1. A cycloalkylcarbonylamino acid derivative represented by formula (I\u2032), or a pharmaceutically acceptable salt thereof:
wherein R1 represents a substituted or unsubstituted aromatic hydrocarbon group, substituted or unsubstituted heterocyclic group, a group R4O\u2014,
wherein R4 is a substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted or unsubstituted aromatic hydrocarbon group or substituted or unsubstituted heterocyclic group; wherein an oxazolyl group and a thiazolyl group are excluded from the heterocyclic group of R1,
R2\u2032 represents an alkyl group represented by Ra(Rb)CH\u2014
wherein Ra and Rb respectively and independently are a hydrogen atom, substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted or unsubstituted aromatic hydrocarbon group or substituted or unsubstituted heterocyclic group; and,
ring A represents a cyclic alkylidene group having 6 carbon atoms;
provided that, in the case R2\u2032 is a 2,2-dimethylpropyl group or a 2-(methylthio)ethyl group, R4 is not a t-butyl group, and in the case R2\u2032 is a methyl group, R4 is not a benzyl group;
a substituent of an alkyl group in the groups represented by R4, Ra, and Rb is a group selected from a hydroxyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, alkoxy group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, amido group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group;
a substituent of an alkenyl group or alkynyl group in the groups Ra, Rb and R4 is a group selected from a hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, alkoxy group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, amido group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group; and,
a substituent of an aromatic hydrocarbon group or heterocyclic group in the groups R1 and R4 is selected from a hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, alkoxy group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, amido group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group; and
a substituent of an aromatic hydrocarbon group in the groups Ra and Rb is a group selected from a hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group,
a substituent of a heterocyclic group in the groups Ra and Rb is a group selected from a hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group.
2. The cycloalkylcarbonylamino acid derivative according to claim 1, or a pharmaceutically acceptable salt thereof, wherein the alkyl of R4, Ra, Rb, Rx and Ry is a linear C1-12 alkyl or C3-12 branched or cyclic alkyl, the aromatic hydrocarbon of R1, R4, Ra, Rb, Rx and Ry is a monocyclic or polycyclic C6-18 aromatic hydrocarbon group, the heterocyclic group of R1, R4, Ra, Rb, Rx and Ry is a 3- to 7-membered ring containing at least one nitrogen atom, oxygen atom or sulfur atom as a ring-constituting hetero atom, the alkenyl group of Ra, Rb, R4, Rx and Ry is a linear C2-12 alkenyl group or C3-12 branched or cyclic alkenyl group, and the alkynyl group of Ra, Rb, R4, Rx and Ry is a linear C2-12 alkynyl group or C3-12 branched or cyclic alkynyl group.
3. A cycloalkylcarbonylamino acid derivative represented by formula (I\u2033) or a pharmaceutically acceptable salt thereof:
wherein R1\u2032 is a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted heterocyclic group,
wherein an oxazolyl group and a thiazolyl group are excluded from the heterocyclic group of R1\u2032,
R2\u2032 represents an alkyl group represented by Ra(Rb)CH\u2014
wherein Ra and Rb respectively and independently are a hydrogen atom, substituted or unsubstituted alkyl group, substituted or unsubstituted alkenyl group, substituted or unsubstituted alkynyl group, substituted or unsubstituted aromatic hydrocarbon group, or substituted or unsubstituted heterocyclic group; and
ring A represents a cyclic alkylidene group having 6 carbon atoms;
a substituent of an alkyl group of Ra, and Rb is selected from a hydroxyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, alkoxy group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, amido group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group;
a substituent of an alkenyl group or alkynyl group of Ra, Rb, is selected from a hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, alkoxy group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, amido group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group;
a substituent of an aromatic hydrocarbon group of R1\u2032 is selected from a hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, alkoxy group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, amido group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group;
a substituent of an aromatic hydrocarbon group of Ra and Rb is selected from a hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, alkoxy group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, amido group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group;
a substituent of a heterocyclic group of R1\u2032 is selected from a hydroxyl group, primary or secondary alkyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, alkoxy group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, amido group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group; and
a substituent of a heterocyclic group of Ra and Rb is selected from a hydroxyl group, alkyl group, alkenyl group, alkynyl group, halogen atom, aromatic hydrocarbon group, heterocyclic group, alkoxy group, guanidino group, alkylthio group, alkoxycarbonyl group, aryloxy group, arylthio group, acyl group, sulfonyl group, heterocyclyloxy group, heterocyclylthio group, amido group, ureido group, carboxyl group, carbamoyl group, oxo group, sulfamoyl group, sulfo group, cyano group, nitro group, acyloxy group, azido group, sulfonamido group, mercapto group, alkoxycarbonylamino group and Rx(Ry)N group,
wherein Rx and Ry respectively and independently are a hydrogen atom, alkyl group, alkenyl group, alkynyl group, aromatic hydrocarbon group or heterocyclic group.
4. The cycloalkylcarbonylamino acid derivative according to claim 3, or a pharmaceutically acceptable salt thereof, wherein the alkyl group of Ra and Rb is a linear C1-12 alkyl or C3-12 branched or cyclic alkyl, the aromatic hydrocarbon group of R1\u2032, Ra, and Rb is a monocyclic or polycyclic C6-18 aromatic hydrocarbon group, the heterocyclic group of R1\u2032, Ra, and Rb is a 3- to 7-membered ring containing at least one nitrogen atom, oxygen atom or sulfur atom as a ring-constituting hetero atom, provided that an oxazolyl group and a thiazolyl group are excluded from the heterocyclic group of R1\u2032, the alkenyl group of Ra and Rb is a linear C2-12 alkenyl group or C3-12 branched or cyclic alkenyl group, and the alkynyl group of Ra and Rb is a linear C2-12 alkynyl group or C3-12 branched or cyclic alkynyl group.
