1. The compound of the general formula (I):
136
wherein
R1 is hydrogen or a functional group, which can be converted to hydrogen in vivo,
R2 is hydrogen, C1-6-alkyl, C1-6-alkoxy, C1-6-alkylthio, halogen, cyano, trifluoromethyl, hydroxy, thiol or NR5R6, wherein R5 and R6 independently are hydrogen or C1-6-alkyl,
R3 and R4 independently are hydrogen or C1-6-alkyl, which is optionally substituted with aryl or heteroaryl, which are optionally substituted with one or more substituents selected from nitro, NR7R8, S(O)2NR7R8, C(O)NR7R8, hydroxy, halogen, cyano, trifluoromethyl, OCF3, OCHF2, OCH2CHF2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkylsulfonyl, C(O)OR7, C1-6-alkylcarbonyl, C(NOR7)C1-6alkyl, C3-10-cycloalkyl, C3-10-cycloalkylcarbonyl, C(NOR7)C3-10-cycloalkyl, aryl-C1-6-alkyl, heteroaryl-C1-6-alkyl, arylamino, heteroarylamino, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, C(NOR7)aryl, C(NOR7)heteroaryl, arylthio, heteroarylthio, aryloxy and heteroaryloxy, wherein R7 and R8 independently are hydrogen or C1-6-alkyl,
m is 0, 1 or 2,
n is 1, 2, 3 or 4,
X is a valence bond, O, S, S(O), S(O)2 or CF2,
p is 0, 1, 2 or 3,
Y is O, S, S(O), S(O)2 or NR9, wherein R9 is hydrogen or C1-6-alkyl,
q is 0, 1, 2or 3,
V is
heteroaryl, aryl, C3-10-cycloalkyl, C3-8-heterocyclyl or aryl annulated with C3-8-heterocyclyl,
which are optionally substituted with one or more substituents selected from nitro, NR10R11, S(O)2NR10R11, C(O)NR10R11, hydroxy, halogen, cyano, trifluoromethyl, OCF3, OCHF2, OCH2CHF2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkylsulfonyl, C(O)OR10, C1-6-alkylcarbonyl, C(NOR10)C1-6-alkyl, oxo, C3-10-cycloalkyl, C3-10-cycloalkylcarbonyl, C(NOR10)C3-10-cycloalkyl, heteroaryl-C1-6-alkyl, arylamino, heteroarylamino, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, C(NOR10)aryl, C(NOR10)heteroaryl, arylthio, heteroarylthio, and heteroaryloxy, wherein R10 and R11 independently are hydrogen or C1-6-alkyl,
aryl-C1-6-alkyl, aryl or aryloxy, which are optionally substituted with one or more substituents selected from
nitro, hydroxy, C1-6-alkyl, C1-6-alkoxy, cyano, trifluoromethyl, OCF3, halogen
C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl,
which are optionally substituted with one or more substituents selected from C3-10-cycloalkyl, aryl, C3-8-heterocyclyl and heteroaryl, which are optionally substituted with one or more substituents selected from
nitro, NR12R13, S(O)2NR12R13, C(O)NR12R13, hydroxy, halogen, cyano, trifluoromethyl, OCF3, OCHF2, OCH2CHF2, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C1-6-alkoxy, C1-6-alkylthio, C1-6-alkylsulfonyl, C(O)OR12, C1-6-alkylcarbonyl, C(NOR12)C1-6-alkyl, C3-10-cycloalkyl, C3-10-cycloalkylcarbonyl, C(NOR12)C3-10-cycloalkyl, aryl-C1-6-alkyl, heteroaryl-C1-6-alkyl, arylamino, heteroarylamino, aroyl, heteroaroyl, arylsulfonyl, heteroarylsulfonyl, C(NOR12)aryl, C(NOR12)heteroaryl, arylthio, heteroarylthio, aryloxy and heteroaryloxy, wherein R12 and R13 independently are hydrogen or C1-6-alkyl,
with the proviso that when
R1, R2, R3 and R4 are hydrogen, X is a valence bond, m is 0, n is 3, p is 0 and Y is S, (CH2)qV must not be (CH2)2NH2,
as well as any optical or geometric isomer or tautomeric form thereof including mixtures of these or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 wherein R1 is hydrogen.
