What is claimed is:
1. A box for conveniently storing and dispensing food comprising:
a front wall having a first and a second opening and an inside surface;
a back wall;
a first and a second side wall;
a bottom flap and a first and a second top flap;
a first slide and a second slide that are in contact with the inside surface of the front wall, each of said slides having an opening;
wherein said front wall, said back wall, said first and second side walls, and said top and bottom flaps are interconnected so as to form a box, said first slide being movable between an open position in which said first slide opening substantially aligns with said first front wall opening and a closed position in which said first slide opening is entirely out of alignment with said first front wall opening; and
said second slide being independently movable from said first slide, said second slide being movable between an open position in which said second slide opening substantially aligns with said second front wall opening and a closed position in which said second slide opening is entirely out of alignment with said second front wall opening.
2. A box as defined in claim 1, wherein said box further comprises a supporting wall disposed adjacent to at least a portion of the inside surface of said front wall, said supporting wall having an opening that is aligned with one of said front wall openings.
3. A box as defined in claim 2, wherein at least one of said slides is disposed in between said front Wall and said supporting wall.
4. A box as defined in claim 1, wherein said box further comprises an interior, said interior having a first compartment and a second compartment, said first compartment being opened when said first slide is in the open position, said second compartment being opened when said second slide is in the open position.
5. A box as defined in claim 4, wherein an interior wall separates said first compartment from said second compartment.
6. A box as defined in claim 4, wherein said box further comprises a front compartment wall disposed adjacent to a portion of the inside surface of said front wall, said supporting wall having an opening that is aligned with one of said front wall openings, said front compartment wall extending across the width of one of said compartments.
7. A box as defined in claim 1, wherein said box has a top opening and said box further comprises a top inner flap that extends across said top opening.
8. A box as defined in claim 1, wherein said box has a stop for defining the position of at least one of said slides in the open position of said at least one slide.
9. A box as defined in claim 1, wherein said box has a first stop for defining the position of said first slide in the open position of said first slide and a second stop for defining the position of said second slide in the open position of said second slide.
10. A box as defined in claim 1, wherein the openings in said slides are substantially the same shape as the openings in said front wall.
11. A box as defined in claim 1, wherein said top flaps are connected to said back wall in an articulated manner, such that a user may lift said top flaps to slide said slides between said open and said closed positions.
12. A box as defined in claim 1, wherein said box is made of sulfate cellulose cardboard.
13. A box for conveniently storing and dispensing food comprising:
a front wall having a first and a second opening and an inside surface;
a back wall;
a first and a second side wall;
a bottom flap and a first and a second top flap;
a first slide and a second slide that are in contact with the inside surface of the front wall, each of said slides having an opening;
wherein said front wall, said back wall, said first and second side walls, and said top and bottom flaps are interconnected so as to form a box, said first slide being movable between an open position in which said first slide opening substantially aligns with said first front wall opening and a closed position in which said first slide opening is entirely out of alignment with said first front wall opening;
said second slide being independently movable from said first slide, said first slide being movable between an open position in which said second slide opening substantially aligns with said second front wall opening and a closed position in which said second slide opening is entirely out of alignment with said second front wall opening;
said box further comprising an interior, said interior having a first compartment and a second compartment, said first compartment being opened when said first slide is in the open position, said second compartment being opened when said second slide is in the open position, an interior wall separating said first compartment from said second compartment;
said box further having a top opening and a top inner flap that extends across said top opening; and
wherein said box has a first stop for defining the position of said first slide in the open position of said first slide and a second stop for defining the position of said second slide in the open position of said second slide.
14. A box as defined in claim 13, wherein the shapes of the openings in said slides are different than the shapes of the openings in said front wall.
15. A box as defined in claim 13, wherein said top flaps are connected to said back wall in an articulated manner, such that a user may lift said top flaps to slide said slides between said open and said closed positions.
16. A box as defined in claim 13, wherein said box is made of sulfate cellulose cardboard.
17. A box as defined in claim 13, wherein said box further comprises a front compartment wall disposed adjacent to a portion of the inside surface of said front wall, said supporting wall having an opening that is aligned with one of said front wall openings, said front compartment wall extending across the width of one of said compartments.
18. A box for conveniently storing and dispensing food comprising:
a front wail having a first and a second opening and an inside surface;
a back wall;
a first and a second side wall;
a bottom flap and a first and a second top flap;
a first slide and a second slide that are in contact with the inside surface of the front wall, each of said slides having an opening;
wherein said front wall, said back wall, said first and second side walls, and said top and bottom flaps are interconnected so as to form a box, said first slide being movable between an open position in which said first slide opening substantially aligns with said first front wall opening and a closed position in which said first slide opening is entirely out of alignment with said first front wall opening;
said second slide being independently movable from said first slide, said first slide being movable between an open position in which said second slide opening substantially aligns with said second front wall opening and a closed position in which said second slide opening is entirely out of alignment with said second front wall opening; and
at least one bag inside said box comprising at least one removable area, said removable area being positioned adjacent to at least one of said front wall openings.
