1. An organic electroluminescent device comprising:
a first electrode;
a second electrode; and
an electroluminescent film containing an organic compound capable of causing an electroluminescence and being provided between the first electrode and the second electrode,
wherein a carrier generation layer is embodied in the electroluminescent film, the carrier generation layer being a floating electrode,
wherein a first insulating film is provided between the first electrode and the electroluminescent film,
wherein a second insulating film is provided between the second electrode and the electroluminescent film,
wherein the carrier generation layer comprises a conductive film, a first electron injection region on the conductive film, a second electron injection region under the conductive film,
wherein the conductive film is in contact with the first and second electron injection regions.
2. The organic electroluminescent device according to claim 1,
wherein the electroluminescent film comprises a layer having bipolar property.
3. The organic electroluminescent device according to claim 1,
wherein the organic electroluminescent device is configured to be driven by an alternating current bias.
4. The organic electroluminescent device according to claim 3,
wherein a waveform of the alternating current bias is selected from a sine wave, a square wave, and a triangle wave.
5. The organic electroluminescent device according to claim 1,
wherein the carrier generation layer has an electric conductivity of 1010 Sm or more.
6. The organic electroluminescent device according to claim 1,
wherein a drive frequency of the organic electroluminescent device is in a range of 1 to 100 kHz.
7. The organic electroluminescent device according to claim 1,
wherein the first and second electron injection regions are cluster-like.
8. The organic electroluminescent device according to claim 1,
wherein parts of top and upper surfaces of the conductive film are in contact with the electroluminescent film.
9. The organic electroluminescent device according to claim 1, wherein the first and second electron injection regions comprise one selected from the group consisting of Al:Li, Ca, and LiF.
10. The organic electroluminescent device according to claim 1, wherein the first and second insulating films prevent a carrier injection from the first and second electrodes to the electroluminescent film, respectively.
11. A display device comprising the organic electroluminescent device according to claim 1.
12. An organic electroluminescent device comprising:
a first electrode;
a second electrode; and
an electroluminescent film containing an organic compound capable of causing an electroluminescence and being provided between the first electrode and the second electrode,
wherein a carrier generation layer is embodied in the electroluminescent film, the carrier generation layer being a floating electrode,
wherein a first insulating film is provided between the first electrode and the electroluminescent film,
wherein a second insulating film is provided between the second electrode and the electroluminescent film, and
wherein the carrier generation layer comprises a conductive film, a first hole injection region on the conductive film, a second hole injection region under the conductive film,
wherein the conductive film is in contact with the first and second hole injection regions.
13. The organic electroluminescent device according to claim 12, wherein the electroluminescent film comprises a layer having bipolar property.
14. The organic electroluminescent device according to claim 12, wherein the organic electroluminescent device is configured to be driven by an alternating current bias.
15. The organic electroluminescent device according to claim 14, wherein a waveform of the alternating current bias is selected from a sine wave, a square wave, and a triangle wave.
16. The organic electroluminescent device according to claim 12, wherein the carrier generation layer has an electric conductivity of 10\u221210 Sm or more.
17. The organic electroluminescent device according to claim 12, wherein a drive frequency of the organic electroluminescent device is in a range of 1 to 100 kHz.
18. The organic electroluminescent device according to claim 12, wherein the first and second hole injection regions are cluster-like.
19. The organic electroluminescent device according to claim 16, wherein parts of top and upper surfaces of the conductive film are in contact with the electroluminescent film.
20. The organic electroluminescent device according to claim 12, wherein the first and second hole injection regions comprise one selected from the group consisting of Au and ITO.
21. The organic electroluminescent device according to claim 12, wherein the first and second insulating films prevent a carrier injection from the first and second electrodes to the electroluminescent film, respectively.
22. A display device comprising the organic electroluminescent device according to claim 12.
23. A lighting comprising an organic electroluminescent device:
the organic electroluminescent device comprising:
a first electrode;
a second electrode; and
an electroluminescent film containing an organic compound capable of causing an electroluminescence and being provided between the first electrode and the second electrode,
wherein a carrier generation layer is embodied in the electroluminescent film, the carrier generation layer being a floating electrode,
wherein a first insulating film is provided between the first electrode and the electroluminescent film,
wherein a second insulating film is provided between the second electrode and the electroluminescent film, and
wherein the carrier generation layer comprises a conductive film, a first electron injection region on the conductive film, a second electron injection region under the conductive film,
wherein the conductive film is in contact with the first and second electron injection regions.
24. The lighting according to claim 23, wherein the electroluminescent film comprises a layer having bipolar property.
25. The lighting according to claim 23, wherein the organic electroluminescent device is configured to be driven by an alternating current bias.
26. The lighting according to claim 25, wherein a waveform of the alternating current bias is selected from a sine wave, a square wave, and a triangle wave.
27. The lighting according to claim 23, wherein the carrier generation layer has an electric conductivity of 10\u221210 Sm or more.
28. The lighting according to claim 23, wherein a drive frequency of the organic electroluminescent device is in a range of 1 to 100 kHz.
29. The lighting according to claim 23, wherein the first and second electro injection regions are cluster-like.
30. The lighting according to claim 23, wherein parts of top and upper surfaces of the conductive film are in contact with the electroluminescent film.
31. The lighting according to claim 23, wherein the first and second electron injection regions comprise one selected from the group consisting of Al:Li, Ca, and LiF.
32. The lighting according to claim 23, wherein the first and second insulating films prevent a carrier injection from the first and second electrodes to the electroluminescent film, respectively.