5. The cycloalkylcarbonylamino acid derivative according to claim 1 or 2, or a pharmaceutically acceptable salt thereof, wherein R1 is a substituted or unsubstituted aromatic hydrocarbon group, or substituted or unsubstituted heterocyclic group, provided that an oxazolyl group and a thiazolyl group are excluded from the heterocyclic group of R1, and R2\u2032 is an alkyl group represented by Ra(Rb)CH\u2014
wherein Ra and Rb respectively and independently are a hydrogen atom, substituted or unsubstituted alkyl group, substituted or unsubstituted aromatic hydrocarbon group or substituted or unsubstituted heterocyclic group.
6. A process for producing a cycloalkylcarbonylamino acid derivative represented by formula (I\u2032) comprising: condensing an oxazolone derivative represented by formula (I0) with an amino alcohol derivative represented by formula (VII\u2032):
wherein R1, R2\u2032 and ring A are the same as defined in claim 1.
7. The cycloalkylcarbonylamino acid derivative according to claim 1 or 2, or a pharmaceutically acceptable salt thereof, wherein R2\u2032 is an isopropyl group.
8. The cycloalkylcarbonylamino acid derivative according to claim 3 or 4, or a pharmaceutically acceptable salt thereof, wherein R2\u2032 is an isopropyl group.
9. The cycloalkylcarbonylamino acid derivative according to claim 3 or 4, or a pharmaceutically acceptable salt thereof, wherein in the formula (I\u2033), R1\u2032 is a substituted or unsubstituted aromatic hydrocarbon group, or substituted or unsubstituted heterocyclic group, provided that an oxazolyl group and a thiazolyl group are excluded from the heterocyclic group of R1\u2032, and R2\u2032 is an alkyl group of Ra(Rb)CH\u2014
wherein Ra and Rb respectively and independently are a hydrogen atom, substituted or unsubstituted alkyl group, substituted or unsubstituted aromatic hydrocarbon group or substituted or unsubstituted heterocyclic group.
10. The cycloalkylcarbonylamino acid derivative according to claim 1 or 2, or a pharmaceutically acceptable salt thereof, wherein in the formula (I\u2032), R1 is a 3- to 7-membered heterocyclic group, containing at least one nitrogen atom, oxygen atom or sulfur atom as a ring-constituting hetero atom, provided that an oxazolyl group and a thiazolyl group are excluded from the heterocyclic group of R1, or a substituted aromatic hydrocarbon group, R2\u2032 is a C1-4 alkyl group, and ring A is a cyclohexylidene group.
11. The cycloalkylcarbonylamino acid derivative according to claim 3 or 4, or a pharmaceutically acceptable salt thereof, wherein in the formula (I\u2033), R1\u2032 is a 3- to 7-membered heterocyclic group, containing at least one nitrogen atom, oxygen atom or sulfur atom as a ring-constituting hetero atom, provided that an oxazolyl group and a thiazolyl group are excluded from the heterocyclic group of R1\u2032, or a substituted aromatic hydrocarbon group, R2\u2032 is a C1-4 alkyl group, and ring A is a cyclohexylidene group.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A reception apparatus which receives a first and second message, the reception apparatus comprising:
a determination unit configured to determine correspondence between the first message and the second message;
an acquisition unit configured to acquire data length information expressing a data length from the first message; and
an extraction unit configured to extract data which has the data length based on the data length information from the second message when the determination unit determines that the first message corresponds to the second message.
2. The reception apparatus according to claim 1, wherein the first message includes identification information about a corresponding second message, and the determination unit uses the identification information to determine whether the first message corresponds to the second message.
3. The reception apparatus according to claim 1, wherein the acquisition unit acquires, from the first message, first data length information including identification information about first data included in the second message and second data length information including identification information about second data included in the second message, and
the extraction unit extracts the first data included in the second message based on the first data length information and extracts second data included in the second message based on the second data length information.
4. The reception apparatus according to claim 1, further comprising:
a detection unit configured to detect a character string expressing start of the data from the second message,
wherein the extraction unit extracts the data which has the data length based on the detected character string and the data length information.
5. The reception apparatus according to claim 2, further comprising:
a storage unit configured to correlate and store the data length information and the identification information about the second message; and
a detection unit configured to detect a character string expressing separation of the data from other data from the second message,
wherein when the data length information corresponding to the received second message is not stored in the storage unit, the extraction unit extracts data which has the data length in response to the detection of the character string by the detection unit.
6. A method for extracting data performed by a reception apparatus which receives a first and second message, the method comprising:
determining whether the first message corresponds to the second message;
acquiring data length information expressing data length from the first message; and
extracting data which has the data length based on the data length information from the second message when the second message is determined to correspond to the first message.
7. A computer readable program for causing a computer which receives a first and second message to execute instructions, the program comprising:
determining whether the first message corresponds to the second message;
acquiring data length information expressing data length from the first message; and
extracting data which has the data length based on the data length information from the second message when the second message is determined to correspond to the first message.
8. A transmission apparatus which transmits a first and second message, the transmission apparatus comprising:
a generation unit configured to generate the first message so that data length information related to a data length of the second message which corresponds to the first message is included in the first message; and
a transmission unit configured to transmit the first message and the second message.
9. A method for processing a message by a transmission apparatus which transmits a first and second message and a reception apparatus which receives the first and second message, the method comprising:
causing the transmission apparatus to generate the first message so that data length information related to a data length of the second message which corresponds to the first message is included in the first message, and
transmit the first message and the second message; and
causing the reception apparatus to receive the first and second message,
determine whether the first message corresponds to the second message,
acquire the data length information expressing the data length from the first message, and
extract data which has the data length based on the data length information from the second message when the second message is determined to correspond to the first message.