Author: claimsbot

1. A memory structure comprising;
a) a substrate;
b) a plurality of bottom electrodes overlying the substrate;
c) a plurality of top electrodes overlying the bottom electrodes; and
d) a continuous active layer interposed between the plurality of top electrodes and the plurality of bottom electrodes, wherein the continuous active layer is a perovskite material.
2. The memory structure of claim 1, wherein the bottom electrodes comprise a bottom electrode material that allows for epitaxial formation of the continuous active layer overlying the bottom electrodes.
3. The memory structure of claim 2, wherein the bottom electrode material is YBCO.
4. The memory structure of claim 1, wherein the bottom electrode material is platinum.
5. The memory structure of claim 1, wherein the continuous active layer is a colossal magnetoresistance (CMR) material.
6. The memory structure of claim 1, wherein the continuous active layer is Pr0.7Ca0.3MnO8 (PCMO).
7. The memory structure of claim 1, wherein the continuous active layer is Gd0.7Ca0.3BaCo2O5+5.
8. The memory structure of claim 1, wherein the substrate comprises an amorphous material, a polycrystalline material or a crystalline material.
9. The memory structure of claim 8, wherein the substrate comprises Si, LaAlO3, or TiN.
10. The memory structure of claim 1, wherein the plurality of bottom electrodes comprise substantially parallel rows.
11. The memory structure of claim 1, wherein the plurality of top electrodes comprise substantially parallel lows.
12. The memory structure of claim 1, wherein the plurality of bottom electrodes and the plurality of top electrodes overlying the plurality of bottom electrodes form a cross point array.
13. The memory structure of claim 12, wherein the plurality of top electrodes overlie the plurality of bottom electrodes at a substantially ninety degree angle.
14. The memory structure of claim 1, wherein the plurality of bottom electrodes is between about 5 nm and 500 nm thick.
15. The memory structure of claim 1, wherein the continuous active layer is between about 5 nm and 600 nm thick.
16. The memory structure of claim 1, wherein the plurality of top electrodes comprise platinum, copper, silver, or gold.
17. A memory structure comprising;
a) a substrate;
b) a plurality of bottom electrodes overlying the substrate, wherein the plurality of bottom electrodes comprise substantially parallel rows;
c) a plurality of top electrodes, which comprise substantially parallel rows, overlying the bottom electrodes at a substantially ninety degree angle, whereby a cross point is formed at each point where one of the plurality of top electrodes crosses over one of the plurality of bottom electrodes; and
d) a continuous active layer interposed between the plurality of top electrodes and the plurality of bottom electrodes and extending through more than one cross point.
18. The memory structure of claim 17, wherein the continuous active layer is Pr0.7Ca0.3MnO3 (PCMO).
19. The memory structure of claim 17, wherein the continuous active layer is Gd0.7Ca0.3BaCo2O5+5.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. An oral dosage form of a compound selected from boronic acids which have a neutral thrombin PI domain linked to a hydrophobic moiety capable of binding to the thrombin S2 and S3 subsites, and salts, prodrugs and prodrug salts of such acids, the dosage form comprising a solid phase formulation comprising the compound and being adapted for reconstitution of the formulation to form a liquid preparation.
2. The dosage form of claim 1 wherein the thrombin P1 domain comprises a neutral aminoboronic acid residue.
3. The dosage form of claim 1 wherein the boronic acid is of formula (I):
wherein
Y comprises a moiety which, together with the fragment \u2014CH(R9)\u2014B(OH)2, has affinity for the substrate binding site of thrombin; and
R9 is a straight chain alkyl group interrupted by one or more ether linkages and in which the total number of oxygen and carbon atoms is 3, 4, 5 or 6 or R9 is \u2014(CH2)m\u2014W where m is from 2, 3, 4 or 5 and W is \u2014OH or halogen, wherein halogen is F, Cl, Br or I.
4. The dosage form of claim 3 wherein R9 is an alkoxyalkyl group.
5. The dosage form of claim 3 wherein Y comprises
an amino group bonded to structural fragment \u2014CH(R9)\u2014B(OH)2, and
a hydrophobic moiety which is linked to said amino group and which, together with said structural fragment, has affinity for the substrate binding site of thrombin.
