1. A cell, wherein said cell has been genetically engineered to disrupt expression of a protein of Table 1.
2. The cell of claim 1, wherein the protein is selected from argininosuccinate lyase, cystathionine G-lyase, cystathionine b-synthase, glycine N-methyltransferase, pyrroline-5-carboxylate synthetase, phenylalanine 4-monooxygenase, carbamoyl-phosphate synthase (ammonia), ornithine carbamoyltransferase (mitochondrial), ornithine transaminase (mitochondrial), methionine adenosyltransferase, adenosylhomocysteinase, propionyl-CoA carboxylase (mitochondrial), methylmalonyl-CoA epimerase (mitochondrial), methylmalonyl-CoA mutase, myo-Inositol-1-phosphate synthase, thymidylate synthase, nucleoside-diphosphatase (dUDP), carbonate anhydrase, adenosine kinase, sarcosine oxidase, alphaketobutyrate dehydrogenase (mitochondrial), phosphatidylserine decarboxylase, glucose-6-phosphate isomerase, myo-inositol 1-phosphatase, ribonucleoside-diphosphate reductase, and dihydropteridine reductase.
3. The cell of claim 1, wherein said cell further comprises an exogenous nucleic acid, wherein said exogenous nucleic acid comprises an expressible nucleic acid comprising a nucleic acid encoding said protein lacking expression in said cell.
4. The cell of claim 3, wherein said exogenous nucleic acid further comprises an expressible nucleic acid encoding a product.
5. A composition comprising a cell, wherein said cell lacks expression of a protein of Table 1, and an expressible nucleic acid comprising a nucleic acid encoding said protein lacking expression in said cell.
6. The composition of claim 5, wherein the protein is selected from argininosuccinate lyase, cystathionine G-lyase, cystathionine b-synthase, glycine N-methyltransferase, pyrroline-5-carboxylate synthetase, phenylalanine 4-monooxygenase, carbamoyl-phosphate synthase (ammonia), ornithine carbamoyltransferase (mitochondrial), ornithine transaminase (mitochondrial), methionine adenosyltransferase, adenosylhomocysteinase, propionyl-CoA carboxylase (mitochondrial), methylmalonyl-CoA epimerase (mitochondrial), methylmalonyl-CoA mutase, myo-Inositol-1-phosphate synthase, thymidylate synthase, nucleoside-diphosphatase (dUDP), carbonate anhydrase, adenosine kinase, sarcosine oxidase, alphaketobutyrate dehydrogenase (mitochondrial), phosphatidylserine decarboxylase, glucose-6-phosphate isomerase, myo-inositol 1-phosphatase, ribonucleoside-diphosphate reductase, and dihydropteridine reductase.
7. The composition of claim 5, wherein said exogenous nucleic acid further comprises an expressible nucleic acid encoding a product.
8. A kit comprising the composition of claim 5.
9. The kit of claim 8, wherein the protein is selected from argininosuccinate lyase, cystathionine G-lyase, cystathionine b-synthase, glycine N-methyltransferase, pyrroline-5-carboxylate synthetase, phenylalanine 4-monooxygenase, carbamoyl-phosphate synthase (ammonia), ornithine carbamoyltransferase (mitochondrial), ornithine transaminase (mitochondrial), methionine adenosyltransferase, adenosylhomocysteinase, propionyl-CoA carboxylase (mitochondrial), methylmalonyl-CoA epimerase (mitochondrial), methylmalonyl-CoA mutase, myo-Inositol-1-phosphate synthase, thymidylate synthase, nucleoside-diphosphatase (dUDP), carbonate anhydrase, adenosine kinase, sarcosine oxidase, alphaketobutyrate dehydrogenase (mitochondrial), phosphatidylserine decarboxylase, glucose-6-phosphate isomerase, myo-inositol 1-phosphatase, ribonucleoside-diphosphate reductase, and dihydropteridine reductase.
10. The kit of claim 8, wherein the kit further comprises the components of a selection medium for culturing said cell, wherein the components of the selection medium exclude the component of Table 1 that complements the lack of expression of said protein.
11. The kit of claim 10, wherein the kit further comprises the component of Table 1 that complements the lack of expression of said protein.
12. The kit of claim 11, wherein the component of Table 1 is selected from arginine, cysteine, proline, tyrosine, myo-inositol, thymidine, ethanolamine, glucose, asparagine and glutamine.
13. A method of selecting for an exogenous nucleic acid in a cell, comprising:
(a) contacting cells with an exogenous nucleic acid, wherein said cells lack expression of a protein of Table 1 and wherein said exogenous nucleic acid comprises a nucleic acid encoding said protein lacking expression in said cell, wherein said contacting results in uptake of said exogenous nucleic acid into at least one of said cells;
(b) placing said cells in a selection medium, wherein the components of the selection medium exclude the component of Table 1 that complements the lack of expression of said protein; and
(c) culturing said cells in said selection medium, whereby culturing said cells selects for at least one cell that expresses from said exogenous nucleic acid the protein lacking expression in said cell.
