1. A method for the production of a plastic part (5) that has an opaque body and a front surface with at least one translucent area delineated from an opaque area, comprising the steps of
a) injection molding a blank (1) from an opaque plastic component with a recessed volume (2) in the blank corresponding in shape and position to the translucent area, the recessed volume (2) extending from an opening in a face of said blank and inwardly of said blank; and
b) over-molding at least said face of the blank (1) with a layer of a coloured plastic component in a manner to over-span the opening in the face of the blank (1), the layer being sufficiently thin to be translucent.
2. The method according to claim 1, wherein both plastic components are injected consecutively in the same mold.
3. The method according to claim 1, wherein the opaque plastic component is injected in a first mold and the coloured plastic component is injected in a second mold.
4. The method according to claim 1, wherein the recessed volume (2) extends completely through the blank (1).
5. The method according to claim 1, wherein the recessed volume (2) extends perpendicularly to said face of the blank (1).
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of formula II
wherein:
Q is pyrazole or imidazole;
R1, R2, and R3 are independently hydrogen, alkyl, substituted alkyl or halogen;
R4 is hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, halogen, cycloalkyl, or substituted cycloalkyl;
R5 is hydrogen, alkyl, substituted alkyl, alkylidene, substituted alkylidene, haloalkyl, arylalkyl, alkanoyl, substituted alkanoyl, aminoalkyl, substituted aminoalkyl, hydroxyalkyl, amide, substituted amide, carbamate, substituted carbamate, ureido, sulfonamide, substituted sulfonamide, alkylsulfone, heterocycloalkyl, substituted heterocycloalkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloalkylalkyl, thioalkyl, alkylsulfonyl, alkylsulfinyl, carboxy, alkoxycarbonyl, carbamoyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylheteroaryl, arylalkoxycarbonyl, heteroarylalkyl, aryloxyalkyl, aryloxyaryl, heterocyclyl substituted heterocyclyl, alkylcarbonyl, substituted heteroalkyl, heteroalkenyl, substituted heteroalkenyl, heteroalkynyl, substituted heteroalkynyl, arylsulfonyl, arylalkylsulfonyl, alkylsulfonyl, or alkylaminocarbonyl, \u2014COalkyl, \u2014CO substituted alkyl; \u2014COaryl, \u2014CO substituted aryl, \u2014CO heteroaryl, \u2014CO substituted heteroaryl, \u2014CO heterocyclyl, \u2014CO substituted heterocyclyl, \u2014CONHalkyl, \u2014CONH substituted alkyl; \u2014CONH aryl, \u2014CONH substituted aryl, \u2014CONH heteroaryl, \u2014CONH substituted heteroaryl, \u2014CONH heterocyclyl, \u2014CONH substituted heterocyclyl, \u2014SO2 alkyl, \u2014SO2 substituted alkyl; \u2014SO2 aryl, \u2014SO2 substituted aryl, \u2014SO2 heteroaryl, \u2014SO2 substituted heteroaryl, \u2014SO2 heterocyclyl or \u2014SO2 substituted heterocyclyl;
R6 is hydrogen, halogen, cyano, hydroxy, oxo, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, substituted heteroalkenyl, heteroalkynyl or substituted heteroalkynyl;
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.