6. The dosage form of claim 5 wherein Y comprises an amino acid which binds to the S2 subsite of thrombin, the amino acid being N-terminally linked to a moiety which binds the S3 subsite of thrombin.
7. The dosage form of claim 6 wherein Y is an optionally N-terminally protected dipeptide which binds to the S3 and S2 binding sites of thrombin and the peptide linkages in the acid are optionally and independently N-substituted by a C1-C13 hydrocarbyl optionally containing in-chain or in-ring nitrogen, oxygen or sulfur and optionally substituted by a substituent selected from halo, hydroxy and trifluoromethyl.
8. The dosage form of claim 7 wherein the S3-binding amino acid residue is of (R) configuration, the S2-binding residue is of (S) configuration, and the fragment \u2014NHCH(R9)\u2014B(OH)2 is of (R) configuration.
9. The dosage form of claim 1 wherein said compound is a pharmaceutically acceptable base addition salt of a said acid.
10. An oral pharmaceutical dosage form adapted to be reconstituted either
prior to administration into a liquid for oral administration, or
in the mouth,
and comprising a compound selected from boronic acids of formula (III) and salts, prodrugs and prodrug salts thereof:
where:
X is H (to form NH2) or an amino-protecting group;
aa1 is an amino acid having a hydrocarbyl side chain containing no more than 20 carbon atoms and comprising at least one cyclic group having up to 13 carbon atoms;
aa2 is an imino acid having from 4 to 6 ring members; and
R1 is a group of the formula \u2014CH2)s-Z, where s is 2, 3 or 4 and Z is \u2014OH, \u2014OMe, \u2014OEt or halogen, wherein halogen is F, Cl, Br or I.
11. The dosage form of claim 10 wherein aa1 is selected from Phe, Dpa and wholly or partially hydrogenated analogues thereof.
12. The dosage form of claim 10 wherein aa2 is a residue of an imino acid of formula (IV)
where R11 is \u2014CH2\u2014, \u2014CH2\u2014CH2\u2014, \u2014CH2\u2550CH2\u2014, \u2014S\u2014CH2\u2014, \u2014S\u2014C(CH3)2\u2014 or \u2014CH2\u2014CH2\u2014CH2\u2014, which residue, when the ring contained therein is 5- or 6-membered, is optionally substituted at one or more \u2014CH2\u2014 groups by from 1 to 3 C1-C3 alkyl groups.
13. The dosage form of claim 10 wherein aa1 is of (R)-configuration, aa2 is of (S)-configuration and the fragment \u2014NH\u2014CH(R1)\u2014B(OH)2 is of (R)-configuration.
14. The dosage form of claim 10 wherein R1 is 2-bromoethyl, 2-chloroethyl, 2-methoxyethyl, 3-bromopropyl, 3-chloropropyl or 3-methoxypropyl.
15. The dosage form of claim 10 where X is R6\u2014(CH2)p\u2014C(O)\u2014, R6\u2014(CH2)p\u2014S(O)2\u2014, R6\u2014(CH2)p\u2014NH\u2014C(O)\u2014 or R6\u2014(CH2)p\u2014O\u2014C(O)\u2014 wherein p is 0, 1, 2, 3, 4, 5 or 6 and R6 is H or a 5 to 13-membered cyclic group optionally substituted by one or more halogens andor by 1, 2 or 3 substituents selected from amino, nitro, hydroxy, a C5-C6 cyclic group, C1-C4 alkyl and C1-C4 alkyl containing, andor linked to the cyclic group through, an in-chain O, the aforesaid alkyl groups optionally being substituted by a substituent selected from halogen, amino, nitro, hydroxy and a C5-C6 cyclic group.
16. The dosage form of claim 10 wherein the boronic acid is of formula (VIII):
X\u2014(R)-Phe-(S)-Pro-(R)-Mpg-B(OH)2\u2003\u2003(VIII).
