1. An inductor comprising:
a body; and
a first and a second external electrode disposed on end surfaces of the body,
wherein the body includes:
a coil support layer;
a conductive coil disposed on at least one surface of the coil support layer;
a lamination part formed in a gap of the conductive coil and on an upper surface thereof;
an insulating coating part formed to enclose an overall surface of the conductive coil on which the lamination part is formed; and
an upper and a lower cover layer covering the overall surface of the conductive coil on which the insulating coating part is formed.
2. The inductor of claim 1, wherein the conductive coil is disposed to have a spiral shape.
3. The inductor of claim 1, wherein the conductive coil is provided in plural, and the plurality of coils are disposed on both surfaces of the coil support layer to be vertically symmetrical to each other.
4. The inductor of claim 1, wherein the insulating coating part is formed of a material containing epoxy.
5. The inductor of claim 1, wherein the insulating coating part has an average thickness of about 0.5 \u03bcm to about 15 \u03bcm.
6. The inductor of claim 1, wherein the coil support layer is a substrate formed of an insulating material.
7. The inductor of claim 1, wherein the conductive coil has a thickness of about 100 \u03bcm or more.
8. The inductor of claim 1, wherein a gap interval of the conductive coil is about 8 \u03bcm to about 12 \u03bcm.
9. A manufacturing method of an inductor, the manufacturing method comprising:
preparing a coil support layer;
forming a conductive coil on at least one surface of the coil support layer;
forming a lamination part in a gap of the conductive coil and on an upper surface thereof by performing a lamination process on one surface of the coil support layer;
forming an insulating coating part to cover an overall surface of the conductive coil having the lamination part formed thereon by coating a circumference of the conductive coil having the lamination part formed thereon, with an insulating material;
preparing a body including upper and lower cover layers formed thereon by covering the coil support layer on which the insulating coating part is formed in such a manner that both end surfaces of the coil support layer are exposed; and
forming a first and a second external electrode on both end surfaces of the body to be connected to the exposed end surfaces of the coil support layer, respectively.
10. The manufacturing method of claim 9, wherein the conductive coil is formed to have a spiral shape.
11. The manufacturing method of claim 9, wherein in the forming of the conductive coil, the conductive coil is provided in plural, and the plurality of coils are formed on both surfaces of the coil support layer to be vertically symmetrical to each other.
12. The manufacturing method of claim 9, wherein in the forming of the insulating coating part, a material containing epoxy is used as the insulating material.
13. The manufacturing method of claim 9, wherein in the forming of the insulating coating part, the coating is performed such that an average thickness of the insulating coating part is about 0.5 \u03bcm to about 15 \u03bcm.
14. The manufacturing method of claim 9, wherein in the preparing of the coil support layer, the coil support layer is a substrate formed of an insulating material.
15. The manufacturing method of claim 9, wherein in the forming of the conductive coil, the conductive coil has a thickness of about 100 \u03bcm or more.
16. The manufacturing method of claim 9, wherein in the forming of the conductive coil, a gap interval of the conductive coil is about 8 \u03bcm to about 12 \u03bcm.
17. The inductor of claim 1, wherein the inductor is manufactured by a method comprising:
preparing a coil support layer;
forming a conductive coil on at least one surface of the coil support layer;
forming a lamination part in a gap of the conductive coil and on an upper surface thereof by performing a lamination process on one surface of the coil support layer;
forming an insulating coating part to cover an overall surface of the conductive coil having the lamination part formed thereon by coating a circumference of the conductive coil having the lamination part formed thereon, with an insulating material;
preparing a body including upper and lower cover layers formed thereon by covering the coil support layer on which the insulating coating part is formed in such a manner that both end surfaces of the coil support layer are exposed; and
forming a first and a second external electrode on both end surfaces of the body to be connected to the exposed end surfaces of the coil support layer, respectively.
18. An inductor comprising:
a body; and
a first and a second external electrode disposed on end surfaces of the body,
wherein the body includes:
a coil support layer,
a conductive coil disposed on at least one surface of the coil support layer,
a lamination layer formed in a gap of the conductive coil and partially on an upper surface of the conductive coil, and
an insulating layer enclosing the conductive coil and the lamination layer that is partially formed on the upper surface of the conductive coil,
the insulation layer overlapping the lamination layer on the upper surface of the conductive coil and overlapping the upper surface of conductive coil.
19. The inductor of claim 18, wherein the conductive coil is provided in plural, and the plurality of coils are disposed on both surfaces of the coil support layer to be vertically symmetrical to each other.
20. The inductor of claim 18, wherein the insulating layer has an average thickness of about 0.5 \u03bcm to about 15 \u03bcm.
21. The inductor of claim 18, wherein a gap interval of the conductive coil is about 8 \u03bcm to about 12 \u03bcm.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound selected from the group consisting of N-unsubstituted, N-alkylated, and N-acylated
14-O-(amino(C0-4)alkyl-hydroxy-cyclobutylsulfanyl)-acetyl-mutilins,
14-O-(amino(C0-4)alkyl-hydroxy-cyclopentylsulfanyl)-acetyl-mutilins,
14-O-(amino(C0-4)alkyl-hydroxy-cycloheptylsulfanyl)-acetyl-mutilins,
14-O-(amino(C0-4)alkyl-hydroxy-cyclooctylsulfanyl)-acetyl-mutilins, and
14-O-(amino(C0-4)alkyl-hydroxy-bicycloalkylsulfanyl)-acetyl-mutilins,
wherein bicycloalkyl is a group of formula
\u2003wherein o is 0, 1, 2, 3, or 4, and p is 0, 1, 2, 3, or 4.
