1.-30. (canceled)
31. A method for treating a disease mediated at least in part by \u03b14 integrin in a patient, which method comprises administering a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of a compound of formula I
wherein:
R1 is selected from the group consisting of C1 to C4 alkyl and C1 to C4 haloalkyl; and
R2 is selected from the group consisting of C1 to C4 alkyl, C2 to C4 alkenyl, C2 to C4 alkynyl, and C1-C6 cycloalkyl
or a pharmaceutically acceptable salt or ester thereof.
32. A method for reducing andor preventing an inflammatory component of a disease in a mammalian patient which method comprises administering to said mammal the pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of a compound of formula I
wherein:
R1 is selected from the group consisting of C1 to C4 alkyl and C1 to C4 haloalkyl; and
R2 is selected from the group consisting of C1 to C4 alkyl C2 to C4 alkenyl C2 to C4 alkynyl, and C3-C6 cycloalkyl
or a pharmaceutically acceptable salt or ester thereof.
33. A method for reducing andor preventing an autoimmune response in a mammalian patient which method comprises administering to said mammal the pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of a compound of formula I
wherein:
R1 is selected from the group consisting of C1 to C4 alkyl and C1 to C4 haloalkyl, and
R2 is selected from the group consisting of C1 to C4 alkyl, C2 to C4 alkenyl, C2 to C4 alkynyl, and C3-C6 cycloalkyl
or a pharmaceutically acceptable salt or ester thereof.
34. The method of claim 31, wherein the disease is selected from asthma, multiple sclerosis and inflammatory bowel disease.
35. The method of claim 31 wherein the disease is Crohn’s disease.
36. The method of claim 31, wherein the disease is rheumatoid arthritis.
37.-38. (canceled)
39. The method of claim 31, wherein R1 is C1 to C2 alkyl.
40. The method of claim 31, wherein R1 is methyl or trifluoromethyl.
41. The method of claim 31, wherein R1 is methyl.
42. The method of claim 31, wherein R2 is C1 to C4 alkyl.
43. The method of claim 31, wherein R2 is C1 to C3 alkyl.
44. The method of claim 43, wherein R2 is methyl or ethyl.
45. The method of claim 43, wherein R2 is isopropyl.
46. The method of claim 31, wherein R2 is C3 to C6 cycloalkyl.
47. The method of claim 46, wherein R2 is cyclopentyl.
48. The method of claim 31, wherein R2 is C2 to C4 alkenyl.
49. The method of claim 48, wherein R2 is allyl.
50. The method of claim 31, wherein R2 is C2 to C4 alkynyl.
51. The method of claim 50, wherein R2 is propargyl.
52. The method of claim 31, wherein the compound is selected from the group consisting of:
(S)-2-(2-(diethylamino)-5-(N-ethyl-1,1,1-trifluoromethylsulfonamido)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid;
(S)-2-(2-(diethylamino)-5-(N-isopropylmethylsulfonamido)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid;
(S)-2-(5-(N-cyclopentylmethylsulfonamido)-2-(diethylamino)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid;
(S)-2-(2-(diethylamino)-5-(N-methylmethylsulfonamido)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid;
(S)-2-(2-(diethylamino)-5-(N-(prop-2-ynyl)methylsulfonamido)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid;
(S)-2-(2-(diethylamino)-5-(N-ethylmethylsulfonamido)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid;
(S)-2-(5-(N-allylmethyl sulfonamido)-2-(diethylamino)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid; (S)-2-(2-(diethylamino)-5-(N-ethyl butylsulfonamido)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)-propanoic acid;
(S)-2-(5-(3-chloro-N-ethylpropylsulfonamido)-2-(diethylamino)-pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid;
(S)-2-(5-(3-chloro-N-methylpropyl-sulfonamido)-2-(diethylamino)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid;
(S)-2-(2-(diethylamino)-5-(N-ethyl-3,3,3-trifluoropropylsulfonamido)-pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)propanoic acid;
(S)-2-(2-(diethylamino)-5-(N-ethylpropylsulfonamido)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)phenyl)-propanoic acid; and
(S)-2-(2-(diethylamino)-5-(N-ethyl-2-methylpropyl sulfonamido)pyrimidin-4-ylamino)-3-(4-(pyrrolidine-1-carbonyloxy)-phenyl)propanoic acid;
and pharmaceutically acceptable salts or esters, thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A radio apparatus, comprising:
an antenna that transmits and receives a radio signal;
a modulatingdemodulating module, connected to the antenna, which modulates a transmission signal to a radio-frequency signal, and demodulates a reception signal from a radio-frequency signal;
a signal processing module, connected to the modulatingdemodulating module, which performs signal processing for a transmissionreception signal; and
a CPU, connected to the signal processing module, which performs protocol processing for a transmissionreception signal,
wherein the signal processing module includes plural functional blocks, which perform signal processing for transmission signal data or reception signal data, and whose function is defined by an installed program, and
wherein each of the functional blocks sends, to the functional block of the prior stage, busy state information indicating whether the functional block is in preparation to receive next transmission signal data or next reception signal data as a backward control signal, and outputs, to the functional block of the next stage, transmission signal data or reception signal data having been processed in the functional block when receiving busy state information indicating in preparation to receive next transmission signal data or reception signal data from a functional block of a subsequent stage.
2. The radio apparatus according to claim 1, wherein each of the functional blocks is supplied with a clock signal from a common clock oscillator, performs signal processing according to the clock signal, and transfers the transmission signal data or the reception signal data to a functional block of a prior stage or a subsequent stage according to the clock signal.
