Author: claimsbot

1. A system for passing TDM traffic through a packet switch, comprising
a packet switch having a plurality of data ports and configured to route FSDU (fixed sized data unit) packets between the plurality of data ports;
a TDM encapsulation circuit coupled to a data flow of TDM data and having a circuit demultiplexer for processing an incoming data flow of TDM data to buffer data associated with different TDM circuits into different buffer locations, and for accessing a connection table having information representative of the plurality of data ports being supported by the packet switch including two or more data ports associated with a respective route through which an FSDU associated with a respective circuit is routed by the packet switch,
a timer for monitoring a frame boundary, and
a FSDU generator for generating an FSDU and filling the generated FSDU with data associated with a respective one of the TDM circuits and for generating header information representative of information for allowing the packet switch to route the generated FSDU to a respective one of said plurality of data ports, said respective port being associated with the respective one of the TDM circuits.
2. A system according to claim 1, further comprising
a merge circuit for merging the generated FSDU with packet flow data being sent to the packet switch.
3. A system according to claim 1, further comprising
a decapsulation circuit for processing a generated FSDU passed through the packet switch to provide data to one or more TDM circuits sending data from a port of the packet switch.
4. A system according to claim 1, further including
a priority switch for associating a routing priority level with a generated FSDU.
5. A system according to claim 4, further comprising
a bandwidth allocation process for allocating bandwidth for generated FSDU traffic to provide a predetermined latency period for routing traffic through the packet switch.
6. A system according to claim 1, further comprising
a jitter buffer for reducing variable delays arising from passing through the packet switch.
7. A system according to claim 6, wherein
the jitter buffer has a size selected as a function of a minimum and maximum latency for data passing through the packet switch.
8. A system according to claim 6, wherein
the jitter buffer has a size selected to maintain jitter below 125 microseconds.
9. A system according to claim 1, wherein
the packet switch includes ports capable of supporting a combination of traffic types.
10. A system according to claim 1, wherein
traffic types include packet type traffic and TDM type traffic.
11. A system according to claim 1, further comprising a dropped-circuit detector for detecting a dropped TDM circuit.
12. A system according to claim 11, wherein the FSDU generator responds to the dropped-circuit detector to adjust the contents of the FSDU.
13. A process for passing TDM traffic through a packet switch, comprising
providing a packet switch having a plurality of data ports and configured to route FSDU packets between the plurality of data ports;
identifying a TDM data flow,
encapsulating the TDM data flow by sorting the TDM data flow into different respective buffer locations,
accessing a connection table having information representative of the plurality of data ports being supported by the packet switch including two or more data ports associated with a respective route through which an FSDU packet associated with a respective circuit is routed by the packet switch,
generating an FSDU that can pass through the packet switch and filling the generated FSDU with data associated with a respective one of the TDM circuits,
generating header information representative of information for routing the generated FSDU to one of said plurality of data ports associated with the respective one of the TDM circuits, and
combining the generated FSDU with a flow of packet data being sent to the packet switch.
14. A process according to claim 13, further comprising processing a generated FSDU having been passed through the packet switch to reconstruct a TDM data flow circuit at an output port of the packet switch.
15. A process according to claim 14, further comprising monitoring the number of TDM circuits within the TDM data flow to identify a change in the number of TDM circuits.
16. A process according to claim 15, further comprising altering the contents of the generated FSDU as a function of a detected change in the number of circuits in the TDM data flow.
17. A process according to claim 13, further comprising setting a timer to establish a time period for filling the generated FSDU.