3. The compound according to claim 1 wherein R2 is hydrogen.
4. The compound according to claim 1 wherein R3 and R4 are both hydrogen.
5. The compound according to claim 1 wherein m is 1 and n is 2.
6. The compound according to claim 1 wherein m is 0 and n is 3 or 4.
7. The compound according to claim 1 wherein m is 1 and n is 1.
8. The compound according to claim 1 wherein p is 1.
9. The compound according to claim 1 wherein p is 2.
10. The compound according to claim 1 wherein X is a valence bond.
11. The compound according to claim 1 wherein X is O.
12. The compound according to claim 1 wherein Y is O.
13. The compound according to claim 1 wherein q is 0.
14. The compound according to claim 1 wherein q is 1.
15. The compound according to claim 1 wherein V is selected from aryl annulated with C3-8-heterocyclyl, heteroaryl and aryl.
16. The compound according to claim 15 wherein V is selected from aryl and aryl annulated with C3-8-heterocyclyl.
17. The compound according to claim 16 wherein V is selected from phenyl, naphthyl, tetrahydronaphthyl and 3,4-methylenedioxyphenyl.
18. The compound according to claim 17 wherein V is phenyl.
19. The compound according to claim 18 wherein V is naphthyl.
20. The compound according to claim 15 wherein V is unsubstituted or substituted with one or two substituents independently selected from
halogen, C3-10-cycloalkylcarbonyl, cyano, C1-6-alkylcarbonyl, C(O)OR10, C1-6-alkyl, C1-6-alkoxy, CF3 and OCF3, wherein R10 is
aryl-C1-6-alkyl, aryl or aryloxy.
21. The compound according to claim 20 wherein V is unsubstituted or substituted with one or two substituents independently selected from
halogen, C3-10-cycloalkylcarbonyl, cyano, C1-6-alkylcarbonyl, C(O)OR10, C1-8-alkyl, C1-6-alkoxy, CF3 and OCF3, wherein R10 is
phenyl-C1-6-alkyl, phenyl or phenoxy.
22. The compound according to claim 21 wherein V is unsubstituted or substituted with one or two substituents independently selected from phenyl, phenoxy and trifluoromethyl.
23. The compound according to claim 1 wherein V is C1-6-alkyl or C2-6-alkenyl.
24. The compound according to claim 23 wherein V is C1-6-alkyl or C2-6-alkenyl, which is substituted with aryl.
25. The compound according to claim 24 wherein V is C1-6-alkyl or C2-6-alkenyl, which is substituted with phenyl.
26. The compound according to claim 1 of the general formula (Ie):
137
wherein R1, R2, R3, R4 and V are defined according to claim 1.
27. The compound according to claim 1 of the general formula (If):
138
wherein R1, R2, R3, R4 and V are defined according to claim 1.
28. The compound according to claim 1 of the general formula (Ig):
139
wherein R1, R2, R3, R4 and V are defined according to claim 1.
29. The compound according to claim 1 of the general formula (Ih):
140
wherein R1, R2, R3, R4 and V are defined according to claim 1.
30. The compound according to claim 1 of the general formula (Ii):
141
wherein R1, R2, R3, R4 and V are defined according to claim 1.
31. A method of treating obesity comprising administering the compound of claim 1 to a patient in need thereof.
32. A method of suppressing appetite, comprising administering the compound of claim 1 to a patient in need thereof.
33. A method of treating type 2 diabetes comprising administering the compound of claim 1 to a patient in need thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A bag making machine, comprising:
an input section;
a sealing section disposed to receive a film from the input section and apply at least one seal thereto, wherein the sealing section includes a seal bar having a heat pipe, wherein the heat pipe has a relief zone; and
an output section disposed to receive the film from the sealing section.
2. The bag making machine of claim 1, wherein the relief zone includes a valve.
3. The bag making machine of claim 2, wherein the valve is reusable.
4. The bag making machine of claim 1, wherein the relief zone is a destructive relief zone.
5. The bag making machine of claim 4, wherein the heat pipe has a generally closed cylindrical shape with a first end and a second end, and wherein the relief zone is located at the first end.
6. The bag making machine of claim 5, further comprising a second relief zone located at the second end.
7. The bag making machine of claim 6, further comprising a fluid disposed in the heat pipe.
8. The bag making machine of claim 7, further comprising a liquid disposed in the heat pipe, and wherein the heat pipe is within the seal bar.
9. A method of making bags, comprising:
receiving a film;
applying at least one seal to the film with at least one seal bar that includes a heat pipe;
relieving pressure in the heat pipe through a relief zone when the pressure in the pipe near the relief zone substantially exceeds a desired level; and
processing the film after sealing the film.