17. The dosage form of claim 9 wherein the salt comprises a salt of the boronic acid with a metal.
18. The dosage form of claim 17 wherein the metal comprises an alkali metal.
19. The dosage form of claim 1 which comprises boronate ions derived from the boronic acid and has a stoichiometry consistent with the boronate ions carrying a single negative charge.
20. The dosage form of claim 1 which comprises:
a pharmaceutical formulation which contains said compound and is in the form of powder or granules; and
a sealed container in which the formulation is contained and from which the formulation is to be dispensed for reconstitution.
21-22. (canceled)
23. The dosage form of claim 20 wherein the container is a sachet.
24. The dosage form of claim 1 wherein the solid phase formulation is a pharmaceutical formulation in the form of an effervescent tablet which contains an effervescent system, or is a fast melt pharmaceutical formulation.
25. (canceled)
26. The dosage form of claim 20 which comprises from about 0.2 to about 1.5 mol of the compound, calculated on the basis of the boronic acid.
27. (canceled)
28. The dosage form of claim 1 which is adapted to be reconstituted to form a solution having a volume of from about 50 ml to about 150 ml.
29. A pharmaceutical formulation comprising a pharmaceutically acceptable base addition salt of the acid Cbz-(R)-Phe-(S)-Pro-(R)-Mpg-B(OH)2, the formulation being in the form of a powder or granules in a sachet or of an effervescent tablet.
30. A method of making an oral dosage form for preventing thrombosis, comprising:
reacting a boronic acid which has a neutral thrombin P1 domain linked to a hydrophobic moiety capable of binding to the thrombin S2 and S3 subsites with a base selected from the group consisting of basic metal compounds and organic nitrogen-containing compounds having a pKb of at least 7, to form a reaction product; and
formulating the reaction product into a solid phase formulation which comprises the reaction product and is adapted for reconstitution of the formulation to form a liquid preparation.
31. A method for the manufacture of a medicament to be reconstituted to form a drinkable preparation, comprising making the medicament with a compound as defined in claim 1.
32-33. (canceled)
34. A method of preparing an anticoagulant preparation, comprising reconstituting, into a liquid preparation for oral administration a solid phase formulation comprising:
a) a first species selected from the group consisting of a boronic acid of formula (I) below, said acid when in the form of a boronate anion thereof, an equilibrium form of said boronic acid and of said boronate ion, and combinations thereof:
wherein
Y comprises a hydrophobic moiety which, together with the aminoboronic acid residue \u2014NHCH(R9)\u2014B(OH)2, has affinity for the substrate binding site of thrombin; and
R9 is a straight chain alkyl group interrupted by one or more ether linkages and in which the total number of oxygen and carbon atoms is 3, 4, 5 or 6 or R9 is \u2014(CH2)m\u2014W where m is 2, 3, 4 or 5 and W is \u2014OH or halogen, wherein halogen is F, Cl, Br or I; and

(b) a second species selected from the group consisting of pharmaceutically acceptable metal ions and strongly basic organic nitrogen-containing compounds.
35. A method of inhibiting thrombin in the treatment of disease, comprising administering perorally to a subject in need thereof a therapeutically effective amount of a compound as defined in claim 1, said compound being put into solution or suspension from a solid phase formulation prior to the compound entering the stomach.
36. The method of claim 35, wherein the compound is put into solution or suspension by reconstituting with a liquid prior to administration or in saliva in the mouth.
37. A method of preventing thrombosis in the haemodialysis circuit of a patient, comprising reconstituting into a drinkable preparation a solid formulation comprising a salt as defined in claim 9, and orally administering the drinkable preparation.
38-39. (canceled)
40. A method of preventing deep vein thrombosis during an airplane flight in a subject comprising administering to the subject a therapeutically effective amount of a compound as defined in claim 1.
41-42. (canceled)
43. A method of preventing thrombosis in intermittent apheresis comprising administering a therapeutically effective amount of a compound as defined in claim 1, wherein said intermittent apheresis is not hemodialysis.
