Author: claimsbot

What we claim is:

1. A diagnostic ultrasound apparatus for obtaining an image of a region to be scanned by scanning an object with a beam-shaped ultrasound signal, an ultrasound contrast agent being injected into the object, comprising:
scanning means for transmitting the ultrasound signal a plurality of times in each direction composing the region to be scanned and receiving an echo signal in response to each transmission;
subtracting means for obtaining a difference signal by performing subtraction between the echo signals received with two times of transmission among the plurality of times of transmission;
producing mean for independently producing both of the echo signal received with any time of transmission of the plurality of times of transmission and the difference signal into individual tomographic images; and
displaying means for displaying the individual tomographic images at the same time.
2. The diagnostic ultrasound apparatus of claim 1, wherein the plurality of times of transmission is two times of transmission in each raster composing each direction.
3. The diagnostic ultrasound apparatus of claim 2, wherein the producing means has processing means for processing any of a first echo signal and a second echo signal received with the two times of transmission and the difference signal under processing conditions mutually independent of each other into data of two tomographic images.
4. The diagnostic ultrasound apparatus of claim 3, wherein the processing conditions include at least one of a reception gain, a dynamic range, cut-off frequency and bandwidth of an echo filter, and a frame-to-frame after-image processing.
5. The diagnostic ultrasound apparatus of claim 3, wherein the processing conditions include at least one of a correction processing technique and a color encoding technique performed when mapping intensities of the echo signal on a video screen.
6. The diagnostic ultrasound apparatus of claim 1, wherein the displaying means has means for displaying the individual tomographic images in mutually different colors.
7. The diagnostic ultrasound apparatus of claim 1, wherein the displaying means is means for displaying the individual tomographic images with either one tomographic image superposed on the other tomographic image.
8. The diagnostic ultrasound apparatus of claim 7, wherein the displaying means is means for displaying the tomographic image based on the difference signal, which serves as the other tomographic image, superposed on the tomographic image based on the echo signal, which servers as the one tomographic image.
9. The diagnostic ultrasound apparatus of claim 8, wherein the displaying means is means for displaying, of the one and other images, either one image in gray scales and the remaining image in colors.
10. The diagnostic ultrasound apparatus of claim 8, wherein the displaying means is means for displaying the one and other images in mutually different colors.
11. The diagnostic ultrasound apparatus of claim 1, wherein the displaying means is means for displaying the individual tomographic images in parallel with each other on a screen.
12. The diagnostic ultrasound apparatus of claim 1, wherein the producing means has image memorizing means capable of individually memorizing image data of the individual tomographic images and individually reading out the image data thereof.
13. The diagnostic ultrasound apparatus of claim 12, wherein the displaying means has means for individually reading out the image data of the tomographic images from the image memorizing means and mans for commanding a switchover of display modes consisting of superposed display of the individual tomographic images, parallel display of the individual tomographic images, and sole display of either one of the individual tomographic images on the bases on the read-out image data.
14. The diagnostic ultrasound apparatus of claim 13, wherein the displaying means include means for independently setting at least one of a correction processing technique and color encoding technique accordingly to which of the echo signal and the difference signal corresponds to the read-out image data and mapping the image data on a video screen.
15. The diagnostic ultrasound apparatus of claim 1, wherein the ultrasound contrast agent is a contrast agent of which main constituent is microbubbles, and the scanning means is means for additionally transmitting an ultrasound signal to excite the microbubbles in each direction.
16. The diagnostic ultrasound apparatus of claim 1, wherein the additional transmission of the exciting ultrasound signal interleaves in time between two times of transmission selected from the plurality of times of transmission.
17. The diagnostic ultrasound apparatus of claim 1, wherein the displaying means has means for commanding a switchover of display modes consisting of superposed display of the individual tomographic images, parallel display of the individual tomographic images, and sole display of either one of the individual tomographic images.
18. The diagnostic ultrasound apparatus of claim 1, wherein the echo signal experiencing the subtraction executed by the subtraction means is a radio frequency signal of the echo signal before detected.
19. The diagnostic ultrasound apparatus of claim 8, wherein the displaying means has superposition control means that is changeable in a superposition balance of intensity when the other tomographic image is superposed on the one tomographic image.
20. The diagnostic ultrasound apparatus of claim 19, wherein the superposition control means has manual-change commanding means capable of manually changing the superposition balance.
