Author: claimsbot

1. A compound of formula III,
wherein:
Y represents \u2014C(O)\u2014Z;
X represents n-butyl; and
Z represents phenyl substituted in the para-position by \u2014OH, \u2014OCH3, \u2014O-benzyl or \u2014ORa where Ra is \u2014(CH2)3\u2014N(Rb2)Rb3, and Rb2 and Rb3 are butyl.
2. The compound of claim 1 wherein Z represents phenyl substituted in the para-position by \u2014OH, \u2014OCH3 or \u2014O-benzyl.
3. A process for the preparation of a compound of a compound of formula III,
wherein X represents hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms, and Y represents \u2014C(O)Z, which process comprises a reaction according to one of (i), (ii), (iii), (iv), (v), (vi) or (vii):
(i) reaction of a compound of formula VII,
Z\u2014C(O)\u2014CH3\u2003\u2003VII
wherein Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12;
with a compound of formula VIII,
X\u2014C(O)-L1\u2003\u2003VIII
wherein L1 represents a suitable leaving group;
(ii) reaction of a compound of formula IX,
X\u2014C(O)\u2014CH3\u2003\u2003IX
wherein X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms;
with a compound of formula X,
Z\u2014C(O)-L1\u2003\u2003X
wherein Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12; and L1 is a suitable leaving group;
(iii) for compounds of formula III, in which Z represents aryl or heteroaryl substituted by \u2014OH, reaction of a corresponding compound of formula XI,
H3C\u2014C(O)\u2014Za\u2003\u2003XI
wherein Za represents aryl or heteroaryl substituted with \u2014O\u2014C(O)\u2014X (in which X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms), with base;
(iv) decarboxylation of a compound of formula XII,
or a protected derivative thereof, wherein X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms, and Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12;
(v) hydrolysis of a compound of formula XIII,
wherein Rs1 and Rs2 independently represent hydrogen, a C1-6 alkyl optionally substituted by one or more halo atoms, or Rs1 and Rs2 are linked together to form, together with the nitrogen atom to which they are necessarily attached, a 4- to 8-membered heterocycloalkyl group, and X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms, and Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12;
(vi) reaction of a compound of formula XIV,
Z\u2014H\u2003\u2003XIV
wherein Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014N(Ra10)S(O)2Ra11 and Ra12;
with either:
(A) a compound of formula XV,
X\u2014C(O)\u2014CH2\u2014C(O)-L1\u2003\u2003XV
or a protected derivative thereof, wherein X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms, and L1 is a suitable leaving group; or
(B) a compound of formula XVI,
X\u2014C(O)\u2014CH2\u2014CN\u2003\u2003XVI
or a protected derivative thereof, wherein X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms; or
(vii) reduction of a compound of formula XVIA,
or reduction a compound of formula XVIB,
wherein in both formula XVIA and formula XVIB, X is hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms and Z is aryl or heteroaryl, both of which are optionally substituted by one or more substituents selected from the group consisting of \u2014ORa, halo, \u2014NO2, \u2014CN, \u2014C(O)2Ra1, \u2014SRa3, \u2014S(O)Ra4, \u2014S(O)2Ra5, \u2014N(Ra6)Ra7, \u2014N(Ra8)C(O)Ra9, \u2014R(Ra10)S(O)2Ra11 and Ra12, in the presence of aqueous acid
and wherein Ra represents an oxy-protecting group, hydrogen or a C1-6 alkyl optionally substituted by one or more substituents selected from the group consisting of halo, \u2014C(O)2Rb1 and \u2014N(Rb2)Rb3; where Ra1, Ra3, Ra6, Ra7, Ra8, Ra9, Ra10, Rb1, Rb2 and Rb3 independently represent hydrogen or a C1-6 alkyl optionally substituted by one or more halo atoms; and where Ra4, Ra5, Ra11; and Ra12 independently represent a C1-6 alkyl optionally substituted by one or more halo atoms.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method of determining the concentration of an analyte in a biological sample, comprising:
inserting an analyte sensor in a sensor port of an analyte monitoring device, the sensor port comprising:
a first set of contacts positioned along a top portion and a bottom portion of the sensor port for contacting a first analyte sensor having an opposing electrode contact configuration;
a second set of contacts positioned on the top portion or the bottom portion of the sensor port for contacting a second analyte sensor having a co-planar electrode contact configuration;
wherein the analyte monitoring device comprises a processor programmed to:
receive a signal indicative of the concentration of the analyte from the first set of contacts, and
receive a signal indicative of the concentration of the analyte from the second set of contacts; and

