claimsbot – Page 17999 – All The Claims

1460755527-a0fc854f-724d-4e5c-8703-645b05c23d35

1. A nasal ventilation interface for the purpose of supplying ventilation gas to a person’s airway, the interface comprising:
a generally tubular construction with a distal end configured with a first and a second tube for engagement with a person’s nostrils and each defining an angulated fenestration in alignment with and directly opposed to a nostril opening, the angulated fenestration being diagonally oriented with respect to a person’s face to define a nostril airflow direction outward from the face and downward from the nostril, a proximal end configured for attachment to a ventilation gas supply hose;
a coupler connecting the first and second distal ends of the tubes; and
a lifting device applied substantially directly under the nose to the distal end of the first and second tubes, wherein the lift creates and maintains an upward engagement force between the respective first and second distal ends of the tubes and the nostrils, and maintains the angulated fenestration oriented along the nostril airflow direction.
2. The interface of claim 1, wherein the lifting device is a first strap attachable to the distal end of the tubes via the coupler.
3. The interface of claim 2, wherein the first strap comprises two ends, wherein the two ends extend bilaterally away from the nose and join at the back or side of the head.
4. The interface of claim 2, wherein the first strap further comprises a malleable member.
5. The interface of claim 2, wherein the first strap further comprises a shape memory member.
6. The interface of claim 2, wherein the tension and location of the first strap are adjustable.
7. The interface of claim 2, further comprising a facial pad, wherein the facial pad is attachable to the first strap and positions the distal end of the interface beneath the nose.
8. A nasal ventilation interface apparatus for the purpose of supplying ventilation gas to a person’s airway, the apparatus comprising: a generally tubular construction with a distal end comprising a first and second tube configured to engage a person’s nostrils and each defining an angulated fenestration in alignment with and directly opposed to a nostril opening, the angulated fenestration being diagonally oriented with respect to a person’s face to define a nostril airflow direction outward from the face and downward from the nostril, and a proximal end configured to attach to a ventilation gas supply hose, wherein the distal end comprises a facial pad positioned between the tubes and skin between the user’s nose and upper lip, and wherein the facial pad cushions the user’s shin and tilts the distal end of the tubes to maintain the angulated fenestration oriented along the nostril airflow direction and align each of the first tube and the second tube with a rim of the user’s nostrils.
9. The apparatus of claim 8, wherein the facial pad is comprised of a viscoelastic material and the pair of tubes are comprised of a plastic material.
10. The apparatus of claim 8, wherein the facial pad is comprised of an energy absorption material.
11. The apparatus of claim 8, wherein the facial pad is adjustable or a variety of facial pad sizes can be interchanged.
12. The apparatus of claim 8, wherein the facial pad is integral to a coupler, a head strap connector, the first and second tubes, or sealing cushions.
13. The apparatus of claim 8, wherein the facial pad is attached to a head strap connector with a hinge.
14. A nasal ventilation interface apparatus for the purpose of supplying ventilation gas to a person’s airway comprising:
a generally tubular construction with a distal end comprising a first and a second tube configured to engage a person’s nostrils and each defining an angulated fenestration in alignment with and directly opposed to a nostril opening, the angulated fenestration being diagonally oriented with respect to a person’s face to define a nostril airflow direction outward from the face and downward from the nostril, and a proximal end configured to attach to a ventilation gas supply hose,
a band member substantially circumventing the head from the chin to the top of the head, wherein the band member applies upward compression on the chin so as to bias the mouth in a close state, and
a first connector between the first tube and the band member and a second connector between the second tube and the band member, wherein the first connector and the second connector apply an upward lifting force on distal ends of the first tube and the second tube to maintain a seal with the nostrils, and maintain the angulated fenestration oriented along the nostril airflow direction.
15. The apparatus of claim 14, wherein the hand member provides an upward force on the distal end first and second tubes, wherein the force maintains compression between the nostrils and the distal ends of the first and second tubes wherein the compression substantially seals the first and second tubes to the nostrils.
16. The apparatus of claim 14, wherein the distal end of the tubes is generally circular and comprises an inner diameter generally approximately equal to or less than the diameter of the nostril opening of the user.
17. The apparatus of claim 16, wherein the distal end of the tubes has an inner diameter of about 6 mm to about 22 mm.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A stream manager comprising:
a processor; and
a memory that stores processor-executable instructions therein where the processor interfaces with the memory and executes the processor-executable instructions to enable the following:
receive a request initiated by a user of a user device to stream a desired piece of content;
create segments for an adaptive stream manifest file corresponding to the desired piece of content;
cause the adaptive stream manifest file with references to the segments to be streamed to the user device which is configured to request, receive and playback the desired piece of content;
receive an input initiated by the user of the user device indicating that the desired piece of content should be modified;
create additional segments for the adaptive stream manifest file corresponding to the modified piece of content; and
cause the adaptive stream manifest file with references to the additional segments to be streamed to the user device which is configured to request, receive and playback the modified piece of content.
2. The stream manager of claim 1, wherein the input from the user is an implied input.
3. The stream manager of claim 2, wherein the implied input includes one or more of the following an updated account status, demographics, and prior viewing habits.
4. The stream manager of claim 1, wherein the input from the user is an explicit input.
5. The stream manager of claim 4, wherein the explicit input includes one or more of the following a request to change a channel, a request to view an alternate scene, a request to zoom-in, and a request to alter a resolution of the content.
6. The stream manager of claim 1, wherein:
the desired piece of content has advertising therein; and
the modified piece of content does not have advertising therein.
7. The stream manager of claim 1, wherein:
the desired piece of content is a trailer for a movie; and
the modified piece of content is the movie.
8. The stream manager of claim 1, wherein:
the desired piece of content is provided by a first content provider; and
the modified piece of content is provided by a second content provider.
9. A method implemented by a stream manager for creating an adaptive stream manifest file which is streamed to a user device, the method comprising:
receiving a request initiated by a user of the user device to stream a desired piece of content;
creating segments for the adaptive stream manifest file corresponding to the desired piece of content;
causing the adaptive stream manifest file with references to the segments to be streamed to the user device which is configured to request, receive and playback the desired piece of content;
receiving an input initiated by the user of the user device indicating that the desired piece of content should be modified;
creating additional segments for the adaptive stream manifest file corresponding to the modified piece of content; and
causing the adaptive stream manifest file with references to the additional segments to be streamed to the user device which is configured to request, receive and playback the modified piece of content.
10. The method of claim 9, wherein the input from the user is an implied input.
11. The method of claim 10, wherein the implied input includes one or more of the following an updated account status, demographics, and prior viewing habits.
12. The method of claim 9, wherein the input from the user is an explicit input.
13. The method of claim 12, wherein the explicit input includes one or more of the following a request to change a channel, a request to view an alternate scene, a request to zoom-in, and a request to alter a resolution of the content.
14. The method of claim 9, wherein:
the desired piece of content has advertising therein; and
the modified piece of content does not have advertising therein.
15. The method of claim 9, wherein:
the desired piece of content is a trailer for a movie; and
the modified piece of content is the movie.
16. The method of claim 9, wherein:
the desired piece of content is provided by a first content provider; and
the modified piece of content is provided by a second content provider.
17. A method implemented by a stream manager for creating an adaptive stream manifest file which is streamed to a user device, the method comprising:
receiving a content file with one or more descriptive labels associated with one or more scenes of the content file;
segmenting the content file while taking into account the one or more descriptive labels associated with the one or more scenes of the content file;
storing each segment and associated one or more descriptive labels of the content file;
receiving a request initiated by a user of the user device to stream the content file;
adding references associated with the segments to the adaptive stream manifest file;
causing the adaptive stream manifest file containing the references to the segments associated with the content file to be streamed to the user device which is configured to request, receive and playback the content file;
receiving an input initiated by the user of the user device indicating that the content file should be modified based on at least one of the one or more descriptive labels;
modifying the content file to include only the segments per the input from the user; and
causing the adaptive stream manifest file with references to the segments associated with the modified content file to be streamed to the user device which is configured to request, receive and playback the modified content file.
18. The method of claim 17, wherein the one or more descriptive labels associated with the one or more scenes of the content file:
indicate importance of the corresponding scene in regard to a plot of a show in the content file;
indicate a particular subject of the corresponding scene in regard to different parts of a news program in the content file;
indicate a particular character associated with the corresponding scene in regard to a show in the content file; or
indicate a particular keyword associated with the corresponding scene in regard to a show in the content file.
19. A stream manager comprising:
a processor; and
a memory that stores processor-executable instructions therein where the processor interfaces with the memory and executes the processor-executable instructions to enable the following:
receive a content file with one or more descriptive labels associated with one or more scenes of the content file;
segment the content file while taking into account the one or more descriptive labels associated with the one or more scenes of the content file;
store each segment and associated one or more descriptive labels of the content file;
receive a request initiated by a user of a user device to stream the content file;
add references associated with the segments to an adaptive stream manifest file;
cause the adaptive stream manifest file containing references to the segments associated with the content file to be streamed to the user device which is configured to receive and playback the content file;
receive an input initiated by the user of the user device indicating that the content file should be modified based on at least one of the one or more descriptive labels;
modify the content file to include only the segments per the input from the user; and
cause the adaptive stream manifest file with references to the segments associated with the modified content file to be streamed to the user device which is configured to request, receive and playback the modified content file.
20. The stream manager of claim 19, wherein the one or more descriptive labels associated with the one or more scenes of the content file:
indicate importance of the corresponding scene in regard to a plot of a show in the content file;
indicate a particular subject of the corresponding scene in regard to different parts of a news program in the content file;
indicate a particular character associated with the corresponding scene in regard to a show in the content file; or
indicate a particular keyword associated with the corresponding scene in regard to a show in the content file.

