1. An ophthalmic device, comprising;
a mass of material, the mass of material including an acrylic material, the acrylic material including a substantial portion of hydrophobic acrylate; and
therapeutic agent associated with the mass of material wherein the therapeutic agent is hydrophobic and has a PC Log P that is at least 1.0;
wherein the mass of material is configured for insertion into an eye of a human.
2. An ophthalmic device as in claim 1 wherein the therapeutic agent has a PC Log P that is at least 2.0.
3. An ophthalmic device as in claim 1 wherein the hydrophobic acrylate is includes HEMA.
4. An ophthalmic device as in claim 1 wherein the acrylic material includes a substantial portion of hydrophilic acrylate.
5. An ophthalmic device as in claim 4 wherein the hydrophilic acrylate includes PEMA.
6. An ophthalmic device as in claim 4 wherein the mass of material releases a controlled amount of therapeutic agent when submerged in basic salt solution and wherein the hydrophobic acrylate and the hydrophilic acrylate are present in the mass of material in amounts such that the controlled amount of therapeutic agent is less than 60% of the total therapeutic agent in a time period that is at least 5 days.
7. An ophthalmic device as in claim 4 wherein the amount of hydrophilic acrylate and hydrophobic acrylate are selected to provide a predetermined release profile for the therapeutic agent.
8. An ophthalmic device as in claim 1 wherein the therapeutic agent includes an anti-inflammatory agent.
9. An ophthalmic device as in claim 8 wherein the anti-inflammatory agent is nepafenac.
10. An ophthalmic device as in claim 1 wherein the mass of material is an IOL selected from an Aphakic IOL, an AC Phakic IOL and a PC Phakic IOL.
11. An ophthalmic device as in claim 1 wherein the mass of material is a haptic of an IOL.
12. An ophthalmic device as in claim 1 wherein the mass of material is located at least partially within an eye of an individual.
13. An ophthalmic device as in claim 1 wherein the mass of material is configured as part or the whole of an IOL, a haptic of an IOL or a separate piece that is inserted in the eye with or without an IOL.
14. An ophthalmic device as in claim 1 wherein the mass of material releases a controlled amount of therapeutic agent when submerged in basic salt solution.
15. An ophthalmic device as in claim 14 wherein less than 50% by weight of the therapeutic agent is released from the ophthalmic device in the basic salt solution over a period that is at least one week.
16. A method of forming an ophthalmic device, the method comprising:
providing a mass of material, the mass of material including an acrylic material wherein a substantial portion of acrylic material is a hydrophobic acrylate; and
submerging the mass of material in a solution that includes solvent and a therapeutic agent thereby loading the mass of material with therapeutic agent wherein the therapeutic agent is hydrophobic and has a PC Log P that is at least 1.0.
17. A method as in claim 16, further comprising:
surgically locating the mass of material in an eye of a human.
18. A method as in claim 16 wherein the mass of material is configured as part or the whole of an IOL, a haptic of an IOL or a separate piece that is inserted in the eye with or without an IOL.
19. A method as in claim 16 wherein the mass of material releases a controlled amount of the therapeutic agent when submerged in basic salt solution.
20. A method as in claim 19 wherein less than 50% by weight of the therapeutic agent is released from the ophthalmic device in the basic salt solution over a period that is at least one week.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of establishing a real-time dialog session between an organization and a user simultaneously present on a presence aware network, comprising:
associating a first presence handle with said organization;
associating a second presence handle with said user;
registering said second presence handle with said presence aware network;
connecting a message application server to said presence aware network using said first presence handle;
said message application server:
detecting said user on said presence aware network using said second presence handle, and
sending a first message to said user; said user:
receiving said first message and sending a second message to said message application server;
said message application server:
receiving and responding to said second message thereby establishing a dialog session between said user and said organization.
2. The method as in claim 1, wherein said message application server is associated with a plurality of applications and said step of responding to said second message includes selecting an appropriate application form said plurality of applications to establish said dialog session.
3. The method as in claim 2, wherein said message application server tracks and stores user and organization data and said application selection step includes selecting one of said plurality of applications based on said user and organization data.
4. The method as in claim 1, wherein the presence aware network is an instant messaging network utilizing a presence communications protocol.
5. The method as in claim 4, wherein the instant messaging network is AOL\xae Instant Messenger\u2122 (\u201cAIM\u201d), Yahoo\xae Messenger, MSN\xae Messenger, ICQ\xae, or Jabber\xae.
6. The method as in claim 4, wherein the presence communications protocol is Session Initiation Protocol (\u201cSIP\u201d) and SIP for Instant Messaging and Leveraging Extensions (\u201cSIMPLE\u201d) or Extensible Messaging and Presence Protocol(\u201cXMPP\u201d).
