1. A device for implantation in within a luminal body, comprising;
a generally cylindrical body defining at least one internal passage positioned longitudinally therein;
a non-permeable material applied to the cylindrical body; and
at least one therapeutic agent applied to the at least one of the cylindrical body and the non-permeable material.
2. The device of claim 1 wherein the cylindrical body is manufactured from at least one material selected from the group consisting of stainless steel, Titanium, Nickel-Titanium alloys, shape memory alloys,
3. The device of claim 1 wherein the cylindrical body further comprises at least two modular stent bodies coupled together to form a unitary structure.
4. The device of claim 1 wherein the non-permeable material comprises a biologically compatible material selected from a group consisting of polyurethane, paralyene, polyester, Teflon, polypropylene, polyethylene, polyamides, polycarbonate, poly-methyl-methacrylate, poly-butyl-methacrylate, polyvinyl alcohol, polyvinyl acetate, silicone elastomer, polytetrafluoroethylene, polyacrylonitrile, polyvinyl chloride, polystyrene, and polyvinyl propylene.
5. The device of claim wherein the non-permeable material is selectively applied to a portion of the cylindrical body.
6. The device of claim 1 wherein the non-permeable material is applied to an outside surface of the cylindrical body.
7. The device of claim 1 wherein the non-permeable material is applied to an inside surface of the cylindrical body.
8. The device of claim 1 wherein the non-permeable material is applied to an entire length of the cylindrical body.
9. The device of claim 1 wherein the non-permeable material is applied to a portion of the cylindrical body less than the entire length of the cylindrical body.
10. The device of claim 1 wherein the non-permeable material comprises a coating applied to the cylindrical body.
11. The device of claim 10 wherein the non-permeable material coating is applied to the cylindrical body using at least one method selected from the group consisting of sprayed, dipped, and vapor-deposited.
12. The device of claim 1 wherein the non-permeable material comprises a membrane applied to the cylindrical body.
13. The device of claim 1 wherein the therapeutic agent is selected from the group consisting of paralyene, anticoagulants, RGD peptide-containing compounds, heparin, antithrombin compounds, platelet receptor antagonists, anti-thrombin antibodies, anti-platelet receptor antibodies, aspirin, protaglandin inhibitors, platelet inhibitors, tick anti-platelet peptide, vascular cell antiproliferative agents, growth factor inhibitors, growth factor receptor antagonists, transcriptional repressor, translational repressor, antisense DNA, antisense RNA, replication inhibitor, inhibitory antibodies, antibodies directed against growth factors, cytotoxic agents, cytoskeleton inhibitors, peroxisome proliferator-activated receptor gamma agonists, molecular chaperone inhibitors, bifunctional molecules, cholesterol-lowering agents, vasodilating agents, agents which interfere with endogenous vasoactive mechanisms, anti-inflammatory agents, anti-platelet, anti-fibrinolytic agents, anti-neoplastic agents, anti-allergic agents, anti-rejection agents, metaloprotease inhibitors, anti-microbial or anti-bacterial, anti-viral agents, hormones, vasoactive substances, anti-invasive factors, anti-cancer drugs, antibodies, lymphokines, anti-angiogenic agents, radioactive agents, gene therapy drugs, paclitaxel, docetaxel, docetaxel derivatives, epothilones, nitric oxide release agents, heparin, aspirin, coumadin, D-phenylalanyl-prolyl-arginine chloromethylketone (PPACK), hirudin, polypeptide from angiostatin, polypeptide from endostatin, benzoquinone ansamycins, geldanamycin, herbimycin, macbecin, methotrexate, 5-fluorouracil, estradiol, P-selectin Glycoprotein ligand-1 chimera, abciximab, exochelin, eleutherobin, sarcodictyin, fludarabine, sirolimus, rapamycin, ABT-578, certican, Sulindac, tranilast, thiazolidinediones, rosiglitazone, troglitazone, pioglitazone, darglitazone, englitazone, tetracyclines, VEGF, transforming growth factor (TGF)-beta, insulin-like growth factor (IGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), RGD peptide, estrogens, 17 beta-estradiol, beta gamma ray emitter (radioactive) agents, gamma ray emitter (radioactive) agents, and various marking agents including radio-opaque, echogenic, ACE inhibitorARB combination therapy, Doxycycline and other MMP inhibitors (i.e., tetracycline); COX-2 inhibitors, Cerivastatin, Oleic acid, Selective iNOS inhibitor (ON1714, BBS-2), Roxithromycin, Curcumin\u2014gingerol, Beta blockers (cardioselective or carvedilol), NSAIDS and magnetically resonating materials.
