1-16. (canceled)
17. A method for treating post-traumatic stress disorder comprising administering a heterocyclic compound represented by the formula (I) or a salt thereof to a human or animal:
wherein ring Q represented by
represents
wherein
represents \u2014NH\u2014CH2\u2014, \u2014N\u2550CH\u2014, \u2014CH2\u2014NH\u2014 or \u2014CH\u2550N\u2014; and
the carbon-carbon bond
between the 3-position and 4-position of the heterocyclic skeleton containing Z and Y represents a single bond or a double bond;
the ring Q may have at least one substituent selected from the group consisting of a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a hydroxy group, a lower alkoxy group, a halogenated lower alkyl group, an aryl group, an aryl lower alkyl group, an aryl lower alkoxy group, an arylcarbonyl group, a lower alkenyloxy group, a lower alkanoyl group, a lower alkanoyloxy group, a cycloalkyl group, a cycloalkyl lower alkyl group, a halogen atom, a carbamoyl group which may have a lower alkyl group, a carboxy group, a lower alkoxycarbonyl group, an amino group which may have a lower alkanoyl group, a nitro group, a hydroxy lower alkyl group, an amino lower alkyl group which may have a lower alkyl group, a thienyl group, a saturated 3- to 8-membered heteromonocyclic group containing 1 to 2 nitrogen atoms-substituted lower alkyl group and an oxo group;
R2 represents a hydrogen atom or a lower alkyl group; and
A represents \u2014O-A1- (wherein A1 represents an alkylene group which may be substituted with a hydroxy group (wherein the one oxygen atom may replace a carbon of the alkylene chain) or a lower alkenylene group) or a lower alkylene group;
provided that when A represents a lower alkylene group, the ring Q represents a bicyclic group selected from the group consisting of:
wherein the carbon-carbon-bond
represents a single bond or a double bond.
18. The method according to claim 17, wherein the heterocyclic compound of the formula (1) is selected from the group consisting of:
(1) 7-4-(4-benzobthiophen-4-yl-piperazin-1-yl)butoxy-1H-quinolin-2-one,
(2) 7-3-(4-benzobthiophen-4-yl-piperazin-1-yl)propoxy-1H-quinolin-2-one,
(3) 7-3-(4-benzobthiophen-4-ylpiperazin-1-yl)propoxy-3,4-dihydro-1H-quinolin-2-one,
(4) 7-4-(4-benzobthiophen-4-yl-piperazin-1-yl)butoxy-3,4-dihydro-1H-quinolin-2-one,
(5) 7-4-(4-benzobthiophen-4-yl-piperazin-1-yl)butoxy-1-methyl-3,4-dihydro-1H-quinolin-2-one and
(6) 6-3-(4-benzobthiophen-4-yl-piperazin-1-yl)propoxy-3,4-dihydro-1H-quinolin-2-one;
or a salt thereof.
19. The method according to claim 17, wherein the heterocyclic compound of the formula (1) is selected from the group of:
(1) 7-3-(4-benzobthiophen-4-yl-piperazin-1-yl)propoxy-3,4-dihydro-2H-isoquinolin-1-one
(2) 7-3-(4-benzobthiophen-4-yl-piperazin-1-yl)propoxy-2-methyl-3,4-dihydro-2H-isoquinolin-1-one,
(3) 7-4-(4-benzobthiophen-4-yl-piperazin-1-yl)butoxy-2-methyl-3,4-dihydro-2H-isoquinolin-1-one,
(4) 7-4-(4-benzobthiophen-4-yl-piperazin-1-yl)butoxy-3,4-dihydro-2H-isoqunoinline-1-one,
(5) 7-3-(4-benzobthiophen-4-yl-piperazin-1-yl)propoxy-2H-isoquinolin-1-one and
(6) 7-3-(4-benzo(b)thiophen-4-yl-piperazin-1-yl)propoxy-2-methyl-2H-isoquinolin-1-one;
or a salt thereof.
20. The method according to claim 18, wherein the heterocyclic compound of formula (1) is 7-4-(4-benzobthiophen-4-yl-piperazin-1-yl)butoxy-1H-quinolin-2-one.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A document handler comprising:
a document receptacle receiving document sheets for processing; and
a plurality of user guidance graphic elements disposed on the document receptacle, the plurality of user guidance graphic elements corresponding to a plurality of document loadings supported by the document handler, each user guidance graphic element including: (i) a sheet representation indicating a correct orientation of long and short edges of the document sheet for the corresponding loading and (ii) a symbol or image disposed in the sheet representation and having visually distinguishable up and down directions indicating correct up and down directions of the document sheet for the corresponding loading.
2. The document handler as set forth in claim 1, wherein the plurality of user guidance graphic elements include elements for supported document loadings including a long-edge feed loading and a short-edge feed loading.
3. The document handler as set forth in claim 1, wherein the plurality of user guidance graphic elements include elements for supported document loadings including a portrait document loading and a landscape document loading.
