1. An N-cyclopropyl-4-hydroxy-3-pyrrolidine carboxamide derivative represented by the following chemical formula (V):
(wherein R1 is an amino-protecting group), or an enantiomeric isomer thereof.
2. The N-cyclopropyl-4-hydroxy-3-pyrrolidine carboxamide derivative, or enantiomeric isomer thereof according to claim 1, wherein the amino-protecting group that R1 represents is a benzyl group, a p-methoxybenzyl group, a methoxycarbonyl group, an ethoxycarbonyl group, a propyloxycarbonyl group, an isopropyloxycarbonyl group, a butyloxycarbonyl group, an isobutyloxycarbonyl group, a tert-butyloxycarbonyl group, or a benzyloxycarbonyl group.
3. The N-cyclopropyl-4-hydroxy-3-pyrrolidine carboxamide derivative, or enantiomeric isomer thereof according to claim 1, wherein the compound of the chemical formula (V) is selected from the group consisting of (3R,4S)-3-(N-cyclopropyl)carbamoyl-4-hydroxypyrrolidine-1-carboxylic acid benzyl ester, (3S,4R)-3-(N-cyclopropyl)carbamoyl-4-hydroxypyrrolidine-1-carboxylic acid benzyl ester, (3R,4S)-3-(N-cyclopropyl)carbamoyl-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester, (3S,4R)-3-(N-cyclopropyl)carbamoyl-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester, (3R,4S)-1-benzyl-N-cyclopropyl-4-hydroxy-3-pyrrolidine carboxamide and (3S,4R)-1-benzyl-N-cyclopropyl-4-hydroxy-3-pyrrolidine carboxamide.
4. A method for producing a N-cyclopropyl-4-hydroxy-3-pyrrolidine carboxylic amide derivative represented by the following chemical formula (V):
(wherein R1 is a protecting group for the amino group) or an enantiomeric isomer thereof, comprising the steps of:
asymmetrically hydrogenating, with a transitional metal catalyst, a 1-protected-4-oxo-3-pyrrolidine carboxylic acid ester derivative represented by the following chemical formula (I):
(wherein R1 is as defined above; and R2 is a lower alkyl group) to obtain a 4-hydroxy-3-pyrrolidine carboxylic acid ester derivative of the following chemical formula (II):
(wherein R1 and R2 are as defined above) or an enantiomeric isomer thereof;
hydrolyzing the ester group of the compound of the chemical formula (II) to obtain a 4-hydroxy-3-pyrrolidine carboxylic acid represented by the following chemical formula (III):
(wherein R1 is as defined above) or an enantiomeric isomer thereof; and
condensing the compound of the chemical formula (III) with cyclopropylamine (IV):
to obtain an N-cyclopropyl-4-hydroxy-3-pyrrolidine carboxylic amide derivative represented by chemical formula (V) or an enantiomeric isomer thereof.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A resin molded article which makes transmitted light satisfy following Mathematical Formula 1 or Mathematical Formula 2 in case of irradiation with a light source in a single wavelength:
Abs (\u0394X)=|X1\u2212X2|>0.05\u2003\u2003Mathematical formula 1
X1=\u03c7 value of a CIE 1931 color space for the resin molded article with a thickness of 1.0 mm
X2=\u03c7 value of a CIE 1931 color space for the resin molded article with a thickness of
Abs (\u0394Y)=|Y1\u2212Y2|>0.05\u2003\u2003Mathematical Formula 2
Y1=y value of a CIE 1931 color space for the resin molded article with a thickness of 1.0 mm
Y2=y value of a CIE 1931 color space for the resin molded article with a thickness of 1.5 mm.
2. The resin molded article of claim 1, wherein the resin molded article is prepared by a coloring resin composition comprising:
a transparent thermoplastic resin;
a dye for coloring a resin (B); and
a functional black dye (C) obtained by mixing an anthraquinone-based dye (c1) and a perinone-based dye (c2).
3. The resin molded article of claim 2, wherein the coloring resin composition comprises 0.01 to 0.10 parts by weight of the dye for coloring a resin (B); and 0.1 to 1.0 parts by weight of the functional black dye (C) based on 100 parts by weight of the transparent thermoplastic resin.
4. The resin molded article of claim 2, wherein the transparent thermoplastic resin has transmissivity of 85% or more.
5. The resin molded article of claim 2, wherein the dye for coloring a resin (B) is selected from the group consisting of an azo-based dye (b1), an anthraquinone-based dye (b2), and a methine-based dye (b3).
6. The resin molded article of claim 5, wherein the azo-based dye (b1) is a compound comprising a chemical structure of following Chemical Formula 1, the anthraquinone-based dye (b2) is a compound comprising a chemical structure of following Chemical Formula 2, and the methine-based dye (b3) is a compound comprising a chemical structure of following Chemical Formula 3:
7. The resin molded article of claim 2, wherein the functional black dye (C) is obtained by mixing 20 to 70% by weight of the anthraquinone-based dye (c1) and 30 to 80% by weight of the perinone-based dye (c2).
8. The resin molded article of claim 7, wherein the anthraquinone-based dye (c1) is a compound comprising a chemical structure of following Chemical Formula 4, and the perinone-based dye (c2) is a compound comprising a chemical structure of following Chemical Formula 5:
9. The resin molded article of claim 1, wherein the resin molded article is characterized in that the thicknesses of the molded article vary in a stepwise manner by forming one or more stepped parts on the molded article.
10. The resin molded article of claim 1, wherein the molded article is characterized in that a width between one side and the opposite side of the molded article continuously varies.
11. A coloring resin composition comprising:
a transparent thermoplastic resin;
a dye for coloring a resin (B); and
a functional black dye (C) obtained by mixing an anthraquinone-based dye (c1) and a perinone-based dye (c2).
12. The coloring resin composition of claim 11, wherein the coloring resin composition comprising:
0.01 to 0.10 parts by weight of the dye for coloring a resin (B); and
0.1 to 1.0 parts by weight of the functional black dye (C) based on 100 parts by weight of the transparent thermoplastic resin.
13. The coloring resin composition of claim 11, wherein the transparent thermoplastic resin has transmissivity of 85% or more.
14. The coloring resin composition of claim 11, wherein the dye for coloring a resin (B) is selected from the group consisting of an azo-based dye (b1), an anthraquinone-based dye (b2), and a methine-based dye (b3).
15. The coloring resin composition of claim 14, wherein the azo-based dye (b1) is a compound comprising a chemical structure of following Chemical Formula 1, the anthraquinone-based dye (b2) is a compound comprising a chemical structure of following Chemical Formula 2, and the methine-based dye (b3) is a compound comprising a chemical structure of following Chemical Formula 3:
16. The coloring resin composition of claim 12, wherein the functional black dye (C) is obtained by mixing 20 to 70% by weight of the anthraquinone-based dye (c1) and 30 to 80% by weight of the perinone-based dye (c2).
17. The coloring resin composition of claim 16, wherein the anthraquinone-based dye (c1) is a compound comprising a chemical structure of following Chemical Formula 4, and the perinone-based dye (c2) is a compound comprising a chemical structure of following Chemical Formula 5: