1. A compound represented by the formula (1)
wherein
A is a CH, and
B is sulfur;
R1 is a phenyl, wherein the phenyl is substituted with one or more substituents selected from the group consisting of chlorine, trifluoromethyl, and t-butyl,
L1 is a bond,
X is OH,
R2 is methyl,
L2 is a bond,
L3 is NH,
L4 is NH,
Y is sulfur, and
R3 is phenyl substituted with a carboxy group,
a tautomer, prodrug or pharmaceutically acceptable salt of the compound.
2. 4-{(2-1-5-(4-t-butylphenyl)-4-hydroxy-3-thienylethylidenehydrazine)cabonothioylamino}benzoic acid, a tautomer thereof or a pharmaceutically acceptable salt thereof.
3. 4-((2-(1-5-(3,4-dichlorophenyl)-4-hydroxy-3-thienylethyliden)hydrazine)carbonothioylamino)benzoic acid, a tautomer thereof or a pharmaceutically acceptable salt thereof.
4. 4-(2-{1-5-(4-trifluoromethylphenyl)-4-hydroxy-3-thienylethylidene}hydrazino)carbonylbenzoic acid, a tautomer thereof or a pharmaceutically acceptable salt thereof.
5. 4-{(2-{1-5-(3-trifluoromethylphenyl)-4-hydroxy-3-thienylethylidene}hydrazino)-carbonothioylamino}benzoic acid, a tautomer thereof or a pharmaceutically acceptable salt thereof.
6. 3-{(2-(1-5-(3,4-dichlorophenyl)-4-hydroxy-3-thienylethylidene)hydrazine)-carbonothioylamino}benzoic acid, a tautomer thereof or a pharmaceutically acceptable salt thereof.
7. 3-((2-(1-5-(4-t-butylphenyl)-4-hydroxy-3-thienylethylidene)hydrazine)-carbonothioylamino)benzoic acid, a tautomer thereof or a pharmaceutically acceptable salt thereof.
8. 3-((2-(1-5-(4-chlorophenyl)-4-hydroxy-3-thienylethylidene)hydrazine)-carbonothioylamino)benzoic acid, a tautomer thereof or a pharmaceutically acceptable salt thereof.
9. 3-((2-(1-5-(3-chlorophenyl)-4-hydroxy-3-thienylethylidene)hydrazine)-carbonothioylamino)benzoic acid, a tautomer thereof or a pharmaceutically acceptable salt thereof.
10. A composition comprising at least one compound of claim 1, a tautomer thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof; and at least one carrier.
11. A composition comprising the compound of claim 2, a tautomer thereof, or a pharmaceutically acceptable salt thereof; and at least one carrier.
12. A composition comprising the compound of claim 3, a tautomer thereof, or a pharmaceutically acceptable salt thereof; and at least one carrier.
13. A composition comprising the compound of claim 4, a tautomer thereof, or a pharmaceutically acceptable salt thereof; and at least one carrier.
14. A composition comprising the compound of claim 5, a tautomer thereof, or a pharmaceutically acceptable salt thereof; and at least one carrier.
15. A composition comprising the compound of claim 6, a tautomer thereof, or a pharmaceutically acceptable salt thereof; and at least one carrier.
16. A composition comprising the compound of claim 7, a tautomer thereof, or a pharmaceutically acceptable salt thereof; and at least one carrier.
17. A composition comprising the compound of claim 8, a tautomer thereof, or a pharmaceutically acceptable salt thereof; and at least one carrier.
18. A composition comprising the compound of claim 9, a tautomer thereof or a pharmaceutically acceptable salt thereof; and at least one carrier.
19. A method of treating thrombocytopenia in a patient in need thereof, the method comprising administering to the patient an effective amount of at least one compound of claim 1, a tautomer thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof to treat the thrombocytopenia.
20. A method of treating thrombocytopenia in a patient in need thereof, the method comprising administering to the patient an effective amount of at least one compound of claim 2, a tautomer thereof, or a pharmaceutically acceptable salt thereof to treat the thrombocytopenia.
21. A method of treating thrombocytopenia in a patient in need thereof, the method comprising administering to the patient an effective amount of at least one compound of claim 3, a tautomer thereof, or a pharmaceutically acceptable salt thereof to treat the thrombocytopenia.