1460755518-044edbe0-c117-40c5-bf1c-e592503f802b

1. A compound of structural formula I:
or a pharmaceutically acceptable salt thereof, wherein:
T is N;
U is CR1;
V is CR2;
W is CR4;
X is selected from:
(1) \u2014O\u2014, and
(2) \u2014O\u2014CH2\u2014;

Y is selected from:
(1) C3-l0cycloalkyl,
(2) C3-l0cycloalkenyl,
(3) C2-10cycloheteroalkyl,
(4) C2-10cycloheteroalkenyl,
(5) aryl, and
(6) heteroaryl,

wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from C1-6alkyl, \u2014OH and \u2014NH2,and wherein each alkyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from Rc;
each R1 and R2 is independently selected from:
(1) hydrogen,
(2) halogen,
(3) CN,
(4) CF3,
(5) \u2014C1-6alkyl,
(6) \u2014C2-6alkenyl,
(7) \u2014C2-6alkynyl,
(8) \u2014(CH2)pC3-10cycloalkyl,
(9) \u2014(CH2)pC3-7cycloalkyl-aryl,
(10) \u2014(CH2)pC3-7cycloalkyl-heteroaryl,
(11) \u2014(CH2)pC4-l0cycloalkenyl,
(12) \u2014(CH2)pC4-7cycloalkenyl-aryl,
(13) \u2014(CH2)pC4-7cycloalkenyl-heteroaryl,
(14) \u2014(CH2)pC2-10cycloheteroalkyl,
(15) \u2014(CH2)pC2-10cycloheteroalkenyl,
(16) \u2014(CH2)paryl,
(17) \u2014(CH2)paryl-C1-8alkyl,
(18) \u2014(CH2)paryl-C2-8alkenyl,
(19) \u2014(CH2)paryl-C2-8alkynyl-C1-8alkyl,
(20) \u2014(CH2)paryl-C2-8alkynyl-C3-7cycloalkyl,
(21) \u2014(CH2)paryl-C2-8alkynyl-C3-7cycloalkenyl,
(22) \u2014(CH2)paryl-C2-8alkynyl-C2-10cycloheteroalkyl,
(23) \u2014(CH2)paryl-C2-8alkynyl-C2-10cycloheteroalkenyl,
(24) \u2014(CH2)paryl-C2-8alkynyl-aryl,
(25) \u2014(CH2)paryl-C2-8alkynyl-heteroaryl,
(26) \u2014(CH2)paryl-C3-7cycloalkyl,
(27) \u2014(CH2)paryl-C2-10cycloheteroalkyl,
(28) \u2014(CH2)paryl-C2-10cycloheteroalkenyl,
(29) \u2014(CH2)paryl-aryl,
(30) \u2014(CH2)paryl-heteroaryl,
(31) \u2014(CH2)pheteroaryl,
(32) \u2014C2-6alkenyl-alkyl,
(33) \u2014C2-6alkenyl-aryl,
(34) \u2014C2-6alkenyl-heteroaryl,
(35) \u2014C2-6alkenyl-C3-7cycloalkyl,
(36) \u2014C2-6alkenyl-C3-7cycloalkenyl,
(37) \u2014C2-6alkenyl-C2-7cycloheteroalkyl,
(38) \u2014C2-6alkenyl-C2-7cycloheteroalkenyl,
(39) \u2014C2-6alkynyl-(CH2)1-3\u2014O-aryl,
(40) \u2014C2-6alkynyl-alkyl,
(41) \u2014C2-6alkynyl-aryl,
(42) \u2014C2-6alkynyl-heteroaryl,
(43) \u2014C2-6alkynyl-C3-7cycloalkyl,
(44) \u2014C2-6alkynyl-C3-7cycloalkenyl,
(45) \u2014C2-6alkynyl-C2-7cycloheteroalkyl,
(46) \u2014C2-6alkynyl-C2-7cycloheteroalkenyl, and
(47) \u2014C(O)NH\u2014(CH2)0-3phenyl,

wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from: halogen, CF3 , \u2014OH, \u2014NH2,\u2014C1-6alkyl, \u2014OC1-6alkyl, \u2014NHC1-6alkyl, and \u2014N(C1-6alkyl)2, wherein each alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, phenyl, aryl and heteroaryl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra,
provided that at least one of and only one of R1 and R2 is selected from the group consisting of:
hydrogen, halogen, \u2014CN, \u2014CF3, \u2014C1-6alkyl, \u2014C2-6alkenyl and \u2014C2-6alkynyl;
each R4 is independently selected from:
(1) hydrogen,
(2) halogen,
(3) \u2014C1-6 alkyl,
(4) \u2014C2-6 alkenyl,
(5) \u2014C2-6 alkynyl,
(6) \u2014CN,
(7) \u2014CF3,
(8) \u2014OH,
(9) \u2014OC1-6alkyl,
(10) \u2014NH2,
(11) \u2014NHC1-6alkyl,
(12) \u2014N(C1-6alkyl)2,
(13) \u2014SC1-6alkyl,
(14) \u2014SOC1-6alkyl,
(15) \u2014SO2C1-6alkyl,
(16) \u2014NHSO2C1-6alkyl,
(17) \u2014NHC(O)C1-6alkyl,
(18) \u2014SO2NHC1-6alkyl, and
(19) \u2014C(O)NHC1-6alkyl;

R5is selected from:
(1) hydrogen,
(2) \u2014C1-6alkyl,
(3) \u2014CH2CO2H, and
(4) \u2014CH2CO2C1-6alkyl;

each Ra is independently selected from the group consisting of:
(1) \u2014(CH2)m-halogen,
(2) oxo,
(3) \u2014(CH2)mOH,
(4) \u2014(CH2)mN(Rj)2,
(5) \u2014(CH2)mNO2,
(6) \u2014(CH2)mCN,
(7) \u2014C1-6alkyl,
(8) \u2014(CH2)mCF3,
(9) \u2014(CH2)mOCF3,
(10)\u2014O\u2014(CH2)m\u2014OC1-6alkyl,
(11)\u2014(CH2)mC(O)N(Rj)2,
(12)\u2014(CH2)mC(=N\u2014OH)N(Rj)2,
(13)\u2014(CH2)mOC1-6alkyl,
(14) \u2014(CH2)mO\u2014(CH2)m\u2014C3-7cycloalkyl,
(15) \u2014(CH2)mO\u2014(CH2)m\u2014C2-7cycloheteroalkyl,
(16) \u2014(CH2)mO\u2014(CH2)m-aryl,
(17) \u2014(CH2)mO\u2014(CH2)m-heterolaryl,
(18) \u2014(CH2)mSC1-6alkyl,
(19) \u2014(CH2)mS(O)C1-6alkyl,
(20) \u2014(CH2)mSO2C1-6alkyl,
(21) \u2014(CH2)mSO2C3-7cycloalkyl,
(22) \u2014(CH2)mSO2C2-7cycloheteroalkyl,
(23) \u2014(CH2)mSO2-aryl,
(24) \u2014(CH2)mSO2-heteroaryl,
(25) \u2014(CH2)mSO2NHC1-6alkyl,
(26) \u2014(CH2)mSO2NHC3-7cycloalkyl,
(27) \u2014(CH2)mSO2NHC2-7cycloheteroalkyl,
(28) \u2014(CH2)mSO2NH-aryl,
(29) \u2014(CH2)mSO2NH-heteroaryl,
(30) \u2014(CH2)mNHSO2\u2014C1-6alkyl,
(31) \u2014(CH2)mNHSO2\u2014C3-7cycloalkyl,
(32) \u2014(CH2)mNHSO2\u2014C2-7cycloheteroalkyl,
(33) \u2014(CH2)mNHSO2-aryl,
(34) \u2014(CH2)mNHSO2NH-heteroaryl,
(35) \u2014(CH2)mN(Rj)\u2014C1-6alkyl,
(36) \u2014(CH2)mN(Rj)\u2014C3-7cycloalkyl,
(37) \u2014(CH2)mN(Rj)\u2014C2-7cycloheteroalkyl,
(38) \u2014(CH2)mN(Rj)\u2014C2-7cycloheteroalkenyl,
(39) \u2014(CH2)mN(Rj)-aryl,
(40) \u2014(CH2)mN(Rj)-heteroaryl,
(41) \u2014(CH2)mC(O)Rf,
(42) \u2014(CH2)mC(O)N(Rj)2,
(43) \u2014(CH2)mN(Rj)C(O)N(Rj)2,
(44) \u2014(CH2)mCO2H,
(45) \u2014(CH2)mOCOH,
(46) \u2014(CH2)mCO2Rf,
(47) \u2014(CH2)mOCORf,
(48) \u2014(CH2)mC3-7cycloalkyl,
(49) \u2014(CH2)mC3-7cycloalkenyl,
(50) \u2014(CH2)mC2-6cycloheteroalkyl,
(51) \u2014(CH2)mC2-6cycloheteroalkenyl,
(52) \u2014(CH2)maryl, and
(53) \u2014(CH2)mheteroaryl,

wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from: oxo, \u2014(CH2)l-3OH, \u2014CN, \u2014NH2, \u2014NH(C1-6alkyl), \u2014N(C1-6alkyl)2, \u2014C1-6alkyl (CH3) , OC1-6alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C1-6alkyl, \u2014C3-7cycloalkyl, phenyl, CH2phenyl, heteroaryl and CH2heteroaryl, and wherein alkyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: oxo, \u2014(CH2)0-5OH, \u2014CN, \u2014NH2, \u2014NH(C1-6alkyl), \u2014N(C1-6alkyl)2, \u2014C1-6alkyl, OC1-6alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C1-6alkyl, -SO2C1-6 alkyl, \u2014C3-7cycloalkyl, phenyl, CH2phenyl, heteroaryl and CH2heteroaryl;
each Rb is independently selected from:
(1) hydrogen,
(2) \u2014C1-6alkyl,
(3) \u2014C3-6cycloalkyl,
(4) \u2014C3-6cycloalkenyl,
(5) \u2014C2-6cycloheteroalkyl,
(6) \u2014C2-6cycloheteroalkenyl,
(7) aryl,
(8) heteroaryl,
(9) \u2014(CH2)t-halogen,
(10) \u2014(CH2)s\u2014OH,
(11) \u2014NO2,
(12) \u2014NH2,
(13) \u2014NH(C1-6alkyl),
(14) \u2014N(C1-6alkyl)2,
(15) \u2014OC1-6alkyl,
(16) \u2014(CH2)qCO2H,
(17) \u2014(CH2)qCO2C1-6alkyl,
(18) \u2014CF3,
(19) \u2014CN,
(20) \u2014SO2C1-6alkyl, and
(21) \u2014(CH2)sCON(Re)2,

