1. A radio transceiver comprising:
an antenna;
a local oscillator for generating a local oscillator signal at a local oscillator frequency;
a receiver capable of receiving a first radio frequency signal from the antenna at a receiver input and having a first mixer for mixing a signal derived from the first radio signal with the said local oscillator signal to generate an intermediate frequency signal, and a receiver output for providing an output signal dependant on the intermediate frequency signal;
a transmitter capable of receiving an input signal at a transmitter input and having a second mixer for mixing a signal derived from the input signal with a local oscillator signal to generate a second radio frequency signal for transmission;
a switching arrangement having a normal configuration in which the transmitter is coupled to the antenna to apply the second radio frequency signal to the antenna, and a testing configuration in which the transmitter is coupled to the receiver input to apply the second radio frequency signal to the receiver input; and
a signal processor coupled to the transmitter input and the receiver output and capable of, when the switching arrangement is in the testing configuration, applying a testing signal to the transmitter input to cause the transmitter to generate a radio frequency test signal, and determining from the output signal of the receiver the response of the receiver to the radio frequency test signal.
2. A radio transceiver as claimed in claim 1, wherein the local oscillator is capable of generating an in-phase signal and a quadrature signal, the first mixer is arranged to mix the said signal derived from the first radio signal with the in-phase signal, and the receiver comprises a third mixer arranged to mix the said signal derived from the first radio signal with the quadrature signal.
3. A radio transceiver as claimed in claim 2, wherein the local oscillator is adjustable by the signal processor to vary the phase difference between the in-phase and quadrature signals.
4. A radio transceiver as claimed in claim 2, wherein the local oscillator is adjustable by the signal processor to vary the phase difference between the in-phase and quadrature signals so as to reduce the response of the receiver to the test signal.
5. A radio transceiver as claimed in claim 2,
wherein the gain of at least one of the first and third mixers is adjustable by the signal processor so as to reduce the response of the receiver to the test signal.
6. A radio transceiver as claimed in claim 4,
wherein the switching arrangement is operable by the signal processor, and the signal processor has a testing mode in which it is capable of: setting the switching arrangement to the testing configuration, determining from the output signal of the receiver the response of the receiver to the radio frequency test signal, and adjusting the local oscillator andor at least one of the first and third mixers to reduce the response of the receiver to the test signal.
7. A radio transceiver as claimed in claim 1,
wherein the receiver comprises at least two intermediate frequency stages.
8. A radio transceiver as claimed in claim 1,
wherein the local oscillator signal applied to the second mixer is generated by the said local oscillator.
9. A radio transceiver as claimed in claim 1,
wherein the signal processor includes a digital synthesiser for generating the test signal.
10. A radio transceiver as claimed in claim 1,
wherein the signal processor includes a modulator for generating the test signal.
11. A radio transceiver as claimed in claim 1,
wherein the testing signal is at the negative of the intermediate frequency.
12. A radio transceiver as claimed in claim 1,
including a second switching arrangement having a normal configuration in which the said signal derived from the input signal is coupled to the second mixer and a testing configuration in which the said signal derived from the input signal is coupled to an intermediate frequency section of the receiver as a testing signal.
13. A radio transceiver as claimed in claim 12, wherein the signal processor is capable of, when the second switching arrangement is in the testing configuration, generating the testing signal, and determining from the output signal of the receiver the response of at least the intermediate frequency section of the receiver to the testing signal.
14. A method of testing a radio transceiver comprising an antenna; a local oscillator for generating a local oscillator signal at a local oscillator frequency; a receiver capable of receiving a first radio frequency signal from the antenna at a receiver input and having a first mixer for mixing a signal derived from the first radio signal with the said local oscillator signal to generate an intermediate frequency signal, and a receiver output for providing an output signal dependant on the intermediate frequency signal; a transmitter capable of receiving an input signal at a transmitter input and having a second mixer for mixing a signal derived from the input signal with a local oscillator signal to generate a second radio frequency signal for transmission; a switching arrangement having a normal configuration in which the transmitter is coupled to the antenna to apply the second radio frequency signal to the antenna, and a testing configuration in which the transmitter is coupled to the receiver input to apply the second radio frequency signal to the receiver input; the method comprising:
setting the switching arrangement to the testing configuration;
applying a testing signal to the transmitter input to cause the transmitter to generate a radio frequency test signal; and
detecting the output signal of the receiver to determine the response of the receiver to the test signal.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A recombinant adenovirus vector comprising sequences encoding structural and non-structural elements of an adenovirus serotype from a subgroup other than subgroup C operably linked to expression control sequences, wherein the recombinant adenovirus vector does not comprise nucleic acid encoding E1B-55K protein and E4-orf6 protein from the serotype from a subgroup other than subgroup C, wherein said recombinant adenovirus vector further comprises a nucleotide sequence encoding a functional E4-orf6 protein of an adenovirus serotype of subgroup C operably linked to expression control sequences.
2. The recombinant adenovirus vector of claim 1, wherein the serotype from a subgroup other than subgroup C is from subgroup B.
3. The recombinant adenovirus vector according to claim 2, wherein the serotype from subgroup B is selected from the group consisting of adenovirus serotypes 11, 14, 16, 21, 34, 35 and 50.
4. The recombinant adenovirus vector according to claim 1, wherein the adenovirus serotype of subgroup C is adenovirus serotype 5.
5. The recombinant adenovirus vector according to claim 1, further comprising a nucleotide sequence encoding a non-adenoviral peptide.
6. A pharmaceutical composition comprising the recombinant adenoviral vector according to claim 1 and a pharmaceutical carrier.
7. A recombinant, replication defective, adenovirus vector of a serotype from a subgroup other than subgroup C comprising:
an adenovirus nucleotide sequence encoding the recombinant, replication defective, adenovirus vector, wherein the vector does not comprise nucleic acid encoding E1B-55K protein and E4-orf6 protein from the serotype from a subgroup other than subgroup C; and
a nucleic acid sequence encoding a functional E4-orf6 protein from an adenoviral serotype of subgroup C operably linked to expression control sequences, and wherein the E4-orf6 protein is compatible with an E1B-55K protein produced in a complementing cell used to generate the recombinant, replication defective, adenovirus vector.
8. The recombinant, replication defective, adenovirus vector of claim 7, wherein the functional E4-orf6 protein is from adenovirus serotype 5.
9. The recombinant, replication defective, adenovirus vector of claim 7, wherein the serotype from a subgroup other than subgroup C is an adenovirus serotype selected from the group consisting of adenovirus serotypes 11, 14, 16, 21, 34, 35, and 50.
10. The recombinant, replication defective, adenovirus vector of claim 7, further comprising a nucleotide sequence encoding a non-adenoviral peptide.