1. A method of depositing copper on a substrate comprising: contacting a substrate to be plated with copper into a copper electroplating bath comprising: a source of copper ions, an electrolyte, and a leveling agent, wherein the leveling agent is a reaction product of one or more cyclodiaza-compounds with one or more epoxide-containing compounds; wherein at least one cyclodiaza-compound has the formula (I)
wherein E=C(O) or CR3R4; G=CR5R6 or a chemical bond; R1 and R2 are independently chosen from H, (C1-C6)alkyl and (C6-C10)aryl; R3 to R10 are independently chosen from H, (C1-C6)alkyl, (C6-C10)aryl and hydroxyl; each of R1 and R2, R2 and R3, R3 and R5, R5 and R7, R7 and R9, and R9 and R1 may be taken together to form a chemical bond; and any of R1 to R10 on adjacent ring atoms may be taken together along with the atoms to which they are attached to form a 5- or 6-membered saturated or unsaturated ring; and applying a current density for a period of time sufficient to deposit a copper layer on the substrate.
2. The method of claim 1 wherein the epoxide-containing compound comprises from 1 to 3 epoxy groups.
3. The method of claim 2 wherein the epoxide-containing compound is chosen from compounds of the formulae
where Y, Y1 and Y2 are independently chosen from H and (C1-C4)alkyl; each Y3 is independently chosen from H, an epoxy group, and (C1-C6)alkyl; X=CH2X2 or (C2-C6)alkenyl; X1=H or (C1-C5)alkyl; X2=halogen, O(C1-C3)alkyl or O(C1-C3)haloalkyl; A=OR11 or R12; R11=((CR13R14)mO)n, (aryl-O)p, CR13R14\u2014Z\u2014CR13R14O or OZ1tO; R12=(CH2)y; A1 is a (C5-C12)cycloalkyl ring or a 5- to 6-membered cyclicsulfone ring; Z=a 5- or 6-membered ring; Z1 is R15OArOR15, (R16O)aAr(OR16)a, or (R16O)aCy(OR16)a; Z2=SO2 or
Cy=(C5-C12)cycloalkyl; each R13 and R14 are independently chosen from H, CH3 and OH; each R15 represents (C1-C8)alkyl; each R16 represents a (C2-C6)alkyleneoxy; each a=1-10; m=1-6; n=1-20; p=1-6; q=1-6; r=0-4; t=1-4; v=0-3; and y=0-6; wherein Y1 and Y2 may be taken together to form a (C8-C12)cyclic compound.
4. The method of claim 1 wherein the copper electroplating bath further comprises an accelerator.
5. The method of claim 1 wherein at least one of the cyclodiaza-compounds has the formulae (IIa) or (IIb)
wherein R1 and R2 are independently chosen from H, (C1-C6)alkyl and (C6-C10)aryl; R4 and R7 to R10 are independently chosen from H, (C1-C6)alkyl, (C6-C10)aryl and hydroxyl; R7 and R9 may be taken together to form a chemical bond; and any of R1, R4 and R7 to R10 on adjacent ring atoms may be taken together along with the atoms to which they are attached to form a 5- or 6-membered saturated or unsaturated ring.
6. The method of claim 1 wherein at least one of the cyclodiaza-compounds has the formulae (IIIa) or (IIIb)
wherein R1 and R2 are independently chosen from H, (C1-C6)alkyl and (C6-C10)aryl; R4 and R5 to R10 are independently chosen from H, (C1-C6)alkyl, (C6-C10)aryl and hydroxyl; each of R1 and R2, R5 and R7, R7 and R9, and R9 and R1 may be taken together to form a chemical bond; and any of R1 and R5 to R10 on adjacent ring atoms may be taken together along with the atoms to which they are attached to form a 5- or 6-membered saturated or unsaturated ring.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1.-4. (canceled)
5. A system to alleviate a symptom of chronic obstructive pulmonary disease in a lung of a patient wherein the system comprises:
at least one conduit having a first end which includes a first aperture, a second end which includes a second aperture, and a lumen which connects, in fluid communication, the first aperture and the second aperture;
an airway connection device which is adapted to connect the first end of the conduit to an artificial opening through a wall of a proximal airway wherein the proximal airway is a region of a trachea and a bronchus external to the lung;
a lung connection device which is adapted to connect the second end of the conduit to an artificial opening through a visceral membrane of the lung;
an access fitting connected to the conduit between the first end of the conduit and the second end of the conduit which is adapted to seal the lumen and allow at least intermittent access to the lumen from outside the patient;
whereby the system is adapted to allow air to exit the lung via the artificial opening through the visceral membrane, enter the lumen through the second aperture, exit the lumen through the first aperture, and enter the proximal airway through the artificial opening in the wall of the proximal airway.