14. The method of claim 13, wherein the protein is selected from argininosuccinate lyase, cystathionine G-lyase, cystathionine b-synthase, glycine N-methyltransferase, pyrroline-5-carboxylate synthetase, phenylalanine 4-monooxygenase, carbamoyl-phosphate synthase (ammonia), ornithine carbamoyltransferase (mitochondrial), ornithine transaminase (mitochondrial), methionine adenosyltransferase, adenosylhomocysteinase, propionyl-CoA carboxylase (mitochondrial), methylmalonyl-CoA epimerase (mitochondrial), methylmalonyl-CoA mutase, myo-Inositol-1-phosphate synthase, thymidylate synthase, nucleoside-diphosphatase (dUDP), carbonate anhydrase, adenosine kinase, sarcosine oxidase, alphaketobutyrate dehydrogenase (mitochondrial), phosphatidylserine decarboxylase, glucose-6-phosphate isomerase, myo-inositol 1-phosphatase, ribonucleoside-diphosphate reductase, and dihydropteridine reductase.
15. The method of claim 13, wherein the component of Table 1 is selected from arginine, cysteine, proline, tyrosine, myo-inositol, thymidine, ethanolamine, glucose, asparagine and glutamine.
16. The method of claim 13, wherein said exogenous nucleic acid further comprises an expressible nucleic acid encoding a product.
17. The method of claim 13, wherein said product is expressed in said selected cell.
18. The method of claim 17, further comprising isolating the product expressed in the selected cell.
19. A method of expressing a product in a cell, comprising:
(a) contacting cells with an exogenous nucleic acid, wherein said cells lack expression of a protein of Table 1 and wherein said exogenous nucleic acid comprises a nucleic acid encoding said protein lacking expression in said cell and an expressible nucleic acid encoding said product, wherein said contacting results in uptake of said exogenous nucleic acid into at least one of said cells;
(b) placing said cells in a selection medium, wherein the components of the selection medium exclude the component of Table 1 that complements the lack of expression of said protein;
(c) culturing said cells in said selection medium, whereby culturing said cells selects for at least one cell that expresses from said exogenous nucleic acid the protein lacking expression in said cell; and
(d) culturing said selected cell under conditions for expression of said product.
20. The method of claim 19, wherein the protein is selected from argininosuccinate lyase, cystathionine G-lyase, cystathionine b-synthase, glycine N-methyltransferase, pyrroline-5-carboxylate synthetase, phenylalanine 4-monooxygenase, carbamoyl-phosphate synthase (ammonia), ornithine carbamoyltransferase (mitochondrial), ornithine transaminase (mitochondrial), methionine adenosyltransferase, adenosylhomocysteinase, propionyl-CoA carboxylase (mitochondrial), methylmalonyl-CoA epimerase (mitochondrial), methylmalonyl-CoA mutase, myo-Inositol-1-phosphate synthase, thymidylate synthase, nucleoside-diphosphatase (dUDP), carbonate anhydrase, adenosine kinase, sarcosine oxidase, alphaketobutyrate dehydrogenase (mitochondrial), phosphatidylserine decarboxylase, glucose-6-phosphate isomerase, myo-inositol 1-phosphatase, ribonucleoside-diphosphate reductase, and dihydropteridine reductase.
21. The method of claim 19, wherein the component is selected from arginine, cysteine, proline, tyrosine, myo-inositol, thymidine, ethanolamine, glucose, asparagine and glutamine.
22. The method of claim 19, further comprising isolating the product expressed in the selected cell.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A communication apparatus having a transmission function for transmitting data to another apparatus using a transmission protocol selected from a plurality of transmission protocols, comprising:
an authentication unit configured to authenticate a user;
an acquisition unit configured to acquire a destination information item associated with the user authenticated by said authentication unit;
a storage unit configured to store a plurality of destination information items;
a setting unit configured to configure settings such that use of a specific transmission protocol for transmission using the destination information item acquired by said acquisition unit is permitted, and the use of the specific transmission protocol for transmission using other destination information items than the destination information item acquired by said acquisition unit is restricted; and
a display restriction unit configured to be operable when the settings are configured by said setting unit, to permit display of a destination information item which matches the destination information item acquired by said acquisition unit, but to restrict display of destination information items other than the acquired destination information item, among the destination information items which are stored by said storage unit and associated with the specific transmission protocol.
2. The communication apparatus according to claim 1,
wherein the communication apparatus is connected to an LDAP server via a network, and
wherein said authentication unit performs the authentication through communication with the LDAP server.