18. A process according to claim 17, wherein the time period is set to the TDM frame boundary period.
19. A process according to claim 13, further comprising buffering a generated TDM circuit at an output port to reduce latency induced time variations.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A compound of Formula I:
or its pharmaceutically acceptable salt or prodrug thereof, wherein:
R1 is a piperazinyl, which can be optionally substituted by 1, 2, 3 or 4 R1a;
R1a is H, halogen, cyano-group, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, ORa, SRa, NRbRc, NRbC(O)Rd, NRbS(O)2Rd, C(O)NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, wherein the said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl can be optionally substituted with 1, 2 or 3 groups independently selected from cyano-group, halogen, ORa, SRa, NRbRc, NRb(CO)Rd, NRbS(O)2Rd, C(O)NRbRc, S(O)2NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
Alternatively, two R1a groups taken together with the atoms attached to them can form a cycloalkyl and heterocycloalkyl of 3, 4, 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from cyano-group, halogen, ORa, SRa, NRbRc, NRb(CO)Rd, NRbS(O)2Rd, C(O)NRbRc, S(O)2 NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
R2 is H, halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl or C2-6 alkynyl;
Alternatively, two R2 groups taken together with the atoms attached to them can form a cycloalkyl and heterocycloalkyl of 3, 4, 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from cyano-group, halogen, ORa, SRa, NRbRc, NRb(CO)Rd, NRbS(O)2Rd, C(O)NRbRc, S(O)2NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, and C2-6 alkynyl;
R3 is H, halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, or heterocycloalkyl;
Alternatively, two R3 groups taken together with the atoms attached to them can form a cycloalkyl and heterocycloalkyl of 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, and C2-6 alkynyl;
W\u2014X is amide bond;
Y is heteroaryl, which can be optionally substituted by 1, 2 or 3 R4;
Z is heteroaryl, which can be optionally substituted by 1, 2 or 3 R5;
R4 and R5 are independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, NRb(CO)Rd, C(O)NRbRc, NRbS(O)2Rd, S(O)2NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
Alternatively, two R4 or two R4 groups taken together with the atoms attached to them respectively, can form a cycloalkyl and heterocycloalkyl of 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, and C2-6 alkynyl;
Ra, Rb, Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
Alternatively, the Rb and Rc groups taken together with the nitrogen atom attached to them can form a heterocycloalkyl of 4, 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
n is an integer from zero to four; and
m is an integer from zero to two.
2. A compound of Formula II:
or its pharmaceutically acceptable salt or prodrug,
wherein:
R1 is a piperazinyl, which can be optionally substituted by 1, 2, 3 or 4 R1a;
R1a is H, halogen, cyano-group, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, ORa, SRa, NRbRc, NRbC(O)Rd, NRbS(O)2Rd, C(O)NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, wherein the said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl can be optionally substituted with 1, 2 or 3 groups independently selected from cyano-group, halogen, ORa, SRa, NRbRc, NRb(CO)Rd, NRbS(O)2Rd, C(O)NRbRc, S(O)2NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6cyanoalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
Alternatively, two R1a groups taken together with the atoms attached to them can form a cycloalkyl and heterocycloalkyl of 3, 4, 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from cyano-group, halogen, ORa, SRa, NRbRc, NRb(CO)Rd, NRbS(O)2Rd, C(O)NRbRc, S(O)2 NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
Y is heteroaryl, which can be optionally substituted by 1, 2 or 3 R4;
Z is heteroaryl, which can be optionally substituted by 1, 2 or 3 R5;
R4 and R5 are independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, NRb(CO)Rd, C(O)NRbRc, NRbS(O)2Rd, S(O)2NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
Alternatively, two R4 or two R4 groups taken together with the atoms attached to them respectively, can form a cycloalkyl and heterocycloalkyl of 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, and C2-6 alkynyl;
Ra, Rb, Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
Alternatively, the Rb and Rc groups taken together with the nitrogen atom attached to them can form a heterocycloalkyl of 4, 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl.
