1. Method of adapting a composite signature of a phenotype which is derived from measurements of specimen, the method comprising the steps of:
providing for a composite signature of a phenotype,
wherein the composite signature comprises data of type A which were generated by measuring the specimen with a first modality of measuring,
wherein the data of type A comprise at least one value of modality features a1 . . . ac,
wherein the composite signature comprises data of type B which were generated by measuring the specimen with a second modality of measuring,
wherein the data of type B comprise values of at least one modality features b1 . . . bk,
adapting the value of the feature bi based on a determined correlation between the value of modality feature bi and between the value of a modality feature cj when measured with a third modality of measuring,
wherein feature bi is out of b1 . . . bk,
wherein the adaption leads to an adapted composite signature of the phenotype, and
applying a signature evaluation tool to the adapted composite signature,
wherein the signature evaluation tool was derived from data measured by the third modality.
2. Method according to claim 1, further comprising the step
determining the correlation between the value of modality feature bi
and between the value of a modality feature cj when measured with a third modality of measuring the specimen.
3. Method according to claim 1,
wherein the correlation defines how values of features b1 . . . bk of the second modality match or correlate with values of modality features cj of the third modality, wherein cj is out of c1 . . . cn.
4. Method according to claim 1,
wherein the second modality of measuring is a first medical imaging method, and
wherein the third modality of measuring is a second medical imaging method.
5. Method according to claim 1,
wherein the second modality of measuring and the third modality of measuring are independently chosen from the group comprising ultrasound imaging, Doppler ultrasound imaging, X-ray imaging, MRI, PET, PAM (FTG), BSGI, transcription profiling, gene andor noncoding RNA profiling, SNPs, CNPs, proteome profiling, DNA methylation, histone methylation profiling, acetylation, phosphorylation states, gene expression profiling, copy number polymorphism profiling, single nucleotide polymorphism profiling, histone acetylation profiling, proteomic profiling, phosphorylation state profiling, and any combination thereof.
6. Method according to claim 1,
further comprising the step
calculating a result about the nature of the phenotype based on the application of the signature evaluation tool to the adapted composite signature.
7. Method according to claim 1,
wherein the determination of the correlation is performed for several features b1 . . . bk with respect to at least one feature out of c1 . . . cn,
the method further comprising the step
selecting the features out of b1 . . . bk whose determined correlation indicate a match with at least one feature out of c1 . . . cn, wherein the match is above a predefined threshold.
8. Method according to claim 1,
further comprising the step
providing for a mapping matrix with matrix elements bcij,
providing for the composite signature of a phenotype in vector form, and
wherein the matrix elements bcij respectively indicate the determined correlation between the values of features bi and cj.
9. Method according to claim 1,
wherein the first modality is a method to obtain clinic-pathological data.
10. Method according to claim 9,
wherein the data of type A are clinic-pathological data,
further comprising the step
keeping the clinic-pathological data unchanged during the method.
11. Method according to claim 1, wherein the phenotype is cancer, further comprising the step
calculating a recurrence risk of the cancer by applying the signature evaluation tool to the adapted composite signature.
12. Method according to claim 1,
wherein the composite signature comprises data which is generated by at least two different modalities of measuring the specimen, the method making the composite signature usable for a signature evaluation tool that is derived from data measured by the third modality.
13. Medical imaging apparatus for adapting a composite signature of a phenotype which is derived from measurements of a specimen, wherein the medical imaging apparatus comprises:
a receiving section adapted to receive data of type A which were generated by measuring the specimen with a first modality of measuring;
an imaging device adapted to generate data of type B by measuring the specimen with a second modality of measuring,
wherein the medical imaging apparatus is configured to generate a composite signature of the phenotype,
wherein the composite signature comprises data of type A and type B,
wherein the data of type A comprise values of modality features a1 . . . aq
wherein the data of type B comprise values of modality features b1 . . . bk,
wherein the medical imaging apparatus is configured to adapt the value of the feature bi based on a determined correlation between the value of feature bi and between the value of a feature cj when measured with a third modality,
wherein feature bi is out of b1 . . . bk,
wherein the medical imaging apparatus is configured to generate an adapted composite signature,
wherein the medical imaging apparatus is configured to apply a signature evaluation tool to the adapted composite signature, and
wherein the signature evaluation tool was derived from data measured by the third modality.
