1. A method for monitoring a patient and graphically representing ST-segment deviations derived from electrocardiogram (ECG) signals from a plurality of leads, each ECG signal including a sequence of ST-segments between a QRS complex and a T wave, the method comprising:
obtaining a first set of data corresponding to a baseline ST-segment deviation from an isoelectric value for each of the plurality of leads at a first point in time;
obtaining a second set of data corresponding to an ST-segment deviation from an isoelectric value for each of the plurality of leads at a second point in time (\u201ccurrent ST-segment deviation\u201d);
displaying a graph comprising:
a first axis representing ST-segment deviation values; and
a second axis representing the plurality of leads, wherein each of the plurality of leads is associated with a respective location along the second axis;
displaying a first set of bar graphs representing the baseline ST-segment deviations, wherein each first bar graph is displayed with respect to one of the locations corresponding to a respective lead and is aligned relative to the first axis based on the baseline ST-segment deviation for the respective lead; and
displaying a second set of bar graphs representing the current ST-segment deviations, wherein each second bar graph is displayed with respect to one of the locations corresponding to a respective lead and is aligned relative to the first axis based on the current ST-segment deviation for the respective lead;
displaying a graphical indication in addition to the bar graphs to indicate whether the current ST-segment deviation for a particular lead is increasing or decreasing with respect to the baseline ST-segment deviation for that lead.
2. The method of claim 1, wherein the graphical indication comprises one of an arrow or arrow head.
3. The method of claim 1, wherein the graphical indication comprises a directed line segment.
4. The method of claim 1, wherein the graphical indication is displayed on one or both of the first and second bar graph for a lead.
5. The method of claim 1, wherein the graphical indication is displayed adjacent to one or both of the first and second bar graph for a lead.
6. The method of claim 8, further comprising:
displaying one or more threshold lines substantially parallel to the second linear axis, each threshold line representing a threshold ST-segment deviation value.
7. A patient monitoring system for graphically representing ST-segment deviation derived from electrocardiogram (ECG) signals from a plurality of leads, each ECG signal including a sequence of ST-segments between a QRS complex and a T wave, the system comprising:
a processor configured to obtain a first set of data corresponding to a baseline ST-segment deviation from an isoelectric value for each of the plurality of leads at a first point in time and a second set of data corresponding to an ST-segment deviation from an isoelectric value for each of the plurality of leads at a second point in time (\u201ccurrent ST-segment deviation\u201d), wherein the processor is further configured to process the ECG signals to determine, for each of the plurality of leads, baseline ST-segment deviations from an isoelectric value and current ST-segment deviations from the isoelectric value;
a display module configured to display a graph in a user interface, the graph comprising:
a first axis representing ST-segment deviation values; and
a second axis representing the plurality of leads, wherein each of the plurality of leads is associated with a respective location along the second axis;
wherein the display module is further configured to:
display a first set of graphic indicia representing the baseline ST-segment deviations, each graphic indicia in the first set being displayed with respect to one of the locations corresponding to a respective lead and being aligned relative to the first axis based on the baseline ST-segment deviation for the respective lead; and
displays a second set of graphic indicia representing the current ST-segment deviations, each graphic indicia in the second set being displayed with respect to one of the locations corresponding to a respective lead and being aligned relative to the first axis based on the current ST-segment deviation for the respective lead; and
displays a third set of graphical indicia to indicate whether the current ST-segment deviation for a particular lead is increasing or decreasing with respect to the baseline ST-segment deviation for that lead.
8. The patient monitoring system of claim 7, wherein the third set of graphical indicia comprises one of an arrow or arrow head.
9. The patient monitoring system of claim 7, wherein the third set of graphical indicia comprises a directed line segment.
10. The patient monitoring system of claim 7, wherein the third set of graphical indicia is displayed on one or both of the first set of graphical indicia and the second set of graphical indicia for a lead.
