1. A method of making a multilayer balloon for a catheter having a nominal working diameter, comprising:
forming a tube having at least a first layer and a second layer having a combined wall thickness, the first layer made of a first polymer material having a first maximum blow-up-ratio and the second layer made of a second polymer material having a second maximum blow-up-ratio greater than the first maximum blow-up-ratio, wherein the second layer is an inner layer relative to the first layer; and
forming the multilayer balloon from the tube in a balloon mold having an inner diameter corresponding to the balloon’s nominal working diameter, wherein the at least first and second layers of the multilayer balloon define a compliance less than that of a single layer balloon made of the first polymer material with a wall thickness equal to the combined wall thickness.
2. The method of claim 1, wherein the multilayer balloon is formed by radially expanding the tube in the balloon mold.
3. The method of claim 1, wherein the inner diameter of the first layer of the tube is selected so that the ratio of the inner diameter of the mold to the inner diameter of the first layer of the tube before being radially expanded in the mold is substantially at the maximum blow-up-ratio of the first polymer material, and the inner diameter of the second layer of the tube is selected so that the ratio of the inner diameter of the mold to the inner diameter of the second layer of the tube before being radially expanded in the mold is substantially at the maximum blow-up-ratio of the second polymer material.
4. The method of claim 3, wherein the multilayer balloon is formed by radially expanding the tube to the mold inner diameter so that the first layer is substantially at the first maximum blow-up-ratio and the second layer is substantially at the second maximum blow-up-ratio.
5. The method of claim 1, wherein the nominal working diameter of the multilayer balloon corresponds to an inner mold diameter used to form the balloon, and the first layer is substantially at the first maximum blow-up-ratio and the second layer is substantially at the second maximum blow-up-ratio when the multilayer balloon is substantially at the nominal working diameter.
6. The method of claim 1, wherein tube is formed by coextrusion.
7. The method of claim 1, wherein the second maximum blow-up-ratio is about 15 to about 40 percent greater than the first maximum blow-up-ratio.
8. The method of claim 1, wherein the first maximum blow-up-ratio is about 6 to about 7.
9. The method of claim 1, wherein the second maximum blow-up-ratio is about 7 to about 8.
10. The method of claim 1, wherein the first maximum blow-up-ratio is about 6 to about 7 and the second maximum blow-up-ratio is about 7 to about 8.
11. The method of claim 1, wherein the second layer has a thickness of about 5 to about 15 percent of the combined wall thickness.
12. The method of claim 1, wherein the first layer has a first Shore durometer hardness and the second layer has a second Shore durometer hardness lower than the first Shore durometer hardness.
13. The method of claim 12, wherein the first Shore durometer hardness is about 70 D to about 72 D.
14. The method of claim 12, wherein the second Shore durometer hardness is about 60 D to about 70 D.
15. The method of claim 12, wherein the first Shore durometer hardness is about 70 D to about 72 D and the second Shore durometer hardness is about 60 D to about 70 D.
16. The method of claim 1, wherein the balloon has a noncompliant limited radial expansion beyond the nominal working diameter at pressures above a nominal pressure
17. The method of claim 16, wherein the nominal pressure is about 6 to about 12 atm.
18. The method of claim 17, wherein the nominal pressure is about 7 to about 9 atm.
19. The method of claim 1, wherein the balloon has a higher modulus than a single layer balloon made of the first polymer material with a wall thickness equal to the combined wall thickness.
20. The method of claim 1, wherein the second layer defines an inner surface of the balloon.
21. The method of claim 20, wherein the first layer defines an outer surface of the balloon.
22. The method of claim 21, wherein the at least first and second layers further include a mid layer between the first layer and the second layer.
23. The method of claim 22, wherein the mid layer is a tie layer.
24. The method of claim 22, wherein the mid layer has a maximum blow-up-ratio greater than the first maximum blow-up-ratio and less than the second maximum blow-up-ratio.
25. The method of claim 22, wherein the first layer has a first Shore durometer hardness, the second layer has a second Shore durometer hardness lower than the first Shore durometer hardness, and the mid layer has a third Shore durometer hardness lower than the first Shore durometer hardness and greater than the second Shore durometer hardness.
26. The method of claim 25, wherein the first Shore durometer hardness is about 70 D to about 72 D and the second Shore durometer hardness is about 60 D to about 70 D.
27. The method of claim 22, wherein the second layer and the mid layer collectively have a total thickness of about 5 to about 15 percent of the combined wall thickness of the first, second, and mid layers.
