1. An apparatus deployable in a blood vessel to alter flow to an aneurysm packed with aneurysm coils, comprising:
a base having a vessel facing side and an aneurysm facing side;
the base comprising a shape sufficient to substantially cover a neck of the aneurysm, the base adapted to reside in the vessel;
a connector;
the connector formed as a coil and adapted to connect to the aneurysm coils separately packed into the aneurysm;
at least one of the base or the connector comprising a carrier, a binder, and a growth factor; and
the connector coupled to at leas tone of the aneurysm facing side and the vessel facing side,
wherein the connector anchors the base about the neck of the aneurysm to alter flow about the aneurysm and allow flow through the vessel.
2. The apparatus according to claim 1, wherein:
the base comprises graft material.
3. The apparatus according to claim 1, wherein:
the base comprises self-expanding material such that the base can be delivered in a small package and expands on deployment to cover the neck of the aneurysm.
4. The apparatus according to claim 3, wherein the base also comprises graft material.
5. The apparatus according to claim 1, wherein the at least one coil is deformed such that on activation the at least one coil engages the aneurysm coils packed in the aneurysm to provide a force tending to seat the base about the neck of the aneurysm.
6. The apparatus according to claim 1, wherein only the at least one coil is a growth and comprises a carrier, a binder, and a growth factor.
7. The apparatus according to claim 6, wherein the carrier is polyvinyl alcohol (PVA).
8. The apparatus of claim 6, wherein the carrier is polyethylene terephthalate (PET).
9. The apparatus according to claim 6, wherein the binder is acidic gelatin hydrogel.
10. The apparatus according to claim 6, wherein the growth factor is basic fibroblast growth factor (bFGF).
11. The apparatus according to claim 6, wherein the growth factor is transferring growth factor.
12. The apparatus according to claim 6, wherein the growth factor is vascular endothelial growth factor.
13. The apparatus according to claim 1, wherein only the base comprises the carrier, the binder, and the growth factor.
14. The apparatus according to claim 13, wherein the carrier is polyvinyl alcohol (PVA).
15. The apparatus of claim 13, wherein the carrier is polyethylene terephthalate (PET).
16. The apparatus according to claim 13, wherein the binder is acidic gelatin hydrogel.
17. The apparatus according to claim 13, wherein the growth factor is basic fibroblast growth factor (bFGF).
18. The apparatus according to claim 13, wherein the growth factor is transferring growth factor.
19. The apparatus according to claim 13, wherein the growth factor is vascular endothelial growth factor.
20. The apparatus according to claim 13, wherein the base comprises a coil that is arranged in the shape of a spiral.
21. The apparatus according to claim 20, wherein the base coil comprises a shaped memory alloy that is activated on thermal manipulation.
22. The apparatus according to claim 1, wherein only the vessel facing side of the base comprises a carrier, a binder, and a growth factor.
23. The apparatus according to claim 22, wherein the carrier is polyvinyl alcohol (PVA).
24. The apparatus of claim 22, wherein the carrier is polyethylene terephthalate (PET).
25. The apparatus according to claim 22, wherein the binder is acidic gelatin hydrogel.
26. The apparatus according to claim 25, wherein the growth factor is basic fibroblast growth factor (bFGF).
27. The apparatus according to claim 22, wherein the growth factor is transferring growth factor.
28. The apparatus according to claim 22, wherein the growth factor is vascular endothelial growth factor.
29. The apparatus according to claim 1, wherein only the aneurysm facing side of the base comprises a carrier, a binder, and a growth factor.
30. The apparatus according to claim 29, wherein the carrier is polyvinyl alcohol (PVA).
31. The apparatus of claim 29, wherein the carrier is polyethylene terephthalate (PET).
32. The apparatus according to claim 29, wherein the binder is acidic gelatin hydrogel.
33. The apparatus according to claim 29, wherein the growth factor is basic fibroblast growth factor (bFGF).
34. The apparatus according to claim 29, wherein the growth factor is transferring growth factor.
35. The apparatus according to claim 29, wherein the growth factor is vascular endothelial growth factor.
36. A method for obstructing the flow of blood through the neck of an aneurysm packed with aneurysm coils, the method comprising the steps of:
selecting an aneurysm base comprising a carrier, a binder, and a growth factor of sufficient size to substantially cover the neck of the aneurysm
passing a catheter to the site of the aneurysm;
inserting an anchor into the aneurysm;
deploying the aneurysm base to substantially cover the neck of the aneurysm in a blood vessel to substantially block the neck of the aneurysm; and
anchoring the aneurysm base about the neck of the aneurysm by packing the anchor into the aneurysm coils separately packed in the aneurysm to alter the flow of blood to the aneurysm and allow flow through the vessel.
37. An aneurysm stent, comprising:
a base of sufficient size to substantially cover a neck of an aneurysm to reside in a blood vessel, the base comprising a carrier, a binder, and a growth factor;
at least one connector coupled to the base;
the at least one connector comprising at least one coil to pack into aneurysm coils separately packed in an aneurysm; and
the at least one connector to be inserted into the aneurysm and, upon insertion, to anchor the base about a neck of the aneurysm without blocking the vessel.
38. The aneurysm stent according to claim 37, wherein the at least one connector comprises:
the at least one coil being tightly wound and extending from the base through the aneurysm neck and into the aneurysm;
the at least one tightly wound coil expands after insertion to pack the aneurysm and anchor the stent.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A composition comprising an adhesive material comprising:
(a) a first compound, wherein the first compound is a maleimide, wherein the maleimide has the structure:
wherein:
Q is selected from the group consisting of a substituted or an unsubstituted alkyl, cycloalkyl, aryl, heterocylclic, alkenyl or alkylene,
R is selected from the group consisting of H and methyl, and
n is an integer having the value 1 or 3-6; and
(b) a second compound, wherein the second compound is selected from the group consisting of:
2. The composition of claim 1, wherein the maleimide is a liquid.
3. The composition of claim 1, wherein the second compound is an aromatic diene having the structure selected from the group consisting of
4. The composition of claim 1, further comprising an additional compound selected from the group consisting of an acrylate, a methacrylate, a maleimide other than the first compound, a vinyl ether, a vinyl ester, a styrenic and an additional allyl functional compound.
5. The composition of claim 1, further comprising at least one curing initiator, reactive diluent, filler, or a combination thereof.
6. The composition of claim 5, wherein the filler is conductive.
7. The composition of claim 6, wherein the filler is thermally or electrically conductive.
8. The composition of claim 5, wherein the at least one curing initiator comprises 0.1 wt % to about 5 wt % based on total weight of the composition.
9. The composition of claim 5, wherein the curing initiator comprises a free-radical initiator or a photoinitiator.
10. The composition of claim 5 comprising:
a) 2 weight percent to about 98 weight percent (wt %) of the adhesive material;
b) 0 to about 90 wt % of the filler; and
c) 0.1 wt % to about 4 wt %, of at least one coupling agent, wherein the composition is a die-attach paste.
11. The composition of claim 10, wherein the at least one curing initiator is present at 0.1 wt % to about 5 wt %.
12. The composition of claim 10, further comprising an additional compound selected from the group consisting of an acrylate, a methacrylate, a maleimide other than the first compound, a vinyl ether, a vinyl ester, a styrenic and an additional allyl functional compound.
13. The adhesive composition of claim 10, wherein the coupling agent is a silicate ester, a metal acrylate salt, or a titanate.