10. The method of claim 9, wherein relieving includes opening a valve.
11. The method of claim 10, further comprising closing the valve.
12. The method of claim 9, wherein relieving includes destroying at least a portion of the relief zone.
13. The method of claim 12, further comprising dispersing heat from hot zones on the at least one seal bar with a fluid in the heat pipe, and wherein the heat pipe is within the seal bar.
14. A bag making machine, comprising:
an input section;
a sealing section disposed to receive a film from the input section and apply at least one seal thereto, wherein the sealing section includes a seal bar having a heat pipe, wherein the heat pipe has a means for relieving pressure within the heat pipe; and
an output section disposed to receive the film from the sealing section.
15. The bag making machine of claim 14, wherein the heat pipe has a generally closed cylindrical shape with a first end and a second end, and wherein the means for relieving is located at the first end.
16. The bag making machine of claim 15, further comprising a fluid disposed in the heat pipe.
17. The bag making machine of claim 16, further comprising a liquid disposed in the heat pipe.
18. A bag making machine, comprising:
an input section;
a sealing section disposed to receive a film from the input section and apply at least one seal thereto, wherein the sealing section includes a seal bar having a heat pipe, wherein the heat pipe has a means for relieving pressure in the heat pipe when the pressure in the heat pipe near the means for relieving substantially exceeds a desired level; and
an output section disposed to receive the film from the sealing section.
19. The bag making machine of claim 18, wherein the heat pipe has a generally closed cylindrical shape with a first end and a second end, and wherein the means for relieving is located at the first end.
20. The bag making machine of claim 19, further comprising a fluid disposed in the heat pipe.
21. The bag making machine of claim 20, further comprising a liquid disposed in the heat pipe.
22. A seal bar for a bag making machine, comprising:
a surface disposed to impart a seal on a film;
at least one heat pipe in or adjacent the seal bar; and
a relief zone on the at least one heat pipe.
23. The seal bar of claim 22, wherein the relief zone includes a valve.
24. The seal bar of claim 23, wherein the valve is reusable.
25. The seal bar of claim 22, wherein the relief zone is a destructive relief zone.
26. The seal bar of claim 25, wherein the at least one heat pipe has a generally closed cylindrical shape with a first end and a second end, and wherein the relief zone is located at the first end.
27. The seal bar of claim 22, further comprising a fluid disposed in the at least one heat pipe.
28. The seal bar of claim 27, further comprising a liquid disposed in the at least one heat pipe.
29. The seal bar of claim 26, further comprising a second relief zone located at the second end.
30. A heat pipe, such as that for a bag machine, comprising a pipe, and a relief zone on the pipe, whereby when the pressure in the heat pipe near the relief zone substantially exceeds a desired level, the relief zone vents the pressure.
31. The heat pipe of claim 30, wherein the relief zone includes a valve.
32. The heat pipe of claim 31, wherein the valve is reusable.
33. The heat pipe of claim 30, wherein the relief zone is destructive relief zone.
34. The heat pipe of claim 33, wherein the heat pipe has a generally closed cylindrical shape, whereby the plurality of surfaces include a first end and a second end, and wherein the relief zone is located at the first end.
35. The heat pipe of claim 34, wherein the heat pipe has second relief zone located at the second end.
36. The heat pipe of claim 35, further comprising a fluid disposed in the heat pipe.
37. The heat pipe of claim 36, further comprising a liquid disposed in the heat pipe.
38. A method of preventing excess pressure in a heat pipe, such as that for a bag machine, comprising relieving the pressure in the heat pipe through a relief zone when the pressure in the pipe near the relief zone substantially exceeds a desired level.
39. The method of claim 38, wherein relieving includes opening a valve.
40. The method of claim 39, further comprising closing the valve.
41. The method of claim 38, wherein relieving includes destroying at least a portion of the relief zone.
42. A heat pipe, such as that for a bag machine, comprising:
a pipe; and
means for venting pressure when the pressure in the heat pipe near the means for venting substantially exceeds a desired level.
43. The heat pipe of claim 42, wherein the pipe has a generally closed cylindrical shape with a first end and a second end, and wherein the means for venting is located at the first end.
44. The heat pipe of claim 43, further comprising a second means for venting pressure when the pressure in the heat pipe near the second means for venting substantially exceeds a desired level.