Author: claimsbot

1. A pharmaceutical composition in solid dosage form comprising, as active ingredient, MTC, said composition further comprising at least one diluent suitable for direct compression, characterised in that the MTC exists in a substantially pure and stable polymorphic form.
2. A composition as claimed in claim 1, wherein the MTC is in polymorph Form A.
3. A composition as claimed in claim 1 or claim 2, wherein the amount of MTC in the composition is more than about 10% ww, or more than 20%, or more than 30% ww.
4. A composition as claimed in claim 3, wherein the amount of MTC is less than about 75% ww, or less than 60% or less than 50% ww.
5. A composition as claimed in claim 4, wherein the amount of MTC in the composition is from about 10% ww (or 20% or 30%) to about 70% ww (or 60% or 50%).
6. A composition as claimed in any preceding claim, which comprises at least 15% ww, at least 20%, at least 30%, at least 40% or at least 50% ww of diluent(s).
7. A composition as claimed in any preceding claim, wherein the diluent(s) are selected from the group consisting of microcrystalline cellulose, lactose, mannitol, calcium salts such as calcium phosphate dibasic, calcium sulphate and calcium carbonate, and sugars such as lactose, sucrose, dextrose and maltodextrin.
8. A composition as claimed in any preceding claim, which further comprises a lubricant.
9. A composition as claimed in claim 8, wherein the lubricant is selected from the group consisting of magnesium stearate, calcium stearate, sodium stearyl fumarate, stearic acid, glycerylbehaptate, polyethylene glycol, ethylene oxide polymers, sodium lauryl sulphate, magnesium lauryl stearate, mixtures of magnesium stearate with sodium lauryl sulphate, and hydrogenated vegetable oil.
10. A composition as claimed in claim 8, wherein the lubricant is magnesium stearate.
11. A composition as claimed in any one of claims 8 to 10, which comprises from about 0.5 to about 5.0% ww lubricant.
12. A composition as claimed in any preceding claim, which further comprises one or more disintegrants selected from the group consisting of crosslinked polyvinylpyrrolidone, sodium starch glycolate, crosslinked sodium carboxymethyl cellulose (sodium croscarmellose), and pregelatinized starch.
13. A composition as claimed in any preceding claim, which further comprises a binder selected from the group consisting of cellulose derivatives (carboxymethylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, hydroxyethylcellulose, ethylcellulose, microcrystalline cellulose) and sugars such as lactose, sucrose, dextrose, glucose, maltodextrin, and mannitol, xylitol, polymethacrylates, polyvinylpyrrolidone, sorbitol, pregelatinized starch, alginic acids, and salts thereof such as sodium alginate, magnesium aluminum silicate, polyethylene glycol, and the like.
14. A composition as claimed in any preceding claim, which is a tablet.
15. A composition as claimed in any preceding claim, which is a capsule.
16. A composition as claimed in claim 14, to which a film coating has been applied.
17. A composition as claimed in claim 14, wherein the film coating comprises hydroxypropylmethylcellulose (HPMC) or polyvinyl alcohol-part hydrolysed (PVA).
18. A composition as claimed in claim 14, wherein the capsule is an HPMC or Gelatin capsule.
19. A free-flowing, cohesive powder, comprising MTC in a substantially pure polymorphic form, at least one diluent suitable for direct compression, and optionally one or more other excipients, said powder being capable of being directly compressed into a pharmaceutical composition according to any preceding claim.
20. A process for the manufacture of a pharmaceutical composition according to claim 1, which process comprises the dry compression process of an intimate powder mixture of MTC in a substantially pure polymorphic form with at least one diluent suitable for direct compression, and optionally one or more other excipients.
21. A process according to claim 20, which process comprises the direct compression of an intimate powder mixture of MTC in a substantially pure polymorphic form with at least one diluent suitable for direct compression, and optionally one or more other excipients.
22. A process as claimed in claim 20, which is a direct compression process in which MTC, diluent(s) and other optional excipients are blended together in solid, particulate form to create an intimate mixture, and then compressed using a tablet machine.
23. A process as claimed in claim 20, which is a dry granulation process in which MTC, diluent(s) and other optional excipients are formed into a compressed mass, milled and then compressed using a tablet machine.
24. A process as claimed in claim 20, which is a moist granulation process in which the diluent(s) are wet massed using a granulating fluid and the wet mass is then dried to form granules which are subsequently blended with MTC and compressed to form tablets.
25. A process as claimed in any one of claims 20 to 24, which further comprises the step of applying a film coating to the tablets.