21. A diagnostic ultrasound apparatus for obtaining an image of a region to be scanned by scanning an object with a beam-shaped ultrasound signal, an ultrasound medium being injected into the object:
scanning means for transmitting the ultrasound signal a plurality of times in each direction composing the region to be scanned and receiving an echo signal in response to each transmission;
subtracting means for obtaining a difference signal by performing subtraction between the echo signals received with two times of transmission among the plurality of times of transmission;
addition means for obtaining an average signal by performing average between the echo signals received with two times of transmission among the plurality of times of transmission;
producing mean for independently producing both of the difference signal and the average signal into individual tomographic images; and
displaying means for displaying the individual tomographic images at the same time.
22. The diagnostic ultrasound apparatus of claim 21, wherein the plurality of times of transmission is two times of transmission in each raster composing each direction.
23. The diagnostic ultrasound apparatus of claim 22, wherein the producing means includes processing means for processing the average signal and the difference signal with processing conditions mutually independent of each other into data of two tomographic images.
24. The diagnostic ultrasound apparatus of claim 21, wherein the displaying means is means for displaying the individual tomographic images in either one of a superposition manner and a parallel manner.
25. The diagnostic ultrasound apparatus of claim 21, wherein the subtraction means is means for performing the subtraction of the echo signal received by the first-time transmission of the plurality of times of transmission and the echo signal received by any-time transmission selected from the second-time or later transmission of the plurality of times of transmission, and
the addition means is means for performing the addition of the echo signal received by the first-time transmission of the plurality of times of transmission and the echo signal received by any-time transmission selected from the second-time or later transmission of the plurality of times of transmission.
26. An ultrasound imaging method for obtaining an image of a region to be scanned by scanning an object with a beam-shaped ultrasound signal, an ultrasound contrast agent being injected into the object, comprising the steps of:
transmitting the ultrasound signal a plurality of times in each direction composing the region to be scanned and receiving an echo signal in response to each transmission;
obtaining a difference signal by performing subtraction of the echo signals received with two times of transmission among the plurality of times of transmission;
independently producing both of the echo signal received with any time of transmission of the plurality of times of transmission and the difference signal into individual tomographic images; and
displaying the individual tomographic images at the same time.
27. An ultrasound imaging method for obtaining an image of a region to be scanned by scanning an object with a beam-shaped ultrasound signal, an ultrasound contrast agent being injected into the object, comprising the steps of:
transmitting the ultrasound signal a plurality of times in each direction composing the region to be scanned and receiving an echo signal in response to each transmission;
calculating a difference signal by performing subtraction of the echo signals received with two times of transmission among the plurality of times of transmission;
calculating an average signal by performing average between the echo signals received with two times of transmission among the plurality of times of transmission;
independently producing both of the difference signal and the average signal into individual tomographic images; and
displaying the individual tomographic images at the same time.
28. A diagnostic ultrasound apparatus for obtaining an image of a region to be scanned by scanning an object with a beam-shaped ultrasound signal, an ultrasound contrast agent being injected into the object:
an ultrasound probe for transmitting and receiving the ultrasound signal;
a transmitter for exciting the ultrasound probe responsively to each rate pulse so as to cause the ultrasound probe to output the ultrasound signal;
a receiver for delaying and adding an echo signal received by the ultrasound probe;
a controller for causing the transmitter to transmit the ultrasound signal a plurality of times in each direction composing the region to be scanned and causing the receiver to receive the echo signal in response to each transmission;
a subtracter for obtaining a difference signal by performing subtraction between the echo signals received with two times of transmission among the plurality of times of transmission;
a producer for independently producing both of the echo signal received with any time of transmission of the plurality of times of transmission and the difference signal into individual tomographic images; and
a display for displaying the individual tomographic images at the same time.
29. The diagnostic ultrasound apparatus of claim 28, wherein the plurality of times of transmission is two times of transmission in each raster composing each direction.
30. The diagnostic ultrasound apparatus of claim 29, wherein the producer has a processor for processing any of a first echo signal and a second echo signal received with the two times of transmission and the difference signal under processing conditions mutually independent of each other into data of two tomographic images.
31. The diagnostic ultrasound apparatus of claim 28, wherein the display is configured to display the individual tomographic images with either one tomographic image superposed on the other tomographic image.