3. The compound or its pharmaceutically acceptable salt or prodrug thereof according to claim 1, wherein:
R1 is a piperidinyl, which can be optionally substituted by 1, 2, 3 or 4 R1a;
R1a is H, halogen, cyano-group, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, ORa, SRa, NRbRc, NRbC(O)Rd, NRbS(O)2Rd, C(O)NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, wherein the said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl can be optionally substituted by 1, 2 or 3 groups independently selected from cyano-group, halogen, ORa, SRa, NRbRc, NRb(CO)Rd, NRbS(O)2Rd, C(O)NRbRc, S(O)2 NRbC(O)Rd, C(O)ORa, S(O)2Rd, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
Alternatively, two R1a groups taken together with the atoms attached to them can form a cycloalkyl and heterocycloalkyl of 3, 4, 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from cyano-group, halogen, ORa, SRa, NRbRc, NRb(CO)Rd, NRbS(O)2Rd, C(O)NRbRc, S(O)2 NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
Y is selected from pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, thiazolyl, isothiazolyl, imidazolyl, oxazolyl, isoxazolyl, triazolyl or pyrazolyl, and can be substituted by 1, 2, or 3 R4;
Z is selected from pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, thiazolyl, isothiazolyl, imidazolyl, oxazolyl, isoxazolyl, triazolyl, pyrazolyl, azotic oxazolyl, pyrindol, pyrrolo-pyrimidyl, pyrazolo-pyridyl, pyrazolo-pyrimidyl, quinolyl, isoquinolyl, quinazolyl, piperazinyl or morpholinyl, and can be substituted by 1, 2, or 3 R5;
R4 and R5 are independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, NRb(CO)Rd, C(O)NRbRc, NRbS(O)2Rd, S(O)2NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
Alternatively, two R4 or two R5 groups taken together with the atoms attached to them respectively, can form a cycloalkyl and heterocycloalkyl of 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, and C2-6 alkynyl;
Ra, Rb, Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl; and
Alternatively, Rb and Rc taken together with the nitrogen atom attached to them respectively, can form a heterocycloalkyl of 4, 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl.
4. The compound or its pharmaceutically acceptable salt or prodrug thereof according to claim 1, having Formula IIa:
wherein:
R6 and R7 are independently selected from H, cyano-group, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, and C2-6 alkynyl;
Alternatively, R6 and R7 taken together with the atoms attached to them respectively, can form a 5, 6 or 7-membered carbocyclic or heterocyclic ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl and C2-6 alkynyl;
R8 is H, C1-6 alkyl, C2-6 hydroxyalkyl, C2-6 haloalkyl, C1-6 cyanoalkyl, C(O)NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C3-6 alkenyl, C3-6 alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, wherein the said C1-6 alkyl, C3-6 alkenyl, C3-6 alkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa and NRbRc;
Y is selected from pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, thiazolyl, isothiazolyl, imidazolyl, oxazolyl, isoxazolyl, triazolyl or pyrazolyl, and can be substituted by 1, 2, or 3 R4;
Z is selected from pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, thiazolyl, isothiazolyl, imidazolyl, oxazolyl, isoxazolyl, triazolyl, pyrazolyl, azotic oxazolyl, pyrindol, pyrrolo-pyrimidyl, pyrazolo-pyridyl, pyrazolo-pyrimidyl, quinolyl, isoquinolyl, quinazolyl, piperazinyl or morpholinyl, and can be substituted by 1, 2, or 3 R5;
R4 and R5 are independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, NRb(CO)Rd, C(O)NRbRc, NRbS(O)2Rd, S(O)2NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
Alternatively, two R4 or two R5 groups taken together with the atoms attached to them respectively, can form a cycloalkyl and heterocycloalkyl of 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl and C2-6 alkynyl;
Ra, Rb, Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
Alternatively, Rb and Rc taken together with the nitrogen atom attached to them respectively, can form a heterocycloalkyl of 4, 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl; and
p is an integer from one to two.