26. A process as claimed in claim 25, wherein the step of applying a film coating is carried out in a coating pan and comprises pre-heating of the coating pan, prior to introduction of the tablets to be coated.
27. A process as claimed in claim 26, wherein the temperature of the tablets is maintained during coating at a temperature of 38-48\xb0 C., more preferably 42-44\xb0 C.
28. A method of treatment or prophylaxis of a disease condition in a patient, said method comprising administering to said patient a therapeutically-effective amount of a solid dosage form composition as claimed in any one of claims 1 to 18.
29. A method as claimed in claim 28 wherein the disease is a tauopathy.
30. A drug product for the treatment of a disease state associated with tau protein aggregation in a mammal suffering therefrom, comprising a container labeled or accompanied by a label indicating that the drug product is for the treatment of said disease, the container containing one or more dosage units each comprising a solid dosage form composition as claimed in any one of claims 1 to 18.
31. Use of system comprising a diluent and direct compression for enhancing the stability of a substantially pure MTC polymorph in a pharmaceutical composition.
32. Use as claimed in claim 31, wherein the pharmaceutical composition is the solid dosage form composition as claimed in any one of claims 1 to 14 or claim 16 or claim 17.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of positioning a patient support apparatus powered by a line voltage at a desired speed, comprising:
receiving a control signal indicative of the line voltage supplied to the patient support apparatus; and
driving a motor configured to move the patient support apparatus at the desired speed using the control signal, wherein driving the motor further includes driving the motor at the desired speed for a first period corresponding to a first portion of a distance traveled by the support apparatus and at a second desired speed for a second period corresponding to a second portion of the distance traveled by the support apparatus.
2. The method of claim 1, wherein using the control signal further includes customizing the desired speed.
3. The method of claim 1, wherein receiving the control signal further includes determining a voltage indicative of the line voltage.
4. The method of claim 1, wherein receiving the control signal further includes receiving input from a voltage regulator device.
5. The method of claim 1, wherein receiving the control signal further includes determining a voltage delivered to the motor.
6. The method of claim 1, wherein receiving the control signal further includes receiving a measurement determined by at least one of a: a voltage sensor and a current sensor.
7. The method of claim 1, wherein driving the motor further includes comparing a determined voltage to a reference voltage.
8. The method of claim 1, wherein driving the motor further includes modifying a duty cycle of the motor according to the control signal.
9. The method of claim 1, wherein driving the motor further includes correlating the control signal to a power level associated with the desired speed.
10. The method of claim 1, wherein driving the motor further includes increasing a duty cycle if a determined voltage is less than a reference voltage.
11. The method of claim 1, wherein driving the motor further includes decreasing a duty cycle if a determined voltage is greater than a reference voltage.
12. The method of claim 1, wherein driving the motor further includes generating the control signal.
13. The method of claim 1, wherein receiving the control signal further includes receiving at least one of: directional data indicative of a desired direction of movement of the support surface, a speed measurement, a voltage level, a load and a patient weight.
14. A method of positioning a patient support apparatus at a desired speed, comprising:
receiving input indicating a desired speed at a controller of the patient support apparatus, wherein the patient support apparatus includes a moveable support surface, wherein receiving the input further includes receiving input particular to at least one of a direction, a first portion of a distance traveled by the movable support apparatus, and a second desired speed for a second period corresponding to a second portion of the distance traveled by the movable support apparatus;
processing the input to generate a control signal; and
moving the moveable support surface at the desired speed in response to receiving the control signal.
15. The method of claim 14, wherein receiving the input further includes receiving a reference voltage.
16. The method of claim 14, further comprising programmatically restricting a range in which the movable support surface moves.
17. The method of claim 14, wherein processing the input further includes correlating the input to a power level.
18. A patient support apparatus, comprising:
a moveable support surface;
an electric motor for driving the moveable support surface at a desired speed in response to a power signal comprising a power level;
a sensor having an output used to generate a control signal indicative of line voltage supplied to the patient support apparatus; and
a controller for processing the control signal and initiating generation of the power signal according to the control signal.
19. The apparatus of claim 18, wherein the control signal includes a voltage indicative of the line voltage.
20. The apparatus of claim 18, further comprising an input means for modifying the desired speed.
21. The apparatus of claim 18, wherein the controller is configured to compare a determined voltage derived from the control signal to a reference voltage.
22. The apparatus of claim 18, wherein the controller is configured to modify a duty cycle of the motor according to the control signal.