3. The communication apparatus according to claim 2, wherein when the authentication is successfully performed by said authentication unit, said acquisition unit acquires the destination information item from the LDAP server.
4. The communication apparatus according to claim 1, wherein the transmission protocols include at least SMTP and SMB.
5. The communication apparatus according to claim 1, comprising a new information input unit configured to input a new destination information item, and
a control unit configured to be operable when the settings are configured by said setting unit, to perform control to prevent said new information input unit from inputting a destination information item associated with the specific transmission protocol.
6. A communication apparatus having a transmission function for transmitting data to another apparatus using a transmission protocol selected from a plurality of transmission protocols, comprising:
an authentication unit configured to authenticate a user;
an acquisition unit configured to acquire a destination information item associated with the user authenticated by said authentication unit and detailed information on the destination information item;
a destination table configured to store a plurality of destination information items and detailed information on each of the destination information items; and
an edit restriction unit configured to be operable when a specific destination information item selected by the user authenticated by said authentication unit so as to check the detailed information is associated with a predetermined transmission protocol, to restrict editing of the detailed information on the specific destination information item.
7. The communication apparatus according to claim 6, wherein when the specific destination information item selected so as to check the detailed information is not either selected from the destination table or associated with the predetermined transmission protocol, the editing of the detailed information on the specific destination information item is not restricted.
8. The communication apparatus according to claim 6, wherein even when the specific destination information item is associated with the predetermined transmission protocol, if the specific destination information item is not a predetermined destination information item, the editing of the detailed information on the specific destination information item is not restricted.
9. The communication apparatus according to claim 8, wherein the predetermined transmission protocol is an E-mail transmission protocol for E-mail transmission, and
wherein when the specific destination information item is associated with the E-mail transmission protocol and when the specific destination information item is the predetermined destination information item, said edit restriction unit disables at least the editing of an address included in the destination information item.
10. The communication apparatus according to claim 8, wherein the predetermined transmission protocol is a file transmission protocol for file transmission, and
wherein when the specific destination information item is associated with the file transmission protocol and when the specific destination information item is the predetermined destination information item, said edit restriction unit disables at least the editing of a network folder path included in the destination information item.
11. A method of controlling a communication apparatus having a transmission function for transmitting data to another apparatus using a transmission protocol selected from a plurality of transmission protocols, comprising:
authenticating a user;
acquiring a destination information item associated with the authenticated user;
storing a plurality of destination information items;
configuring settings such that use of a specific transmission protocol for transmission using the acquired destination information item is permitted, and the use of the specific transmission protocol for transmission using other destination information items than the acquired destination information item is restricted, and
permitting, when the settings are configured by said setting unit, display of a destination information item which matches the acquired destination information item, but restricting display of destination information items other than the acquired destination information item, among the stored destination information items which are associated with the specific transmission protocol.
12. A method of controlling a communication apparatus that has a transmission function for transmitting data to another apparatus using a transmission protocol selected from a plurality of transmission protocols, and is provided with a destination table having a plurality of destination information items recorded therein and having detailed information on each of the destination information items stored therein, comprising:
authenticating a user;
acquiring a destination information item associated with the authenticated user and detailed information on the destination information item; and
restricting, when a specific destination information item selected by the authenticated user so as to check the detailed information is associated with a predetermined transmission protocol, editing of the detailed information on the specific destination information item.
13. A non-transitory computer-readable storage medium storing a computer-executable program for causing a computer to execute a method of controlling a communication apparatus having a transmission function for transmitting data to another apparatus using a transmission protocol selected from a plurality of transmission protocols,
wherein the method comprises:
acquiring a destination information item associated with the authenticated user;
storing a plurality of destination information items;
configuring settings such that use of a specific transmission protocol for transmission using the acquired destination information item is permitted, and the use of the specific transmission protocol for transmission using other destination information items than the acquired destination information item is restricted, and
permitting, when the settings are configured by said setting unit, display of a destination information item which matches the acquired destination information item, but restricting display of destination information items other than the acquired destination information item, among the stored destination information items which are associated with the specific transmission protocol.
14. A non-transitory computer-readable storage medium storing a computer-executable program for causing a computer to execute a method of controlling a communication apparatus that has a transmission function for transmitting data to another apparatus using a transmission protocol selected from a plurality of transmission protocols, and is provided with a destination table having a plurality of destination information items recorded therein and having detailed information on each of the destination information items stored therein,
wherein the method comprises:
authenticating a user;
acquiring a destination information item associated with the authenticated user and detailed information on the destination information item; and
restricting, when a specific destination information item selected by the authenticated user so as to check the detailed information is associated with a predetermined transmission protocol, editing of the detailed information on the specific destination information item.