19. A box as defined in claim 18, wherein said removable portion is defined by at least one line of weakness on said bag.
20. A box as defined in claim 18, wherein said removable portion is removably attached to said bag with a pressure sensitive adhesive.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of detecting a pathogen, the method comprising:
contacting a body fluid of a person or animal suspected of having an infectious disease with a composition comprising a compound which is at least 90% pure of formula (III):
(M)x-(S)y-(M\u2032)z\u2003\u2003(III)
wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M\u2032 is independently a mycolic acid residue including a \u03b2-hydroxy acid moiety and each S is a monosaccharide unit;
wherein each M and M\u2032 is independently selected from a mycolic acid residue of formula (IV):
wherein R is an optionally-substituted alkyl or alkenyl group; R1 is an optionally-substituted alkly or alkenyl group; R4 is an optionally-substituted alkylene or alkenylene group; each of R2 and R3 is an optionally-substituted alkylene or alkenylene group; Y is CH2; X includes a cyclopropyl moiety or an alkene; and Z includes a cyclopropyl group or the moiety C=A or C-AR5, wherein A is O, S, or NR5; and the each R5 may independently be hydrogen or an alkyl group; and
determining whether an antibody in the body fluid has bound to the compound of formula III.
2. A method according to claim 1, wherein x is 1, y is 2 and z is 0 or 1.
3. A method according to claim 2, wherein the compound of formula III comprises a trehalose unit.
4. A method according to claim 1, wherein R is an unsubstituted alkyl chain having 16 to 30 carbon atoms; R1 is an alkyl chain having from 12 to 24 carbon atoms; each of R2, R3\u2032 and R4 is an alkylene moiety having from 6 to 20 carbon atoms.
5. A method according to claim 1, wherein R2 and R3 have a combined total of from 10 to 20 carbon atoms and X includes a cyclopropyl unit.
6. The method of claim 1, wherein the composition further comprises:
a pharmaceutically acceptable carrier.
7. The method of claim 1, wherein determining whether the antibody in the body fluid has bound to the compound of formula III includes detecting a second, marked antibody bound to the antibody in the body fluid.
8. The method of claim 1, wherein the body fluid is selected from a group consisting of: blood, serum, plasma, pleural effusion, ascites fluid, and urine.
9. The method of claim 1, wherein the pathogen is Mycobacterium tuberculosis.
10. A method of treating a disease of the immune system in a mammal, the method comprising:
administering to the mammal an effective amount of a composition comprising a compound which is at least 90% pure of formula (III):
(M)x-(S)y-(M\u2032)z\u2003\u2003(III)
wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M\u2032 is independently a mycolic acid residue including a \u03b2-hydroxy acid moiety and each S is a monosaccharide unit;
wherein each M and M\u2032 is independently selected from a mycolic acid residue of formula (IV):
wherein R is an optionally-substituted alkyl or alkenyl group; R1 is an optionally-substituted alkly or alkenyl group; R4 is an optionally-substituted alkylene or alkenylene group; each of R2 and R3 is an optionally-substituted alkylene or alkenylene group; Y is CH2; X includes a cyclopropyl moiety or an alkene; and Z includes a cyclopropyl group or the moiety C=A or C-AR5, wherein A is O, S, or NR5; and the each R5 may independently be hydrogen or an alkyl group.
11. A method of vaccination of a mammal, the method comprising administering to the mammal a vaccine composition comprising an antigen and a compound which is at least 90% pure of formula (III):
(M)x-(S)y-(M\u2032)z\u2003\u2003(III)
wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M\u2032 is independently a mycolic acid residue including a \u03b2-hydroxy acid moiety and each S is a monosaccharide unit;
wherein each M and M\u2032 is independently selected from a mycolic acid residue of formula (IV):
wherein R is an optionally-substituted alkyl or alkenyl group; R1 is an optionally-substituted alkly or alkenyl group; R4 is an optionally-substituted alkylene or alkenylene group; each of R2 and R3 is an optionally-substituted alkylene or alkenylene group; Y is CH2; X includes a cyclopropyl moiety or an alkene; and Z includes a cyclopropyl group or the moiety C=A or C-AR5, wherein A is O, S, or NR5; and the each R5 may independently be hydrogen or an alkyl group.