28. The method of claim 1, wherein the first polymer material is an elastomer.
29. The method of claim 1, wherein the second polymer material is an elastomer.
30. The method of claim 1, wherein the first polymer material is a polyamide, a polyurethane, a polyester, or polyether block amide.
31. The method of claim 1, wherein the second polymer material is a polyamide, a polyurethane, a polyester, or polyether block amide.
32. The method of claim 1, wherein the first polymer material is a polyether block amide and the second polymer material is a polyether block amide.
33. The method of claim 32, wherein the first polymer material has a Shore durometer hardness of about 70 D to about 72 D and the second polymer material has a Shore durometer hardness of about 63 D.
34. The method of claim 1, the first layer has a first elongation and the second layer has a second elongation about 10 to about 50 percent more than the elongation of the first layer.
35. The method of claim 1, wherein the at least first and second layers collectively define a rated burst pressure of about 14 to about 22 atm.
36. The method of claim 35, wherein the rated burst pressure is about 18 to about 20 atm.
37. The method of claim 1, wherein the at least first and second layers collectively define a burst pressure greater than about 15 percent less than a single layer balloon made of the first polymer material having a wall thickness equal to the combined wall thickness.
38. The method of claim 37, wherein the burst pressure of the at least first and second layers is greater than a single layer balloon made of the first polymer material having a wall thickness equal to the combined wall thickness.
39. The method of claim 1, wherein the at least first and second layers collectively define a flexural modulus of about 90 to about 95 percent of the flexural modulus of a single layer balloon made of the first polymer material having a wall thickness equal to the combined wall thickness.
40. The method of claim 1, wherein the first layer is bonded directly to the second layer.
41. The method of claim 1, wherein the multilayer balloon has a rupture pressure generally equal to or greater than that of a single layer balloon made of the first polymer material having a wall thickness equal to the combined wall thickness.
42. The method of claim 1, wherein the multilayer balloon is generally noncompliant with a compliance of less than about 0.03 mmatm between nominal pressure and a rated burst pressure.
43. The method of claim 42, wherein the multilayer balloon compliance from nominal pressure to a rated burst pressure is less than about 0.018 minatm.
44. The method of claim 1, further comprising releasably mounting a radially expandable stent on the multilayer balloon.
45. A method of making a balloon catheter, comprising:
forming a tube having at least a first layer and a second layer having a combined wall thickness, the first layer made of a first polymer material having a first maximum blow-up-ratio and the second layer made of a second polymer material having a second maximum blow-up-ratio greater than the first maximum blow-up-ratio, wherein the second layer is an inner layer relative to the first layer;
forming a multilayer balloon from the tube in a balloon mold having an inner diameter corresponding to the balloon’s nominal working diameter, wherein the at least first and second layers of the multilayer balloon define a compliance less than that of a single layer balloon made of the first polymer material with a wall thickness equal to the combined wall thickness;
forming an elongate catheter shaft having a proximal section, a distal section, and an inflation lumen; and
joining the multilayer balloon to the distal section of the shaft.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A squash plant comprising at least a first set of the chromosomes of squash line LEB 48-4101 or squash line ZGY 130-1072, a sample of seed of said lines having been deposited under ATCC Accession Number PTA-11348, and ATCC Accession Number PTA-11349, respectively.
2. A seed comprising at least a first set of the chromosomes of squash line LEB 48-4101 or squash line ZGY 130-1072, a sample of seed of said lines having been deposited under ATCC Accession Number PTA-11348, and ATCC Accession Number PTA-11349, respectively.
3. The plant of claim 1, which is inbred.
4. The plant of claim 1, which is hybrid.
5. The plant of claim 4, wherein the hybrid plant is squash hybrid RX 04858033, a sample of seed of said hybrid RX 04858033 having been deposited under ATCC Accession Number PTA-11347.
6. The plant of claim 1, wherein the plant is a plant of line LEB 48-4101 or line ZGY 130-1072.
7. A plant part of the plant of claim 1.
8. The plant part of claim 7, further defined as a leaf, a ovule, pollen, a fruit, or a cell.
9. A squash plant having all the physiological and morphological characteristics of the squash plant of claim 5.
10. A squash plant having all the physiological and morphological characteristics of the squash plant of claim 6.
11. A tissue culture of regenerable cells of the plant of claim 1.
12. The tissue culture according to claim 11, comprising cells or protoplasts from a plant part selected from the group consisting of embryos, meristems, cotyledons, pollen, leaves, anthers, roots, root tips, pistil, flower, seed and stalks.
13. A squash plant regenerated from the tissue culture of claim 12.
14. A method of vegetatively propagating the plant of claim 1 comprising the steps of:
(a) collecting tissue capable of being propagated from a plant according to claim 1;
(b) cultivating said tissue to obtain proliferated shoots; and
(c) rooting said proliferated shoots to obtain rooted plantlets.
