1. A deformable substrate with microstructured surface composed of applied material, wherein the applied material is configured as individual pixels.
2. The deformable substrate according to claim 1, wherein the pixels are composed of a cured coating.
3. The deformable substrate according to claim 1, wherein it comprises pixel of different properties, in particular pixels of different form andor different size andor different physical andor chemical properties and or with different spacing andor arrangement relative to one another.
4. The deformable substrate according claim 1, wherein it comprises pixels which comprise different properties vertical to the substrate surface.
5. The deformable substrate according to claim 1, wherein the pixels are arranged in the form of a pattern.
6. A method for the production of a microstructured surface on a deformable substrate by applying material, comprising applying the material in the form of individual pixels.
7. The method according to claim 6, comprising applying material in liquid form.
8. The method according to claim 6, comprising applying pixels with different properties.
9. The method according to claim 6, wherein pixels are applied which comprise different properties vertical to the substrate surface, in particular composition, preferably in such a manner that a pixel layer with a first property is applied initially, and subsequently one or several further pixel layers with one or several other properties.
10. The method according to claim 6, wherein the pixels are arranged in the form of a pattern.
11. The method according to claim 6, wherein the pixels are printed, preferably by means of screen printing or an electronic printing method without printing plate.
12. The method according to claim 6, wherein the pixels are first printed onto a peel-off film and are then transferred from there to the substrate surface.
13. The deformable substrate according to claim 2, wherein the cured coating is lubricating lacquer.
14. The deformable substrate according claim 4, wherein it comprises pixels which comprise different composition vertical to the substrate surface.
15. The method according to claim 7, comprising applying material as a laquer.
16. The method according to claim 7, comprising applying material as a lubricating lacquer.
17. The method according to claim 8, comprising applying pixels with at least one of:
different form,
different size,
different physical properties,
different chemical properties, and
different spacings relative to one another.
18. The method according to claim 9, wherein pixels are applied which comprise different composition vertical to the substrate surface.
19. The method according to claim 9, wherein pixels are applied which comprise different properties vertical to the substrate surface, in such a manner that a pixel layer with a first property is applied initially, and subsequently one or several further pixel layers with one or several other properties.
20. The method according to claim 11, wherein said printing is by means of inkjet or laser printing.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula I or a compound of formula II:
A-X\u2014Y\u2014(CH(OC(\u2550O)R1))n\u2014Z\u2014X1\u2014Y\u2014(CH(OC(\u2550O)R1))n\u2014W\u2014W1\u2014R2\u2003\u2003I
A-(CH(OC(\u2550O)R3))n\u2014W\u2014W1\u2014R2\u2003\u2003II
wherein;
A is an anionic group;
X is a (C1-C4)alkylene;
Y is \u2014NHC(\u2550O)\u2014;
each n is independently 2, 3, 4, 5 or 6;
Z is \u2014C(\u2550O)NH\u2014;
X1 is a (C2-C6)alkylene;
W is \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, or is absent;
W1 is O, S or NH;
each R1 is independently a hydrophobic chain;
R2 is a polyether; and
each R3 is independently (C1-C8)alkyl wherein each (C1-C8)alkyl is independently substituted with one or more \u2014O(C\u2550O)R1 groups;
or a salt thereof.
2. The compound of claim 1 which is a compound of formula I:
A-X\u2014Y\u2014(CH(OC(\u2550O)R1))n\u2014Z\u2014X1\u2014Y\u2014(CH(OC(\u2550O)R1))n\u2014W\u2014W1\u2014R2\u2003\u2003(I)
wherein;
A is an anionic group;
X is a (C1-C4)alkylene;
Y is \u2014NHC(\u2550O)\u2014;
each n is independently 2, 3, 4, 5 or 6;
Z is \u2014C(\u2550O)NH\u2014;
X1 is a (C2-C6)alkylene;
W is \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, or is absent;
W1 is O, S or NH;
each R1 is independently a hydrophobic chain; and
R2 is a polyether;
or a salt thereof.
