceutically acceptable salt by reacting it with a pharmaceutically acceptable acid.
9. The process according to claim 8, further comprising a previous step of submitting a compound of formula (IV) or a salt thereof, or any stereoisomer or mixture thereof,
wherein B is a birradical selected from the group consisting of \u2014(CH2)n-1\u2014 and \u2014(CH2)\u2014 phenyl-, and n, R1, R2, R3, and t are as defined in claim 1, respectively; to a reduction reaction to yield a compound of formula (III) or a salt thereof, or any stereoisomer or mixture thereof.
10. The process according to claim 9, further comprising a previous step of:
(a) reacting a compound of formula (V) or a salt thereof, or any stereoisomer or mixture thereof wherein R1, R2, R3, and t are as defined in claim 1, respectively,
with a compound of formula (VI)
Br\u2014(CH2)n-1\u2014CN\u2003\u2003(VI)
to yield a compound of formula (IV) wherein B is \u2014(CH2)n-1\u2014 and n is as defined in claim 1, respectively; or alternatively,
(a\u2032) with p-cyanobenzaldehyde to yield a compound of formula (IV\u2032e)
and then submitting the compound thus obtained to a reduction reaction to yield a compound of formula (IV) wherein B is \u2014(CH2)-phenyl-.
11. A method of treatment of Alzheimer’s disease comprising administering a therapeutically effective amount of the compound of formula (I) as defined in claim 1, together with pharmaceutically acceptable excipients or carriers in a mammal suffering from Alzheimer’s disease.
12. A pharmaceutical composition comprising a therapeutically effective amount of a compound as defined in claim 1, together with appropriate amounts of one or more pharmaceutically acceptable excipients or carriers.
13. A compound of formula (III) or a salt thereof, or any stereoisomer or mixture thereof,
wherein:
R1 is a (C1-C2) alkyl radical;
R2 and R3 are radicals independently selected from the group consisting of F, Cl, and methyl;
A is a birradical selected from the group consisting of \u2014(CH2)n\u2014 and \u2014(CH2)-phenyl-(CH2)\u2014;
t is an integer from 0 to 1; and
n is an integer from 8 to 15.
14. A compound selected from the group consisting of:
a compound of formula (IV) or a salt thereof, or any stereoisomer or mixture thereof,
a compound of formula (IV\u2032e),
wherein:
R1 is a (C1-C2) alkyl radical;
R2 and R3 are radicals independently selected from the group consisting of F, Cl, and methyl;
t is an integer from 0 to 1;
B is a birradical selected from the group consisting of \u2014(CH2)n-1\u2014 and \u2014(CH2)-phenyl-, and
n is an integer from 8 to 15.
15. A method according to claim 11 wherein the mammal is a human.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A lighting system, comprising:
first and second light collecting modules, each having a frame which carries a window and an optical fiber which receives light flowing through the window;
wherein the first and second modules include first and second light collecting module housings, respectively, the modules being coupled together so they are repeatably rotatable, as a unit, between first and second positions;
wherein the first and second light collecting module housings carry the corresponding frames.
2. The system of claim 1, wherein the second light collecting module rotates in response to rotation of the first light collecting module.
3. The system of claim 1, further including a rotation motor operatively coupled to the first light collecting module.
4. The system of claim 3, wherein the second light collecting module is coupled to the rotation motor through the first light collecting module.
5. The system of claim 1, wherein the windows of the first and second light collecting modules are Fresnel lenses.
6. The system of claim 1, wherein the first and second light collecting modules are coupled together with an arm.
7. The system of claim 1, further including a third light collecting module coupled to the second light collecting module, wherein the third light collecting module includes a window and an optical fiber which receives light flowing through the window.
8. A lighting system, comprising:
a first light collecting module having a frame which carries a window, and a plurality of optical fibers which receives light flowing through the window; and
a first window cleaning system carried by the first light collecting module, the first window cleaning system being repeatably moveable relative to the window of the first light collecting module;
wherein the frame is repeatably rotatably relative to the first light collecting module.
9. The system of claim 8, further including a second light collecting module having a window and a plurality of optical fibers which receives light flowing through the window.
10. The system of claim 9, further including a second window cleaning system carried by the second light collecting module, the second window cleaning system being repeatably moveable relative to the window of the second light collecting module.
11. The system of claim 8, further including a rotation motor operatively coupled to the first light collecting module.
12. The system of claim 8, further including a tracking system operatively coupled to the first light collecting module, the first light collecting module being rotated in response to a tracking signal from the tracking system.
13. The system of claim 12, further including a solar power system which powers the first cleaning system andor the tracking system.
14. A lighting system, comprising:
first and second light collecting modules, each having a frame which carries a window and an optical fiber which receives light flowing through the window;
wherein the first and second modules include first and second light collecting module housings, respectively, the modules being coupled together so they are repeatably rotatable, as a unit, between first and second positions;
wherein the first and second light collecting module housings carry the corresponding frames; and
a light emitting fixture operatively coupled to the optical fiber of the first light collecting module, the light emitting fixture including an electrical light positioned proximate to a light emitting end of the optical fiber of the first light collecting module.