15. The method of claim 14, further comprising growing at least a first plant from said rooted plantlets.
16. A method of introducing a desired trait into a squash line comprising:
(a) crossing a plant of line LEB 48-4101 or ZGY 130-1072 with a second squash plant that comprises a desired trait to produce F1 progeny, a sample of seed of said lines having been deposited under ATCC Accession Number PTA-11348, and ATCC Accession Number PTA-11349, respectively;
(b) selecting an F1 progeny that comprises the desired trait;
(c) backcrossing the selected F1 progeny with a plant of line LEB 48-4101 or ZGY 130-1072 to produce backcross progeny;
(d) selecting backcross progeny comprising the desired trait and the physiological and morphological characteristic of squash line LEB 48-4101 or ZGY 130-1072; and
(e) repeating steps (c) and (d) three or more times to produce selected fourth or higher backcross progeny that comprise the desired trait.
17. A squash plant produced by the method of claim 16.
18. A method of producing a plant comprising an added trait, the method comprising introducing a transgene conferring the trait into a plant of hybrid RX 04858033, line LEB 48-4101 or line ZGY 130-1072, a sample of seed of said hybrid and lines having been deposited under ATCC Accession Number PTA-11347, ATCC Accession Number PTA-11348, and ATCC Accession Number PTA-11349, respectively.
19. A plant produced by the method of claim 18.
20. The plant of claim 1, comprising a transgene.
21. The plant of claim 20, wherein the transgene confers a trait selected from the group consisting of male sterility, herbicide tolerance, insect resistance, pest resistance, disease resistance, modified fatty acid metabolism, environmental stress tolerance, modified carbohydrate metabolism and modified protein metabolism.
22. The plant of claim 1, comprising a single locus conversion.
23. The plant of claim 22, wherein the single locus conversion confers a trait selected from the group consisting of male sterility, herbicide tolerance, insect resistance, pest resistance, disease resistance, modified fatty acid metabolism, environmental stress tolerance, modified carbohydrate metabolism and modified protein metabolism.
24. A method for producing a seed of a plant derived from at least one of hybrid RX 04858033, line LEB 48-4101 or line ZGY 130-1072 comprising the steps of:
(a) crossing a squash plant of hybrid RX 04858033, line LEB 48-4101 or line ZGY 130-1072 with itself or a second squash plant; a sample of seed of said hybrid and lines having been deposited under ATCC Accession Number PTA-11347, ATCC Accession Number PTA-11348, and ATCC Accession Number PTA-11349, respectively; and
(b) allowing seed of a hybrid RX 04858033, line LEB 48-4101 or line ZGY 130-1072-derived squash plant to form.
25. The method of claim 24, further comprising the steps of:
(c) selfing a plant grown from said hybrid RX 04858033, LEB 48-4101 or ZGY 130-1072-derived squash seed to yield additional hybrid RX 04858033, line LEB 48-4101 or line ZGY 130-1072-derived squash seed;
(d) growing said additional hybrid RX 04858033, line LEB 48-4101 or line ZGY 130-1072-derived squash seed of step (c) to yield additional hybrid RX 04858033, line LEB 48-4101 or line ZGY 130-1072-derived squash plants; and
(e) repeating the crossing and growing steps of (c) and (d) to generate at least a first further hybrid RX 04858033, line LEB 48-4101 or line ZGY 130-1072-derived squash plant.
26. The method of claim 24, wherein the second squash plant is of an inbred squash line.
27. The method of claim 24, comprising crossing line LEB 48-4101 with line ZGY 130-1072, a sample of seed of said lines having been deposited under ATCC Accession Number PTA-11348, and ATCC Accession Number PTA-11349, respectively.
28. The method of claim 25, further comprising:
(f) crossing the further hybrid RX 04858033, LEB 48-4101 or ZGY 130-1072-derived squash plant with a second squash plant to produce seed of a hybrid progeny plant.
29. A hybrid seed produced by the method of claim 27.
30. A plant produced by growing the seed of claim 27.
31. A plant part of the plant of claim 30.
32. The plant part of claim 31, further defined as a leaf, a flower, a fruit, an ovule, pollen, or a cell.
33. A method of producing a squash seed comprising crossing the plant of claim 1 with itself or a second squash plant and allowing seed to form.
34. A method of producing a squash fruit comprising:
(a) obtaining a plant according to claim 1, wherein the plant has been cultivated to maturity; and
(b) collecting a squash from the plant.