1. An integrated cryptographic apparatus providing confidentiality and integrity comprising:
an integrated cryptographic module including a confidentiality and an integrity performances;
a hash function unit for detecting whether a message is modified by using the integrated cryptographic module; and
a block cipher unit for constructing a data encryption algorithm by using the integrated cryptographic module.
2. The apparatus of claim 1, wherein the integrated cryptographic module generates outputs with respect to input bit string by using operations including S-box, circular movement, and XOR.
3. The apparatus of claim 1, wherein the hash function unit includes:
a message pre-processing unit converting an input bit string of an arbitrary length into a 32-bit word array;
a message compressing unit compressing the converted 32-bit word array; and
a hash value output unit outputting a hash value of a certain hash length by using a value output from the message compressing unit.
4. The apparatus of claim 3, wherein the message pre-processing unit adds one 1 and at least one 0 to a last bit so that the input bit string becomes a 32-bit multiple.
5. The apparatus of claim 3, wherein the message compressing unit sequentially compresses a message converted into a 32-bit word array by using a state updating function.
6. The apparatus of claim 5, wherein the state updating function updates an input by repeatedly applying the integrated cryptographic module to the input.
7. The apparatus of claim 3, wherein the hash value output unit performs a state updating function which corresponds to a length of the hash function.
8. The apparatus of claim 1, wherein the block cipher unit includes a function for outputting a 128-bit ciphertext by repeatedly applying the integrated cryptographic module to a 128-bit plaintext and a 128-bit key.
9. An integrated cryptographic method providing confidentiality and integrity comprising:
generating a hash function for detecting whether a message is modified by using an integrated cryptographic module including a confidentiality and an integrity performances; and
generating a block cipher for constructing a data cryptographic algorithm by using the integrated cryptographic module.
10. The method of claim 9, wherein the integrated cryptographic module generates outputs with respect to input bit string by using operations including S-box, circular movement, and XOR.
11. The method of claim 9, wherein said generating the hash function includes:
a message pre-processing for converting an input bit string of an arbitrary length into a 32-bit word array;
a message compressing for compressing the converted 32-bit word array; and
a hash value outputting for outputting a hash value of a certain hash length by using a value output from the message compressing unit.
12. The method of claim 11, wherein said message pre-processing adds one 1 and at least one 0 to a last bit so that the input bit string becomes a 32-bit multiple.
13. The method of claim 11, wherein said message compressing sequentially compresses a message converted into a 32-bit word array by using a state updating function.
14. The method of claim 13, wherein the state updating function updates an input by repeatedly applying the integrated cryptographic module to the input.
15. The method of claim 11, wherein said hash value outputting performs a state updating function which corresponds to a length of the hash function.
16. The method of claim 9, said generating the block cipher is a function for outputting a 128-bit ciphertext by repeatedly applying the integrated cryptographic module to a 128-bit plaintext and a 128-bit key.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of delivering an otic drug to the ear comprising the steps of
(a) preparing an otic composition comprising the otic drug and a carrier, wherein the carrier comprises a low molecular weight compound having a molecular weight of 150-4000, the carrier reversibly changes from solid to liquid at a temperature of 32-37\xb0 C., and the low molecular weight compound has the formula:
wherein R1 is \u2014H, \u2014OH, \u2014COOH, CnH2n+1-2m, COOCnH2n+1-2m, \u2014COO(CH2CH2O)nCH2CH2OH, \u2014CH2R3, or
R2, R3 and R4 are independently \u2014H, \u2014OH, \u2014COOH, \u2014CnH2n+1-2m,
\u2014OOCCnH2n+1-2m, \u2014COOCnH2n+1-2m, \u2014COO(CH2CH2O)nCH2CH2OH, \u2014CnH2n+1-2mCOO(CH2CH2O)nCH2CH2OH,
\u2014OOCCnH2n+1-2mCOOCn\u2032H2n\u2032+1-2m\u2032, \u2014COO\u2212Na+, \u2014COO\u2212K+, \u2014SO3H,
\u2014SO3\u2212Na+, \u2014SO3\u2212K+, \u2014NH2, \u2014Cl,
n, n\u2032 and n\u2033 are independently 0-50; and
m, m\u2032 and m\u2033 are independently 0-10,
and
(b) inserting the composition prepared in step (a) in the ear canal.
2. The method of claim 1, wherein the composition prepared in step (a) is dropped, injected, deposited, or sprayed into the external ear.
3. The method of claim 2 wherein the composition prepared in step (a) is warmed to a temperature above 32\xb0 C. and administered topically or locally as an ear drop or through a cannula.
4. The method of claim 1 wherein the composition prepared in step (a) does not contain any polymeric ingredient and the carrier consists essentially of one or more low molecular weight compounds of formula (I).
5. The method of claim 1 wherein the low molecular weight compound of formula (I) has a molecular weight \xb12000.
6. The method of claim 1 wherein
R1 is, \u2014CnH2n+1-2m, \u2014COOCnH2n+1-2m, \u2014COO(CH2CH2O)nCH2CH2OH, \u2014CH2R3, or
R2, R3 and R4 are independently \u2014H, \u2014OH, \u2014COOH, \u2014CnH2n+1-2m, OOCCnH2n+1-2m, \u2014COOCnH2n+1-2m, \u2014COO(CH2CH2O)nCH2CH2OH,
\u2014CnH2n+1-2mCOO(CH2CH2O)nCH2CH2OH, or \u2014OOCCnH2n+1-2mCOOCn\u2032H2n\u2032+1-2m\u2032;
n, n\u2032 and n\u2033 are independently 0-40; and
m, m\u2032 and m\u2033 are independently 0-5.
7. The method of claim 6 wherein
R1 is
R2, R3 and R4 are independently \u2014H, \u2014OH, \u2014COOH, \u2014CnH2n+1-2m, or \u2014OOCCnH2n\u22121-2m;
n, n\u2032 and n\u2033 are independently 0-30; and
m, m\u2032 and m\u2033 are independently 0-3.
8. The method of claim 1 wherein the total concentration of the low molecular weight compound of formula (I) in the composition prepared in step (a) is at least 10% (ww).
9. The method of claim 1 wherein the otic drug is one or more compounds selected from the group consisting of anti-infective agents; non-steroidal anti-inflammatory agents; steroidal anti-inflammatory agents; and anti-pain agents.