7. The method as in claim 1, wherein the establishment of a dialog session between the user and the organization is subject to user opt-in or opt-out.
8. A method of establishing a dialog session between an organization and a plurality of users, all simultaneously present on a presence aware network, comprising:
associating user presence handles with said plurality of users;
storing said plurality of user presence handles in a communication list;
logging in, registering and storing at least one of said plurality of user presence handles in a registration server;
connecting a message application server to the presence aware network;
said message application server:
detecting said at least one of said registered plurality of user presence handles; and
sending a first message to said at least one of said registered plurality of users;
said at least one of said registered plurality of users:
receiving said first message and sending a second message to said message application server;
said message application server:
receiving and responding to said second message thereby establishing a dialog session between said at least one of said registered plurality of users and said organization.
9. The method as in claim 8, wherein said message application server is associated with a plurality of applications and said step of responding to said second message includes selecting an appropriate application form said plurality of applications to establish said dialog session.
10. The method as in claim 9, wherein said message application server tracks and stores user and organization data and said application selection step includes selecting one of said plurality of applications based on said user and organization data.
11. The method as in claim 8, wherein the presence aware network is an instant messaging network utilizing a presence communications protocol.
12. The method as in claim 11, wherein the instant messaging network is AOL\xae Instant Messenger\u2122 (\u201cAIM\u201d), Yahoo\xae Messenger, MSN\xae Messenger, ICQ\xae, or Jabber\xae.
13. The method as in claim 11, wherein the presence communications protocol is Session Initiation Protocol (\u201cSIP\u201d) and SIP for Instant Messaging and Leveraging Extensions (\u201cSIMPLE\u201d) or Extensible Messaging and Presence Protocol(\u201cXMPP\u201d).
14. The method as in claim 8, wherein the establishment of a dialog session between the user and the organization is subject to user opt-in or opt-out.
15. A method of establishing a dialog session between an organization and a user, both simultaneously present on a presence aware network, comprising:
associating a service presence handle with a message application server;
connecting said message application server to the presence aware network;
said message application server:
alerting said user of said connection via said service presence handle; said user:
in response to said alert, sending a first message to said message application server;
said message application server:
receiving said first message and sending a second message to said user; said user:
receiving and responding to said second message thereby establishing a dialog session between said user and said organization.
16. The method as in claim 15, wherein said message application server is associated with a plurality of applications and said step of responding to said second message includes selecting an appropriate application form said plurality of applications to establish said dialog session.
17. The method as in claim 16, wherein said message application server tracks and stores user and organization data and said application selection step includes selecting one of said plurality of applications based on said user and organization data.
18. The method as in claim 15, wherein the presence aware network is an instant messaging network utilizing a presence communications protocol.
19. The method as in claim 18, wherein the instant messaging network is AOL\xae Instant Messenger\u2122 (\u201cAIM\u201d), Yahoo\xae Messenger, MSN\xae Messenger, ICQ\xae, or Jabber\xae.
20. The method as in claim 18, wherein the presence communications protocol is Session Initiation Protocol (\u201cSIP\u201d) and SIP for Instant Messaging and Leveraging Extensions (\u201cSIMPLE\u201d) or Extensible Messaging and Presence Protocol(\u201cXMPP\u201d).
21. The method as in claim 15, wherein the establishment of a dialog session between the user and the organization is subject to user opt-in or opt-out.
22. A method of establishing a dialog session between a message application server and a user device, both simultaneously present on a presence aware network, comprising:
associating location data with said user device;
connecting said user device to the presence aware network;
connecting said message application server to the presence aware network;
said message application server:
detecting said location data; and
sending a first message to said user device;
said user device:
receiving said first message and sending a second message to said message application server;
said message application server:
receiving and responding to said second message thereby establishing a dialog session between said user device and said message application server.
23. The method as in claim 22, wherein said message application server is associated with a plurality of applications and said step of responding to said second message includes selecting an appropriate application form said plurality of applications to establish said dialog session.
24. The method as in claim 23, wherein said message application server tracks and stores user and organization data and said application selection step includes selecting one of said plurality of applications based on said user and organization data.
25. The method as in claim 22, wherein the presence aware network is an instant messaging network utilizing a presence communications protocol.
26. The method as in claim 25, wherein the instant messaging network is AOL\xae Instant Messenger\u2122 (\u201cAIM\u201d), Yahoo\xae Messenger, MSN\xae Messenger, ICQ\xae, or Jabber\xae.
27. The method as in claim 25, wherein the presence communications protocol is Session Initiation Protocol (\u201cSIP\u201d) and SIP for Instant Messaging and Leveraging Extensions (\u201cSIMPLE\u201d) or Extensible Messaging and Presence Protocol(\u201cXMPP\u201d).
28. The method as in claim 22, wherein the establishment of a dialog session between the user and the organization is subject to user opt-in or opt-out.