44. The method of claim 43, wherein the intermittent apheresis is extracorporeal liver detoxification.
45. The method of claim 43, wherein the compound is an oral medicament or is a parenteral medicament.
46. A method for the prevention of thrombosis in the haemodialysis circuit of a patient undergoing haemodialysis, comprising administering a therapeutically effective amount of a compound selected from boronic acids which have a neutral thrombin P1 domain linked to a hydrophobic moiety capable of binding to the thrombin S2 and S3 subsites, and salts, prodrugs and prodrug salts of such acids, the compound not being a base addition salt of such a boronic acid.
47. The method of claim 46 wherein the boronic acid is of formula (I):
wherein
Y comprises a moiety which, together with the fragment \u2014CH(R9)\u2014B(OH)2, has affinity for the substrate binding site of thrombin and R9 is an alkoxyalkyl group, and wherein Y comprises an amino acid which binds to the S2 subsite of thrombin, the amino acid being N-terminally linked to a moiety which binds the S3 subsite of thrombin, the S3-binding amino acid residue is of (R) configuration, the S2-binding residue is of (S) configuration, and the fragment \u2014CH(R9)\u2014B(OH)2 is of (R) configuration.
48. The method of claim 46 wherein the boronic acid is of formula (III):
where:
X is H (to form NH2) or an amino-protecting group;
aa1 is an amino acid having a hydrocarbyl side chain containing no more than 20 carbon atoms and comprising at least one cyclic group having up to 13 carbon atoms;
aa2 is an imino acid having from 4 to 6 ring members;
R1 is a group of the formula \u2014(CH2)s-Z, where s is 2, 3 or 4 and Z is \u2014OH, \u2014OMe, \u2014OEt or halogen, wherein halogen is F, Cl, Br or I.
49. The method of claim 46 wherein the boronic acid is a compound designated TRI 50c of the following formula
Cbz-(R)-Phe-(S)-Pro-(R)-Mpg-B(OH)2.
50. The dosage form of claim 10 wherein the prodrugs are boronic acid derivatives capable of hydrolysing to release the free boronic acid.
51. A method for preventing flight deep vein thrombosis or thrombosis in intermittent apheresis, wherein said intermittent apheresis is not hemodialysis, comprising administering a therapeutically effective amount of a composition of matter comprising
a) a first species selected from the group consisting of a boronic acid of formula (I) below, said acid when in the form of a boronate anion thereof, an equilibrium form of said boronic acid and of said boronate ion, and combinations thereof:
wherein
Y comprises a hydrophobic moiety which, together with the aminoboronic acid residue \u2014NHCH(R9)\u2014B(OH)2, has affinity for the substrate binding site of thrombin; and
R9 is a straight chain alkyl group interrupted by one or more ether linkages and in which the total number of oxygen and carbon atoms is 3, 4, 5 or 6 or R9 is \u2014(CH2)m\u2014W where m is 2, 3, 4 or 5 and W is \u2014OH or halogen, wherein halogen is F, Cl, Br or I; and

(b) a second species selected from the group consisting of pharmaceutically acceptable metal ions and strongly basic organic nitrogen-containing compounds.
52. An aqueous solution comprising a pharmaceutically acceptable base addition salt of a boronic acid which has a neutral thrombin P1 domain linked to a hydrophobic moiety capable of binding to the thrombin S2 and S3 subsites, the solution having a pH of about 9 or more.
53. The solution of claim 52 wherein the pH is about 9 to about 9.5.
54. An aqueous solution comprising a pharmaceutically acceptable base addition salt of a boronic acid which has a neutral thrombin P1 domain linked to a hydrophobic moiety capable of binding to the thrombin S2 and S3 subsites and a pharmaceutically acceptable organic acid, the solution having a pH of from about 4 to about 8.

1. A method for controlling a portable media device, the method comprising, by an accessory communicatively coupled to the portable media device:
receiving a tag notification from the portable media device, the tag notification indicating that track identification information is available for a currently playing track of a broadcast being received by the portable media device;
receiving a tag request signal indicative of a user request to tag the track; and
in response to the tag request signal, transmitting a tagging command to the portable media device, wherein the tagging command instructs the portable media device to store the track identification information in a persistent storage medium in the portable media device.