32. The diagnostic ultrasound apparatus of claim 31, wherein the display is changeable in a superposition balance of intensity when the other tomographic image is superposed on the one tomographic image.
33. The diagnostic ultrasound apparatus of claim 32, wherein the display is configured to be capable of manually changing the superposition balance.
34. The diagnostic ultrasound apparatus of claim 28, wherein the echo signal experiencing the subtraction executed by the subtracter is a radio frequency signal of the echo signal before detected.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method comprising:
segmenting a variable bit rate representation of an image sequence into a plurality of segments utilizing a processor; and
creating a second representation of the image sequence, wherein a block of information of a first segment of the plurality of segments is interlaced with blocks of information of a second segment of the plurality of segments,
wherein the second representation of the image sequence comprises a fragment header indicating the block of information of the first segment of the plurality of segments interlaced with the blocks of information of the second segment of the plurality of segments.
2. The method of claim 1, wherein the second segment of the plurality of segments comprises more blocks of information than the first segment of the plurality of segments.
3. The method of claim 1, wherein each segment of the plurality of segments spans a same time interval.
4. The method of claim 1, wherein after creating the second representation of the image sequence, the first and second segments of the plurality of segments comprise a same number of blocks of information.
5. The method of claim 1, wherein the variable bit rate representation comprises a plurality of packets of blocks of information and wherein a block of information from the first segment of the plurality of segments is removed from the first segment.
6. The method of claim 1, further comprising:
extending a size of each segment of the plurality of segments to cause each segment to have a size within an upper bound after creating the second representation.
7. The method of claim 1, further comprising:
removing a frame from the image sequence to cause each segment of the plurality of segments to have a size within an upper bound after creating the second representation.
8. The method of claim 1, further comprising:
streaming the second representation of the image sequence via a communication network; and
reconstructing frames of the image sequence.
9. The method of claim 8, wherein reconstructing frames of the image sequence comprises:
storing blocks of information from the first segment interlaced with blocks of information from the second segment in a buffer; and
reconstructing frames of the image sequence based on blocks of information stored in the buffer and blocks of information received in real time.
10. A non-transitory computer-readable storage medium encoded with a set of computer executable instructions for processing a variable bit rate representation of an image sequence, the set of computer executable instructions which, when executed by a processor cause the processor to perform operations comprising:
segmenting a variable bit rate representation of an image sequence into a plurality of segments; and
creating a second representation of the image sequence wherein a block of information from a first segment of the plurality of segments is interlaced with blocks of information of a second segment of the plurality of segments,
wherein the second representation of the image sequence comprises a fragment header indicating the block of information of the first segment of the plurality of segments interlaced with the blocks of information of the second segment of the plurality of segments.
11. The non-transitory computer-readable storage medium of claim 10, wherein the operations further comprise determining that the second segment of the plurality of segments comprises more blocks of information than the first segment of the plurality of segments.
12. The non-transitory computer-readable storage medium of claim 10, wherein each segment of the plurality of segments spans a same time interval.
13. The non-transitory computer-readable storage medium of claim 10, wherein after creating the second representation of the image sequence, the first and second segments of the plurality of segments comprise a same number of blocks of information.
14. The non-transitory computer-readable storage medium of claim 10, wherein the variable bit rate representation comprises a plurality of packets of blocks of information.
15. The non-transitory computer-readable storage medium of claim 10, wherein a block of information from the first segment of the plurality of segments is removed from the first segment.
16. The non-transitory computer-readable storage medium of claim 10, wherein the operations further comprise extending a size of each segment of the plurality of segments, and
wherein after creating the second representation, each segment has a size within an upper bound.
17. The non-transitory computer-readable storage medium of claim 10, wherein the operations further comprise removing a frame from the image sequence, and
wherein after creating the second representation, each segment of the plurality of segments has a size within an upper bound.
18. A system for processing a variable bit rate representation of an image sequence, the system comprising:
a buffer coupled to a processor, wherein the buffer comprises computer instructions which, when executed, cause the processor to perform operations comprising:
segmenting a variable bit rate representation of an image sequence into a plurality of segments; and
creating a second representation of the image sequence wherein a block of information from a first segment of the plurality of segments is interlaced with blocks of information of a second segment of the plurality of segments,
wherein the second representation of the image sequence comprises a fragment header indicating the block of information of the first segment of the plurality of segments interlaced with the blocks of information of the second segment of the plurality of segments.