3. The compound of claim 1 which is a compound of formula II:
A-(CH(OC(\u2550O)R3))n\u2014W\u2014W1\u2014R2\u2003\u2003II
wherein;
A is an anionic group;
n is 2, 3, 4, 5 or 6;
W is \u2014C(\u2550O)\u2014, \u2014C(\u2550S)\u2014, or is absent;
W1 is O, S or NH;
each R1 is independently a hydrophobic chain;
R2 is a polyether; and
each R3 is independently (C1-C8)alkyl wherein each (C1-C8)alkyl is independently substituted with one or more \u2014O(C\u2550O)R1 groups;
or a salt thereof.
4. The compound of claim 1 wherein A is selected from carboxy, \u2014SO3H and \u2014PO3H.
5-7. (canceled)
8. The compound of claim 1 wherein the compound of formula I is a compound of formula Ia:
wherein;
X is a (C1-C4)alkylene;
each n is independently 2, 3 4, 5 or 6;
X1 is a (C2-C6)alkylene;
each R1 is independently a hydrophobic chain; and
R2 is a polyether;
or a salt thereof.
9. The compound of claim 1 wherein the compound of formula II is a compound of formula IIa:
wherein:
n is 2, 3, 4, 5 or 6;
each R1 is independently a hydrophobic chain;
R2 is a polyether; and
each R3 is independently (C1-C8)alkyl wherein each (C1-C8)alkyl is independently substituted with one or more \u2014O(C\u2550O)R1 groups;
or a salt thereof.
10. The compound of claim 1 wherein the polyether is a poly(alkylene oxide) having between about 2 and about 150 repeating units.
11. The compound of claim 10, wherein each alkylene oxide unit comprises straight or branched (C2-C4) alkylene oxide.
12. The compound of claim 1 wherein the polyether is a poly(ethylene oxide) having between about 2 and about 150 repeating units.
13. The compound of claim 1, wherein the polyether comprises an alkoxy-terminal group.
14. (canceled)
15. The compound of claim 1 wherein the polyether has the following structure:
R5\u2014(R6\u2014O\u2014)a\u2014R6\u2014
wherein R5 is a 1 to 20 carbon straight-chain or branched alkyl group, \u2014OH, \u2014OR7, \u2014NH2, \u2014NHR7, \u2014NHR7R8, \u2014CO2H, \u2014SO3H (sulfo), \u2014CH2\u2014OH, \u2014CH2\u2014OR7, \u2014CH2\u2014O\u2014CH2\u2014R7, \u2014CH2\u2014NH2, \u2014CH2\u2014NHR7, \u2014CH2\u2014NR7R8, \u2014CH2CO2H, \u2014CH2SO3H, or \u2014O\u2014C(\u2550O)\u2014CH2\u2014CH2\u2014C(\u2550O)\u2014O\u2014;
R6 is a 1 to 10 carbon straight-chain or branched divalent alkylene group;
each R7 and R8 is independently a 1 to 6 carbon straight-chain or branched alkylene group; and
a is an integer from 2 to 150, inclusive.
16. The compound of claim 1 wherein the each R1 is independently (C1-C24)alkyl, (C2-C24)alkene or (C2-C24)alkyne.
17. The compound of claim 1 wherein each R1 is independently a fatty acid, wherein the fatty acid is caprylic, capric, lauric, myristic, myristoleic, palmitic, palmitoleic, stearic, oleic, linoleic, arachidic, behenic, or erucic acid, or a mixture thereof.
18. The compound of claim 1 wherein the each R1 is independently a (C6-C18)alkyl.
19. (canceled)
20. The compound of claim 1 wherein the each n is independently 2 or 4.
21-24. (canceled)
25. The compound of claim 9 wherein each R3 is independently a (C3-C6)alkyl.
26. The compound of claim 1 selected from:
and salts thereof.
27. A pharmaceutical composition comprising a compound of formula I or formula II as described in claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
28. A method for preventing the uptake of LDL by a cell comprising contacting the cell with a compound of formula I or formula II as described in claim 1.
29. A method for inhibiting atherosclerosis or atherosclerotic development in a mammal, comprising administering an anti-atherosclerosis or anti-atherosclerotic development amount of a compound of formula I or formula II as described in claim 1, or a pharmaceutically acceptable salt thereof, to the mammal.