1. A method of removing a biofilm on a surface of a medical instrument selected from the group consisting of an endoscope, a catheter, an artificial dialyzer, and a circuit of an artificial dialyzer, comprising:
contacting a biofilm-removing agent with the biofilm, wherein said biofilm-removing agent comprises a basic amino acid derivative represented by the following formula (1) or a salt thereof:
wherein R1 represents a linear- or branched-alkyl group having 4 to 18 carbon atoms or a linear- or branched-alkenyl group having 4 to 18 carbon atoms; X and Y each represent a group selected from the groups represented by the following formulas:
and m represents an integer from 1 to 5.
2. A method of removing a biofilm according to claim 1, wherein in the formula (1), m is 3, and Y is \u2014NH\u2014C(\u2014NH2)\u2550NH.
3. A method of removing a biofilm according to claim 1, wherein in the formula (1), X is \u2014OCH2\u2014CH(\u2014OH)CH2\u2014.
4. A method of removing a biofilm according to claim 1, wherein the basic amino acid derivative represented by formula (1) or a salt thereof is present in a biofilm-removing composition, which composition also contains one or more members selected from the group consisting of surfactants, other than the basic amino acid derivative represented by formula (1) or a salt thereof, and chelating agents.
5. A method of removing a biofilm according to claim 1, wherein the basic amino acid derivative represented by formula (1) or a salt thereof is present in a biofilm-removing composition, which composition also contains an alkali agent, and a surfactant other than the basic amino acid derivative represented by formula (1) or a salt thereof.
6. A method of removing a biofilm according to claim 1, wherein a concentration of the amino acid derivative of formula (1) or the salt thereof in the biofilm-removing agent is 0.001 to 80% by weight.
7. A method of removing a biofilm according to claim 1, wherein the biofilm-removing agent is contained in an aqueous solution and is contacted with the biofilm by way of immersion, coating or spraying of a surface on which the biofilm is formed, and wherein physical force is optionally applied to the biofilm with a sponge, a towel, a brush, or a water jet.
8. A method of removing a biofilm according to claim 1,
wherein the biofilm is contacted with the biofilm-removing agent containing the amino acid derivative of formula (1) or the salt thereof by immersing the medical instrument in an aqueous solution containing the biofilm-removing agent, or by placing the medical instrument in a water jet of an aqueous solution containing the biofilm-removing agent, or by immersing the medical instrument in an aqueous solution containing the biofilm-removing agent while applying ultrasonic vibration to the aqueous solution having the medical instrument immersed therein.
9. A method of removing a biofilm according to claim 8, wherein the medical instrument is an endoscope selected from the group consisting of a laryngendoscope, a bronchoscope, a upper gastrointestinal endoscope, a small intestine endoscope, a large intestine endoscope, a thoracoscope, a laparoscope, a cystoscope, a cholangioscope, an arthroscope and an angioscope.
10. A method of removing a biofilm according to claim 8, wherein the aqueous solution contains the amino acid derivative of formula (1) or a salt thereof in a concentration of 0.2 to 20% by weight.
11. A method of removing a biofilm according to claim 1, wherein the biofilm-removing agent containing the amino acid derivative of formula (1) or the salt thereof is present in an aqueous solution having a pH of 4.5 to 12.2.
12. A method of removing a biofilm according to claim 1, wherein the biofilm contains Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens or Staphylococcus epidermidis.
13. A method of removing a biofilm according to claim 8, wherein the biofilm-removing agent containing the amino acid derivative of formula (1) or the salt thereof is present in an aqueous solution having a pH of 4.5 to 12.2; and wherein the biofilm contains Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens or Staphylococcus epidermidis.
14. A method of removing a biofilm according to claim 1, wherein the biofilm-removing agent is in an aqueous solution having a pH of 4.5 to 12.2, wherein the amino acid derivative of formula (1) or the salt thereof is contained in the aqueous solution in a concentration of 0.2 to 20% by weight; and wherein the biofilm contains Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens or Staphylococcus epidermidis.