5. The compound or its pharmaceutically acceptable salt or prodrug thereof according to claim 1, having formula IIb:
wherein:
R9 and R10 are independently selected from H, C1-6 alkyl, C2-6 hydroxyalkyl, C2-6 haloalkyl, C1-6 cyanoalkyl, C(O)NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, C3-6 alkenyl, C3-6 alkynyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, wherein the said C1-6 alkyl, C3-6 alkenyl, C3-6 alkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa or NRbRc;
Alternatively, R9 and R10 taken together with the atoms attached to them respectively, can form a cycloalkyl or heterocycloalkyl of 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl;
R11 is H, halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl;
Y is selected from pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, thiazolyl, isothiazolyl, imidazolyl, oxazolyl, isoxazolyl, triazolyl or pyrazolyl, and can be substituted by 1, 2, or 3 R4;
Z is selected from pyridyl, pyrimidyl, pyridazinyl, pyrazinyl, triazinyl, thiazolyl, isothiazolyl, imidazolyl, oxazolyl, isoxazolyl, triazolyl, pyrazolyl, azotic oxazolyl, pyrindol, pyrrolo-pyrimidyl, pyrazolo-pyridyl, pyrazolo-pyrimidyl, quinolyl, isoquinolyl, quinazolyl, piperazinyl or morpholinyl, and can be substituted by 1, 2, or 3 R5;
R4 and R5 are independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 hydroxyalkyl, C1-6 haloalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, NRb(CO)Rd, C(O)NRbRc, NRbS(O)2Rd, S(O)2NRbRc, C(O)Rd, C(O)ORa, S(O)2Rd, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
Alternatively, two R4 or two R5 groups taken together with the atoms attached to them respectively, can form a cycloalkyl or heterocycloalkyl of 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, ORa, SRa, NRbRc, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, and C2-6 alkynyl;
Ra, Rb, Rc and Rd are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl;
Alternatively, Rb and Rc taken together with the nitrogen atom attached to them respectively, can form a heterocycloalkyl of 4, 5, 6 or 7-membered ring, and can be optionally substituted by 1, 2 or 3 groups independently selected from halogen, cyano-group, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl and heterocycloalkyl; and
q is an integer from zero to three.
6. The compound or its pharmaceutically acceptable salt or prodrug thereof according to claim 1, wherein the said compound is selected from:
1-(4-Methylpiperazin-1-yl)-N-(4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl)-2,3-dihydro-1H-inden-5-carboxamide;
tert-Butyl 4-{5-({(4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl}amino)carbonyl)-2,3-dihydro-1H-inden-1-yl}piperazin-1-carboxylate;
N-(4-Methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl)-1-piperazin-1-yl-2,3-dihydro-1H-indene-5-carboxamide;
1-(4-Ethylpiperazin-1-yl)-N-(4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl)-2,3-dihydro-1H-indene-5-carboxamide;
1-(4-Isopropylpiperazin-1-yl)-N-(4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl)-2,3-dihydro-1H-indene-5-carboxamide;
1-4-(2-Hydroxyethyl)piperazin-1-yl-N-(4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl)-2,3-dihydro-1H-indene-5-carboxamide;
1-4-Acetylpiperazin-1-yl)-N-(4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl)-2,3-dihydro-1H-indene-5-carboxamide;
N-3-(4,5\u2032-Bipyrimidin-2-ylamino)-4-methylphenyl-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-indene-5-carboxamide;
1-(3S)-3-(Dimethylamino)pyrrolidin-1-yl-N-{4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl}-2,3-dihydro-1H-indene-5-carboxamide;
1-(3R)-3-(Dimethylamino)pyrrolidin-1-yl-N-{4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl}-2,3-dihydro-1H-indene-5-carboxamide;
(1S)-1-(4-Methylpiperazin-1-yl)-N-(4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl)-2,3-dihydro-1H-indene-5-carboxamide;
(1R)-1-(4-Methylpiperazin-1-yl)-N-(4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl)-2,3-dihydro-1H-indene-5-carboxamide;
(1S)\u2014N-3-(4,5\u2032-Bipyrimidin-2-ylamino)-4-methylphenyl-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-indene-5-carboxamide;
(1R)\u2014N-3-(4,5\u2032-Bipyrimidin-2-ylamino)-4-methylphenyl-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-indene-5-carboxamide;
(1S)-1-(4-Methylpiperazin-1-yl)-N-(4-methyl-3-(4-pyridin-4-ylpyrimidin-2-yl)aminophenyl)-2,3-dihydro-1H-indene-5-carboxamide; and
(1S)-1-(4-Methylpiperazin-1-yl)-N-(4-methyl-3-(4-pyridin-3-ylpyrimidin-2-yl)aminophenyl)-2,3-dihydro-1H-indene-5-carboxamide sulfate.
