1. A computerized derivable kinetic characterization measurement method for live cell kinetic characterization comprising the steps of:
a) Inputting kinetic recognition data for a plurality of time frames;
b) Performing single cell measurement using the kinetic recognition data for a plurality of time frames having single cell feature for a plurality of time frames output;
c) Performing kinetic measurement using the single cell feature for a plurality of time frames having kinetic feature output;
d) Performing trajectory measurement using the single cell feature for a plurality of time frames and the kinetic feature having trajectory feature output.
2. The kinetic characterization measurement method of claim 1 wherein the single cell measurement method performs cell morphological profiling measurement having cell morphological profiling feature output.
3. The kinetic characterization measurement method of claim 1 further comprises an interval measurement step using the kinetic feature having interval feature output.
4. The kinetic characterization measurement method of claim 3 further comprises a cell state classifier step using the interval feature to generate cell state output.
5. The kinetic characterization measurement method of claim 4 further comprises a state based measurement using the single cell feature, the kinetic feature and the cell state having state based feature output.
6. A computerized cell morphological profiling measurement method for live cell kinetic characterization comprising the steps of:
a) Inputting cell of interest mask;
b) Performing center determination using the cell of interest mask having cell center output;
c) Performing polar coordinate transformation using the cell center and the cell of interest mask having polar cell region output;
d) Performing polar domain morphological profiling measurement using the polar cell region having cell morphological profiling feature output.
7. The computerized cell morphological profiling measurement method of claim 6 wherein the cell morphological profiling feature is derived from a given angle range.
8. The cell morphological profiling feature derived from a given angle range of claim 7 selects feature from a set consisting of maximum radius, minimum radius, mean radius, normalized mean radius, radius standard deviation, radius coefficient of variation, processes count, mean process radius, normalized mean process radius, process radius standard deviation, process radius coefficient of variation, and rank statistics.
9. The computerized cell morphological profiling measurement method of claim 6 wherein the cell morphological profiling feature is derived from multiple angle ranges.
10. The cell morphological profiling feature derived from multiple angle ranges of claim 9 selects feature from a set consisting of mean of the features from multiple angle ranges, standard deviation of the features from multiple angle ranges, contrast of the features between two selected angle ranges, correlation of the features between multiple selected angle ranges.
11. The computerized cell morphological profiling measurement method of claim 6 further calculates change of at least one cell morphological profiling feature between a specified time interval.
12. The computerized cell morphological profiling measurement method of claim 6 further calculates trajectory feature of at least one cell morphological profiling feature for a specified time interval.
13. The computerized cell morphological profiling measurement method of claim 6 further inputs cell state and calculates state based trajectory feature of at least one cell morphological profiling feature for a specified time interval.
14. The computerized cell morphological profiling measurement method of claim 11 further inputs cell state and calculates state based feature for change of at least one cell morphological profiling feature for the specified time interval and a second specified time interval.
15. A computerized cell morphological grayscale profiling measurement method for live cell kinetic characterization comprising the steps of:
a) Inputting cell of interest mask and cell image;
b) Performing center determination using the cell of interest mask having cell center output;
c) Performing polar coordinate transformation using the cell center, the cell of interest mask and the cell image having polar cell region and polar cell image output;
d) Performing polar domain grayscale morphological profiling measurement using the polar cell region and polar cell image having cell morphological grayscale profiling feature output.
16. The cell morphological grayscale profiling feature of claim 15 is derived from a given angle range and selects feature from a set consisting of maximum intensity, minimum intensity, mean intensity, normalized mean intensity, intensity standard deviation, intensity coefficient of variation and intensity rank statistics.
17. The computerized cell morphological grayscale profiling measurement method of claim 15 wherein the cell morphological grayscale profiling feature is derived from multiple angle ranges.
18. The computerized cell morphological grayscale profiling measurement method of claim 15 further calculates change of at least one cell morphological grayscale profiling feature between a specified time interval.
19. The computerized cell morphological grayscale profiling measurement method of claim 15 further calculates trajectory feature of at least one cell morphological grayscale profiling feature for a specified time interval.
20. The computerized cell morphological grayscale profiling measurement method of claim 15 further inputs cell state and calculates state based trajectory feature of at least one cell morphological grayscale profiling feature for a specified time interval.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. An annular support for a vane, the vane having an aerofoil section with a radially inner base and a radially outer tip, the annular support comprising a gas path surface which, in use, faces an annular gas path,
wherein the annular support is locally thickened by a projection extending radially from the gas path surface, the projection at least partly defining the perimeter of an aperture for receiving the tip or base of the aerofoil section.