2. The method of claim 1 further comprising:
in response to receiving the tag notification, alerting the user that the track identification information is available.
3. The method of claim 2 wherein:
alerting the user includes illuminating a tag control of a user input device; and
receiving the tag request signal includes detecting user operation of the tag control.
4. The method of claim 1 further comprising:
in response to transmitting the tagging command, receiving a tag success notification from the portable media device, wherein the tag success notification indicates that the track identification has been stored in the persistent storage medium in the portable media device.
5. An accessory comprising:
a media device interface configured to exchange commands from a plurality of commands with a portable media device;
a user interface configured to receive user input; and
a controller coupled to the media device interface and the user interface, the controller being configured to interpret the received user input as instructions for invoking a functionality of a broadcast receiver and to instruct the media device interface to send a corresponding command from the plurality of commands, the controller being further configured to process commands received from the portable media device by the media device interface,
wherein the plurality of commands includes:
a button status command sendable by the accessory, the button status command including a button status bitmask, wherein different bits of the button status bitmask correspond to different functions of the broadcast receiver, the bits of the button status bitmask including a tag bit corresponding to an instruction to store track identifying metadata; and
a notification command receivable by the accessory, the notification command including one of a plurality of event identifiers, wherein the plurality of event identifiers includes a first event identifier indicating detection of track identifying metadata for a current track and a second event identifier indicating successful storing of the track identifying metadata.
6. The accessory of claim 5 further comprising:
a speaker,
wherein the media device interface is further configured to receive an audio signal from the portable media device for delivery to the speaker.
7. The accessory of claim 5 wherein the user interface includes a tag control and wherein the controller is further configured such that, in response to user operation of the tag control, the controller instructs the media device interface to send the button status command with the tag bit active.
8. The accessory of claim 7 wherein the user interface is further configured such that the tag control is made operative in response to receiving a notification command including the first event identifier.
9. The accessory of claim 5 wherein the plurality of event identifiers further includes:
a third event identifier indicating that the portable media device has entered a broadcast-receiving mode of operation; and
a fourth event identifier indicating that the portable media device has exited the broadcast-receiving mode of operation.
10. The accessory of claim 5 wherein the plurality of commands further includes:
a broadcast-receiving mode entry command sendable by the accessory to instruct the portable media device to enter a broadcast-receiving mode of operation; and
a broadcast-receiving mode exit command sendable by the accessory to instruct the portable media device to exit the broadcast-receiving mode of operation.
11. A method for operating a portable media device, the method comprising:
receiving a track of a broadcast;
detecting track identifying metadata associated with the track;
in response to detecting the track-identifying metadata, sending a tag notification to an accessory communicably coupled to the portable media device, the tag notification indicating that the track identifying metadata is available;
receiving, from the accessory, an instruction to tag the track;
in response to the instruction, storing the track identifying metadata in a storage medium of the portable media device; and
sending a success notification to the accessory, the success notification indicating that the track identifying metadata has been stored in the storage medium.
12. The method of claim 11 further comprising:
detecting an end of the track; and
in response to detecting the end of the track, sending an end-track notification to the accessory.
13. The method of claim 12 wherein the end-track notification includes a notification that the track identifying metadata is no longer available.
14. The method of claim 11 wherein the portable media device is operable in a broadcast-receiving mode or another mode, the method comprising:
at a time when the portable media device is operating in the other mode, receiving, from the accessory, an instruction to enter the broadcast-receiving mode; and
switching to the broadcast-receiving mode in response to the instruction.
15. The method of claim 14 further comprising:
at a time when the portable media device is operating in the broadcast-receiving mode, receiving, from the accessory, an instruction to exit the broadcast-receiving mode; and
switching to the other mode in response to the instruction.
16. The method of claim 11 wherein the instruction to tag the track comprises a command and an associated bitmask, wherein different bits of the bitmask correspond to different functions of a broadcast receiver of the portable media device, and wherein the bits of the bitmask include a tag bit corresponding to the instruction to tag the track.
17. The method of claim 11 further comprising:
providing an audio signal corresponding to the track to the accessory.