6. The system of claim 5, further comprising at least one valve in the lumen wherein the valve prevents mucus from entering the lung from the lumen.
7. The system of claim 5, wherein the airway connection device is adapted to create an airtight seal between the first end of the conduit and the wall of the proximal airway.
8. The system of claim 5, wherein the lung connection device is adapted to maintain an airtight seal between the second end of the conduit and the visceral membrane of the lung.
9. The system of claim 5, wherein the conduit comprises a first section and a second section and wherein the first section is detachably coupled to the second section by the access fitting.
10. The system of claim 5, wherein the access fitting comprises a subcutaneous access port.
11. The system of claim 5, wherein the access fitting comprises a percutaneous access port.
12. The system of claim 5, wherein the access fitting comprises an access port.
13. The system of claim 5, wherein the access fitting is adapted to be external to the patient.
14. A system to alleviate a symptom of chronic obstructive pulmonary disease by creating a ventilation bypass between a lung of a patient and an airway of the patient wherein the airway is a region of a natural airway of the lower respiratory tract of the patient external to the lung, and wherein:
the system comprises a conduit having first and second ends and an access fitting connected to the conduit between the first end of the conduit and the second end of the conduit;
the access fitting is adapted to allow intermittent access into the conduit from outside the patient;
the first end of the conduit is adapted to be connected with the airway of the patient and sealed to a wall of the airway of the patient;
the second end of the conduit is adapted to be connected with lung of a patient and is sealed to the lung of the patient; and
the conduit is adapted to create a direct fluid communication between the lung of the patient and the airway of the patient along a path through the patient outside the lung and the airway of the patient thereby providing a ventilation bypass which permits air to exit the lung and enter the airway via the conduit.
15. The system of claim 14, wherein the first end of the conduit comprises an expandable feature that is adapted to engage the airway.
16. The system of claim 14, wherein the second end of the conduit comprises an expandable feature that is adapted to engage the lung.
17. The system of claim 14, wherein the first end of the conduit comprises an expandable feature that is adapted to engage the airway and the second end of the conduit comprises an expandable feature that is adapted to engage the lung.
18. The system of claim 14, wherein the conduit comprises at least one valve to prevent substances from entering the lung via the conduit.
19. The system of claim 14, wherein the conduit comprises a one-way check valve to allow exhalation while preventing substances from entering the lung via the conduit.
20. The system of claim 14, wherein the conduit comprises at least one filter to prevent substances from entering the lung via the conduit.
21. The system of claim 14, wherein the airway is a region of a bronchus of the patient external to the lung.
22. The system of claim 14, wherein the airway is a region of a trachea of the patient external to the lung.
23. A system to alleviate a symptom of chronic obstructive pulmonary disease in a lung of a patient by creating a ventilation bypass between the lung and an airway of the patient wherein the airway is a region of a natural airway of the lower respiratory tract of the patient external to the lung, and wherein the system comprises:
at least one conduit having a first end, a second end, and a lumen which connects, in fluid communication, the first end and the second end;
a first connector which is adapted to connect the first end of the conduit to an artificial opening through a wall of the airway such that air may enter the airway through the wall of the airway via the lumen of the conduit;
a second connector which is adapted to connect the second end of the conduit to an artificial opening in a visceral membrane of the lung such that air may leave the lung through the artificial opening in the visceral membrane of the lung via the lumen of the conduit;
an access port connected to the conduit between the first end of the conduit and the second end of the conduit adapted to allowing intermittent access to the lumen of the conduit from outside the patient.
24. The system of claim 23, wherein at least one of the first connector and second connector comprises an expandable feature.