2. A casing for a vane, the vane having an aerofoil section with a radially inner base and a radially outer tip, the casing comprising a radially inner casing and a radially outer casing defining an annular gas path therebetween,
wherein the radially inner casing is locally thickened by a projection extending radially outwards into the gas path, the projection at least partly defining the perimeter of an aperture for receiving the base of the aerofoil section andor the radially outer casing is locally thickened by a projection extending radially inwards into the gas path, the projection at least partly defining the perimeter of an aperture for receiving the tip of the aerofoil section.
3. A vane assembly comprising:
a vane having an aerofoil section with a radially inner base and a radially outer tip;
a radially inner casing and a radially outer casing defining an annular gas path therebetween,
wherein the radially inner casing is locally thickened by a projection extending radially outwards into the gas path, the projection at least partly defining the perimeter of an aperture which houses the base of the aerofoil section andor the radially outer casing is locally thickened by a projection extending radially inwards into the gas path, the projection at least partly defining the perimeter of an aperture which houses the tip of the aerofoil section.
4. A casing according to claim 2, wherein the radially inner casing is locally thickened by a projection extending radially outwards into the gas path, the projection at least partly defining the perimeter of an aperture which housesfor receiving the base of the aerofoil section and the radially outer casing is locally thickened by a projection extending radially inwards into the gas path, the projection at least partly defining the perimeter of an aperture which housesfor receiving the tip of the aerofoil section.
5. A support according to claim 1 wherein the or each projection has a radially extending side surface that is curved or sloped.
6. A support according to claim 1 wherein the or each aperture is at least partly lined with a liner.
7. A support according to claim 1 wherein the liner extends beyond the projection.
8. An annular support for a vane, the vane having an aerofoil section with a radially inner base and a radially outer tip, the annular support comprising:
a gas path surface which, in use, faces an annular gas path, the gas path surface having an aperture for receiving the tip or base of the aerofoil section, and
a liner lining the aperture,
wherein the liner extends from the aperture beyond the gas path surface.
9. A casing for a vane, the vane having an aerofoil section with a radially inner base and a radially outer tip, the casing comprising:
a radially inner casing having an aperture for receiving the radially inner base of the vane; and
a radially outer casing having an aperture for receiving the radially outer tip of the vane, the radially inner casing and radially outer casing defining an annular gas path therebetween; wherein the aperture in the radially inner casing is provided with a liner extending radially beyond the aperture outwards into the gas path andor the aperture in the radially outer casing is provided with a liner extending radially beyond the aperture inwards into the gas path.
10. A vane assembly comprising:
a vane having an aerofoil section with a radially inner base and a radially outer tip;
a radially inner casing having an aperture housing the radially inner base of the vane; and
a radially outer casing having an aperture housing the radially outer tip of the vane, the radially inner casing and radially outer casing defining an annular gas path therebetween;
wherein the aperture in the radially inner casing is provided with a liner extending radially beyond the aperture outwards into the gas path andor the aperture in the radially outer casing is provided with a liner extending radially beyond the aperture inwards into the gas path.
11. A support according to claim 8 wherein the portion of the or each liner extending beyond the respective aperture has a radially extending side surface which is curved or sloped.
12. (canceled)
13. (canceled)
14. An assembly according to claim 3 wherein the radially inner casing is locally thickened by a projection extending radially outwards into the gas path, the projection at least partly defining the perimeter of an aperture which housesfor receiving the base of the aerofoil section and the radially outer casing is locally thickened by a projection extending radially inwards into the gas path, the projection at least partly defining the perimeter of an aperture which housesfor receiving the tip of the aerofoil section.
15. A casing according to claim 2 wherein the or each projection has a radially extending side surface that is curved or sloped.
16. An assembly according to claim 3 wherein the or each projection has a radially extending side surface that is curved or sloped.
17. A casing according to claim 2 wherein the or each aperture is at least partly lined with a liner.
18. An assembly according to claim 3 wherein the or each aperture is at least partly lined with a liner.
19. A casing according to claim 2 wherein the liner extends beyond the projection.
20. An assembly according to claim 3 wherein the liner extends beyond the projection.
21. A casing according to claim 9 wherein the portion of the or each liner extending beyond the respective aperture has a radially extending side surface which is curved or sloped.
22. An assembly according to claim 10 wherein the portion of the or each liner extending beyond the respective aperture has a radially extending side surface which is curved or sloped.