11. The patient monitoring system of claim 7, wherein the third set of graphical indicia is displayed adjacent to on one or both of the first set of graphical indicia and the second set of graphical indicia for a lead.
12. The patient monitoring system of claim 7, wherein the display module is further configured to:
display one or more threshold lines substantially parallel to the second linear axis, each threshold line representing a threshold ST-segment deviation value.
13. A computer-readable medium comprising program code for causing a processor to perform a method for monitoring a patient and graphically representing ST-segment deviations derived from electrocardiogram (ECG) signals from a plurality of leads, each ECG signal including a sequence of ST-segments between a QRS complex and a T wave, the method comprising:
obtaining a first set of data corresponding to a baseline ST-segment deviation from an isoelectric value for each of the plurality of leads at a first point in time;
obtaining a second set of data corresponding to an ST-segment deviation from an isoelectric value for each of the plurality of leads at a second point in time (\u201ccurrent ST-segment deviation\u201d);
displaying a graph comprising:
a first axis representing ST-segment deviation values; and
a second axis representing the plurality of leads, wherein each of the plurality of leads is associated with a respective location along the second axis;
displaying a first set of bar graphs representing the baseline ST-segment deviations, wherein each first bar graph is displayed with respect to one of the locations corresponding to a respective lead and is aligned relative to the first axis based on the baseline ST-segment deviation for the respective lead; and
displaying a second set of bar graphs representing the current ST-segment deviations, wherein each second bar graph is displayed with respect to one of the locations corresponding to a respective lead and is aligned relative to the first axis based on the current ST-segment deviation for the respective lead;
displaying a graphical indication in addition to the bar graphs to indicate whether the current ST-segment deviation for a particular lead is increasing or decreasing with respect to the baseline ST-segment deviation for that lead.
14. The computer-readable medium of claim 13, wherein the graphical indication comprises one of an arrow or arrow head.
15. The computer-readable medium of claim 13, wherein the graphical indication comprises a directed line segment.
16. The computer-readable medium of claim 13, wherein the graphical indication is displayed on one or both of the first and second bar graph for a lead.
17. The computer-readable medium of claim 13, wherein the graphical indication is displayed adjacent to one or both of the first and second bar graph for a lead.
18. The computer-readable medium of claim 13, wherein the method further comprises:
displaying one or more threshold lines substantially parallel to the second linear axis, each threshold line representing a threshold ST-segment deviation value.
19. A method for monitoring a patient and graphically representing ST-segment deviations derived from electrocardiogram (ECG) signals from a plurality of leads, each ECG signal including a sequence of ST-segments between a QRS complex and a T wave, the method comprising:
obtaining a first set of data corresponding to a baseline ST-segment deviation from an isoelectric value for each of the plurality of leads at a first point in time;
obtaining a second set of data corresponding to an ST-segment deviation from an isoelectric value for each of the plurality of leads at a second point in time (\u201ccurrent ST-segment deviation\u201d);
displaying a graph comprising:
a first axis representing ST-segment deviation values; and
a second axis representing the plurality of leads, wherein each of the plurality of leads is associated with a respective location along the second axis;
displaying a first set of bar graphs representing the baseline ST-segment deviations, wherein each first bar graph is displayed with respect to one of the locations corresponding to a respective lead and is aligned relative to the first axis based on the baseline ST-segment deviation for the respective lead;
displaying a second set of bar graphs representing the current ST-segment deviations, wherein each second bar graph is displayed with respect to one of the locations corresponding to a respective lead and is aligned relative to the first axis based on the current ST-segment deviation for the respective lead,
wherein a shape of at least one second bar graph indicates whether the current ST-segment deviation for a particular lead is increasing or decreasing with respect to the baseline ST-segment deviation for that lead.
20. The method of claim 19, wherein the shape of the second bar graph comprises a rectangle with corners removed on a top side to indicate that the current ST-segment deviation is increasing with respect to the baseline ST-segment deviation.