22. A method of treating thrombocytopenia in a patient in need thereof, the method comprising administering to the patient an effective amount of at least one compound of claim 4, a tautomer thereof, or a pharmaceutically acceptable salt thereof to treat the thrombocytopenia.
23. A method of treating thrombocytopenia in a patient in need thereof, the method comprising administering to the patient an effective amount of at least one compound of claim 5, a tautomer thereof, or a pharmaceutically acceptable salt thereof to treat the thrombocytopenia.
24. A method of treating thrombocytopenia in a patient in need thereof, the method comprising administering to the patient an effective amount of at least one compound of claim 6, a tautomer thereof, or a pharmaceutically acceptable salt thereof to treat the thrombocytopenia.
25. A method of treating thrombocytopenia in a patient in need thereof, the method comprising administering to the patient an effective amount of at least one compound of claim 7, a tautomer thereof, or a pharmaceutically acceptable salt thereof to treat the thrombocytopenia.
26. A method of treating thrombocytopenia in a patient in need thereof, the method comprising administering to the patient an effective amount of at least one compound of claim 8, a tautomer thereof, or a pharmaceutically acceptable salt thereof to treat the thrombocytopenia.
27. A method of treating thrombocytopenia in a patient in need thereof, the method comprising administering to the patient an effective amount of at least one compound of claim 9, a tautomer thereof, or a pharmaceutically acceptable salt thereof to treat the thrombocytopenia.
28. A method of increasing platelets, vascular endothelial cells andor endothelial progenitor cells, the method comprising administering to the patient an effective amount of at least one compound of claim 1, a tautomer thereof, a prodrug thereof, or a pharmaceutically acceptable salt thereof to increase platelets, vascular endothelial cells andor endothelial progenitor cells.
29. A method of increasing platelets, vascular endothelial cells andor endothelial progenitor cells, the method comprising administering to the patient an effective amount of at least one compound of claim 2, a tautomer thereof or a pharmaceutically acceptable salt thereof to increase platelets, vascular endothelial cells andor endothelial progenitor cells.
30. A method of increasing platelets, vascular endothelial cells andor endothelial progenitor cells, the method comprising administering to the patient an effective amount of at least one compound of claim 3, a tautomer thereof or a pharmaceutically acceptable salt thereof to increase platelets, vascular endothelial cells andor endothelial progenitor cells.
31. A method of increasing platelets, vascular endothelial cells andor endothelial progenitor cells, the method comprising administering to the patient an effective amount of at least one compound of claim 4, a tautomer thereof or a pharmaceutically acceptable salt thereof to increase platelets, vascular endothelial cells andor endothelial progenitor cells.
32. A method of increasing platelets, vascular endothelial cells andor endothelial progenitor cells, the method comprising administering to the patient an effective amount of at least one compound of claim 5, a tautomer thereof or a pharmaceutically acceptable salt thereof to increase platelets, vascular endothelial cells andor endothelial progenitor cells.
33. A method of increasing platelets, vascular endothelial cells andor endothelial progenitor cells, the method comprising administering to the patient an effective amount of at least one compound of claim 6, a tautomer thereof or a pharmaceutically acceptable salt thereof to increase platelets, vascular endothelial cells andor endothelial progenitor cells.
34. A method of increasing platelets, vascular endothelial cells andor endothelial progenitor cells, the method comprising administering to the patient an effective amount of at least one compound of claim 7, a tautomer thereof or a pharmaceutically acceptable salt thereof to increase platelets, vascular endothelial cells andor endothelial progenitor cells.
35. A method of increasing platelets, vascular endothelial cells andor endothelial progenitor cells, the method comprising administering to the patient an effective amount of at least one compound of claim 8, a tautomer thereof or a pharmaceutically acceptable salt thereof to increase platelets, vascular endothelial cells andor endothelial progenitor cells.
36. A method of increasing platelets, vascular endothelial cells andor endothelial progenitor cells, the method comprising administering to the patient an effective amount of at least one compound of claim 9, a tautomer thereof or a pharmaceutically acceptable salt thereof to increase platelets, vascular endothelial cells andor endothelial progenitor cells.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A planar sensor element for determining at least one gas component, comprising:
a layer structure including:
a measuring cell layer;
a covering layer; and
a heating element disposed directly between the measuring cell layer and the covering layer and generating a heating power, a layer-shaped heating conductor being embedded in the heating element in a layer plane of the layer structure;
wherein the layer plane is at least approximately vertically centered with respect to the sensor element, the measuring cell layer, covering layer and layer plane extending in a horizontal direction;
wherein the covering layer adjoins the heating element on a side of the heating element facing away from the measuring cell layer and does not form part of an oxygen pump cell or an oxygen concentration cell; and
wherein the covering layer extends from the side of the heating element facing away from the measuring cell layer to an end face of the planar sensor element.