2. A compound of formula III
wherein:
Q is pyrazole or imidazole;
R1, R2, and R3 are independently hydrogen, alkyl, substituted alkyl or halogen;
R4 is hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, halogen, cycloalkyl, or substituted cycloalkyl;
R5 is hydrogen, alkyl, substituted alkyl, alkylidene, substituted alkylidene, hydroxy, alkoxy, halogen, haloalkyl, haloalkoxy, oxo, aryloxy, arylalkyl, arylalkyloxy, alkanoyl, substituted alkanoyl, alkanoyloxy, amino, aminoalkyl, substituted aminoalkyl, alkylamino, substituted alkylamino, hydroxyalkyl, disubstituted amino, amide, substituted amide, carbamate, substituted carbamate, ureido, cyano, sulfonamide, substituted sulfonamide, alkylsulfone, heterocycloalkyl, substituted heterocycloalkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloalkylalkyl, cycloalkylalkoxy, nitro, thio, thioalkyl, alkylthio, alkylsulfonyl, alkylsulfinyl, carboxy, alkoxycarbonyl, alkylcarbonyloxy, carbamoyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heteroaryloxy, arylheteroaryl, arylalkoxycarbonyl, heteroarylalkyl, heteroarylalkoxy, aryloxyalkyl, aryloxyaryl, heterocyclyl substituted heterocyclyl, alkylcarbonyl, substituted heteroalkyl, heteroalkenyl, substituted heteroalkenyl, heteroalkynyl, substituted heteroalkynyl, arylamino, arylalkylamino, alkanoylamino, aroylamino, arylalkanoylamino, arylthio, arylalkylthio, arylsulfonyl, arylalkylsulfonyl, alkylsulfonyl, arylcarbonylamino, or alkylaminocarbonyl, \u2014COalkyl, \u2014CO substituted alkyl, \u2014COaryl, \u2014CO substituted aryl, \u2014CO heteroaryl, \u2014CO substituted heteroaryl, \u2014CO heterocyclyl, \u2014CO substituted heterocyclyl, \u2014CONHalkyl, \u2014CONH substituted alkyl; \u2014CONH aryl, \u2014CONH substituted aryl, \u2014CONH heteroaryl, \u2014CONH substituted heteroaryl, \u2014CONH heterocyclyl, \u2014CONH substituted heterocyclyl, \u2014SO2 alkyl, \u2014SO2 substituted alkyl; \u2014SO2 aryl, \u2014SO2 substituted aryl, \u2014SO2 heteroaryl, \u2014SO2 substituted heteroaryl, \u2014SO2 heterocyclyl or \u2014SO2 substituted heterocyclyl;
R6 is hydrogen, halogen, cyano, hydroxy, oxo, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, substituted heteroalkenyl, heteroalkynyl or substituted heteroalkynyl;
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.
3. A compound of formula IV
wherein:
R1, R2, and R3 are independently hydrogen, alkyl, substituted alkyl or halogen;
R4 is hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, halogen, cycloalkyl, or substituted cycloalkyl;
R5 is hydrogen, alkyl, substituted alkyl, alkylidene, substituted alkylidene, haloalkyl, arylalkyl, alkanoyl, substituted alkanoyl, aminoalkyl, substituted aminoalkyl, hydroxyalkyl, amide, substituted amide, carbamate, substituted carbamate, ureido, sulfonamide, substituted sulfonamide, alkylsulfone, heterocycloalkyl, substituted heterocycloalkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloalkylalkyl, thioalkyl, alkylsulfonyl, alkylsulfinyl, carboxy, alkoxycarbonyl, carbamoyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylheteroaryl, arylalkoxycarbonyl, heteroarylalkyl, aryloxyalkyl, aryloxyaryl, heterocyclyl substituted heterocyclyl, alkylcarbonyl, substituted heteroalkyl, heteroalkenyl, substituted heteroalkenyl, heteroalkynyl, substituted heteroalkynyl, arylsulfonyl, arylalkylsulfonyl, alkylsulfonyl, or alkylaminocarbonyl,
\u2014COalkyl, \u2014CO substituted alkyl; \u2014COaryl, \u2014CO substituted aryl, \u2014CO heteroaryl, \u2014CO substituted heteroaryl, \u2014CO heterocyclyl, \u2014CO substituted heterocyclyl, \u2014CONHalkyl, \u2014CONH substituted alkyl; \u2014CONH aryl, \u2014CONH substituted aryl, \u2014CONH heteroaryl, \u2014CONH substituted heteroaryl, \u2014CONH heterocyclyl, \u2014CONH substituted heterocyclyl, \u2014SO2 alkyl, \u2014SO2 substituted alkyl; \u2014SO2 aryl, \u2014SO2 substituted aryl, \u2014SO2 heteroaryl, \u2014SO2 substituted heteroaryl, \u2014SO2 heterocyclyl or \u2014SO2 substituted heterocyclyl;
R6 is hydrogen, halogen, cyano, hydroxy, oxo, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, substituted heteroalkenyl, heteroalkynyl or substituted heteroalkynyl;
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.