21. The method of claim 19, wherein the shape of the second bar graph comprises a rectangle with corners removed on a bottom side to indicate that the current ST-segment deviation is decreasing with respect to the baseline ST-segment deviation.
22. The method of claim 19, wherein the shape of the second bar graph comprises a trapezoid, wherein a smaller base of the trapezoid is on top indicating that the current ST-segment deviation is increasing with respect to the baseline ST-segment deviation.
23. The method of claim 19, wherein the shape of the second bar graph comprises a trapezoid, wherein a smaller base of the trapezoid is on bottom indicating that the current ST-segment deviation is decreasing with respect to the baseline ST-segment deviation.
24. A method for monitoring a patient and graphically representing ST-segment deviations derived from electrocardiogram (ECG) signals from a plurality of leads, each ECG signal including a sequence of ST-segments between a QRS complex and a T wave, the method comprising:
obtaining a first set of data corresponding to a baseline ST-segment deviation from an isoelectric value for each of the plurality of leads at a first point in time;
obtaining a second set of data corresponding to an ST-segment deviation from an isoelectric value for each of the plurality of leads at a second point in time (\u201ccurrent ST-segment deviation\u201d);
displaying a graph comprising:
a first axis representing ST-segment deviation values; and
a second axis representing the plurality of leads, wherein each of the plurality of leads is associated with a respective location along the second axis;
displaying a first set of bar graphs representing the baseline ST-segment deviations, wherein each first bar graph is displayed with respect to one of the locations corresponding to a respective lead and is aligned relative to the first axis based on the baseline ST-segment deviation for the respective lead;
displaying a second set of bar graphs representing the current ST-segment deviations, wherein each second bar graph is displayed with respect to one of the locations corresponding to a respective lead and is aligned relative to the first axis based on the current ST-segment deviation for the respective lead; and
displaying one or more threshold lines substantially parallel to the second linear axis, each threshold line representing a threshold ST-segment deviation value.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. Arylpiperazine compounds of the formula I
25
where
A is a fused heteroaromatic or heteroaliphatic ring comprising one or two nitrogen atoms,
B is CO or CHOH or C(Ar)(OH)
R1 and R2 independently of one another are H, alkyl, C1-C6 or halogen
Ar is phenyl or thiophene, which is unsubstituted or monosubstituted or polysubstituted by halogen, NO2 or CN and
n is 1, 2, 3 or 4,
and their salts and solvates.
2. Compounds of the formula I according to one of the preceding claims, characterized in that the group
26
has one of the following meaning:
27
3. Compounds selected from the following group of compounds 1a to 1h:
28
29
and their salts and solvates.
4. Compounds of the formula I according to claim 1 and their physiologically acceptable salts or solvates as pharmaceutical active compounds.
5. Compounds of the formula I according to claim 1 and their physiologically acceptable salts or solvates as D2 receptor antagonists andor 5HT1A antagonists.
6. Compounds of the formula I according to claim 1 and their physiologically acceptable salts or solvates for use in the control of diseases.
7. Pharmaceutical preparation characterized in that it contains at least one compound of the formula I according to claim 1 andor one of its physiologically acceptable salts or solvates.
8. Use of compounds of the formula I according to claim 1 andor their physiologically acceptable salts or solvates for the production of a medicament.
9. Use of compounds of the formula I according to claim 1 andor their physiologically acceptable salts or solvates for the production of a medicament for the treatment of illnesses of the central nervous system, in particular of mental disorders of the schizophrenia type and for the control of psychotic anxiety states.
10. Process for the preparation of compounds of the formula I and their salts and solvates, characterized in that a compound of the formula II
30
in which R1, R2 and A have the meaning indicated above, is reacted with a compound of the formula III
31
in which Ar, B and n have the meaning indicated above and L is a leaving group and, if B has the meaning CO, the group B is optionally hydrogenated, alkylated or arylated and, if appropriate, a basic or acidic compound of the formula I is converted into one of its salts or solvates by treating with an acid or base.