23. The apparatus of claim 18, wherein the controller is configured to correlate the control signal to a power level associated with the desired speed.
24. The apparatus of claim 18, wherein the controller is configured to increase a duty cycle if a voltage used to generate the control signal is less than a reference voltage.
25. The apparatus of claim 18, wherein the controller is configured to decrease a duty cycle if a voltage used to generate the control signal is greater than a reference voltage.
26. The apparatus of claim 18, further comprising an actuator for mechanically cooperating with the motor to move the moveable support surface.
27. The apparatus of claim 18, wherein the desired speed changes according to the relative position of the moveable support surface.
28. The apparatus of claim 18, wherein the sensor includes a resistor.
29. The apparatus of claim 18, wherein the sensor is configured to determine a current flowing through the electric motor.
30. The apparatus of claim 18, wherein the sensor is configured to determine a motor voltage applied to the electric motor.
31. A patient support apparatus, comprising:
a moveable support surface;
an electric motor for driving the moveable support surface at a desired speed in response to a power signal;
an input mechanism for receiving input indicating the desired speed, wherein receiving the input further includes receiving input particular to at least one of a direction, a first portion of a distance traveled by the movable support surface, and a second desired speed for a second period corresponding to a second portion of the distance traveled by the movable support surface; and
a controller for initiating generation of the power signal configured to cause the electric motor to drive the moveable support surface at the desired speed, wherein the power signal is generated according to the desired speed.

1. An octagonal bulk bin comprising:
a pair of opposite sidewalls, a pair of opposite end walls, and opposed pairs of diagonal corner panels interposed between adjacent said sidewalls and end walls, wherein the sidewails, end walls and diagonal corner panels are joined to one another along vertical folds;
major bottom flaps foldably joined to bottom edges of the sidewalls along horizontal folds;
minor bottom flaps foldably joined to bottom edges of the end walls along horizontal folds;
diagonal bottom flaps foldably joined to bottom edges of the diagonal panels along horizontal folds;
cuts separating said major bottom flaps from respective adjacent diagonal bottom flaps, said cuts terminating in spaced relation to said horizontal folds to prevent initiation of tearing of said vertical folds; and
a foldable web panel interconnecting opposite side edges of each minor bottom flap with adjacent side edges of respective adjacent diagonal bottom flap, each said web panel being defined by first and second divergent fold scores, wherein said first fold score extends in alignment with an adjacent vertical fold and an adjacent side edge of the minor bottom flap, and the second fold score extends to a free end edge of the diagonal bottom flap from a point on the first fold score spaced from the horizontal fold connecting the minor bottom flap to its associated end wall; and
said web panel and a portion of an adjacent minor bottom flap are crushed.
2. An octagonal bulk bin as claimed in claim 1, wherein:
said cuts separating said major bottom flaps from respective adjacent diagonal bottom flaps terminate in a J-shape having a hooked end adjacent but spaced from an intersection of a said horizontal fold with a said vertical fold, said hooked end having a convex side adjacent said intersection and a free end in an adjacent major bottom flap pointing away from said intersection and into said major bottom flap to redirect stress away from said horizontal and vertical folds.
3. An octagonal bulk bin as claimed in claim 1, wherein:
at least a portion of each said diagonal bottom flap is crushed.
4. An octagonal bulk bin as claimed in claim 3, wherein:
said diagonal bottom flap and said web panel are crushed over their entire areas; and
the portion of said adjacent minor bottom flap that is crushed has an arcuately shaped edge.
5. An octagonal bulk bin as claimed in claim 4, wherein:
the crushed area of the diagonal bottom flap comprises a first crushed area, and the crushed web panel and crushed portion of said adjacent minor bottom flap comprise a second crushed area, said first and second crushed areas being crushed to a different extent.
6. An octagonal bulk bin as claimed in claim 5, wherein:
said second crushed area is crushed to a greater extent than said first crushed area.
7. An octagonal bulk bin as claimed in claim 1, wherein:
a pair of spaced apart V-shaped notches are formed in an outer free edge of each minor bottom flap, forming a pair of spaced apart locking tabs on opposite corners of said outer free edge of each minor bottom flap; and
a pair of spaced apart open slots are formed adjacent an outer free edge of each said major bottom flap in a position to be in aligned registry with respective said locking tabs when the major and minor bottom flaps are folded inwardly to closed position across the bottom of said bin, said locking tabs extending into said slots to lock the major and minor bottom flaps in their inwardly folded position.
8. An octagonal bulk bin as claimed in claim 7, wherein:
one of said V-shaped notches of each said pair of notches is shaped differently than the other notch.
