1. A cartridge assembly for reducing the base drag of a projectile in flight, comprising:
a. a low pressure case, having a base and an open end;
b. a high pressure cartridge inserted within said base of said low pressure case, having a closed first end, an open second end, and a continuous side wall running between said first and second ends, thereby defining a hollow interior;
c. propellant, contained within said hollow interior of said high pressure cartridge;
d. a burstable sealing member sealing said open second end of said high pressure cartridge, thereby closing said hollow interior within said high pressure cartridge;
e. wherein said low pressure case includes a charge casing surrounding said high pressure cartridge;
f. a projectile assembly seated in said open end of said low pressure case;
g. wherein said projectile assembly includes an aft closure having an aft opening;
h. wherein said aft closure includes a volume of gas generating material sufficient to inject pressurizing gas into the wake of said projectile assembly, through said aft opening, for a substantial portion of said flight of said projectile;
i. wherein said low pressure case further includes a charge vent hole positioned to direct hot propellant gas from said high pressure cartridge toward said aft opening in said aft closure;
j. said gas generating material being contained within a cavity in said aft closure;
k. said aft opening lying at the aft extreme of said cavity;
l. said aft closure including a forward extreme including a bulkhead;
m. said bulkhead opening into an output allowing fluid communication between said cavity and the area forward of said bulkhead;
n. an igniter charge located proximate said output opening;
o. an ignitable payload located forward of said bulkhead and configured to be ignited by said igniter charge, said ignitable payload having an interior cavity; and
p. a piece of ignition material having a forward portion and an aft portion, said piece of ignition material being located within said interior cavity in said ignitable payload, with said aft portion of said ignition material being proximate said igniter charge.
2. A cartridge assembly as recited in claim 1, wherein said ignitable payload comprises
a volume of illuminant composition proximate said piece of ignition material.
3. A cartridge assembly as recited in claim 1, wherein said bulkhead in said aft closure further comprises a plurality of secondary vents allowing fluid communication between said cavity and the area forward of said bulkhead.
4. A cartridge assembly as recited in claim 3, wherein said plurality of secondary vents are arranged in a radial array around said output opening.
5. A cartridge assembly as recited in claim 1 wherein said ignitable payload includes an explosive charge.
6. A cartridge assembly as recited in claim 2, wherein said ignitable payload includes an explosive charge.
7. A cartridge assembly as recited in claim 1 wherein said ignitable payload includes a volume of smoke material.
8. A cartridge assembly as recited in claim 1, wherein said ignitable payload includes an explosive charge.
9. A cartridge assembly as recited in claim 1, wherein said cavity further comprises at least one mechanical interference feature configured to retain said gas generating material within said cavity.
10. A cartridge assembly as recited in claim 2, wherein said cavity further comprises at least one mechanical interference feature configured to retain said gas generating material within said cavity.
11. A cartridge assembly for reducing the base drag of a projectile in flight, comprising:
a. a low pressure case, having a base and an open end;
b. a high pressure cartridge inserted within said base of said low pressure case, said high pressure cartridge having a hollow interior;
c. propellant, contained within said hollow interior of said high pressure cartridge;
d. a burstable sealing member sealing said high pressure cartridge;
e. a projectile assembly seated in said open end of said low pressure case;
f. wherein said projectile assembly includes an aft closure having an aft opening;
g. wherein said aft closure includes a volume of gas generating material sufficient to inject pressurizing gas into the wake of said projectile assembly, through said aft opening, for a substantial portion of said flight of said projectile;
h. wherein said low pressure case further includes a charge vent hole positioned to direct hot propellant gas from said high pressure cartridge toward said aft opening in said aft closure;
i. said gas generating material being contained within a cavity in said aft closure;
j. said aft opening lying at the aft extreme of said cavity;
k. said aft closure including a forward extreme including a bulkhead;
l. said bulkhead opening into an output allowing fluid communication between said cavity and the area forward of said bulkhead;
m. an igniter charge located proximate said output opening;
n. an ignitable payload located forward of said bulkhead and configured to be ignited by said igniter charge, said ignitable payload having an interior cavity; and
o. a piece of ignition material having a forward portion and an aft portion, said piece of ignition material being located within said interior cavity in said ignitable payload, with said aft portion of said ignition material being proximate said igniter charge.