7. A pharmaceutical composition, wherein said pharmaceutical composition comprises the compound or pharmaceutically acceptable salt or prodrug of claim 1, and at least one pharmaceutically acceptable carrier.

1. A lighting apparatus, comprising:
a light-guiding plate comprising a light-incident surface and a light-emitting surface disposed adjacent to the light-incident surface, wherein two ends of the light-incident surface are connected as a reference line; and
a lighting unit disposed on a side of the light-incident surface, wherein the lighting unit comprises at least one first light source, at least one second light source and a circuit board, the first light source and the second light source are disposed on the circuit board, and light emitted by the first and second light sources enters into the light-guiding plate through the light-incident surface and exits the light-guiding plate through the light-emitting surface;
wherein, a first distance from the first light source to the reference line of the light-incident surface is not equal to a second distance from the second light source to the reference line of the light-incident surface.
2. The lighting apparatus according to claim 1, wherein the light-incident surface of the light-guiding plate is scraggly, wavy, arc-shaped or flat.
3. The lighting apparatus according to claim 1, wherein the light unit comprises a plurality of first light sources and a plurality of second light sources, the first light sources and the second light sources are arranged in straight lines respectively, the straight lines are parallel to the reference line, and perpendicular projections of the first light sources and the second light sources on the light-incident surface are disposed alternately.
4. The lighting apparatus according to claim 3, wherein the light-incident surface of the light-guiding plate has a plurality of recessed portions and a plurality of protruded portions, the first light sources are disposed in the recessed portions, and the second light sources are disposed on the protruded portions.
5. The lighting apparatus according to claim 1, wherein the lighting unit comprises a plurality of first light sources and a plurality of second light sources, and the first light sources and the second light sources are arranged in a curve.
6. A backlight module, comprising:
a light-guiding plate comprising a light-incident surface and a light-emitting surface disposed adjacent to the light-incident surface, wherein two ends of the light-incident surface are connected as a reference line;
at least one optical film disposed adjacent to the light-emitting surface; and
a lighting unit disposed on a side of the light-incident surface, wherein the lighting unit comprises at least one first light source, at least one second light source and a circuit board, the first light source and the second light source are disposed on the circuit board, and light emitted by the first and second light sources enters into the light-guiding plate through the light-incident surface and exits the light-guiding plate through the light-emitting surface;
wherein, a first distance from the first light source to the reference line of the light-incident surface is not equal to a second distance from the second light source to the reference line of the light-incident surface.
7. The backlight module according to claim 6, wherein the light unit comprises a plurality of first light sources and a plurality of second light sources, the first light sources and the second light sources are arranged in straight lines respectively, the straight lines are parallel to the reference line, and perpendicular projections of the first light sources and the second light sources on the light-incident surface are disposed alternately.
8. The backlight module according to claim 7, wherein the light-incident surface of the light-guiding plate has a plurality of recessed portions and a plurality of protruded portions, the first light sources are disposed in the recessed portions, and the second light sources are disposed on the protruded portions.
9. The backlight module according to claim 6, wherein the lighting unit comprises a plurality of first light sources and a plurality of second light sources, and the first light sources and the second light sources are arranged in a curve.