9. An octagonal bulk bin as claimed in claim 8, wherein:
said V-shaped notches have divergent sides forming said V-shape, one of the sides of one of the notches of each pair diverging at a greater angle than the other notch of the pair.
10. An octagonal bulk bin comprising:
a pair of opposite sidewalls, a pair of opposite end walls, and opposed pairs of diagonal corner panels interposed between adjacent said sidewalls and end walls, wherein the sidewalls, end walls and diagonal corner panels are joined to one another along vertical folds;
major bottom flaps foldably joined to bottom edges of the sidewalls along horizontal folds;
minor bottom flaps foldably joined to bottom edges of the end walls along horizontal folds;
diagonal bottom flaps foldably joined to bottom edges of the diagonal corner panels along horizontal folds; and
self locking means for locking said major and minor flaps and said diagonal corner flaps in closed position, said self locking means comprising a pair of notches in a free edge of each said minor bottom flap defining locking tabs at opposite outer corners of said free edge, and a pair of open slots near a free edge of each said major bottom flap in positions to receive the locking tabs when the flaps are folded to a closed position, said notches having divergent side edges defining a V-shape, and the divergent side edges of one notch of each pair diverging to a greater extent than the side edges of the other notch.
11. An octagonal bulk bin as claimed in claim 10, wherein:
a foldable web panel interconnects opposite side edges of each minor bottom flap with adjacent side edges of respective adjacent diagonal bottom flaps.
12. An octagonal bulk bin as claimed in claim 11, wherein:
said web panel and a portion of an adjacent minor bottom flap are crushed.
13. An octagonal bulk bin as claimed in claim 12, wherein:
at least a portion of each said diagonal bottom flap is crushed.
14. An octagonal bulk bin as claimed in claim 10, wherein:
said diagonal bottom flap and said web panel are crushed over their entire areas; and
the portion of said adjacent minor bottom flap that is crushed has an arcuately shaped edge.
15. A blank for making an octagonal bulk bin, comprising:
a unitary piece of generally rectangularly shaped material having a plurality of first, parallel, spaced apart fold scores delimiting adjacent sidewall panels, end wall panels, and diagonal corner panels;
a second fold score extending perpendicular to the first fold scores and defining bottom edges of the sidewall panels, end wall panels and diagonal corner panels;
a bottom-forming flap panel joined to each said bottom edge at said second fold score, said bottom-forming flap panels including a major flap panel connected to the bottom edge of each sidewall panel, a minor flap panel connected to the bottom edge of each end wall panel, and a diagonal flap panel connected to the bottom edge of each diagonal corner panel, said major and minor flap panels having a first width from a free end edge thereof to their folded connection with an associated wall panel, and said diagonal flap panels having a second width from a free end edge thereof to their folded connection with an associated diagonal corner panel;
a cut separating each said major flap panel from an adjacent diagonal flap panel; and
a web panel connecting opposite side edges of each minor flap panel with an adjacent side edge of a respective adjacent diagonal flap panel, each said web panel and an adjacent portion of a said minor flap panel being crushed.
16. A blank as claimed in claim 15, wherein:
at least a portion of said diagonal flap panel is crushed.
17. A blank for making an octagonal bulk bin, comprising:
a unitary piece of generally rectangularly shaped material having a plurality of first, parallel, spaced apart fold scores delimiting adjacent sidewall panels, end wall panels, and diagonal corner panels;
a second fold score extending perpendicular to the first fold scores and defining a bottom edge of the sidewall panels, end wall panels and diagonal corner panels;
a plurality of bottom-forming flap panels joined to the bottom edge at said second fold score, said bottom-forming flap panels including a major flap panel connected to the bottom edge of each sidewall panel, a minor flap panel connected to the bottom edge of each end wall panel, and a diagonal flap panel connected to the bottom edge of each diagonal corner panel, said major and minor flap panels having a first width from a free end edge thereof to their folded connection with an associated wall panel, and said diagonal flap panels having a second width from a free end edge thereof to their folded connection with an associated diagonal corner panel;
a cut separating each said major flap panel from an adjacent diagonal flap panel; and
self locking means on said minor flap panels and major flap panels to lock said panels in closed position, said locking means comprising a pair of notches on a free end edge of each minor flap panel, defining a pair of locking tabs, and a pair of open slots near a free end edge of each major flap panel in positions to receive the locking tabs, said notches having divergent side edges defining a V-shape, and the divergent side edges of one notch of each air diver in to a greater extent than the side edges of the other notch.