wherein each CH2 is unsubstituted or substituted with 1 or 2 halogens, and wherein each alkyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl is unsubstituted or substituted with 1, 2 or 3 halogens;
each Rc is independently selected from:
(1) halogen,
(2) oxo,
(3) \u2014(CH2)rOH,
(4) \u2014(CH2)rN(Re)2,
(5) \u2014(CH2)rCN,
(6) \u2014C1-6alkyl,
(7) \u2014CF3,
(8) \u2014C1-6alkyl\u2014OH,
(9) \u2014OCH2OC1-6alkyl,
(10) \u2014(CH2)rOC1-6alkyl,
(11) \u2014OCH2aryl,
(12) \u2014(CH2)rSC1-6alkyl,
(13) \u2014(CH2)rC(O)Rf,
(14) \u2014(CH2)rC(O)N(Re)2,
(15) \u2014(CH2)rCO2H,
(16) \u2014(CH2)rCO2Rf,
(17) \u2014(CH2)rC3-7cycloalkyl,
(18) \u2014(CH2)rC2-6cycloheteroalkyl,
(19) \u2014(CH2)raryl, and
(20) \u2014(CH2)rheteroaryl,

wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from: oxo, \u2014OH, \u2014CN, \u2014N(Rh)2, \u2014C 1-6alkyl, \u2014OC1-6alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C1-6alkyl, \u2014C3-7cycloalkyl and heteroaryl, and wherein alkyl, cycloalkyl, cycloheteroalkyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: oxo, \u2014OH, \u2014CN, \u2014N(Rh)2, \u2014C 1-6alkyl, \u2014OC 1-6alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C 1-6alkyl, \u2014C3-7cycloalkyl and heteroaryl;
each Re, Rg and Rh is independently selected from:
(1) hydrogen,
(2) \u2014C1-6alkyl, and
(3) \u2014O\u2014C1-6alkyl,

wherein alkyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: \u2014OH, oxo, halogen, C1-6alkyl, \u2014OC1-6alkyl, \u2014NH2, \u2014NH(C1-6alkyl), and \u2014N(C1-6alkyl)2;
each Rj is independently selected from:
(1) hydrogen,
(2) C1-6alkyl,
(3) C3-6cycloalkyl,
(4) \u2014C(O)Ri, and
(5) \u2014SO2Ri,

wherein alkyl and cycloalkyl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: \u2014OH, oxo, halogen, C1-6alkyl, \u2014OC1-6alkyl, \u2014NH2, \u2014NH(C1-6alkyl), and \u2014N(C1-6 alkyl)2;
each Rf and Ri is independently selected from:
(1) C1-6alkyl,
(2) C4-7cycloalkyl,
(3) C4-7cycloalkenyl,
(4) C3-7cycloheteroalkyl,
(5) C3-7cycloheteroalkenyl,
(6) aryl, and
(7) heteroaryl,

wherein alkyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: oxo, \u2014OH, \u2014CN, \u2014NH2, \u2014C1-6alkyl, \u2014OC1-6alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C1-6alkyl, \u2014C3-7cycloalkyl, and heteroaryl;
n is 0, 1, 2, 3 or 4;
m is 0, 1, 2, 3 or 4;
p is 0, 1, 2, or 3;
q is 0, 1, 2, 3 or 4;
r is 0, 1 or 2;
s is 0, 1, 2, 3 or 4; and
t is 0,1,2,3or 4.
2. The compound according to claim 1 wherein:
T is N;
U is CR1;
V is CR2;
W is CR4;
X is selected from:
(1) \u2014O\u2014, and
(2) \u2014O\u2014CH2\u2014;

Y is selected from:
(1) C3-l0cycloalkyl,
(2) C3-l0cycloalkenyl,
(3) C2-10cycloheteroalkyl,
(4) C2-10cycloheteroalkenyl,
(5) aryl, and
(6) heteroaryl,

wherein cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from Rb;
Z is selected from:
(1) oxo,
(2) \u2014CF3,
(3) \u2014C1-6alkyl,
(4) \u2014(CH2)t-halogen,
(5) \u2014(CH2)nCO2H,
(6) \u2014(CH2)nOH, and
(7) \u2014(CH2)SO2C1-6alkyl,
wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from C1-6alkyl, \u2014OH and \u2014NH2, and wherein each alkyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from Rc;
each R1 and R2 is independently selected from:
(1) hydrogen,
(2) halogen,
(3) CN,
(4) CF3,
(5) \u2014Cl-6alkyl,
(6) \u2014C2-6alkenyl,
(7) \u2014C2-6alkynyl,
(8) \u2014(CH2)pC3-10cycloalkyl,
(9) \u2014(CH2)pC3-7cycloalkyl-aryl,
(10) \u2014(CH2)pC3-7cycloalkyl-heteroaryl,
(11) \u2014(CH2)pC4-10cycloalkenyl,
(12) \u2014(CH2)pC4-7cycloalkenyl-aryl,
(13) \u2014(CH2)pC4-7cycloalkenyl-heteroaryl,
(14) \u2014(CH2)pC2-10cycloheteroalkyl,
(15) \u2014(CH2)pC2-10cycloheteroalkenyl,
(16) \u2014(CH2)paryl,
(17) \u2014(CH2)paryl\u2014C3-7cycloalkyl,
(18) \u2014(CH2)paryl\u2014C2-7cycloheteroalkyl,
(19) \u2014(CH2)paryl-aryl,
(20) \u2014(CH2)paryl-heteroaryl,
(21) \u2014(CH2)pheteroaryl,
(22) \u2014C2-6alkenyl-alkyl,
(23) \u2014C2-6alkenyl-aryl,
(24) \u2014C2-6alkenyl-heteroaryl,
(25) \u2014C2-6alkenyl\u2014C3-7cycloalkyl,
(26) \u2014C2-6alkenyl\u2014C3-7cycloalkenyl,
(27) \u2014C2-6alkenyl\u2014C2-7cycloheteroalkyl,
(28) \u2014C2-6alkenyl\u2014C2-7cycloheteroalkenyl,
(29) \u2014C2-6alkynyl\u2014(CH2)1-3\u2014O\u2014aryl,
(30) \u2014C2-6alkynyl-alkyl,
(31) \u2014C2-6alkynyl-aryl,
(32) \u2014C2-6alkynyl-heteroaryl,
(33) \u2014C2-6alkynyl\u2014C3-7cycloalkyl,
(34) \u2014C2-6alkynyl\u2014C3-7cycloalkenyl,
(35) \u2014C2-6alkynyl\u2014C2-7cycloheteroalkyl,
(36) \u2014C2-6alkynyl\u2014C2-7cycloheteroalkenyl, and
(37) \u2014C(O)NH\u2014(CH2)0-3phenyl,

wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from: halogen, CF3, \u2014OH, \u2014NH2, \u2014C1-6alkyl, \u2014OC1-6alkyl, \u2014NHC1-6alkyl, and \u2014N(C1-6alkyl)2, wherein each alkyl, alkenyl and alkynyl is unsubstituted or substituted with 1, 2 or 3 substituents selected from: halogen, CF3, \u2014OH, \u2014NH2, \u2014C1-6alkyl, \u2014OC1-6alkyl, \u2014NHC1-6alkyl, and \u2014N(C1-6alkyl)2, and wherein each cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, phenyl, aryl and heteroaryl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra, provided that at least one of and only one of R1 and R2 is selected from the group consisting of: hydrogen, halogen, \u2014CN, \u2014CF3, \u2014C1-6alkyl, \u2014C2-6alkenyl and\u2014C2-6alkynyl;
each R4 is independently selected from:
(1) hydrogen,
(2) halogen,
(3) \u2014C1-6 alkyl,
(4) \u2014C2-6 alkenyl,
(5) \u2014C2-6 alkenyl,
(6) \u2014CN,
(7) \u2014CF3,
(8) \u2014OH,
(9) \u2014OC1-6alkyl,
(10) \u2014NH2,
(11) \u2014NHC1-6alkyl,
(12) \u2014N(C1-6alkyl)2,
(13) \u2014SC1-6alkyl,
(14) \u2014SOC1-6alkyl,
(15) \u2014SO2C1-6alkyl,
(16) \u2014NHSO2C1-6alkyl,
(17) \u2014NHC(O)C1-6alkyl,
(18) \u2014SO2NHC1-6alkyl, and
(19) \u2014C(O)NHC1-6alkyl;

R5 is selected from:
(1) hydrogen,
(2) \u2014C1-6alkyl,
(3) \u2014CH2CO2H, and
(4) \u2014CH2CO2C1-6alkyl;

each Ra is independently selected from the group consisting of:
(1) halogen,
(2) oxo,
(3) \u2014(CH2)mOH,
(4) \u2014(CH2)mN(Rj)2,
(5) \u2014(CH2)mNO2,
(6) \u2014(CH2)mCN,
(7) \u2014C1-6alkyl,
(8) \u2014(CH2)mCF3,
(9) \u2014(CH2)mOCF3,
(10) \u2014OCH2OC1-6alkyl,
(11) \u2014(CH2)mC(O)N(Rj)2,
(12) \u2014(CH2)mC(=N\u2014OH)N(Rj)2,
(13) \u2014(CH2)mOC1-6alkyl,
(14) \u2014(CH2)mO\u2014(CH2)m\u2014C3-7cycloalkyl,
(15) \u2014(CH2)mO\u2014(CH2)m\u2014C2-7cycloheteroalkyl,
(16) \u2014(CH2)mO\u2014(CH2)m-aryl,
(17) \u2014(CH2)mO\u2014(CH2)m-heteroaryl,
(18) \u2014(CH2)mSC1-6alkyl,
(19) \u2014(CH2)mS(O)C1-6alkyl,
(20) \u2014(CH2)mSO2C1-6alkyl,
(21) \u2014(CH2)mSO2C3-7cycloalkyl,
(22) \u2014(CH2)mSO2C2-7cycloheteroalkyl,
(23) \u2014(CH2)mSO2-aryl,
(24) \u2014(CH2)mSO2-heteroaryl,
(25) \u2014(CH2)mSO2NHC1-6alkyl,
(26) \u2014(CH2)mSO2NHC3-7cycloalkyl,
(27) \u2014(CH2)mSO2NHC2-7cycloheteroalkyl,
(28) \u2014(CH2)mSO2NH-aryl,
(29) \u2014(CH2)mSO2NH-heteroaryl,
(30) \u2014(CH2)mNHSO2\u2014C1-6a1kyl,
(31) \u2014(CH2)mNHSO2\u2014C3-7cycloalkyl,
(32) \u2014(CH2)mNHSO2\u2014C2-7cycloheteroalkyl,
(33) \u2014(CH2)mNHSO2-aryl,
(34) \u2014(CH2)mNHSO2NH-heteroaryl,
(35) \u2014(CH2)mC(O)Rf,
(36) \u2014(CH2)mC(O)N(Rj)2,
(37) \u2014(CH2)mN(Rj)C(O)N(Rj)2,
(38) \u2014(CH2)mCO2H,
(39) \u2014(CH2)mOCOH,
(40) \u2014(CH2)mCO2Rf,
(41) \u2014(CH2)mOCORf,
(42) \u2014(CH2)mC3-7cycloalkyl,
(43) \u2014(CH2)mC3-7cycloalkenyl,
(44) \u2014(CH2)mC2-6cycloheteroalkyl,
(45) \u2014(CH2)mC2-6cycloheteroalkenyl,
(46) \u2014(CH2)maryl, and
(47) \u2014(CH2)mheteroaryl,

wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from: oxo, \u2014(CH2)0-3 OH, \u2014CN, \u2014NH2, \u2014NH(C1-6alkyl), \u2014N(C1-6alkyl)2, \u2014C1-6alkyl, \u2014OC1-6alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C1-6alkyl, \u2014C3-7cycloalkyl, phenyl, CH2phenyl, heteroaryl and CH2heteroaryl, and wherein alkyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: oxo, \u2014(CH2)0-3OH, \u2014CN, \u2014NH2, \u2014NH(C1-6alkyl), \u2014N(C1-6alkyl)2, \u2014C1-6alkyl, \u2014OC1-6alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C1-6alkyl, -SO2C1-6 alkyl, \u2014C3-7cycloalkyl, phenyl, CH2phenyl, heteroaryl and CH2heteroaryl;
each Rb is independently selected from:
(1) hydrogen,
(2) \u2014C1-6alkyl,
(3) \u2014C3-6cycloalkyl,
(4) \u2014C3-6cycloalkenyl,
(5) \u2014C2-6cycloheteroalkyl,
(6) \u2014C2-6cycloheteroalkenyl,
(7) aryl,
(8) heteroaryl,
(9) \u2014(CH2)t-halogen,
(10) \u2014(CH2)s-OH,
(11) \u2014NO2,
(12) \u2014NH2,
(13) \u2014NH(C1-6ablkyl),
(14) \u2014N(C1-6alkyl)2,
(15) \u2014OC1-6alkyl,
(16) \u2014(CH2)qCO2H,
(17) \u2014(CH2)qCO2C1-6alkyl,
(18) \u2014CF3,
(19) \u2014CN,
(20) \u2014SO2C1-6alkyl, and
(21) \u2014(CH2)sCON(Re)2,

wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from: oxo, \u2014OH, \u2014CN, \u2014N(Rh)2, \u2014C 1-6alkyl, \u2014OC1-6alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C1-6 alkyl, \u2014C3\u20147cycloalkyl and heteroaryl, and wherein alkyl, cycloalkyl, cycloheteroalkyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: oxo, \u2014OH, \u2014CN, \u2014N(Rh)2, \u2014C1-6alkyl, \u2014OC1-6 alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C1-6 alkyl, \u2014C3-7cycloalkyl and heteroaryl;
each Re, Rg and Rh is independently selected from:
(1) hydrogen,
(2) \u2014C1-6alkyl, and
(3) \u2014O\u2014Cl-6alkyl,

wherein alkyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: \u2014OH, oxo, halogen, C1-6 alkyl, \u2014OC1-6 alkyl, \u2014NH2, \u2014NH(C1-6 alkyl), and \u2014N(C1-6alkyl)2;
each Rj is independently selected from:
(1) hydrogen,
(2) C1-6alkyl,
(3) C3-6cycloalkyl,
(4) \u2014C(O)Ri, and
(5) \u2014SO2Ri,

wherein alkyl and cycloalkyl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: \u2014OH, oxo, halogen, C1-6alkyl, \u2014OC1-6alkyl, \u2014NH2, \u2014NH(C1-6alkyl), and \u2014N(C1-6 alkyl)2;
each Rf and Ri is independently selected from:
(1) C1-6alkyl,
(2) C4\u20147cycloalkyl,
(3) C4\u20147cycloalkenyl,
(4) C3\u20147cycloheteroalkyl,
(5) C3\u20147cycloheteroalkenyl,
(6) aryl, and
(7) heteroaryl,

wherein alkyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from: oxo, \u2014OH, \u2014CN, \u2014NH2, \u2014C1-6alkyl, \u2014OC1-6alkyl, halogen, \u2014CH2F, \u2014CHF2, \u2014CF3, \u2014CO2H, \u2014CO2C1-6alkyl, \u2014C3-7cycloalkyl, and heteroaryl;
n is 0, 1, 2, 3 or 4;
m is 0, 1, 2, 3 or 4;
p is 0, 1, 2, or 3;
q is 0, 1, 2, 3 or 4;
r is 0, 1 or 2;
s is 0, 1, 2, 3 or 4; and
t is 0, 1, 2, 3 or 4,
or a pharmaceutically acceptable salt thereof.
3. The compound according to claim 2, wherein X is \u2014O\u2014; or a pharmaceutically acceptable salt thereof.
4. The compound according to claim 2, wherein Y is selected from:
(1) C3-10cycloalkyl,
(2) C2-10cycloheteroalkyl, and
(3) aryl,

wherein cycloalkyl, cycloheteroalkyl and aryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from Rb; or a pharmaceutically acceptable salt thereof.
5. The compound according to claim 4, wherein Y is selected from:
(1) C3-7cycloalkyl,
(2) C2-l0cycloheteroalkyl, and
(3) phenyl,

wherein each cycloalkyl, cycloheteroalkyl and phenyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from Rb; or a pharmaceutically acceptable salt thereof.
6. The compound according to claim 2, wherein Z is selected from:
(1) \u2014(CH2)nCO2H, and
(2) \u2014(CH2)nOH,

wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from C1-6alkyl, \u2014OH and \u2014NH2; or a pharmaceutically acceptable salt thereof.
7. The compound according to claim 1, wherein each R1 and R2 is independently selected from:
(1) halogen,
(2) \u2014C4-10cycloalkenyl,
(3) -phenyl,
(4) -phenyl\u2014C2-8alkynyl\u2014C1-8alkyl,
(5) -phenyl\u2014C2-3alkynyl\u2014C3-7cycloalkyl,
(6) -phenyl\u2014C2-3alkynyl\u2014C2-10cycloheteroalkyl,
(7) -phenyl\u2014C3-7cycloalkyl,
(8) -phenyl\u2014C2-7cycloheteroalkyl,
(9) -phenyl\u2014C2-10cycloheteroalkenyl,
(10) -phenyl-aryl,
(11) -phenyl-heteroaryl,
(12) -heteroaryl, and
(13) \u2014C2-6alkynyl-phenyl,

and wherein each alkyl, alkynyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, phenyl, aryl and heteroaryl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra, provided that at least one of and only one of R1 and R2 is selected from halogen; or a pharmaceutically acceptable salt thereof.
8. The compound according to claim 7, wherein R1 is independently selected from:
(1) \u2014C4-10ocycloalkenyl,
(2) -phenyl,
(3) -phenyl\u2014C2alkynylC1-5alkyl,
(4) -phenyl\u2014C2-3alkynyl- C3-7cycloalkyl,
(5) -phenyl\u2014C2-3alkynyl\u2014C2-10cycloheteroalkyl,
(6) -phenyl\u2014C3-7cycloalkyl,
(7) -phenyl\u2014C2-7cycloheteroalkyl,
(8) -phenyl\u2014C2-10cycloheteroalkenyl,
(9) -phenyl-phenyl,
(10) -phenyl-heteroaryl,
(11) -heteroaryl, and
(12) \u2014C2-6alkynyl-phenyl,

wherein each alkyl, alkynyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, phenyl and heteroaryl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra; and
R2 is selected from halogen;
or a pharmaceutically acceptable salt thereof.
9. The compound according to claim 8, wherein each R1 is independently selected from:
(1) -phenyl\u2014C2-7cycloheteroalkyl,
(2) -phenyl\u2014C2-10cycloheteroalkenyl,
(3) -phenyl-phenyl, and
(4) -phenyl-heteroaryl,

wherein each cycloheteroalkyl, cycloheteroalkenyl, heteroaryl and phenyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra; and R2 is halogen;
or a pharmaceutically acceptable salt thereof.
10. The compound according to claim 2, wherein each R1 and R2 is independently selected from:
(1) halogen,
(2) \u2014C4-10cycloalkenyl,
(3) -phenyl,
(4) -phenyl\u2014C3-7cycloalkyl,
(5) -phenyl\u2014C2-7cycloheteroalkyl,
(6) -phenyl-aryl,
(7) -phenyl-heteroaryl,
(8) -heteroaryl, and
(9) \u2014C2-6alkynyl-phenyl,

wherein each alkynyl is unsubstituted or substituted with 1, 2 or 3 substituents selected from: halogen, CF3, \u2014OH, \u2014NH2, \u2014C1-6alkyl, \u2014OC1-6alkyl, \u2014NHC1-6alkyl, and \u2014N(C1-6alkyl)2, and wherein each cycloalkyl, cycloalkenyl, cycloheteroalkyl, phenyl, aryl and heteroaryl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra, provided that at least one of and only one of R1 and R2 is selected from halogen; or a pharmaceutically acceptable salt thereof.
11. The compound according to claim 10, wherein R1 is independently selected from:
(1) \u2014C4-10ocycloalkenyl,
(2) -phenyl,
(3) -phenyl\u2014C3-7cycloalkyl,
(4) -phenyl\u2014C2-7cycloheteroalkyl,
(5) -phenyl-phenyl,
(6) -phenyl-heteroaryl,
(7) -heteroaryl, and
(8) \u2014C2\u20146alkynyl-phenyl,