12. A cartridge assembly as recited in claim 11, wherein said ignitable payload comprises a volume of illuminant composition proximate said piece of ignition material.
13. A cartridge assembly as recited in claim 11, wherein said bulkhead in said aft closure further comprises a plurality of secondary vents allowing fluid communication between said cavity and the area forward of said bulkhead.
14. A cartridge assembly as recited in claim 11, wherein said plurality of secondary vents are arranged in a radial array around said output opening.
15. A cartridge assembly as recited in claim 11 wherein said ignitable payload includes an explosive charge.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A method of diagnosing preeclampsia in a subject, the method comprising the steps of:
(a) contacting a biological sample from the subject with a reagent that specifically binds to at least one marker selected from the group consisting of the nucleic acid and corresponding protein sequences shown in FIG. 3, FIG. 4, or Table 4; and
(b) determining whether or not the marker is overexpressed or underexpressed in the sample; thereby providing a diagnosis for preeclampsia.
2. The method of claim 1, wherein the reagent is an antibody.
3. The method of claim 2, wherein the antibody is monoclonal.
4. The method of claim 1, wherein the reagent is a nucleic acid.
5. The method of claim 1, wherein the reagent is an oligonucleotide.
6. The method of claim 1, wherein the reagent is an RT PCR primer set.
7. The method of claim 1, wherein the sample is a placental biopsy.
8. The method of claim 1, wherein the sample is a blood sample.
9. The method of claim 1, wherein the sample is a urine sample.
10. The method of claim 1, wherein the sample is a saliva sample.
11. The method of claim 1, wherein the sample is cervicovaginal fluid.
12. A method of providing a prediction for the risk for developing preeclampsia in a subject, the method comprising the steps of:
a) contacting a biological sample from the subject with a reagent that specifically binds to at least one marker selected from the group consisting of the nucleic acid and corresponding protein sequences shown in FIG. 3, FIG. 4, or Table 4; and
(b) determining whether or not the marker is overexpressed or underexpressed in the sample; thereby providing a prediction for preeclampsia development.
13. The method of claim 12, wherein the reagent is an antibody.
14. The method of claim 13, wherein the antibody is monoclonal.
15. The method of claim 12, wherein the reagent is a nucleic acid.
16. The method of claim 12, wherein the reagent is an oligonucleotide.
17. The method of claim 12, wherein the reagent is an RT PCR primer set.
18. The method of claim 12, wherein the sample is a placental biopsy.
19. The method of claim 12, wherein the sample is a blood sample.
20. The method of claim 12, wherein the sample is a urine sample.
21. The method of claim 12, wherein the sample is a saliva sample.
22. The method of claim 12, wherein the sample is cervicovaginal fluid.
23. The method of claim 12, wherein the prediction is a prognosis for the development of preeclampsia during a preexisting pregnancy or recurrence of preeclampsia during a subsequent pregnancy.
24. A method of identifying a compound that prevents or treats preeclampsia, the method comprising the steps of:
(a) contacting a compound with a sample comprising a cell that expresses a marker selected from the group consisting of the nucleic acid and corresponding protein sequences shown in FIG. 3, FIG. 4, or Table 4; and
(b) determining the functional effect of the compound on the marker, thereby identifying a compound that prevents or treats preeclampsia.
25. The method of claim 24, wherein the compound is a small molecule.
26. The method of claim 24, wherein the compound is a siRNA.
27. The method of claim 24, wherein the compound is a ribozyme.
28. The method of claim 24, wherein the compound is an antibody.
29. The method of claim 28, wherein the antibody is monoclonal.