4. The document handler as set forth in claim 1, wherein the plurality of user guidance graphic elements include elements for supported document loadings including a long-edge feed portrait document loading, a short-edge feed portrait document loading, a long-edge feed landscape document loading, and a short-edge feed landscape document loading.
5. The document handler as set forth in claim 1, wherein the plurality of user guidance graphic elements are disposed on the document receptacle such that loaded document sheets block at least one of the user guidance graphic elements from view.
6. The document handler as set forth in claim 1, wherein the user guidance graphic elements have no even rotational symmetry.
7. The document handler as set forth in claim 1, wherein the user guidance graphic elements have bilateral symmetry.
8. The document handler as set forth in claim 1, wherein the user guidance graphic elements have neither bilateral symmetry nor even rotational symmetry.
9. The document handler as set forth in claim 1, wherein the plurality of user guidance graphic elements are disposed on the document receptacle as at least one of:
a relief formed into a surface of the document receptacle,
a label adhered to a surface of the document receptacle, and
ink disposed on a surface of the document receptacle.
10. A document handler comprising:
a document receptacle receiving document sheets for processing; and
a user guidance graphic disposed on the document receptacle, the user guidance graphic including at least one guidance graphic element having no even rotational symmetry and visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading document sheets on the document receptacle.
11. The document handler as set forth in claim 10, wherein the user guidance graphic comprises:
a portrait user guidance graphic element having no even rotational symmetry and visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading portrait document sheets on the document receptacle; and
a landscape user guidance graphic element having no even rotational symmetry and visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading landscape document sheets on the document receptacle.
12. The document handler as set forth in claim 10, wherein the document handler is capable of supplying document sheets in either a long-edge feed orientation or a short-edge feed orientation, the user guidance graphic comprising:
a long-edge feed user guidance graphic element having no even rotational symmetry and visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading document sheets for long-edge feeding; and
a short-edge feed user guidance graphic element having no even rotational symmetry and visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading document sheets for short-edge-feeding.
13. The document handler as set forth in claim 10, wherein the document handler is capable of supplying document sheets in either a long-edge feed orientation or a short-edge feed orientation, the user guidance graphic comprising:
a long-edge-feed portrait user guidance graphic element having no even rotational symmetry and visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading portrait document sheets for long-edge feeding;
a short-edge-feed portrait user guidance graphic element having no even rotational symmetry and visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading portrait document sheets for short-edge-feeding;
a long-edge-feed landscape user guidance graphic element having visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading landscape document sheets for long-edge feeding; and
a short-edge-feed landscape user guidance graphic element having visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading landscape document sheets for short-edge-feeding.
14. The document handler as set forth in claim 10, wherein the at least one user guidance graphic element comprises:
a generally rectangular sheet representation aligned on the document receptacle to indicate one of a long edge document feed and a short edge document feed; and
an image or symbol having no even rotational symmetry and visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading document sheets in the long edge or short edge feed position indicated by the generally rectangular sheet representation.
15. The document handler as set forth in claim 14, wherein the image or symbol is selected from a group consisting of: (i) one or more letters and (ii) an image.
16. The document handler as set forth in claim 10, wherein the user guidance graphic is disposed on the document receptacle as at least one of:
a relief formed into a surface of the document receptacle,
a label adhered to a surface of the document receptacle, and
ink disposed on a surface of the document receptacle.
17. An electrostatographic system comprising:
a document receptacle;
at least one electrostatographic marking engine generating electrostatographically marked sheets corresponding to document sheets loaded on the document receptacle;
a finisher that binds the electrostatographically marked sheets; and
a user guidance graphic element disposed on the document receptacle, the user guidance graphic element having visually distinguishable up and down directions aligned on the document receptacle with correct up and down directions for loading the document sheets on the document receptacle such that the electrostatographically marked sheets are bound in a correct orientation by the finisher.
18. The electrostatographic system as set forth in claim 17, wherein the user guidance graphic element includes a plurality of user guidance graphic elements corresponding to a plurality of supported document sheet loadings.
19. The electrostatographic system as set forth in claim 18, wherein the plurality of user guidance graphic elements include elements for supported document loadings including at least two of:
a long-edge feed portrait document loading,
a short-edge feed portrait document loading,
a long-edge feed landscape document loading, and
a short-edge feed landscape document loading.
20. The electrostatographic system as set forth in claim 18, wherein the document receptacle is part of a duplex automatic document handler (DADH).
21. The electrostatographic system as set forth in claim 18, further comprising:
a touch-sensitive user interface for selecting one of the plurality of supported document sheet loadings, the touch-sensitive user interface displaying as selection indicators the plurality of user guidance graphic elements corresponding to the plurality of document sheet loadings.
22. The electrostatographic system as set forth in claim 17, wherein the user guidance graphic element comprises:
a sheet representation aligned on the document receptacle to indicate correct alignment of the long and short sheet edges of the document sheet; and
an image or symbol disposed in the sheet representation and having visually distinguishable up and down directions indicating correct up and down directions of the document sheet.