2. The planar sensor element according to claim 1,
wherein the planar sensor element is formed using a sintering process,
wherein, before the layer structure is sintered, the measuring cell layer includes at least two measuring cell layer foils and the covering layer includes at least one covering layer foil, the covering layer foil having a predetermined thickness, and
wherein a total thickness of the at least two measuring cell layer foils is at least approximately equal to the predetermined thickness.
3. The planar sensor element according to claim 2, wherein the layer structure includes a further layer having a further thickness, and wherein the total thickness includes the further thickness.
4. The planar sensor element according to claim 1, wherein the layer structure further includes a plurality of electrically insulating layers, a first thickness of one of the electrically insulating layers being approximately equal to a second thickness of another one of the electrically insulating layers, and wherein the heating conductor is embedded in the electrically insulating layers, the electrically insulating layers being formed on both sides of the heating conductor.
5. The planar sensor element according to claim 4, wherein the layer structure further includes a sealing frame surrounding the electrically insulating layers, the sealing frame having a frame thickness which is equal to a thickness of the electrically insulating layers.
6. The planar sensor element according to claim 5, wherein the electrically insulating layers include two electrically insulating layers.
7. The planar sensor element according to claim 1, wherein the layer-shaped heating conductor is arranged in the layer plane of the layer structure to obtain an at least approximately homogeneous distribution of the heating power over a cross-section of the sensor element perpendicular to the layer structure.
8. The planar sensor element according to claim 1, wherein the cover layer comprises an entirety of the planar sensor element on one side of the heating element.
9. The planar sensor element according to claim 1, wherein the covering layer is made from stabilized zirconium oxide.
10. The planar sensor element according to claim 1, wherein the measuring cell layer contacts a first planar surface of the heating element and the covering layer contacts a second opposing planar surface of the heating element.
11. The planar sensor element according to claim 1, further comprising a sealing frame around the heating element configured to seal the heating element in a gas-tight manner.
12. A planar sensor element for determining at least one gas component, comprising:
a layer structure including:
at least one of an oxygen pump layer and an oxygen concentration layer;
a covering layer; and
a heating element generating a heating power disposed directly between the covering layer and the at least one of a oxygen pump layer and oxygen concentration layer, a layer-shaped heating conductor being embedded in the heating element in a layer plane of the layer structure;
wherein the layer plane is at least approximately vertically centered with respect to the sensor element, the (i) at least one of an oxygen pump layer and an oxygen concentration layer, (ii) covering layer and (iii) layer plane extending in the horizontal direction;
wherein the covering layer adjoins the heating element on a side of the heating element facing away from the measuring cell layer and does not form a part of another oxygen pump cell or another oxygen concentration cell; and
wherein the covering layer extends from the side of the heating element facing away from the measuring cell layer to an end face of the planar sensor element.
13. A planar sensor element for determining at least one gas component, comprising:
a layer structure including:
a measuring cell layer having at least one surface;
a covering layer; and
a heating element disposed directly between the measuring cell layer and the covering layer and generating a heating power, a layer-shaped heating conductor being embedded in the heating element in a layer plane of the layer structure; and
at least one electrode, each electrode arranged on a respective surface of the measuring cell layer;
wherein the layer-shaped heating conductor is arranged in a layer plane of the layer structure to obtain an at least approximately homogeneous distribution of the heating power over a cross-section of the sensor element perpendicular to the layer structure;
wherein the layer plane is at least approximately vertically centered with respect to the sensor element, the measuring cell layer, covering layer and layer plane extending in the horizontal direction;
wherein the covering layer adjoins the heating element on a side of the heating element facing away from the measuring cell layer and does not form part of an oxygen pump cell or an oxygen concentration cell; and
wherein the covering layer extends from the side of the heating element facing away from the measuring cell layer to an end face of the planar sensor element.