14. The device of claim 1 wherein the therapeutic agent is applied to the cylindrical body.
15. The device of claim 1 wherein the therapeutic agent is applied to the non-permeable material.
16. The device of claim 1 wherein the therapeutic agent is applied to the cylindrical body and the non-permeable material.
17. The device of claim 1 wherein at least one therapeutic agent is applied to the cylindrical body and at least one other therapeutic agent is applied to the non-permeable material.
18. A device for implantation in within a luminal body, comprising;
a cylindrical body defining an internal passage formed longitudinally therein;
a non-permeable material applied to an outside surface of the cylindrical body; and
at least one therapeutic agent applied to the non-permeable material.
19. A method of making a stent, comprising:
providing a cylindrical body defining a longitudinal internal passage;
applying a non-permeable material to an outside surface of the cylindrical body; and
applying at least one therapeutic agent to the non-permeable material.
20. A method for directionally delivering therapeutic agents to a targeted site within a luminal body, comprising:
providing a stent defining a longitudinal internal passage and having a non-permeable material applied to an outside surface of the stent, the non-permeable material having at least one therapeutic agent applied thereto;
positioning the stent within a luminal body;
eluding the therapeutic agent from the non-permeable material into a wall of the luminal body; and
restricting the therapeutic agent from eluding into the internal passage of the stent with the non-permeable material.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A cooled blade for a turbomachine, comprising a platform and an airfoil, and comprising a cavity along the airfoil and the platform with a first opening at one end and a second opening at the other end, a tubular sleeve being housed in the cavity with a first end in the first opening and a second end in the second opening, first spacers on the side of the first end and second spacers on the side of the second end of the sleeve creating a space between the outer face of the sleeve and the wall of the cavity, the blade being arranged so that the sleeve is inserted into the cavity through the first opening, wherein the first spacers are secured to the sleeve and the second spacers are secured to the wall of the cavity along the airfoil.
2. The blade as claimed in the preceding claim wherein the first spacers are placed in a direction forming an angle with the chord of the blade.
3. The blade as claimed in claim 2 wherein the angle is zero.
4. The cooled blade as claimed in claim 1, wherein the sleeve is formed of a metal sheet, the first spacers being bosses obtained by deformation of the metal sheet.
5. The blade as claimed in the claim 4, wherein the bosses are dome-shaped.
6. The blade as claimed in claim 1, wherein the first spacers are arranged in the half of the sleeve situated on the side of the first end.
7. The blade as claimed in claim 1, wherein the second spacers form individual bosses.
8. The blade as claimed in claim 7, wherein the bosses are aligned parallel to the chord.
9. The blade as claimed in claim 1, wherein the second spacers have an elongated shape parallel to a chord of the blade.
10. The blade as claimed in claim 9, wherein the second spacers form a continuous rail.
11. The blade as claimed in one of the preceding claims, wherein the sleeve is perforated for cooling by air impact of the walls of the airfoil.
12. The blade as claimed in claim 1, wherein the first opening is on the outside of the gas stream.
13. The blade as claimed in claim 11, wherein the first opening is on the inside of the gas stream.
14. A method for assembling the blade as claimed in one of the preceding claims wherein the user places the sleeve in the cavity by inserting it by its second end through the first opening.
15. An upstream guide vane element of a turbomachine comprising a blade as claimed in one of claims 1 to 13.
16. A turbine comprising an upstream guide vane element as claimed in claim 15.
17. A turbomachine comprising at least one blade as claimed in one of claims 1 to 13.