depositing the biological sample on the analyte sensor;
receiving, by the processor, the signal from either the first set of contacts or the second set of contacts; and
determining the concentration of the analyte in the biological sample based on the signal.
2. The method of claim 1, wherein the first analyte sensor is a glucose sensor and the second analyte sensor is a ketone sensor.
3. The method of claim 1, wherein both the first and second analyte sensors are glucose sensors.
4. The method of claim 1, further comprising a communication unit.
5. The method of claim 4, wherein the communication unit is configured to provide two-way communication between the sensor port and a device andor network external to the sensor port.
6. The method of claim 4, wherein the communication unit is configured to provide two-way communication between the sensor port and a network external to the sensor port.
7. The method of claim 6, wherein the network is a computer network.
8. The method of claim 4, wherein the communication unit is configured to provide wireless communication between the sensor port and an external device.
9. The method of claim 8, wherein the external device is a medication delivery device or an implanted or partially implanted analyte sensor.
10. The method of claim 8, wherein the external device is an insulin pump.
11. The method of claim 4, wherein the communication unit comprises a Universal Serial Bus (USB) connector.
12. The method of claim 4, wherein the communication unit is configured to provide wireless communication between the sensor port and an external device andor network.
13. The method of claim 12, wherein the communication unit utilizes a wireless communication protocol selected from a radio frequency (RF) protocol and an infrared (IR) protocol.
14. The method of claim 12, wherein the communication unit is configured to provide wireless communication between the sensor port and an external device, the external device comprises a Radio-Frequency Identification (RFID) tag, and the communication unit utilizes an RF wireless communication protocol to communicate with the Radio-Frequency Identification (RFID) tag.
15. The method of claim 12, wherein the communication unit utilizes a wireless communication protocol selected from code division multiple access (CDMA) and Global System for Mobile communications (GSM).
16. The method of claim 1, wherein the sensor port is configured to receive analyte sensors having different widths.
17. The method of claim 16, wherein the sensor port comprises a side wall and a biasing mechanism configured to position the analyte sensors against the sidewall during insertion of the analyte sensors.
18. The method of claim 16, wherein the first analyte sensor has a width which is greater than that of the second analyte sensor.
19. The method of claim 16, wherein the first analyte sensor has a width which is less than that of the second analyte sensor.
20. The method of claim 1, wherein the sensor port comprises an analyte sensor ejector slidably engaged therewith.
21. The method of claim 1, wherein the sensor port comprises at least four sensor port contacts configured to contact the first analyte sensor upon insertion of the first analyte sensor into the sensor port, and at least three sensor port contacts configured to contact the second analyte sensor upon insertion of the second analyte sensor into the sensor port.
22. The method of claim 21, wherein the sensor port comprises at least seven different sensor port contacts.
23. The method of claim 22, wherein the sensor port comprises at least nine different sensor port contacts.
24. The method of claim 21, wherein one of the at least four sensor port contacts is attached to the top portion of the sensor port and three of the at least four sensor port contacts are attached to the bottom portion of the sensor port.
25. The method of claim 21, wherein the at least three sensor port contacts are attached to the top portion of the sensor port.
26. The method of claim 21, wherein the sensor port comprises a protective protrusion extending from the top portion of the sensor port into the interior of the sensor port.