19. The system of claim 18, wherein the variable bit rate representation comprises a plurality of packets of blocks of information.
20. The system of claim 18, wherein a block of information from the first segment of the plurality of segments is removed from the first segment.

What is claimed is:

1. A photoelectric switch comprising:
a light emitting means for periodically emitting pulsed detection light;
a light receiving means for photoelectrically converting said pulsed detection light and thereby outputting corresponding light detection signals; and
a signal processing means for generating an on-off judgment output for switching on or off said photoelectric switch;
said signal processing means including:
a level shifting means for shifting the level of the light detection signals towards a specified level during a specified light receiving period by an amount corresponding to the difference between said specified level and the level of the light detection signal at a time immediately before said pulsed detection light is expected to arrive; and
a condition judging means for judging, on the basis of the light detection signal with the level shifted by said level shifting means, whether or not at least one of conditions to be used for generating said on-off judgment output is satisfied;
wherein said condition judging means serves to generate said on-off judgment output at least on the condition that the levels of the light detection signal at a first timing when a peak of the light detection signal is expected to arrive and at a second timing when a bottom of the light detection signal after an overshoot period is expected to arrive are in a specified size relationship.
2. The photoelectric switch of claim 1 wherein said condition judging means serves to generate said on-off judgment output on an additional condition that the level of the light detection signal at said first timing and said specified level are in a specified size relationship.
3. A photoelectric switch comprising:
a light emitting means for periodically emitting pulsed detection light;
a light receiving means for photoelectrically converting said pulsed detection light and thereby outputting corresponding light detection signals; and
a signal processing means for generating an on-off judgment output for switching on or off said photoelectric switch;
said signal processing means including:
a level shifting means for shifting the level of the light detection signals towards a specified level during a specified light receiving period by an amount corresponding to the difference between said specified level and the level of the light detection signal at a time immediately before said pulsed detection light is expected to arrive; and
a condition judging means for judging, on the basis of the light detection signal with the level shifted by said level shifting means, whether or not at least one of conditions to be used for generating said on-off judgment output is satisfied;
wherein said light emitting means is controlled to emit light at least three times per period of light emission from a fluorescent lamp in an environment of said photoelectric switch; and
wherein said condition judging means obtains a plurality of comparison results by comparing a specified level and the level of the light detection signal at times when a peak of said pulsed detection light is expected to arrive and generates said on-off judgment output according to the majority of the comparison results obtained within a period of light emission.
4. The photoelectric switch of claim 1 wherein said light emitting means includes a driving means for outputting a driving pulse signal at a timing specified by a light emission control signal and a light emitting element for emitting pulsed detection light to a specified target region in response to said driving pulse signal outputted from said light emitting means;
wherein said light receiving means includes a light receiving element for receiving reflection of said pulsed detection light arriving from said target region and carrying out photoelectric conversion on the received reflected light and an amplifier for generating a light detection signal by amplifying the output from said light receiving element.
5. The photoelectric switch of claim 4 wherein said condition judging means serves to generate said on-off judgment output on an additional condition that the level of the light detection signal at said first timing and said specified level are in a specified size relationship.
6. The photoelectric switch of claim 3 wherein said light emitting means includes a driving means for outputting a driving pulse signal at a timing specified by a light emission control signal and a light emitting element for emitting pulsed detection light to a specified target region in response to said driving pulse signal outputted from said light emitting means;
wherein said light receiving means includes a light receiving element for receiving reflection of said pulsed detection light arriving from said target region and carrying out photoelectric conversion on the received reflected light and an amplifier for generating a light detection signal by amplifying the output from said light receiving element.
7. The photoelectric switch of claim 4 wherein said level shifting means comprises an AC signal transmitting circuit having an input side and an output side, said AC signal transmitting circuit functioning to transmit AC components of signals on said input side to said output side, to initialize DC potential to be superposed to the AC component on said output side to a specified potential level, and to repeatedly initialize the DC potential to be superposed to the AC component on said output side to said specified potential immediately before the timing at which said pulsed detection light is expected to arrive.