14. Program element for adapting a composite signature of a phenotype, which is derived from measurements of a specimen ,which program element, when being executed by a processor is adapted to carry out:
receiving a composite signature of a phenotype in form of data,
wherein the composite signature comprise data of type A which were generated by a first modality of measuring the specimen,
wherein the data of type A comprises values of modality features a1 . . . aq
wherein the composite signature comprises data of type B which were generated by a second modality of measuring the specimen,
wherein the data of type B comprise values of modality features b1 . . . bk,
adapting the value of the feature bi which is out of b1 . . . bk based on a determined correlation between the value of feature bi and the value of a feature cj when measured by a third modality,
wherein the adaption leads to an adapted composite signature,
applying a signature evaluation tool to the adapted composite signature, and
wherein the signature evaluation tool is derived from data measured by the third modality.
15. Computer readable medium, in which a program element for adapting a composite signature of a phenotype, which is derived from measurements of a specimen, is stored, which program element, when being executed by a processor is adapted to carry out:
receiving a composite signature of a phenotype in form of data,
wherein the composite signature comprise data of type A which were generated by a first modality of measuring the specimen,
wherein the data of type A comprises values of modality features a1 . . . ac,
wherein the composite signature comprises data of type B which were generated by a second modality of measuring the specimen,
wherein the data of type B comprise values of modality features b1 . . . bk,
adapting the value of the feature bi which is out of b1 . . . bk based on a determined correlation between the value of feature bi and the value of a feature cj when measured by a third modality,
wherein the adaption leads to an adapted composite signature,
applying a signature evaluation tool to the adapted composite signature, and
wherein the signature evaluation tool is derived from data measured by the third modality.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A manufacturing apparatus of a honeycomb structure having a plugged portion, comprising:
film attaching means for attaching a film to the end face of the honeycomb structure in a state where the side surface portion of the honeycomb structure is not covered, the honeycomb structure having porous partition walls and provided with a plurality of cells partitioned by the partition walls and formed so as to extend through the honeycomb structure from one end face of the honeycomb structure to the other end face thereof;
a table portion having a through hole into which the honeycomb structure is to be inserted;
positioning means for moving the table portion or the honeycomb structure in a state where the honeycomb structure to which the film is attached is inserted into the through hole, and positioning and holding the table portion and the honeycomb structure to attach the remaining portion of the film to the table portion so that the film attached to the end face has a flat state;
hole making means for forming, in the film, holes opened so as to correspond to the openings of a part of the cells;
plugging material supply means for supplying a plugging material having fluidity onto the mask provided with the holes or onto the table portion; and
filling means for filling the cells with the plugging material supplied onto the mask or the table portion.
2. A manufacturing apparatus of a honeycomb structure having a plugged portion, comprising:
a table portion having a through hole into which the end face portion of a honeycomb structure is to be inserted, the honeycomb structure having porous partition walls and provided with a plurality of cells partitioned by the partition walls and formed so as to extend through the honeycomb structure from one end of the honeycomb structure to the other end face thereof;
film attaching means for attaching a film to the side of the surface of the table portion;
positioning means for positioning and holding the table portion and the honeycomb structure so as to attach the film to the end face of the honeycomb structure in a state where the end face portion of the honeycomb structure is inserted into the through hole of the table portion provided with the film attached to the side of the surface of the table portion including a region of the through hole and where the side surface portion of the honeycomb structure is not covered;
hole making means for forming, in the film attached to the end face of the honeycomb structure, holes opened so as to correspond to the openings of a part of the cells, thereby forming a mask;
plugging material supply means for supplying a plugging material having fluidity onto the mask provided with the holes or onto the table portion; and
filling means for filling the cells with the plugging material supplied onto the mask or the table portion.