18. A blank as claimed in claim 17, wherein:
a web panel connects opposite side edges of each minor flap panel with an adjacent side edge of a respective adjacent diagonal flap panel, said diagonal flap panel, said web panel, and an adjacent portion of an adjacent minor flap panel being crushed.
19. An octagonal bulk bin comprising:
a pair of opposite sidewalls, a pair of opposite end walls, and opposed pairs of diagonal corner panels interposed between adjacent said sidewalls and end walls, wherein the sidewalls, end walls and diagonal corner panels are joined to one another along vertical folds;
major bottom flaps foldably joined to bottom edges of the sidewalls along horizontal folds;
minor bottom flaps foldably joined to bottom edges of the end walls along horizontal folds;
diagonal bottom flaps foldably joined to bottom edges of the diagonal corner panels along horizontal folds;
a web panel connected between opposite side edges of each minor flap panel and an adjacent side edge of a respective adjacent diagonal flap panel, each said web panel being triangularly shaped and delimited by first and second divergent fold scores and a curvilinear free end edge, wherein said first fold score extends in alignment with an adjacent said vertical fold and an adjacent side edge of a said minor bottom flap, and the second fold score extends to a free end edge of the diagonal bottom flap from a point on the first fold score spaced from the horizontal fold connecting the minor bottom flap to its associated end wall; and
said web panel and a portion of an adjacent minor bottom flap are crushed.
20. A bulk bin as claimed in claim 19, wherein:
said mirror image portion has one side edge defined by said first fold score, a second side edge defined by a score in said minor flap panel extending divergently from said first fold score, and an arcuate end edge.
21. A bulk bin as claimed in claim 20, wherein:
said curvilinear end edge of said web panel is concave and said arcuate end edge of said mirror image portion is convex.
22. A bulk bin as claimed in claim 21, wherein:
each said diagonal bottom flap defines a first area and each said web panel and adjacent mirror image portion together define a second area, said first and second areas being crushed and said first area being crushed to a lesser extent than said second area.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A retractable assembly for immersion-, flow- or add-on measuring systems in analytical process technology for measuring at least one measured variable of a medium in a containment, comprising:
an essentially cylindrical housing;
an immersion tube, which is movable axially in said housing between a service position out of the medium and a process position in the medium;
a sensor for measuring the measured variable, said sensor is arranged in said immersion tube, and said sensor protrudes at least sectionally out of said immersion tube at the end of said immersion tube remote from the medium; and
an openable and closable cover, which surrounds at least said section of the sensor protruding out of said immersion tube, said sensor in the opened state of said cover is mountable and demountable, respectively, in and from the immersion tube, wherein:
said cover at least sectionally travels with the movement of said immersion tube and in the process position is located at least sectionally in said housing.
2. The retractable assembly as claimed in claim 1, wherein:
said cover is so embodied that it is not openable, when said immersion tube is located in the process position.
3. The retractable assembly as claimed in claim 1, wherein:
said cover includes on its end facing the medium an essentially cylindrical section, whose diameter is less than the diameter of the section of said housing, into which said cover moves.
4. The retractable assembly as claimed in claim 1, wherein:
said cover is essentially cylindrically embodied and includes a first half shell as well as a second half shell; and
said first half shell is connected with said second half shell via a shared edge.
5. The retractable assembly as claimed in claim 1, wherein:
said immersion tube includes on its end remote from the medium a first conical section with smaller diameter toward the medium; and
said cover includes a second conical section corresponding to said first conical section;
a web pointing into the interior of said cover is placed on said process remote end region of said second section; and
said second conical section surrounds said first conical section.
6. The retractable assembly as claimed in claim 1, wherein:
a pressurized air energy supply, effects movement from a service position into a process position and vice versa.
7. The retractable assembly as claimed in claim 1, wherein:
movement from said service position into said process position and vice versa is effected by means of a hand drive.
8. The retractable assembly as claimed in claim 1, wherein:
said cover includes a holder for a tool, preferably an open ended wrench or a socket wrench; and
said tool is so embodied that therewith at least the sensor is mountable or demountable, respectively, in and from said immersion tube.
9. The retractable assembly as claimed in claim 1, wherein:
said cover includes, on its end remote from the medium, a cable- andor hose guide.
10. The retractable assembly as claimed in claim 1, wherein:
said cover includes, on its end remote from the medium, a hook.
11. The retractive assembly as claimed in claim 1, wherein:
said hard drive comprises a manual spindle drive.