1. A process for the preparation of a compound of the formula 1, which comprises:
(a) converting a compound of the formula III into a compound of the formula III or its salt with an acid HX, said converting comprises catalytic hydrogenation of the olefinic group and conversion of the cyano group into an amidino group to yield the compound of formula III or its salt with the acid HX, and
(b) reacting the compound of the formula III or its salt with the acid HX with a compound of the formula IV or its salt with the acid HX to yield a compound of the formula I,
wherein the anions X of the formulae I and IV and of the acid HX are physiologically acceptable anions, and are identical or different
17
2. The process as claimed in claim 1, wherein the anions X of the formulae I and IV and of the acid HX are identical.
3. The process as claimed in claim 1, which comprises employing in the catalytic hydrogenation a catalyst, the catalyst comprising a chiral rhodium(I) complex.
4. The process as claimed in claim 3, wherein the chiral rhodium(I) complex comprises a rhodium(I)-()-(2R,4R)-1-tert-butyloxycarbonyl-4-diphenylphosphino-2-(diphenylphosphinomethyl)pyrrolidine complex.
5. The process as claimed in claim 1, wherein the conversion of the cyano group into the amidino group comprises reacting the cyano group with hydroxylamine or an hydroxylammonium salt to yield a resulting N-hydroxyamidine, and hydrogenolysing the resulting N-hydroxyamidine.
6. The process as claimed in claim 1, wherein said reacting is carried out in the presence of a carbodiimide.
7. The process as claimed in claim 1, wherein said reacting is carried out in the presence of dicyclohexylcarbodiimide and 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine.
8. The process as claimed in claim 1, wherein in the said reacting the compound of the formula IV is employed in the form of its salt with the acid HX, and the compound of the formula III is employed in free form.
9. The process as claimed in claim 1, wherein the anions X of the formulae I and IV and of the acid HX are toluene-4-sulfonate.
10. The compound of the formula Ia in which the anion TosO is toluene-4-sulfonate
18
11. A process for preparing a compound of the formula Ia in which the anion TosO is toluene-4-sulfonate, which process comprises:
reacting a compound of the formula III or the toluene-4-sulfonic acid salt thereof with a compound of the formula IVa or the toluene-4-sulfonic acid salt thereof to yield the compound of the formula Ia
19
12. The process as claimed in claim 11, wherein the compound of the formula IVa is employed in the form of its salt with toluene-4-sulfonic acid and the compound of the formula III is employed in free form, and the reacting is carried out in the presence of dicyclohexylcarbodiimide and 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine.
13. A compound of the formula II or a salt thereof
20
14. (Canceled)
15. A compound of the formula III or a salt thereof
21
16. A compound of the formula IV where the anion X is a physiologically acceptable anion, or a salt thereof.
22
17. A process for the preparation of a compound of the formula I:
23
wherein
R1 is C1-C4 alkyl;
R2 is C1-C4 alkyl;
A is CH in the R or S configuration;
B is CH in the R or S configuration; and
G is CH in the R or S configuration,
the process comprising:
(a) converting a compound of the formula II into a compound of the formula III or its salt with an acid HX, the compound of the formula II having the structure:
24
wherein
R1 and B have the same meanings as in the formula I,
said converting comprises catalytic hydrogenation of the olefinic group and conversion of the cyano group into an amidino group to yield the compound of the formula III or its salt with an acid HX;
the compound of the formula III having the structure:
25
wherein
R1, A, and B have the same meanings as in the formula I; and
(b) reacting the compound of the formula III or its salt with the acid HX with a compound of the formula IV or its salt with the acid HX:
26
wherein
R2 and G have the same meanings as in the formula I,
to yield a compound of the formula I,
wherein the anions X of the formulae I and IV and of the acid HX are physiologically acceptable anions, and are identical or different.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A ramp for the loading and unloading of a slider, comprising:
a body having a first surface and a second surface and a plurality of apertures extending between said first and second surfaces, wherein each of said plurality of apertures has a first opening at said first surface and a second opening at said second surface, wherein said first surface has a sloped segment and a straight segment, said sloped segment being acutely angled with respect to said second surface.
2. The ramp of claim 1, wherein said second surface has a non-planar component.
3. The ramp of claim 2, wherein said second surface has an aerodynamic shape to urge air flow into said plurality of apertures.
