1. A compound of formula (I)
or a salt thereof, wherein:
each R is independently selected from fluoro, chloro, cyano, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, trifluoromethoxy and difluoromethoxy; and
n is 1, 2 or 3.
2. The compound of formula (I) as claimed in claim 1, or a salt thereof, which is a compound of formula (IA)
3. The compound of formula (I) as claimed in claim 1, or a salt thereof, which is a compound of formula (IB)
4. The compound as claimed in claim 1 which is selected from
cis-4-(3-Fluoro-4-{5-(2,4,5-trifluoro-phenylamino)-1,3,4oxadiazole-2-carbonyl-amino}-phenoxy)-cyclohexanecarboxylic acid;
cis-4-(3-Fluoro-4-{5-(3,4,5-trifluoro-phenylamino)-1,3,4oxadiazole-2-carbonyl-amino}-phenoxy)-cyclohexanecarboxylic acid;
cis-4-3-Fluoro-4-5-(4-fluorophenyl)amino1,3,4-oxadiazole-2-carbonylaminophenoxycyclohexane-1-carboxylic acid;
trans-4-3-Fluoro-4-5-(2,4,5-trifluorophenyl)amino1,3,4-oxadiazole-2-carbonylaminophenoxycyclohexane-1-carboxylic acid;
trans-4-3-fluoro-4-5-(4-fluorophenyl)amino1,3,4-oxadiazole-2-carbonylaminophenoxycyclohexane-1-carboxylic acid; and
or a pharmaceutically-acceptable salt of any of these.
5. A method for producing an inhibition of DGAT1 activity in a warm-blooded animal in need of such treatment comprising administering to said animal an effective amount of a compound of formula (I) as claimed in claim 1 or a pharmaceutically-acceptable salt thereof.
6. A method of treating diabetes mellitus andor obesity in a warm-blooded animal in need of such treatment comprising administering to said animal an effective amount of a compound of formula (I) as claimed in claim 1 or a pharmaceutically-acceptable salt thereof.
7. A pharmaceutical composition comprising a compound of formula (I) as claimed in claim 1 or a pharmaceutically-acceptable salt thereof, in association with a pharmaceutically-acceptable excipient or carrier.
8. A process for preparing a compound according to claim 1 comprising one of the following steps (wherein all variables are as hereinbefore defined for a compound of formula (I) unless otherwise stated):
a) reacting an amine of formula (2) with a carboxylate salt of formula (3), wherein RP is (1-4C)alkyl group followed by hydrolysis of the RP group
b) cyclising a compound of formula (4) wherein X is S or O and wherein R is (1-4C)alkyl group followed by hydrolysis of the RP group
and optionally thereafter:
1) removing any protecting groups; andor
2) forming a (pharmaceutically-acceptable) salt.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A device for testing a subject for detecting a state of a vascular pathology of the subject, the device comprising:
a sensor signal unit for receiving a sensor signal representative of a blood volume in a body part of the subject;
a comparator for comparing the sensor signal with a reference signal; and
a user interface for conveying a result based on the comparison to a user of the device.
2. The device of claim 1, wherein the sensor signal unit acquires and processes the sensor signal provided by a photoplethysmogram sensor.
3. The device of claim 1, wherein the reference signal is at least one of a sensor signal previously acquired from a test on the subject and a sensor signal acquired from at least one healthy subject.
4. The device of claim 1, further including:
an electrocardiogram signal unit for acquiring an electrocardiogram signal of the subject; and
a synchronizer for synchronizing an acquisition of the sensor signal with the electrocardiogram signal.
5. The device of claim 4, further including:
an electrocardiogram signal processing unit for processing the electrocardiogram signal of the subject; and
a sensor signal processing unit for processing the sensor signal based on the electrocardiogram signal.
6. A method of testing a subject for detecting a state of a vascular pathology of a subject, the method comprising:
sensing a blood volume in a body part of the subject and obtaining a sensor signal representative of the blood volume;
comparing the sensor signal with a reference signal; and
conveying a result based on the comparison to a user of the device.
7. The method of claim 6, further including:
acquiring an electrocardiogram signal of the subject;
synchronizing an acquisition of the sensor signal with the electrocardiogram signal; and
comparing the sensor signal with the reference signal, based on the electrocardiogram signal.