1. A method for the treatment of hyperphagia comprising the administration to a patient in need thereof of a pharmaceutical composition comprising a therapeutically effective amount of a 1-(3-chlorophenyl)-3-alkylpiperazine of formula (I), in racemic (R,S) form or in the form of the (S) enantiomer,
in which
R is a linear or branched alkyl group having from 1 to 3 carbon atoms, or of an addition salt thereof with a pharmaceutically acceptable organic or inorganic acid, and at least one pharmaceutically acceptable excipient.
2. The method according to claim 1, wherein R is methyl or ethyl.
3. The method according to claim 1, characterized in that wherein R is methyl.
4. The method according to any one of the preceding claims, wherein the compound of formula (I) is an enantiomer of (S) configuration.
5. The method according to any one of the preceding claims, wherein said organic acid is selected from the group consisting of maleic, methanesulphonic, paratoluenesulphonic, succinic and citric acid.
6. The method according to any one of the claims from 1 and 2 to 4, wherein said inorganic acid is selected from the group consisting of hydrochloric, hydrobromic, phosphoric and sulphuric acid.
7. The method according to any one of the claims from 1 and 2 to 4, wherein said acid is hydrochloric acid.
8. The method according to claim 4, wherein said acid is selected from the group comprising L(+) lactic and L(+) tartaric acid.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A laser system comprising:
a diode laser array comprised of a plurality of emitters, wherein each of said plurality of emitters emits an output beam from an output facet, and wherein each of said output beams has a fast axis of divergence and a slow axis of divergence; and
a one piece coupling optic adjacent to said output facets of said plurality of emitters of said diode laser array, wherein said one piece coupling optic has a planar back surface which is substantially parallel to a front face of said diode laser array, and wherein said one piece coupling optic further comprises a plurality of optical elements corresponding to said plurality of emitters, wherein each of said plurality of optical elements has a tilted front surface, and wherein each of said plurality of optical elements is shaped to reduce said fast axis of divergence of said output beam of said corresponding emitter of said plurality of emitters; and an optical fiber array comprised of a plurality of optical fibers, wherein said plurality of optical fibers correspond to said plurality of optical elements and said plurality of emitters.
2. The laser system of claim 1, wherein said one piece coupling optic is interposed between said diode laser array and said optical fiber array.
3. The laser system of claim 1, wherein said tilted front surface of each of said plurality of optical elements is adjacent to said output facet of said corresponding emitter of said plurality of emitters, and wherein said planar back surface of each of said plurality of optical elements is adjacent to an input surface of said corresponding optical fiber of said optical fiber array.
4. The laser system of claim 3, further comprising a first AR coating on said tilted front surface of each of said plurality of optical elements and a second AR coating on said planar back surface of each of said plurality of optical elements.
5. The laser system of claim 1, wherein a diameter corresponding to each of said plurality of optical fibers of said optical fiber array is approximately equal to a width corresponding to each of said plurality of emitters of said diode laser array.
6. A The laser system comprising:
a diode laser array comprised of a plurality of emitters, wherein each of said plurality of emitters emits an output beam from an output facet, and wherein each of said output beams has a fast axis of divergence and a slow axis of divergence; and
a one piece coupling optic adjacent to said output facets of said plurality of emitters of said diode laser array, wherein said one piece coupling optic has a planar back surface which is substantially parallel to a front face of said diode laser array, and wherein said one piece coupling optic further comprises:
a plurality of optical elements corresponding to said plurality of emitters,wherein each of said plurality of optical elements has a tilted front surface, and wherein each of said plurality of optical elements is shaped to reduce said fast axis of divergence of said output beam of said corresponding emitter of said plurality of emitters, wherein a wedge angle corresponding to said tilted front surface of each of said plurality of optical elements is greater than 2 mrad and less than 4 mrad.
7. The laser system of claim 6, wherein each of said plurality of optical elements is trapezoidally-shaped.
8. The laser system of claim 6, wherein each of said plurality of optical elements is rectangularly-shaped.
9. The laser system of claim 6, wherein said tilted front surface of each of said plurality of optical elements is adjacent to said output facet of said corresponding emitter of said plurality of emitters.
10. The laser system of claim 6, further comprising a coupling optic mounting bracket, wherein said one piece coupling optic is bonded to said coupling optic mounting bracket, and wherein said coupling optic mounting bracket is attached to said diode laser array.
11. The laser system of claim 6, further comprising:
a coupling optic mounting bracket, wherein said one piece coupling optic is bonded to said coupling optic mounting bracket;
a diode laser array mounting member, wherein said diode laser array is attached to said diode laser array mounting member; and
wherein said coupling optic mounting bracket is attached to said diode laser array mounting member.
12. The laser system of claim 6, further comprising:
a first AR coating applied to said tilted front surface of each of said plurality of optical elements of said one piece coupling optic, wherein said tilted front surface of each of said plurality of optical elements is adjacent to said output facet of said corresponding emitter of said plurality of emitters; and
a second AR coating applied to said planar back surface of each of said plurality of optical elements.
13. A laser system comprising:
a diode laser array comprised of a plurality of emitters, wherein each of said plurality of emitters emits an output beam, and wherein each of said output beams has a fast axis of divergence and a slow axis of divergence;
an optical fiber array comprised of a plurality of optical fibers, wherein said plurality of optical fibers corresponds to said plurality of emitters; and
a one piece coupling optic interposed between said diode laser array and said optical fiber array, wherein said one piece coupling optic has a planar back surface which is substantially parallel to a front face of said diode laser array, and wherein said one piece coupling optic further comprises:
a plurality of optical elements corresponding to said plurality of emitters and said plurality of optical fibers, wherein each of said plurality of optical elements has a tilted front surface and a planar back surface, said tilted front surface adjacent to an emitter output facet of said corresponding emitter of said plurality of emitters and said planar back surface adjacent to an input surface of said corresponding optical fiber of said optical fiber array, and wherein each of said plurality of optical elements is shaped to reduce said fast axis of divergence of said output beam of said corresponding emitter of said plurality of emitters.
14. The laser system of claim 13, wherein each of said plurality of optical elements is trapezoidally-shaped.
15. The laser system of claim 13, wherein each of said plurality of optical elements is rectangularly-shaped.
16. The laser system of claim 13, further comprising a first AR coating on said tilted front surface of each of said plurality of optical elements and a second AR coating on said planar back surface of each of said plurality of optical elements.
17. The laser system of claim 13, wherein a diameter corresponding to each of said plurality of optical fibers of said optical fiber array is approximately equal to a width corresponding to each of said plurality of emitters of said diode laser array.
18. The laser system of claim 13, wherein a wedge angle corresponding to said tilted front surface of each of said plurality of optical elements is greater than 2 mrad and less than 4 mrad.
19. The laser system of claim 13, further comprising a coupling optic mounting bracket, wherein said one piece coupling optic is bonded to said coupling optic mounting bracket, and wherein said coupling optic mounting bracket is attached to said diode laser array.
20. The laser system of claim 13, further comprising:
a coupling optic mounting bracket, wherein said one piece coupling optic is bonded to said coupling optic mounting bracket;
a diode laser array mounting member, wherein said diode laser array is attached to said diode laser array mounting member; and
wherein said coupling optic mounting bracket is attached to said diode laser array mounting member.