8. The photoelectric switch of claim 5 wherein said level shifting means comprises an AC signal transmitting circuit having an input side and an output side, said AC signal transmitting circuit functioning to transmit AC components of signals on said input side to said output side, to initialize DC potential to be superposed to the AC component on said output side to a specified potential level, and to repeatedly initialize the DC potential to be superposed to the AC component on said output side to said specified potential immediately before the timing at which said pulsed detection light is expected to arrive.
9. The photoelectric switch of claim 6 wherein said level shifting means comprises an AC signal transmitting circuit having an input side and an output side, said AC signal transmitting circuit functioning to transmit AC components of signals on said input side to said output side, to initialize DC potential to be superposed to the AC component on said output side to a specified potential level, and to repeatedly initialize the DC potential to be superposed to the AC component on said output side to said specified potential immediately before the timing at which said pulsed detection light is expected to arrive.
10. The photoelectric switch of claim 7 wherein said AC signal transmitting circuit comprises a capacitor inserted between an input terminal and an output terminal and a switch inserted between said output terminal and a position at a specified potential, said switch being controlled to be switched on and off by a gate control signal in synchronism with said light emission control signal.
11. The photoelectric switch of claim 8 wherein said AC signal transmitting circuit comprises a capacitor inserted between an input terminal and an output terminal and a switch inserted between said output terminal and a position at a specified potential, said switch being controlled to be switched on and off by a gate control signal in synchronism with said light emission control signal.
12. The photoelectric switch of claim 9 wherein said AC signal transmitting circuit comprises a capacitor inserted between an input terminal and an output terminal and a switch inserted between said output terminal and a position at a specified potential, said switch being controlled to be switched on and off by a gate control signal in synchronism with said light emission control signal.
13. The photoelectric switch of claim 7 further comprising a microprocessor wherein calculations for ascertaining said size relationship is carried out by software by means of said microprocessor by using digital data obtained by AD conversion of signals outputted from said AC signal transmitting circuit.
14. The photoelectric switch of claim 8 further comprising a microprocessor wherein calculations for ascertaining said size relationship is carried out by software by means of said microprocessor by using digital data obtained by AD conversion of signals outputted from said AC signal transmitting circuit.
15. The photoelectric switch of claim 9 further comprising a microprocessor wherein calculations for ascertaining said size relationship is carried out by software by means of said microprocessor by using digital data obtained by AD conversion of signals outputted from said AC signal transmitting circuit.
16. The photoelectric switch of claim 4 comprising a light emitting apparatus and a light receiving apparatus which are separated from each other, said light emitting means being contained in said light emitting apparatus, said light receiving means and said signal processing means being contained in said light receiving apparatus, said light emission control signals being transmitted from said light emitting apparatus to said light receiving apparatus through a communication line.
17. The photoelectric switch of claim 5 comprising a light emitting apparatus and a light receiving apparatus which are separated from each other, said light emitting means being contained in said light emitting apparatus, said light receiving means and said signal processing means being contained in said light receiving apparatus, said light emission control signals being transmitted from said light emitting apparatus to said light receiving apparatus through a communication line.
18. The photoelectric switch of claim 6 comprising a light emitting apparatus and a light receiving apparatus which are separated from each other, said light emitting means being contained in said light emitting apparatus, said light receiving means and said signal processing means being contained in said light receiving apparatus, said light emission control signals being transmitted from said light emitting apparatus to said light receiving apparatus through a communication line.

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method for the treatment of cancer, or preventing cancer recurrence or progression, comprising administering to a patient, who has undergone a primary cancer therapy, a compound of formula (I), or a pharmaceutically acceptable salt thereof,
on a dosing schedule comprising at least four 28-day treatment cycles,
wherein the 28-day treatment cycle comprises four consecutive weeks in which the compound of formula (I), or pharmaceutically acceptable salt thereof, is administered once a week for the first three weeks of the treatment cycle and the compound of formula (I), or pharmaceutically acceptable salt thereof, is not administered during the fourth week;
wherein ring A is
and
Z1 and Z2 are each independently hydroxyl; or Z1 and Z2 together form a cyclic boronic ester having 2-20 carbon atoms, and optionally one or more heteroatoms selected from N, S, or O.
2. The method of claim 1, wherein the compound of formula (I), or pharmaceutically acceptable salt thereof, is administered orally.
3. The method of claim 1, wherein the compound of formula (I), or pharmaceutically acceptable salt thereof, is administered on days 1, 8, and 15 of each treatment cycle.