10. A display apparatus, comprising:
a display panel; and
a backlight module disposed adjacent to the display panel, wherein the backlight module comprises:
a light-guiding plate comprising a light-incident surface and a light-emitting surface disposed adjacent to the light-incident surface, wherein two ends of the light-incident surface are connected as a reference line,
at least one optical film disposed adjacent to the light-emitting surface, and
a lighting unit disposed on a side of the light-incident surface, wherein the lighting unit comprises at least one first light source, at least one second light source and a circuit board, the first light source and the second light source are disposed on the circuit board, and light emitted by the first and second light sources enters into the light-guiding plate through the light-incident surface and exits the light-guiding plate through the light-emitting surface,
wherein, a first distance from the first light source to the reference line of the light-incident surface is not equal to a second distance from the second light source to the reference line of the light-incident surface.
11. The display apparatus according to claim 10, wherein the light unit comprises a plurality of first light sources and a plurality of second light sources, the first light sources and the second light sources are arranged in straight lines respectively, the straight lines are parallel to the reference line, and perpendicular projections of the first light sources and the second light sources on the light-incident surface are disposed alternately.
12. The display apparatus according to claim 11, wherein the light-incident surface of the light-guiding plate has a plurality of recessed portions and a plurality of protruded portions, the first light sources are disposed in the recessed portions, and the second light sources are disposed on the protruded portions.
13. The display apparatus according to claim 10, wherein the lighting unit comprises a plurality of first light sources and a plurality of second light sources, and the first light sources and the second light sources are arranged in a curve.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1-10. (canceled)
11: A process for manufacturing a laminated glazing unit including at least two glass substrates and at least one plastic interlayer arranged over largest dimensions of the substrates, and including at least one hole through the thickness of the glazing, the process comprising:
superposing the substrates and the interlayer, the substrates and the interlayer having been cut beforehand so as to have respective apertures of which the superposition corresponds to the hole in the glazing unit;
degassing; and
wherein before the degassing, affixing a removable seal, around the periphery of the hole, to an edge face of the glazing unit and to general external faces of the glass substrates, the seal including a web and, connected to this web, two opposed flanges extending in parallel in a same direction and spaced so as to house the thickness of the glazing, the flanges having respective mutually facing internal faces, which each include at least one protruding fastening element and respectively pressed against the general external faces of the substrates, wherein the web includes, on its internal face connecting internal faces of the flanges, at least one groove arranged opposite the edge face of the glazing unit.
12: The process as claimed in claim 11, wherein the one or more protruding fastening elements of the flange of the seal are inclined toward the web.
13: The process as claimed in claim 11, wherein each flange of the seal includes a single fastening element located near the distal end of the flange, at the opposite end to the web.
14: The process as claimed in claim 11, wherein the distance separating the flanges of the seal is smaller than the thickness of the glazing.
15: The process as claimed in claim 11, wherein the seal is extruded and made of a flexible material of ethylene-propylene-diene monomer (EPDM) type.
16: The process as claimed in claim 11, wherein the flanges of the seal cover the external faces of the substrates over a width, in a direction away from the hole, of at least 8 mm, of from 8 to 15 mm.
17: The process as claimed in claim 11, wherein the groove of the seal is locally connected to a gas extraction device, of vacuum pump type, so as to ensure the degassing.
18: The process as claimed in claim 11, wherein an additional seal of known type is placed around the entire external periphery of the glazing unit, the additional seal being connected to a gas extraction device, of vacuum pump type.
19: A laminated glazing unit obtained using the manufacturing process as claimed in claim 11.
20: A laminated glazing unit capable of being obtained using the manufacturing process as claimed in claim 11, comprising:
at least two glass substrates; and
at least one plastic interlayer arranged between the substrates, and provided through its thickness with at least one hole,
wherein the hole is used to house a functional element other than a retaining or fixing element, or receives a window vent, or forms an openable space in an automotive glazing unit of sunroof type and configured to cooperate with a movable glass panel.