18. A portable media device comprising:
a broadcast receiver configured to receive broadcast media content and to extract a content signal and track identifying metadata from the received broadcast media content;
an accessory interface configured to exchange commands from a plurality of commands with an accessory;
a storage device configured to store data; and
a processor coupled to the broadcast receiver and the accessory interface, the processor being configured to process the commands exchanged via the accessory interface,
wherein the plurality of commands includes a button status command receivable by the portable media device, the button status command including a button status bitmask, wherein the button status bitmask includes a tag bit indicative of an instruction to store at least a portion of the metadata extracted from the received broadcast media content,
and wherein the processor is further configured such that, in response to receiving the button status command with the tag bit set, the processor stores at least a portion of the track identifying metadata extracted by the broadcast receiver as a tag in the storage device.
19. The portable media device of claim 18 wherein the plurality of commands further includes:
a notification command sendable by the portable media device in response to detecting an event, the notification command including an event identifier corresponding to the detected event, wherein the detected events include detection of track identifying metadata for a current track and successful storing of the track identifying metadata; and
a registration command receivable from the accessory, the registration command indicating which of the plurality of event identifiers are to be sent to the accessory using the notification command.
20. The portable media device of claim 19 wherein the processor is further configured to execute an application program to control the broadcast receiver and wherein the plurality of commands further includes:
an enter broadcast mode command receivable by the portable media device, the enter broadcast mode command instructing the portable media device to launch the application program; and
an exit broadcast mode command receivable by the portable media device, the exit broadcast mode command instructing the portable media device to quit the application program.
21. The portable media device of claim 20 wherein the detected events further include launching the application program and quitting the application program.
22. The portable media device of claim 18 wherein the broadcast receiver includes a radio tuner.
23. The portable media device of claim 22 wherein the radio tuner is further configured to receive a radio broadcast on at least one of an FM radio band, an AM radio band, or a satellite radio band.
24. The portable media device of claim 18 wherein the broadcast receiver is configured to receive an Internet broadcast.
25. The portable media device of claim 18 wherein the broadcast receiver is configured to receive a television broadcast.
26. The portable media device of claim 18 wherein the accessory interface is further configured to transmit the content signal from the broadcast receiver to the accessory.
27. A method for controlling a portable media device having a broadcast receiver, the method comprising, by an accessory communicatively coupled to the portable media device:
receiving a first notification from the portable media device, the first notification indicating whether the portable media device is operating in a broadcast-receiving mode or a stored media playback mode;
sending a mode switching command to the portable media device in response to the notification, wherein the mode switching command instructs the portable media device to switch between the broadcast-receiving mode and the stored media playback mode; and
in response to the mode switching command, receiving a second notification from the portable media device, the second notification also indicating whether the portable media device is operating in the broadcast-receiving mode or the stored media playback mode, wherein the second notification reflects an effect of the mode switching command on the portable media device.
28. The method of claim 27 further comprising, by the accessory:
prior to receiving the first notification, sending a registration command to the portable media device, the registration command instructing the portable media device to register the accessory to receive a class of notifications associated with a broadcast-receiving application of the portable media device,
wherein the first notification and the second notification are included in the class of notifications associated with the broadcast-receiving application.
29. The method of claim 28 wherein the class of notifications associated with the broadcast-receiving application further includes a tag notification indicating that track-identifying metadata is available for a currently playing track of a broadcast, the method further comprising, by the accessory:
while the portable media device is operating in the broadcast-receiving mode and playing a track, receiving the tag notification from the portable media device;
in response to the tag notification, determining whether a user requests to tag the track; and
in the event that the user requests to tag the track, sending a tagging command to the portable media device, the tagging command instructing the portable media device to tag the track.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of training an initially trained classifier (ITC), the ITC having been generated using a set of verified documents associated with a set of class labels, the set of verified documents having been divided into a training set of documents and a test set of documents, and each class of the set of class labels associated with a class list, the training set of documents having been further divided into an integer number of verified document sets (INVDS), the method comprising:
automatically inputting a set of unverified documents into the ITC, the set of unverified documents divided into an integer number of unverified document sets (UNVDS);
automatically identifying a subset of documents from the UNVDS;
automatically generating a final set of training documents based on the subset of documents and the INVDS;
clustering at least one subset of documents from the INVDS and one subset of documents from the UNVDS using a flat clustering or hierarchical clustering technique; and
training the ITC using the final set of training documents.