15. The system of claim 14, wherein the light emitting fixture emits light from the electrical light andor light emitting end of the optical fiber of the first light collecting module.
16. The system of claim 14, further including a prism coupled to the light emitting end of the optical fiber of the first light collecting module.
17. The system of claim 14, wherein the light emitting end of the optical fiber of the first light collecting module emits light from a ceiling which carries the light emitting fixture.
18. The system of claim 14, wherein the light emitting end of the optical fiber of the first light collecting module emits light from a baffle of the light emitting fixture.
19. The system of claim 14, further including a faceplate assembly, wherein the light emitting end of the optical fiber of the first light collecting module emits light from the faceplate assembly.
20. The system of claim 19, wherein the faceplate assembly includes optically transparent material.
21. The system of claim 1, wherein the second light collecting module housing rotates in response to rotation of the first light collecting module housing.
22. The system of claim 1, further including a rotation motor operatively coupled to the first light collecting module housing.
23. The system of claim 22, wherein the second light collecting module housing is coupled to the rotation motor through the first light collecting module housing.
24. The system of claim 1, further including an arm which couples the first and second light collecting module housings together.
25. The system of claim 1, wherein the window of the first light collecting module is carried by the first light collecting module housing.
26. The system of claim 1, wherein the first light collecting module includes a frame which carries the window.
27. The system of claim 8, wherein the first window cleaning system includes a brush.
28. The system of claim 8, wherein the first window cleaning system includes a fluid conduit, and a nozzle directed at the brush.
29. The system of claim 8, wherein the first window cleaning system includes a fluid conduit and nozzle.
30. The system of claim 8, wherein the first light collecting module includes a guide rail.
31. The system of claim 28, wherein the first window cleaning system includes a wheel carried by the guide rail.
32. A lighting system, comprising:
first and second light collecting modules, each having a frame which carries a window and an optical fiber which receives light flowing through the window;
wherein the first and second first and second light collecting modules include first and second light collecting module housings, respectively, the first and second light collecting modules being coupled together so the first and second light collecting module housings are repeatably rotatable, as a unit, between first and second positions; and
a first window cleaning system carried by the first light collecting module housing, the first window cleaning system being repeatably moveable relative to the window of the first light collecting module;
wherein the frame is repeatably rotatably relative to the first light collecting module.
33. The system of claim 32, further including a second window cleaning system carried by the second light collecting module housing, the second window cleaning system being repeatably moveable relative to the window of the second light collecting module.
34. The system of claim 32, further including a solar power system which powers the first cleaning system.
35. The system of claim 32, further including a light emitting fixture operatively coupled to the optical fiber of the first light collecting module, the light emitting fixture including an electrical light positioned proximate to a light emitting end of the optical fiber of the first light collecting module.
36. The system of claim 35, wherein the light emitting fixture is operatively coupled to the optical fiber of the second light collecting module, the electrical light being positioned proximate to a light emitting end of the optical fiber of the second light collecting module.
37. The system of claim 1, wherein the frame of the first light collecting module is repeatably rotatable relative to the first light collecting module housing.
38. The system of claim 1, wherein the frame includes opposed trunnion pins engaged to the first light collecting module housing.
39. The system of claim 1, further including a movement arm operatively coupled to the frames of the first and second light collecting modules.
40. The system of claim 39, wherein the frames of the first and second light collecting modules rotate in response to the motion of the movement arm.
41. The system of claim 6, wherein the first and second light collecting module housings are spaced apart by the arm.
42. The system of claim 14, wherein the light emitting fixture provides generated light and sunlight from the electrical light and light emitting end of the optical fiber of the first light collecting module, respectively.
43. The system of claim 14, wherein the light emitting fixture provides generated light.
44. The system of claim 14, wherein the light emitting end of the optical fiber of the first light collecting module provides sunlight which corresponds to the light flowing through the window.
45. The system of claim 24, wherein the first and second light collecting module housings are spaced apart by the arm.
46. A lighting system, comprising:
a first light collecting module which includes
a first light collecting module housing;
a first frame rotatably coupled to the first light collecting module housing;
a first window carried by the first frame;
a first optical fiber which receives light flowing through the first window;
a second light collecting module which includes
a second light collecting module housing;
a second frame rotatably coupled to the second light collecting module housing;
a second window carried by the second frame;
a second optical fiber which receives light flowing through the first window;
a movement arm which operatively couples to the first and second frames together, wherein the first and second frames rotate in response to linear motion of the movement arm; and
a rotation arm operatively coupled to the first and second light collecting module housings, wherein the first and second light collecting module housings are spaced apart by the rotation arm.
47. The system of claim 46, wherein the first frame includes opposed trunnion pins engaged with the first light collecting module housing.
48. The system of claim 46, wherein the pitch of the window is adjustable in response to rotating the first frame.
49. The system of claim 46, wherein the pitch of the window is adjustable in response to the linear motion of the movement arm.