3. The radio apparatus according to claim 1, wherein each of the functional blocks outputs, to the functional block of the prior stage, busy state information indicating in preparation to receive the next transmission signal data or the next reception signal data, upon outputting, to the functional block of the subsequent stage, transmission signal data or reception signal data having been processed in the functional block.
4. The radio apparatus according to claim 1, wherein each of the functional blocks:
receives a forward control signal corresponding with the transmission signal data or the reception signal data from the functional block of a prior stage;
performs signal processing for transmission signal data or reception signal data corresponding with the received forward control signal, using the received forward control signal, when the received forward control signal includes information relating to a signal processing of the functional block;
performs signal processing for transmission signal data or reception signal data corresponding with the received forward control signal, without using the received forward control signal, when the received forward control signal does not include information relating to a signal processing of the functional block; and
outputs, to a functional block of a subsequent stage, the processed transmission signal data or the processed reception signal data corresponding with the received forward control signal.
5. The radio apparatus according to claim 4, wherein the forward control signal includes the type of the transmission signal data or the reception signal data corresponding with the received forward control signal, or information indicating whether the transmission signal data or the reception signal data is effective or ineffective.
6. The radio apparatus according to claim 5, wherein the functional blocks dose not performs signal processing when the received forward control signal includes information indicating that the transmission signal data or reception signal data corresponding with the received forward control signal is ineffective.
7. The radio apparatus according to claim 4, wherein the forward control signal is transferred in the same format from a functional block of the forefront stage to a functional block of the final stage of a transmission processing system or a reception processing system, among the plural functional blocks.
8. The radio apparatus according to claim 4,
wherein the CPU notifies the functional block of a change a method of processing the transmission signal data or the reception signal data based on the protocol processing when the change is determined, and notifies the functional block of the forefront stage of a transmission processing system or an reception processing system that information for indicating the change timing is included in the forward control signal corresponding with transmission signal data or reception signal data which is object of the change, and
wherein the functional block notified of the change performs signal processing based on the notified change for the transmission signal data or reception signal data corresponding with the received forward control signal when receiving the forward control signal including the timing information.
9. A radio communication signal processing method in a radio apparatus comprising: an antenna that transmits and receives a radio signal; a modulatingdemodulating module, connected to the antenna, which modulates a transmission signal to a radio-frequency signal, and demodulates a reception signal from a radio-frequency signal; a signal processing module, connected to the modulatingdemodulating module, which performs signal processing for a transmissionreception signal; a CPU, connected to the signal processing module, which performs protocol processing for a transmissionreception signal; plural functional blocks, included in the signal processing module, that perform signal processing for transmission signal data or reception signal data, function of the functional blocks being defined by an installed program, the method comprising:
a first step of sending, to the functional block of the prior stage, busy state information indicating whether the functional block is in preparation to receive next transmission signal data or next reception signal data as a backward control signal, and
a second step of outputting, to the functional block of the next stage, transmission signal data or reception signal data having been subjected to signal processing in the functional block when receiving busy state information indicating in preparation to receive next transmission signal data or reception signal data from a functional block of a subsequent stage.
10. The radio communication signal processing method according to claim 9, further comprising
a third step of supplying each of the functional blocks with a clock signal from a common clock oscillator,
wherein, in the second step, the transmission signal data or the reception signal data is transferred to a functional block of a prior stage or a subsequent stage by using the clock signal.
11. The radio communication signal processing method according to claim 9, further comprising the steps of, in each of the functional blocks, outputting, to the functional block of the prior stage, busy state information indicating in preparation to receive the next transmission signal data or the next reception signal data, upon outputting, to the functional block of the subsequent stage, transmission signal data or reception signal data having been processed in the functional block.
12. The radio communication signal processing method according to claim 9, further comprising:
a fourth step of receiving by each of the functional blocks a forward control signal corresponding with the transmission signal data or the reception signal data from the functional block of a prior stage;
a fifth step of performing signal processing for transmission signal data or reception signal data corresponding with the received forward control signal, using the received forward control signal, when the received forward control signal includes information relating to a signal processing of the functional block, and performing signal processing for transmission signal data or reception signal data corresponding with the received forward control signal, without using the received forward control signal, when the received forward control signal does not include information relating to a signal processing of the functional block.; and
a sixth step of outputting, to a functional block of a subsequent stage, the processed transmission signal data or the processed reception signal data 0corresponding with the received forward control signal.
13. The radio communication signal processing method according to claim 12, further comprising the steps of including in the forward control signal the type of the transmission signal data or the reception signal data corresponding with the received forward control signal, or information indicating whether the transmission signal data or the reception signal data is effective or ineffective.
14. The radio communication signal processing method according to claim 13, wherein, in the fifth step, signal processing in the functional block is not performed when the received forward control signal includes information indicating that the transmission signal data or reception signal data corresponding with the received forward control signal is ineffective.
15. The radio communication signal processing method according to claim 12, further comprising the steps of transferring the forward control signal in the same format from a functional block of the forefront stage to a functional block of the final stage of a transmission processing system or a reception processing system, of the plural functional blocks.
16. The radio communication signal processing method according to claim 12, further comprising:
a seventh step notifying, by the CPU, a functional block of a change a method of processing the transmission signal data or the reception signal data based on the protocol processing when the change is determined;
an eighth step of notifying the functional block of the forefront stage of a transmission processing system or an reception processing system that timing information for indicating the change timing is included in the forward control signal corresponding with transmission signal data or reception signal data which is object of the change, at the same time of performing the seventh step; and
a ninth step of performing, in the functional block notified of the change, signal processing based on the notified change for the transmission signal data or reception signal data corresponding with the received forward control signal when receiving the forward control signal including the timing information.