2. The method of claim 1, further comprising:
executing a first loop code segment comprising a first loop construct written in a computer programming language, wherein the first loop code segment is executed at run time at least n times, wherein n is a value at run time of a first variable in a first loop termination condition;
executing a second loop code segment comprising a second loop construct written in the computer programming language, wherein the second loop code segment is executed at least p\xd7n times, wherein p is a value at run time of a second variable in a second loop termination condition; and
executing a third loop code segment comprising a third loop construct written in the computer programming language, wherein the third loop code segment is executed p\xd7n\xd7q times, wherein q is a value at run time of a third variable in a third loop termination condition.
3. The method of claim 2, further comprising, for each of the n times the first loop code is executed:
assigning a first portion of the INVDS to a first set of documents;
assigning a second portion of the INVDS to a second set of documents, the first portion different from the second portion;
training the ITC for each class associated with the set of class labels using documents in the first set of documents;
applying a plurality of classifiers to the documents in the second set of documents; and
computing a first set of F1 scores associated with documents in the second set of documents.
4. The method of claim 3, wherein the first set of documents and the second set of documents have no documents in common.
5. The method of claim 2, further comprising, for each of the p times the second loop code is executed:
applying at least one profile of a set of profiles to each document of the UNVDS, the at least one profile defining rule to be applied to each document of the UNVDS;
comparing at least one document of the UNVDS to all of the documents included in the first set of documents; and
deleting the at least one document from the UNVDS based on the comparison.
6. The method of claim 5, wherein the rule defines one of a class label
retention scheme, class label addition scheme, or combination thereof.
7. The method of claim 5, comprising applying a plurality of profiles included in the set of profiles to each document of the UNVDS in a decreasing order of profile strictness.
8. The method of claim 5, wherein the at least one document from the UNVDS is deleted if the at least one document from the UNVDS is similar to any of the documents included in the first set of documents.
9. The method of claim 5, wherein comparing the at least one document comprises computing a cosine similarity for the at least one document.
10. The method of claim 5, further comprising, for each of the p times the second loop code is executed:
forming a third set of documents by merging documents included in the first set of documents with documents not deleted from the UNVDS ; and
clustering the third set of documents using the flat clustering or the hierarchical clustering technique.
11. The method of claim 2, further comprising, for each of the q times the third loop code is executed:
applying the ITC to all documents in the UNVDS for each class defined in the set of class labels;
forming the subset of documents from the UNVDS, each document of the subset of documents having at least one class associated therewith;
training a second classifier using documents in the subset of documents and the first set of documents;
applying the second classifier to the second set of documents;
computing a second set of F1 scores associated with documents in the second set of documents;
comparing an F1 score associated with a class label from the second set of F1 scores to a corresponding F1 score associated with the class label from the first set of F1 scores;
updating a best score for the class label based on the comparison; and
adding documents from the subset of documents to a list of candidate documents based on the comparison.
12. The method of claim 11, wherein generating the final set of training documents comprises adding at least one document associated with the list of candidate documents to the training set of documents.
13. The method of claim 1, further comprising:
training a plurality of classifiers using the final set of training documents; and
applying the plurality of classifiers to the test set of documents.
14. A system comprising:
a data store including a set of verified documents and a set of unverified documents, the set of verified documents divided into a training set of documents and a test set of documents, the training set of documents divided into an integer number of verified document sets (INVDS), and the set of unverified documents divided into an integer number of unverified document sets (UNVDS);
a server including a processor and memory operatively coupled to the data store, the memory storing instructions that, in response to receiving a request for access to a service, cause the processor to:
automatically identify a subset of documents from the UNVDS in response to inputting the set of unverified documents into an initially trained classifier (ITC);
automatically generate a final set of training documents based on the subset of documents and the INVDS;

clustering at least one subset of documents from the INVDS and one subset of documents from the UNVDS using a flat clustering or hierarchical clustering technique; and
train the ITC using the final set of training documents.