4. The method of claim 1, wherein the dosing schedule comprises about twenty-six treatment cycles.
5. The method of claim 4, wherein the compound of formula (I), or pharmaceutically acceptable salt thereof, is administered at a first dose for at least four treatment cycles, and a second dose in the treatment cycles 5 through 26.
6. The method of claim 5, wherein the first dose is about 3.0 mg and the second dose is about 4.0 mg.
7. The method of claim 5, wherein the first dose is about 3.0 mg, and the second dose is about 3.0 mg.
8. The method of claim 5, wherein the first dose is about 2.3 mg, and the second dose is about 3.0 mg.
9. The method of claim 5, wherein the first dose is about 2.3 mg, and the second dose is about 2.3 mg.
10. The method of claim 5, wherein the first dose and the second dose are the same.
11. The method of claim 1, wherein the compound of formula (I) is a compound of formula (IV)
or an ester or a pharmaceutically acceptable salt thereof.
12. The method of claim 11, wherein said compound of formula (IV) is administered to the patient in a form of an ester, or a pharmaceutically acceptable salt thereof.
13. The method of claim 12, wherein the ester is a compound of formula (IIIa)
or a pharmaceutically acceptable salt thereof.
14. The method of claim 13, wherein the compound of formula (IIIa) is in a solid dosage form.
15. The method of claim 14, wherein the solid dosage form is capsule.
16. The method of claim 15, wherein the capsule contains a mixture of ixazomib citrate, microcrystalline cellulose, talc, and magnesium stearate.
17. The method of claim 1, wherein the primary cancer therapy comprises a proteasome inhibitor based regimen, or an immunomodulating drug based regimen, or both.
18. The method of claim 1, wherein the primary cancer therapy comprises an autologous stem cell transplant.
19. The method of claim 1, wherein the primary cancer therapy comprises a proteasome inhibitor based regimen, or an immunomodulating drug based regimen, or both, followed by autologous stem cell transplant.
20. The method of claim 1, wherein the primary cancer therapy comprises a proteasome inhibitor based regimen, or an immunomodulating drug based regimen, or both, followed by a conditioning regimen comprising melphalan and autologous stem cell transplant.
21. The method of claim 17, 19 or 20, wherein the proteasome inhibitor based regimen comprises bortezomib, ixazomib, carfilzomib, disulfiram, epigallocatechin-3-gallate, salinosporamid A, ONX0912, CEP-18770, or Epoxomicin.
22. The method of claim 21, wherein the proteasome inhibitor based regimen comprises bortezomib.
23. The method of claim 17, 19 or 20, wherein the immunomodulating drug based regimen comprises lenalidomide or pomalidomide.
24. The method of claim 23, wherein the immunomodulating drug based regimen comprises lenalidomide.
25. The method of claim 18, 19 or 20, wherein the first 28-day treatment cycle begins at least 75 days after autologous stem cell transplant.
26. The method of claim 18, 19 or 20, wherein the first 28-day treatment cycle begins prior to 115 days after autologous stem cell transplant.
27. The method of claim 1, wherein the cancer is multiple myeloma, mantle cell lymphoma, follicular cell lymphoma, T-cell lymphoma, peripheral T-cell lymphoma (PTCL), diffuse large B-cell lymphoma (DLBCL), or Waldenstrom’s Macroglobulinemia.
28. The method of claim 1, wherein the cancer is multiple myeloma or refractory multiple myeloma.
29. The method of claim 1, wherein the cancer is amyloidosis.
30. The method of claim 1, wherein the patient is an individual diagnosed with multiple myeloma or refractory multiple myeloma.
31. The method of claim 1, wherein the method is a maintenance therapy to prevent relapse or recurrence of multiple myeloma in the patient who has undergone a primary cancer therapy.
32. The method of claim 1, wherein the method is a maintenance therapy to prevent progression of multiple myeloma in the patient who has undergone a primary cancer therapy.
33. The method of claim 31 or 32, wherein the patient has achieved complete or partial clinical and hematolotic recovery following the primary cancer therapy.
34. The method of claim 1, wherein the method is a maintenance therapy for treating a patient at risk of developing or experiencing a recurrence of a proteasome-mediated disorder.
35. The method of claim 1, wherein the method is a maintenance therapy for treating a patient at risk of developing or experiencing a recurrence of a cancer selected from multiple myeloma.