1. A water dispersion for ink-jet printing comprising two kinds of carbon blacks (a) and (b) and a water-insoluble polymer which adheres to a surface of the respective carbon blacks (a) and (b), wherein the carbon black (a) has an acid group content of from 0 to 200 \u03bcmolg and the carbon black (b) has an acid group content of more than 200 \u03bcmolg but not more than 1000 \u03bcmolg, and a difference between acid group contents of the carbon blacks (a) and (b) is from 100 to 1000 \u03bcmolg.
2. A water dispersion for ink-jet printing comprising two kinds of carbon blacks (a) and (b) and a water-insoluble polymer, wherein a crosslinked water-insoluble polymer adheres to a surface of the respective carbon blacks (a) and (b), and wherein the carbon black (a) has an acid group content of from 0 to 200 \u03bcmolg and the carbon black (b) has an acid group content of more than 200 \u03bcmolg but not more than 1000 \u03bcmolg, and a difference between acid group contents of the carbon blacks (a) and (b) is from 100 to 1000 \u03bcmolg.
3. The water dispersion for ink-jet printing according to claim 2, wherein the crosslinked water-insoluble polymer is formed by crosslinking the water-insoluble polymer with a crosslinking agent.
4. A water dispersion for ink-jet printing which is produced by a process comprising the following steps I and II:
Step I: dispersing a mixture containing a water-insoluble polymer, carbon black (a) having an acid group content of from 0 to 200 \u03bcmolg, carbon black (b) having an acid group content of more than 200 \u03bcmolg but not more than 1000 \u03bcmolg, an organic solvent and water, in which a difference between acid group contents of the carbon blacks (a) and (b) is from 100 to 1000 \u03bcmolg, to obtain a dispersion; and
Step II: removing the organic solvent from the dispersion obtained in the step I to obtain a water dispersion.
5. The water dispersion for ink-jet printing according to claim 4, wherein the process further comprises the following step III:
Step III: reacting the water dispersion obtained in the step II with a crosslinking agent to obtain a water dispersion containing a crosslinked water-insoluble polymer.
6. The water dispersion for ink-jet printing according to claim 1, wherein the carbon black (b) is a self-dispersible carbon black.
7. The water dispersion for ink-jet printing according to claim 1, wherein the carbon black (a) has an acid group content of from 0 to 100 \u03bcmolg.
8. The water dispersion for ink-jet printing according to claim 1, wherein the carbon black (a) has a DBP (dibutyl phthalate) oil absorption of from 20 to 200 mL100 g.
9. The water dispersion for ink-jet printing according to claim 1, wherein the water-insoluble polymer is a graft polymer comprising a constitutional unit derived from (a) a salt-forming group-containing monomer, a constitutional unit derived from (b) a macromer, and a constitutional unit derived from (c) a monomer containing a straight-chain or branched alkyl group or alkenyl group having 12 to 22 carbon atoms andor a constitutional unit derived from (d) an aromatic ring-containing monomer.
10. A water-based ink for ink-jet printing comprising the water dispersion for ink-jet printing as defined in claim 1.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof,
wherein:
n, p, and q are each 0, such that R2, W, and R5 are absent;
m is 1;
Y and Z are each \u2014CH2\u2014;
R1 is halogen, cyano, C1-6alkyl, C1-6alkoxy, haloC1-6alkoxy or haloC1-6alkyl;
X is N or CH; and
R3 and R4 are independently hydrogen, C1-6alkyl, C1-6alkylsulfonyl, a group having the formula (IIa):
wherein A is oxygen or sulfur, D is \u2014(CH2)t\u2014, \u2014(CH2)tO\u2014 or \u2014O(CH2)t\u2014, wherein t is 0, 1, 2, 3 or 4; and E is C1-6alkyl; C3-7cycloalkyl, optionally substituted by one or more substituents independently selected from halogen, hydroxy, oxo, C1-6alkyl, cyano, CF3, OCF3, C1-6alkoxy and C1-6alkanoyl; or aryl, optionally substituted by one or more substituents independently selected from halogen, C1-6alkyl, CF3, cyano, hydroxy, C1-6alkanoyl, and C1-6alkoxy;
or a group having the formula (IIb)
wherein A is oxygen or sulfur, D is \u2014(CH2)t\u2014, \u2014(CH2)tO\u2014 or \u2014O(CH2)t\u2014, wherein t is 0, 1, 2, 3 or 4; and E is C1-6alkyl; C3-7cycloalkyl, optionally substituted by one or more substituents independently selected from halogen, hydroxy, oxo, C1-6alkyl, cyano, CF3, OCF3, C1-6alkoxy and C1-6alkanoyl; or aryl optionally substituted by one or more substituents independently selected from halogen, C1-6alkyl, CF3, cyano, hydroxy, C1-6alkanoyl, and C1-6alkoxy;
or R3 and R4, together with the nitrogen atom to which R3 and R4 are attached, combine to form a 3-7 membered monocyclic heterocyclic group or a 8-11 membered bicyclic heterocyclic group, wherein each group is optionally substituted by one or more substituents selected from halogen, oxo, C1-6alkyl, cyano, CF3,
C1-6alkoxy, C1-6alkanoyl, aryl and arylC1-6alkyl, wherein the aryl and arylC1-6alkyl are further optionally substituted by one or more halogen, oxo, C1-6alkyl, cyano, CF3,
C1-6alkoxy and C1-6alkanoyl;
which process comprises reacting a compound of formula (VII):
wherein R1, m, X, R2 and n are as defined for formula (I), with a compound of formula (VIII):
wherein W, p, Y, Z, R5, q, R3 and R4 are as defined for formula (I), and L is selected from the group consisting of chloro, bromo, iodo, tosylate, brosylate, nosylate, mesylate, fluorosulfonate, triflate, nonaflate, and tresylate; in the presence of a base, and thereafter optionally:
removing any protecting groups andor
forming a pharmaceutically acceptable salt.
2. The process according to claim 1 wherein the base is triethylamine or N\u2032N-diisopropylethylamine.
3. The process according to claim 1 wherein:
R1 is methyl;
X is CH; and
R3 and R4, together with the nitrogen atom to which R3 and R4 are attached, combine to form a 3-7 membered monocyclic heterocyclic group selected from
wherein w is 0, 1, 2, 3 or 4 and R is independently halogen, oxo, C1-6alkyl, cyano, CF3, C1-6alkoxy, C1-6alkanoyl, aryl and arylC1-6alkyl, wherein the aryl and arylC1-6alkyl are further optionally substituted by one or more halogen, oxo, C1-6alkyl, cyano, CF3, C1-6alkoxy and C1-6alkanoyl.
4. The process according to claim 1 wherein the compound of formula (I) is 1-(3-{2-4-(2-methyl-5-quinolinyl)-1-piperazinylethyl}phenyl)-2-imidazolidinone.