15. A method of removing a biofilm according to claim 8, wherein the biofilm-removing agent is in an aqueous solution having a pH of 4.5 to 12.2, wherein the amino acid derivative of formula (1) or the salt thereof is contained in the aqueous solution in a concentration of 0.2 to 20% by weight; and wherein the biofilm contains Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens or Staphylococcus epidermidis.
16. A method of removing a biofilm according to claim 15, wherein the medical instrument is an endoscope selected from the group consisting of a laryngendoscope, a bronchoscope, a upper gastrointestinal endoscope, a small intestine endoscope, a large intestine endoscope, a thoracoscope, a laparoscope, a cystoscope, a cholangioscope, an arthroscope or an angioscope.
17. A method of removing a biofilm according to claim 1, wherein the biofilm-removing agent is contacted with the biofilm for one to ten minutes.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A beverage bottle with spray device comprising:
a bottle 9 to attach a spray device 10 thereon;
a spray device 10 which includes a lower part of inner lid 2 of which a sealing film 1 is arranged on top, an upper part of inner lid 5 of which a spray 3 is arranged on top and a spray pipe 4 is stored inside, a joint 6 which connects the lower part of inner lid 2 and the upper part of inner lid 5, a lower part of outer lid 7 and an upper part of outer lid 8 which are arranged outside of the lower part of inner lid 2 and the upper part of inner lid 5.
2. A beverage bottle with spray device as defined by claim 1, therein:
purified water including distilled water is filled in said bottle 9.
3. A beverage bottle with spray device as defined by claim 1, therein:
purified water including distilled water with scent is filled in said bottle 9.
4. A beverage bottle with spray device as defined by claim 1, therein:
mineral water is filled in said bottle 9.
5. A beverage bottle with spray device as defined by claim 1, therein:
mineral water with scent is filled in said bottle 9.
6. A beverage bottle with spray device as defined by claim 1, therein:
soft drink is filled in said bottle 9.
7. A beverage bottle with spray device as defined by claim 1, therein:
alcohol is filled in said bottle 9.
8. A beverage bottle with spray device as defined by claim 1, therewith:
said spray pipe 4 is preset into said bottle 9 without stored in said upper part of inner lid 5, without said sealing film 1 on said lower part of inner lid 2.
9. A beverage bottle with spray device as defined by claim 1, therewith:
said spray pipe 4 is preset into said bottle 9, in which purified water including distilled water is filled, without stored in said upper part of inner lid 5, without said sealing film 1 on said lower part of inner lid 2.
10. A beverage bottle with spray device as defined by claim 1, therewith:
said spray pipe 4 is preset into said bottle 9, in which purified water including distilled water with scent is filled, without stored in said upper part of inner lid 5, without said sealing film 1 on said lower part of inner lid 2.
11. A beverage bottle with spray device as defined by claim 1, therewith:
said spray pipe 4 is preset into said bottle 9, in which mineral water is filled, without stored in said upper part of inner lid 5, without said sealing film 1 on said lower part of inner lid 2.
12. A beverage bottle with spray device as defined by claim 1, therewith:
said spray pipe 4 is preset into said bottle 9, in which mineral water with scent is filled, without stored in said upper part of inner lid 5, without said sealing film 1 on said lower part of inner lid 2.
13. A beverage bottle with spray device as defined by claim 1, therewith:
said spray pipe 4 is preset into said bottle 9, in which soft drink is filled, without stored in said upper part of inner lid 5, without said sealing film 1 on said lower part of inner lid 2.
14. A beverage bottle with spray device as defined by claim 1, therewith:
said spray pipe 4 is preset into said bottle 9, in which alcohol is filled, without stored in said upper part of inner lid 5, without said sealing film 1 on said lower part of inner lid 2.
15. A spray device which includes said spray device 10 defined by claim 1 and which is designed to attach to the conventional beverage bottle.