4. The ramp of claim 2, wherein said second surface is concave.
5. The ramp of claim 1, wherein cross-sectional areas of said first and second openings are substantially equal.
6. The ramp of claim 1, wherein said cross-sectional area of said first opening is less than said cross-sectional area of said second opening.
7. The ramp of claim 1, wherein at least one of said plurality of apertures intersects said second surface at an angle to a tangent of said second surface at said second opening.
8. The ramp of claim 1, wherein at least one of said plurality of apertures has a first opening within said straight segment of said first surface.
9. The ramp of claim 1, wherein at least one of said plurality of apertures has a second opening that connects to more than one first opening.
10. A ramp system for loading and unloading two sliders, comprising:
a body having a first portion and a second portion, each said portion including a first surface and a second surface and a plurality of apertures extending between said first and second surfaces, wherein each of said plurality of apertures has a first opening at said first surface and a second opening at said second surface, wherein said first surface has a sloped segment and a straight segment, said sloped segment being acutely angled with respect to said second surface,
wherein said first portion is proximate to a first surface of a disk and said second portion is proximate to a second surface of said disk.
11. A disk drive for storing and retrieving magnetic data, comprising:
a housing;
a rotatable magnetic disk disposed within said housing;
an actuator disposed within said housing and configured to pivot a load beam proximate to a surface of said magnetic disk;
a slider attached to said load beam;
a tab attached to said load beam, said tab extending said load beam in a first direction; and
a ramp including a body having a first surface and a second surface and a plurality of apertures extending between said first and second surfaces, wherein each of said plurality of apertures has a first opening at said first surface and a second opening at said second surface, said ramp situated such that said tab engages a sloped segment of said ramp as said load beam is brought to an outside diameter of said surface of said magnetic disk.
12. The disk drive of claim 11, wherein said tab has a surface facing said ramp, said surface having a non-planar component.
13. The disk drive of claim 11, wherein said tab has a surface facing said ramp, said surface having an aerodynamic shape to urge air flow into said plurality of apertures.
14. The disk drive of claim 11, wherein said tab has a surface facing said ramp, said surface being concave.
15. A method for loading a slider, comprising:
providing a rotatable magnetic disk disposed within a housing;
providing an actuator disposed within said housing and configured to pivot a load beam proximate to a surface of said magnetic disk;
providing a slider attached to said load beam;
providing a tab attached to said load beam, said tab extending said load beam in a first direction;
providing a ramp including a body having a first surface and a second surface and a plurality of apertures extending between said first and second surfaces, wherein each of said plurality of apertures has a first opening at said first surface and a second opening at said second surface, said ramp situated such that said tab engages a sloped segment of said ramp as said load beam is brought to an outside diameter of said surface of said magnetic disk;
rotating said magnetic disk thereby providing an air flow through said plurality of apertures;
pivoting said load beam including said tab attached thereto, wherein said air flow through said plurality of apertures provides a lifting force to said tab as it moves with respect to said ramp, said tab moving from a straight segment of said ramp to a sloped segment of said ramp; and
flying said slider such that said tab disengages from said ramp.
16. The method of claim 15, wherein said lifting force is sufficient to lift said tab off of said ramp such that said tab is provided with an air bearing as it moves with respect to said ramp.
17. A method for unloading a slider, comprising:
providing a rotating magnetic disk disposed within a housing;
providing an actuator disposed within said housing and configured to pivot a load beam proximate to a surface of said magnetic disk;
providing a slider attached to said load beam, said slider flying over said surface of said disk;
providing a tab attached to said load beam, said tab extending said load beam in a first direction;
providing a ramp including a body having a first surface and a second surface and a plurality of apertures extending between said first and second surfaces, wherein each of said plurality of apertures has a first opening at said first surface and a second opening at said second surface, wherein said rotating disk provides a flow of air through said plurality of apertures;
pivoting said load beam including said tab attached thereto, such that said tab engages a sloped segment of said ramp as said load beam is brought to an outside diameter of said disk;
moving said tab over said sloped segment of said ramp and onto said straight segment of said ramp, whereby said flow of air through said plurality of apertures provides a lifting force to said tab; and
reducing said rotation of said disk, thereby reducing the flow of air through said plurality of apertures so that said lifting force is reduced, such that said tab may be supported on said straight segment of said ramp.
18. The method of claim 17, wherein said lifting force while said tab is moving relative to said ramp is sufficient to keep said tab off of said ramp so that said tab is provided with an air bearing as it moves.