3. A manufacturing apparatus of a honeycomb structure having a plugged portion, comprising:
a table portion having a through hole into which the end face portion of a honeycomb structure is to be inserted, the honeycomb structure having porous partition walls and provided with a plurality of cells partitioned by the partition walls and formed so as to extend through the honeycomb structure from one end of the honeycomb structure to the other end face thereof;
positioning means for positioning and holding the table portion and the honeycomb structure so that the surface of the table portion has the same plane as that of the end face of the honeycomb structure in a state where the end face portion of the honeycomb structure is inserted into the through hole of the table portion;
film attaching means for attaching a film to the surface of the table portion and the end face of the honeycomb structure after positioning the table portion and the honeycomb structure;
hole making means for forming, in the film attached to the end face of the honeycomb structure, holes opened so as to correspond to the openings of a part of the cells, thereby forming a mask;
plugging material supply means for supplying a plugging material having fluidity onto the mask provided with the holes or onto the table portion; and
filling means for filling the cells with the plugging material supplied onto the mask or the table portion.
4. The manufacturing apparatus of the honeycomb structure having a plugged portion according to claim 1, further comprising:
moving means for moving the table portion or the honeycomb structure after filling the cells with the plugging material;
peeling means for peeling the mask; and
drying means for drying the honeycomb structure.
5. The manufacturing apparatus of the honeycomb structure having a plugged portion according to claim 2, further comprising:
moving means for moving the table portion or the honeycomb structure after filling the cells with the plugging material;
peeling means for peeling the mask; and
drying means for drying the honeycomb structure.
6. The manufacturing apparatus of the honeycomb structure having a plugged portion according to claim 3, further comprising:
moving means for moving the table portion or the honeycomb structure after filling the cells with the plugging material;
peeling means for peeling the mask; and
drying means for drying the honeycomb structure.
7. The manufacturing apparatus of the honeycomb structure having a plugged portion according to claim 1, wherein the table portion has side wall portions which are arranged on opposite sides of the through hole on the surface of the table portion and which are formed so as to project from the surface of the table portion, whereby the plugging material is prevented from leaking from the surface of the table portion.
8. The manufacturing apparatus of the honeycomb structure having a plugged portion according to claim 2, wherein the table portion has side wall portions which are arranged on opposite sides of the through hole on the surface of the table portion and which are formed so as to project from the surface of the table portion, whereby the plugging material is prevented from leaking from the surface of the table portion.
9. The manufacturing apparatus of the honeycomb structure having a plugged portion according to claim 3, wherein the table portion has side wall portions which are arranged on opposite sides of the through hole on the surface of the table portion and which are formed so as to project from the surface of the table portion, whereby the plugging material is prevented from leaking from the surface of the table portion.
10. The manufacturing apparatus of the honeycomb structure having a plugged portion according to claim 4, wherein the table portion has side wall portions which are arranged on opposite sides of the through hole on the surface of the table portion and which are formed so as to project from the surface of the table portion, whereby the plugging material is prevented from leaking from the surface of the table portion.
11. The manufacturing apparatus of the honeycomb structure having a plugged portion according to claim 5, wherein the table portion has side wall portions which are arranged on opposite sides of the through hole on the surface of the table portion and which are formed so as to project from the surface of the table portion, whereby the plugging material is prevented from leaking from the surface of the table portion.
12. The manufacturing apparatus of the honeycomb structure having a plugged portion according to claim 6, wherein the table portion has side wall portions which are arranged on opposite sides of the through hole on the surface of the table portion and which are formed so as to project from the surface of the table portion, whereby the plugging material is prevented from leaking from the surface of the table portion.