4. A compound of formula V
wherein:
R1, R2, and R3 are independently hydrogen, alkyl, substituted alkyl, or halogen;
R4 is hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, halogen, cycloalkyl, or substituted cycloalkyl;
R5 is hydrogen, alkyl, substituted alkyl, alkylidene, substituted alkylidene, hydroxy, alkoxy, halogen, haloalkyl, haloalkoxy, oxo, aryloxy, arylalkyl, arylalkyloxy, alkanoyl, substituted alkanoyl, alkanoyloxy, amino, aminoalkyl, substituted aminoalkyl, alkylamino, substituted alkylamino, hydroxyalkyl, disubstituted amino, amide, substituted amide, carbamate, substituted carbamate, ureido, cyano, sulfonamide, substituted sulfonamide, alkylsulfone, heterocycloalkyl, substituted heterocycloalkyl, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloalkylalkyl, cycloalkylalkoxy, nitro, thio, thioalkyl, alkylthio, alkylsulfonyl, alkylsulfinyl, carboxy, alkoxycarbonyl, alkylcarbonyloxy, carbamoyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heteroaryloxy, arylheteroaryl, arylalkoxycarbonyl, heteroarylalkyl, heteroarylalkoxy, aryloxyalkyl, aryloxyaryl, heterocyclyl substituted heterocyclyl, alkylcarbonyl, substituted heteroalkyl, heteroalkenyl, substituted heteroalkenyl, heteroalkynyl, substituted heteroalkynyl, arylamino, arylalkylamino, alkanoylamino, aroylamino, arylalkanoylamino, arylthio, arylalkylthio, arylsulfonyl, arylalkylsulfonyl, alkylsulfonyl, arylcarbonylamino, or alkylaminocarbonyl, \u2014COalkyl, \u2014CO substituted alkyl, \u2014COaryl, \u2014CO substituted aryl, \u2014CO heteroaryl, \u2014CO substituted heteroaryl, \u2014CO heterocyclyl, \u2014CO substituted heterocyclyl, \u2014CONHalkyl, \u2014CONH substituted alkyl, \u2014CONH aryl, \u2014CONH substituted aryl, \u2014CONH heteroaryl, \u2014CONH substituted heteroaryl, \u2014CONH heterocyclyl, \u2014CONH substituted heterocyclyl, \u2014SO2 alkyl, \u2014SO2 substituted alkyl; \u2014SO2 aryl, \u2014SO2 substituted aryl, \u2014SO2 heteroaryl, \u2014SO2 substituted heteroaryl, \u2014SO2 heterocyclyl or \u2014SO2 substituted heterocyclyl;
R6 is hydrogen, halogen, cyano, hydroxy, oxo, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, substituted heteroalkenyl, heteroalkynyl or substituted heteroalkynyl;
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.
5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and one or more compounds of claim 1 or a pharmaceutically acceptable salt or stereoisomer thereof.
6. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and one or more compounds of claim 2 or a pharmaceutically acceptable salt or stereoisomer thereof.
7. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and one or more compounds of claim 3 or a pharmaceutically acceptable salt or stereoisomer thereof.
8. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and one or more compounds of claim 4 or a pharmaceutically acceptable salt or stereoisomer thereof.
9. A method for the treatment of breast cancer, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 or a stereoisomer or pharmaceutically acceptable salt thereof.