wherein each alkynyl is unsubstituted or substituted with 1, 2 or 3 substituents selected from: halogen, CF3, \u2014OH, \u2014NH2, \u2014C1-6alkyl, \u2014OC1-6alkyl, \u2014NHC1-6alkyl, and \u2014N(C1-6alkyl)2, and wherein each cycloalkyl, cycloalkenyl, cycloheteroalkyl, phenyl and heteroaryl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra; and
R2 is selected from: halogen;
or a pharmaceutically acceptable salt thereof.
12. The compound according to claim 11, wherein each R1 is independently selected from:
(1) -phenyl\u2014C2-7cycloheteroalkyl, and
(2) -phenyl-phenyl,

wherein each cycloheteroalkyl and phenyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra, and
R2 is selected from halogen;
or a pharmaceutically acceptable salt thereof.
13. The compound according to claim 2, wherein R4 is hydrogen or absent; and R5 is hydrogen; or a pharmaceutically acceptable salt thereof.
14. The compound according to claim 1 wherein:
T is N;
U is \u2014CR1\u2014;
V is \u2014CR2\u2014;
W is \u2014CR4\u2014;
X is selected from:
(1) \u2014O\u2014, and
(2) \u2014O\u2014CH2\u2014;

Y is selected from:
(1) \u2014C3-10ycloalkyl,
(2) \u2014C2-10cycloheteroalkyl, and
(3) -phenyl,

wherein cycloalkyl, cycloheteroalkyl and phenyl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from Rb;
Z is selected from:
(1) oxo,
(2) \u2014CF3,
(3) \u2014C1-6alkyl,
(4) \u2014(CH2)t-halogen,
(5) \u2014(CH2)nCO2H,
(6) \u2014(CH2)nOH, and
(7) \u2014(CH2)nSO2C1-6alkyl,

wherein each alkyl, alkynyl, cycloalkyl, cycloalkenyl, cycloheteroalkyl, cycloheteroalkenyl, phenyl and heteroaryl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra;
R2 is selected from halogen;
R4 is hydrogen; and
R5 is hydrogen;
or a pharmaceutically acceptable salt thereof.
15. The compound according to claim 2 wherein:
T is N;
U is \u2014CR1\u2014;
V is \u2014CR2\u2014;
W is \u2014CR4\u2014;
X is selected from:
(1) \u2014O\u2014, and
(2) \u2014O\u2014CH2\u2014;

Y is selected from:
(1) C3-10cycloalkyl,
(2) C2-10cycloheteroalkyl, and
(3) phenyl,

wherein cycloalkyl, cycloheteroalkyl and phenyl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from Rb;
Z is selected from:
(1) oxo,
(2) CF3,
(3) \u2014C1-6alkyl,
(4) \u2014(CH2)t-halogen,
(5) \u2014(CH2)nCO2H,
(6) \u2014(CH2)nOH, and
(7) \u2014(CH2)nSO2C1-6alkyl,

wherein each alkynyl is unsubstituted or substituted with 1, 2 or 3 substituents selected from:
halogen, CF3, \u2014OH, \u2014NH2, \u2014C1-6alkyl, \u2014OC1-6alkyl, \u2014NHC1-6alkyl, and \u2014N(C1-6alkyl)2, and wherein each cycloalkyl, cycloalkenyl, cycloheteroalkyl, phenyl and heteroaryl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra;
R2 is selected from halogen;
R4 is hydrogen; and
R5 is hydrogen;
or a pharmaceutically acceptable salt thereof.
16. The compound according to claim 2 wherein:
T is N;
U is \u2014CR1\u2014;
V is \u2014CR2\u2014;
W is \u2014CR4\u2014;
X is \u2014O\u2014;
Y is selected from:
(1) C3-7cycloalkyl,
(2) C2-10cycloheteroalkyl, and
(3) phenyl,

wherein each cycloalkyl, cycloheteroalkyl and phenyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from Rb;
Z is selected from:
(1) \u2014(CH2)nCO2H, and
(2) \u2014(CH2)nOH,

wherein each CH2 is unsubstituted or substituted with 1 or 2 substituents selected from C1-6alkyl and \u2014OH;
R1is selected from:
(1) -phenyl\u2014C2-7cycloheteroalkyl, and
(2) -phenyl-phenyl,

wherein each cycloheteroalkyl and phenyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra;
R2 is selected from halogen;
R4 is hydrogen; and
R5 is hydrogen;
or a pharmaceutically acceptable salt thereof.
17. The compound according to claim 16, selected from:
or a pharmaceutically acceptable salt thereof.
18. The compound according to claim 1 wherein:
T is N;
U is\u2014CR1\u2014;
V is\u2014CR2\u2014;
W is\u2014CR4\u2014;
X is\u2014O\u2014;
Y is selected from C2-10cycloheteroalkyl, wherein each cycloheteroalkyl is unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from Rb;
Z is selected from: \u2014(CH2)n OH;
R1 is independently selected from:
(1) -phenyl\u2014C2-10 cycloheteroalkenyl,
(2) -biphenyl, and
(3) -phenyl-heteroaryl,