2. A compound according to claim 1 which is an N-unsubstituted, N-alkylated, or N-acylated 14-O-amino(C0-4)alkyl-hydroxy-cyclopentylsulfanyl)-acetyl-mutilin or an N-unsubstituted, N-alkylated, or N-acylated 14-O-amino(C0-4)alkyl-hydroxy-bicycloalkylsulfanyl)-acetyl-mutilin,
wherein one ring of the bicyclic alkyl is a cyclopentyl ring.
3. A compound of formula (I)
or of formula (II)
wherein
m is 0, 1, 2, 3 or 4;
n is 0, 1, 3 or 4;
o is 0, 1, 2, 3 or 4;
p is 0, 1, 2, 3 or 4;
R is ethyl or vinyl;
R1 is hydrogen or (C1-6)alkyl;
R2 is hydrogen, (C3-6)cycloalkyl, unsubstituted (C1-6)alkyl, or (C1-6)alkyl substituted by one or more of hydroxy, methoxy, halogen, or (C3-6)cycloalkyl, or
R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatom, or
R2 is a group of formula
\u2003wherein
R3 is hydrogen, straight chain or branched (C1-8)alkyl or (C3-8)cycloalkyl, or
R3 is that part of a natural amino acid in D or in L form which remains if the carboxylic acid group is split off, or
R3 is that part of a non natural amino acid in D or in L form which remains if the carboxylic acid group is split off.
4. A compound according to claim 3 of formula (III)
or of formula (IV)
wherein m, n, o, p, R1 and R2 are as defined in claim 3.
5. A compound according to claim 3 of formula (V)
or of formula (VI)
or of formula (VII)
or of formula (VIII)
wherein m, R1 and R2 are as defined in claim 3.
6. A compound according to claim 1, selected from the group consisting of
14-O-{(1R, 2R, 4R)-4-Amino-2-hydroxy-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 4S) diastereomer thereof,
14-O-{(1R, 2R, 4S)-4-Amino-2-hydroxy-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof,
14-O-{(1R, 2R, 4R)-4-Aminomethyl-2-hydroxy-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 4S) diastereomer thereof,
14-O-{(1R, 2R, 4S)-4-Aminomethyl-2-hydroxy-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof,
14-O-{(1R, 2R, 4S)-4-(2,2-Dimethyl-propylamino)-methyl-2-hydroxy-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof,
14-O-{(1R, 2R, 4S)-2-Hydroxy-4-(2,2,2-trifluoro-acetylamino)-methyl-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 4R) diastereomer thereof,
14-O-{(1R, 2R, 3S)-2-Hydroxy 3-2-(2,2,2-trifluoro-acetylamino)-ethyl-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 3R) diastereomer thereof,
14-O-{(1R, 2R, 3S)-3-(2-Amino-ethyl)-2-hydroxy-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 3R) diastereomer thereof,
14-O-{(1R, 2R, 5R)-5-Hydroxy-2-2-(2,2,2-trifluoro-acetylamino)-ethyl-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 5S) diastereomer thereof,
14-O-{(1R, 2R, 5R)-2-(2-Amino-ethyl)-5-hydroxy-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 5S) diastereomer thereof,
14-O-{(1R, 2R, 5R)-2-2-(2,2-Dimethyl-propylamino)-ethyl-5-hydroxy-cyclopentylsulfanyl-acetyl}-mutilin and the (1S, 2S, 5S) diastereomer thereof,
14-O-{(1R, 2R, 5R)-5-Amino-2-hydroxy-cycloheptylsulfanyl-acetyl}-mutilin and the (1S, 2S, 5S), (1R, 2R, 5S)-(1S, 2S, 5R) diastereomers thereof,
14-O-{(1R, 2S, 3S, 5R, 6S)-6-Amino-2-hydroxy-bicyclo3.2.0hept-3-ylsulfanyl-acetyl}-mutilin and the (1S, 2R, 3R, 5S, 6R) diastereomer thereof,
14-O-{(1R, 2S, 3S, 5R, 6S)-6-Formylamino-2-hydroxy-bicyclo3.2.0hept-3-ylsulfanyl-acetyl}-mutilin and the (1S, 2R, 3R, 5S, 6R) diastereomer thereof,
14-O-{(1R, 2S, 3S, 5R, 6S)-6-(2-Amino-acetylamino)-2-hydroxy-bicyclo3.2.0hept-3-ylsulfanyl-acetyl}-mutilin and the (1S, 2R, 3R, 5S, 6R) diastereomer thereof,
14-O-{(1R, 2S, 3S, 5R, 6S)-6-Cyclopropylamino-2-hydroxy-bicyclo3.2.0hept-3-ylsulfanyl-acetyl}-mutilin and the (1S, 2R, 3R, 5S, 6R) diastereomer thereof, and
14-O-{4-Acetylamino-6a-hydroxy-octahydropentalen-1-ylsulfanyl-acetyl}-mutilin.
7. A compound according to claim 1 in the form of a salt andor solvate.
8. A pharmaceutical drug composition comprising a compound of claim 1, in association with at least one pharmaceutical excipient.
9. A pharmaceutical drug composition according to claim 8, further comprising another pharmaceutically active agent.
10. A compound according to claim 3, wherein R2 is (C1-6)alkyl substituted by one hydroxy.
11. A compound according to claim 3, wherein R2 is (C1-6)alkyl substituted by two hydroxy.
12. A compound according to claim 3, wherein R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing 1 nitrogen and 1 additional heteroatom selected from the group consisting of nitrogen and oxygen.