33. The lighting according to claim 23, wherein the lighting is configured to emit white light.
34. A lighting comprising an organic electroluminescent device:
the organic electroluminescent device comprising:
a first electrode;
a second electrode; and
an electroluminescent film containing an organic compound capable of causing an electroluminescence and being provided between the first electrode and the second electrode,
wherein a carrier generation layer is embodied in the electroluminescent film, the carrier generation layer being a floating electrode,
wherein a first insulating film is provided between the first electrode and the electroluminescent film,
wherein a second insulating film is provided between the second electrode and the electroluminescent, and
wherein the carrier generation layer comprises a conductive film, a first hole injection region on the conductive film, a second hole injection region under the conductive film, wherein the conductive film is in contact with the first and second hole injection regions.
35. The lighting according to claim 34, wherein the electroluminescent film comprises a layer having bipolar property.
36. The lighting according to claim 34, wherein the organic electroluminescent device is configured to be driven by an alternating current bias.
37. The lighting according to claim 36, wherein a waveform of the alternating current bias is selected from a sine wave, a square wave, and a triangle wave.
38. The lighting according to claim 34, wherein the carrier generation layer has an electric conductivity of 10\u221210 Sm or more.
39. The lighting according to claim 34, wherein a drive frequency of the organic electroluminescent device is in a range of 1 to 100 kHz.
40. The lighting according to claim 34, wherein the first and second hole injection regions are cluster-like.
41. The lighting according to claim 34, wherein parts of top and upper surfaces of the conductive film are in contact with the electroluminescent film.
42. The lighting according to claim 34, wherein the first and second hole injection regions comprise one selected from the group consisting of Au and ITO.
43. The lighting according to claim 34, wherein the first and second insulating films prevent a carrier injection from the first and second electrodes to the electroluminescent film, respectively.
44. The lighting according to claim 34, wherein the lighting is configured to emit white light.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. Compounds of the general formula (I)
31
in which
32
represents 1 to n groups
33
which are identical to or different from one another, where n is a number 1 to n and n corresponds to the maximum number of possible linkage sites of M,
in which
Ar represents an aryl radical having up to 10 carbon atoms, which additionally to X can optionally be mono- or polysubstituted by alkyl having up to 6 carbon atoms, alkoxy having up to 6 carbon atoms, alkoxycarbonyl having up to 6 carbon atoms, hydroxyl, carboxyl, carboxyalkyl having up to 6 carbon atoms, cyano, nitro, isocyanato, isothiocyanato, halogen, sulphonyl andor sulphonamide,
X represents a direct single bond or alkylene having up to 6 carbon atoms,
M represents a mono-, di-, tri- or tetrapeptide, which is linked via the -amino group andor via amino andor hydroxy groups of the side chains to the n groups
34
which are identical to or different from one another, where further functional groups of the peptide can optionally carry protective groups,
C represents a radical of a cytostatic or of a cytostatic derivative which is linked to m via an amino function or via an oxygen atom,
and their stereoisomers, stereoisomer mixtures and salts.
2. Compounds according to claim 1, characterized in that
Ar represents a phenyl radical which can additionally carry hydroxyl, carboxyl, isothiocyanato or halogen in the para-position to X,
and their stereoisomers, stereoisomer mixtures and salts.
3. Compounds according to one of claims 1 or 2, characterized in that
X represents a single bond or methylene,
and their stereoisomers, stereoisomer mixtures and salts.
4. Compounds according to one of claims 1, 2 or 3, characterized in that M represents a mono-, di- or tripeptide which is linked to the 1 to n groups
35
which are identical to or different from one another via the -amino group andor via amino andor hydroxy groups of the side chains, where further functional groups of the peptide can optionally carry protective groups,
and their stereoisomers, stereoisomer mixtures and salts.
5. Compounds according to one of claims 1 to 4, characterized in that the peptides M consist of amino acid radicals which are derived from alanine, aspartic acid, glutamic acid, glycine, leucine, histidine, lysine, arginine, ornithine, serine, tyrosine, valine or diaminopropionic acid, it being possible for a number of amino acid radicals to be linked in peptide form both via the -amino group and optionally via the side-chain amino functions and also via both functions,
and their stereoisomers, stereoisomer mixtures and salts.
6. Compounds according to one of claims 1 to 5, characterized in that C represents a batracylin, methotrexate, quinolone-a, etoposide, melphalan, taxol or camptothecin radical, a camptothecin derivative modified in the A ring or B ring, a daunomycin or doxorubicin radical, where C is linked to M via an amino or hydroxyl function,
and their stereoisomers, stereoisomer mixtures and salts.
7. Process for the preparation of compounds of the general formula (I) according to claim 1, characterized in that compounds of the general formula (II)
MC(II),
in which C has the meaning indicated in claim 1 and M represents a radical M defined in claim 1, which carries hydrogen atoms on the desired linkage sites and whose other potential linkage sites are blocked by protective groups,
are reacted with compounds of the general formula (III)
ArXNCS(III)
in suitable solvents in the presence of a base to give compounds of the general formula (Ia)
36
in which Ar, X and C have the meanings indicated above and M represents a radical M, whose further potential linkage sites are blocked by protective groups,
and in the case of the introduction of further groups
37
which differ from that or those initially introduced, the corresponding protective groups are optionally selectively removed from the compounds of the formula (Ia), the latter are reacted in the manner indicated above with further compounds of the general formula (III), which differ from those initially introduced, and, if appropriate, this reaction sequence is repeated to introduce further radicals
38
different from the radicals introduced,
and in that remaining protective groups are optionally removed,
in that, furthermore, the stereoisomers are separated, if appropriate according to customary methods, and in that, if appropriate, the compounds are converted into their salts.
8. Use of the compounds of the general formula (I) according to claim 1 for the production of medicaments.
9. Medicaments comprising compounds of the general formula (I) according to claim 1.