1. A mutant of the soluble form of EC 1.1.5.2, also known as pyrroloquinoline quinone (PQQ)-dependent soluble glucose dehydrogenase (s-GDH), having a glycine residue present at a position corresponding to position 348 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus and having an amino acid sequence at least 90% identical thereto.
2. The mutant of claim 1 having an alanine residue present at a position corresponding to position 76 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
3. The mutant of claim 1 having a methionine residue present at a position corresponding to position 76 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
4. The mutant of claim 1 having an aspartic acid residue present at a position corresponding to position 76 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
5. The mutant of claim 1 having a proline residue present at a position corresponding to position 76 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
6. The mutant of claim 1 having a serine residue present at a position corresponding to position 76 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
7. The mutant of claim 1 having a glycine residue present at a position corresponding to position 76 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
8. The mutant of claim 1 having a glutamic acid residue present at a position corresponding to position 76 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
9. The mutant of claim 1 having a glutamic acid residue present at a position corresponding to position 143 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
10. The mutant of claim 1 having serine, histidine, and histidine residues present at positions corresponding to positions 127, 169, and 355, respectively, of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
11. The mutant of claim 1 having a valine residue present at a position corresponding to position 428 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
12. A mutant PQQ-dependent s-GDH having glycine and proline residues present at positions corresponding to positions 348 and 428, respectively, of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus and having an amino acid sequence at least 90% identical thereto.
13. The mutant of claim 12 having methionine and glutamine residues present at positions corresponding to positions 127 and 143, respectively, of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
14. The mutant of claim 12 having a glutamic acid residue present at a position corresponding to position 143 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
15. The mutant of claim 12 having an aspartic acid residue present at a position corresponding to position 245 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
16. The mutant of claim 12 having a valine residue present at a position corresponding to position 341 of the PQQ-dependent s-GDH wild-type sequence from A. calcoaceticus.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A carrier for holding a biological sample vial and a slide for processing, the carrier comprising
a plurality of first locations, each configured to hold a vial; and
a plurality of second locations, each configured to hold only one slide,
wherein each second location is adjacent to one of the first locations, and
wherein each of the second locations is superimposed on a respective first location.
2. The carrier of claim 1, further comprising at least one finger access indentation at each second location.
3. The carrier of claim 1, further comprising at least one finger access indentation at each first location.
4. The carrier of claim 1, the vial having a cap, the first locations each having a depth such that the vial cap is positioned below a surface of the carrier when a vial is positioned therein.
5. The carrier of claim 1, further comprising a trough, wherein each of the first locations is located in the trough.
6. The carrier of claim 5, the vial having a cap, and wherein the first locations have a depth such that the vial cap is positioned above a surface of the trough when a vial is positioned therein.
7. The carrier of claim 5, the vial having a cap, and wherein the first locations have a depth such that the vial cap is positioned below a surface of the trough when a vial is positioned therein.
8. A carrier for holding a biological sample vial and a slide for processing, the carrier comprising
a plurality of first locations, each configured to hold a vial;
a plurality of second locations, each configured to hold only one slide; and
a trough, wherein each of the first locations is located in the trough,
wherein each second location is adjacent to one of the first locations, and
wherein each of the second locations is superimposed on a respective first location such that, when the slide is placed in one of the second locations, the slide bridges the trough.
9. A carrier for holding a biological sample vial and a slide for processing, the carrier comprising
a plurality of first locations, each configured to hold a vial; and
a plurality of second locations, each configured to hold only one slide,
wherein each second location is adjacent to one of the first locations, and
wherein the first and second locations are configured such that slides placed in the second locations are positioned directly above vials placed in the first locations.