15. The system of claim 14, wherein the memory stores instructions that, in response to receiving the request, cause the processor to:
execute a first loop code segment comprising a first loop construct, wherein the first loop code segment is executed at run time at least n times, wherein n is a value at run time of a first variable in a first loop termination condition;
execute a second loop code segment comprising a second loop construct, wherein the second loop code segment is executed at least p\xd7n times, wherein p is a value at run time of a second variable in a second loop termination condition; and
execute a third loop code segment comprising a third loop construct, wherein the third loop code segment is executed p\xd7n\xd7q times, wherein q is a value at run time of a third variable in a third loop termination condition.
16. The system of claim 15, wherein the memory stores instructions that, for each of the n times the processor executes the first loop, cause the processor to:
assign a first portion of the INVDS to a first set of documents;
assign a second portion of the INVDS to a second set of documents, the first portion different from the second portion;
train the ITC for each class associated with the set of class labels using documents in the first set of documents;
apply a plurality of classifiers to the documents in the second set of documents; and
compute a first set of F1 scores associated with documents in the second set of documents.
17. The system of claim 16, wherein the first set of documents and the second set of documents have no documents in common.
18. The system of claim 15, wherein the memory stores instructions that, for each of the p times the second loop code is executed, cause the processor to:
apply at least one profile of a set of profiles to each document of the UNVDS, the at least one profile defining a rule to be applied to each document of the UNVDS;
compare at least one document of the UNVDS to all of the documents included in the first set of documents; and
delete the at least one document from the UNVDS based on the comparison.
19. The system of claim 18, wherein the rule defines a class label retention scheme, class label addition scheme, or combination thereof.
20. The system of claim 18, wherein the memory stores instructions that cause the processor to apply a plurality of profiles included in the set of profiles to each document of the UNVDS in a decreasing order of profile strictness.
21. The system of claim 18, wherein the memory stores instructions that cause the processor to delete the at least one document from the UNVDS if the at least one document from the UNVDS is similar to any of the documents included in the first set of documents.
22. The system of claim 18, wherein the memory stores instructions that cause the processor to compute a cosine similarity for the at least one document to be used during the comparison.
23. The system of claim 18, wherein the memory stores instructions that, for each of the p times the second loop code is executed, cause the processor to:
form a third set of documents by merging documents included in the first set of documents with documents not deleted from the UNVDS ; and
cluster the third set of documents using the flat clustering or hierarchical clustering technique.
24. The system of claim 15, wherein the memory stores instructions that, for each of the q times the third loop code is executed, cause the processor to:
apply the ITC to all documents in the UNVDS for each class defined in the set of class labels;
form the subset of documents from the UNVDS, each document of the subset of documents having at least one class associated therewith;
train a second classifier using documents in the subset of documents and the first set of documents;
apply the second classifier to the second set of documents;
compute a second set of F1 scores associated with documents in the second set of documents;
compare an F1 score associated with a class label from the second set of F1 scores to a corresponding F1 score associated with the class label from the first set of F1 scores;
update a best score for the class label based on the comparison; and
add documents from the subset of documents to a list of candidate documents based on the comparison.
25. The system of claim 24, wherein the memory stores instructions that, in response to receiving the request, cause the processor to add at least one document associated with the list of candidate documents to the training set of documents to form the final set of training documents.
26. The system of claim 14, wherein the memory stores instructions that, in response to receiving the request, cause the processor to:
train a plurality of classifiers using the final set of training documents; and
apply the plurality of classifiers to the test set of documents.
27. An article comprising a non-transitory machine-readable medium storing machine-readable instructions that, when applied to the machine, cause the machine to:
automatically identify a subset of documents from an integer number of unverified document sets (UNVDS) in response to inputting the UNVDS into an initially trained classifier (ITC);
automatically generate a final set of training documents based on the subset of documents and the INVDS;
clustering at least one subset of documents from the INVDS and one subset of documents from the UNVDS using a flat clustering or hierarchical clustering technique; and
train the ITC using the final set of training documents.