wherein each cycloheteroalkenyl, phenyl, biphenyl and heteroaryl is unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from Ra;
R2 is selected from halogen;
R4 is hydrogen; and
R5 is hydrogen;
or a pharmaceutically acceptable salt thereof.
19. The compound according to claim 18, selected from:
or a pharmaceutically acceptable salt thereof.
20. A composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier.
21. A composition comprising a compound according to claim 1 and a compound selected from simvastatin, ezetimibe, taranabant and sitagliptin; and a pharmaceutically acceptable carrier.
22. A method of treating a disorder, condition or disease responsive to the activation of AMP-activated protein kinase in a patient in need thereof comprising administration of a therapeutically effective amount of a compound according to claim 1, wherein the disorder, condition, or disease is selected from the group consisting of:
Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, hypertension, and cancer.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A machine readable medium that stores instructions which when performed by a wireless device, cause the wireless device to perform operations for configuring a full duplex communication, the operations comprising:
determine an echo cancellation parameter;
send the echo cancellation parameter to a controlling wireless device;
receive a full duplex communication parameter, the full duplex communication parameter determined by the controlling wireless device based upon the echo cancellation parameter; and
responsive to receiving the full duplex communication parameter, simultaneously transmitting packets to and receiving packets from the controlling wireless device using the full duplex communication parameter on the same wireless channel.
2. The machine-readable medium of claim 1, wherein the wireless device is not capable of cancelling out interference from transmissions at maximum power to a level at or below a receiver of the wireless device’s noise floor, and wherein the operations of calculating the full duplex communication parameter comprise calculating the full duplex communication parameter to allow echo cancellation circuitry of the wireless device to cancel a transmission made by the wireless device.
3. The machine-readable medium of claim 1, wherein the echo cancellation parameter is sent in a Medium Access Control (MAC) management message and the full duplex communication parameter is received in a MAC management message.
4. The machine-readable medium of claim 1, wherein the echo cancellation parameter is one of: an amount of echo cancellation the wireless device is capable of, a receiver noise figure, a maximum modulation and coding scheme (MCS), a measurement of the wireless medium, a transmission power, and a full-duplex period duration.
5. The machine-readable medium of claim 1, wherein the full duplex communication parameter is a modulation and coding scheme (MCS).
6. The machine-readable medium of claim 1, wherein the wireless device and the controlling wireless device operate according to one of an 802.11 family of standards.
7. The machine-readable medium of claim 1, wherein the wireless device includes a first and a second antenna, and wherein the operations of simultaneously transmitting packets to and receiving packets from the controlling wireless device comprises using the first antenna for receiving the packets and the second antenna for transmitting the packets to the controlling wireless device.
8. A machine readable medium that stores instructions which when performed by a wireless device, cause the wireless device to perform operations for configuring a full duplex communication, the operations comprising:
determine a first echo cancellation parameter specific to the wireless device;
receive a second echo cancellation parameter from a controlled wireless device;
calculate a full duplex communication parameter, the full duplex communication parameter determined based upon the first and second echo cancellation parameters;
send the full duplex communication parameter to the controlled wireless device; and
responsive to receiving the full duplex communication parameter, simultaneously transmitting packets to and receiving packets from the controlled wireless device using the full duplex communication parameter on the same wireless channel.
9. The machine readable medium of claim 8, wherein the wireless device is not capable of cancelling out interference from transmissions at maximum power to a level at or below a receiver of the wireless device’s noise floor and wherein the operations of calculating the full duplex communication parameter comprise operations for calculating the full duplex communication parameter to allow echo cancellation circuitry of the wireless device to cancel a transmission made by the wireless device and to allow echo cancellation circuitry of the controlled wireless device to cancel a transmission made by the controlled wireless device.
10. The machine readable medium of claim 9, wherein the full duplex communication parameter is a modulation and coding scheme (MCS) and wherein the operations of calculating the MCS comprise calculating the MCS so as to prioritize a connection throughput between the wireless device and the controlled wireless device over a connection latency between the wireless device and the controlled wireless device.
11. The machine readable medium of claim 9, wherein the full duplex communication parameter is a modulation and coding scheme (MCS) and wherein the operations of calculating the MCS comprise calculating the MCS so as to prioritize a connection latency between the wireless device and the controlled wireless device over a connection throughput between the wireless device and the controlled wireless device.
12. The machine readable medium of claim 8, wherein the second echo cancellation parameter is received in a Medium Access Control (MAC) management message and the full duplex communication parameter is sent in a MAC management message.
13. The machine readable medium of claim 8, wherein the echo cancellation parameter is one of: an amount of echo cancellation the wireless device is capable of, a receiver noise figure, a maximum modulation and coding scheme (MCS), a measurement of the wireless medium, a transmission power, and a full-duplex period duration.
14. The machine readable medium of claim 1, wherein the full duplex communication parameter is a modulation and coding scheme (MCS).
15. A wireless device comprising:
a memory and one or more processors configured to include:
a Medium Access Control (MAC) layer module configured to:
determine an echo cancellation parameter;
send the echo cancellation parameter to a controlling wireless device;
receive a full duplex communication parameter, the full duplex communication parameter determined by the controlling wireless device based upon the echo cancellation parameter; and
responsive to receiving the full duplex communication parameter, cause a physical layer module to simultaneously transmit packets to and receive packets from the controlling wireless device using the full duplex communication parameter on the same wireless channel.
16. The wireless device of claim 15, wherein the wireless device is not capable of cancelling out interference from transmissions at maximum power to a level at or below a receiver of the wireless device’s noise floor and wherein the full duplex communication parameter is calculated to allow echo cancellation circuitry of the wireless device to cancel a transmission made by the wireless device.
17. The wireless device of claim 15, wherein the echo cancellation parameter is sent in a Medium Access Control (MAC) management message and the full duplex communication parameter is received in a MAC management message.
18. The wireless device of claim 15, wherein the echo cancellation parameter is one of: an amount of echo cancellation the wireless device is capable of, a receiver noise figure, a maximum modulation and coding scheme (MCS), a measurement of the wireless medium, a transmission power, and a full-duplex period duration.
19. The wireless device of claim 15, wherein the wireless device includes a first antenna and wherein the physical layer is configured to simultaneously transmit packets to and receive packets from the controlling wireless device using the first antenna to both receive the packets and transmit the packets.
20. The wireless device of claim 15, wherein the MAC layer module is configured to send a block acknowledgment acknowledging a plurality of received packets.
21. The wireless device of claim 15, wherein the MAC layer module is configured to:
receive a packet that requires an immediate response and in response:
wait until a current packet is finished transmission;
wait a predetermined amount of time; and
cause an acknowledgment to the packet that requires an immediate response to be transmitted.
22. A wireless device comprising:
a memory and one or more processors configured to include:
a Medium Access Control (MAC) layer module configured to:
determine a first echo cancellation parameter specific to the wireless device;
receive a second echo cancellation parameter from a controlled wireless device;
calculate a full duplex communication parameter, the full duplex communication
parameter determined based upon the first and second echo cancellation parameters;
send the full duplex communication parameter to the controlled wireless device; and
responsive to receiving the full duplex communication parameter, cause a physical layer module to simultaneously transmit packets to and receive packets from the controlled wireless device using the full duplex communication parameter on the same wireless channel.
23. The wireless device of claim 22, wherein the wireless device is not capable of cancelling out interference from transmissions at maximum power to a level at or below a receiver of the wireless device’s noise floor, and wherein the MAC layer is configured to calculate the full duplex communication parameter to allow echo cancellation circuitry of the wireless device to cancel a transmission made by the wireless device and to allow echo cancellation circuitry of the controlled wireless device to cancel a transmission made by the controlled wireless device.
24. The wireless device of claim 23, wherein the MAC layer is configured to calculate the MCS so as to prioritize a connection throughput between the wireless device and the controlled wireless device over a connection latency between the wireless device and the controlled wireless device.
25. The wireless device of claim 23, wherein the MAC layer is configured to calculate the MCS so as to prioritize a connection latency between the wireless device and the controlled wireless device over a connection throughput between the wireless device and the controlled wireless device.
26. The wireless device of claim 22, comprising an antenna coupled to the physical layer.