1. A method effective for at least a week for prevention of microbial colony growth on an inanimate surface which is a plastic, metal, glass or ceramic surface, comprising the step of covering the surface with a dry or substantially dry film formed from a composition comprising a polyvinyl alcohol, a quaternary ammonium compound and a surfactant which does not inactivate the quaternary compound.
2. (canceled)
3. A method according to claim 1 wherein the film is formed in situ by coating the surface with a solution or emulsion comprising a polyvinyl alcohol and a quaternary ammonium compound and then causing or allowing it to dry or substantially dry.
4. A method according to claim 1 wherein the film is effective for prevention of microbial colony growth thereon for at least four weeks.
5. A method according to claim 1 wherein the polyvinyl alcohol has a hydrolysis range of greater than 96 mole %.
6. A method according to claim 1 wherein the quaternary ammonium compound comprises from 0.5% to 75% ww of the dried film composition.
7. A method according claim 1 wherein the quaternary ammonium compound is an alkyl benzalkonium compound.
8. A method according to claim 7 wherein the quaternary ammonium compound is an n-alkyl dimethyl benzyl ammonium halide.
9. A method according to claim 1 wherein the polyvinyl alcohol forms a complex with the quaternary compound.
10. A method according to claim 1 wherein the composition further includes a surfactant is a non-ionic, cationic or amphoteric surfactant which does not inactivate the quaternary compound.
11. A method according to claim 1 wherein the surfactant is a C12 to C18 straight chain alcohol or ethoxylated alcohol.
12. A composition effective for at least a week for prevention of microbial colony growth on an inanimate surface which is a plastic, metal, glass or ceramic surface, comprising a dry or substantially dry film formed from a composition containing a complex formed between a polyvinyl alcohols a quaternary ammonium compound and a surfactant which does not inactivate the quaternary compound.
13. (canceled)
14. A composition according to claim 12 wherein the polyvinyl alcohol has an average degree of hydrolysis of greater than 96 mole %.
15. A composition according to claim 12 wherein the quaternary ammonium compound comprises from 0.5% to 75% ww of the dried film composition.
16. A composition according to claim 12 wherein the quaternary ammonium compound is an alkyl benzalkonium compound.
17. A composition according to claim 12 wherein the quaternary ammonium compound is an n-alkyl dimethyl benzyl ammonium halide.
18. A composition according to claim 12 wherein the composition comprises polyvinyl alcohol and a quaternary ammonium compound in an aqueous solution or emulsion.
19. A composition according to claim 13 wherein the surfactant is a non-ionic, cationic or amphoteric surfactant.
20. A composition according to claim 13 wherein the surfactant comprises a C12 to C18 straight chain alcohol or ethoxylated alcohol.
21-22. (canceled)

The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.

1. A method comprising:
restraining a plurality of spectrally labeled bodies with affinity binding so as to define a multiplexed array, wherein the spectrally labeled bodies are spatially resolved and comprise a plurality of fluorescent labels used to encode discrete and different emission spectra wherein each emission spectrum has a plurality of signals at differing wavelengths;
directing an image of the multiplexed array of bodies onto a sensor to sense spectra generated by the bodies; and
identifying the bodies from the spectra sensed by the sensor.
2. The method of claim 1, wherein the bodies are affixed to each other.
3. The method of claim 1, wherein the bodies are restrained within an array of openings affixed in a support structure.
4. The method of claim 1, wherein the sensor is a CCD camera.
5. A method of claim 1, wherein the spectrally labeled bodies include polymers.
6. A method of claim 1, wherein affinity binding is facilitated by a chemical moiety.
7. A method of claim 1, wherein the affinity binding is specific.
8. A method of claim 1, wherein the plurality of signals include a reference signal.
9. A method of claim 1, wherein the affinity binding is facilitated with a binding pair.
10. The method of claim 1, wherein the bodies are restrained to a support structure.
11. The method of claim 1, wherein the bodies are restrained in the multiplexed array by an array of discrete binding sites.
12. A method of claim 8, wherein the reference signal identifies a spectral code family.
13. A method of claim 9, wherein one member of the binding pair is affixed to at least one of the plurality of spectrally labeled bodies and the other member is affixed to a site of the multiplexed array.
14. The method of claim 10, wherein the support structure has a substantially planar surface.
15. The method of claim 10, wherein the support structure contains a plurality of openings sized to accommodate one of the spectrally labeled bodies.
16. The method of claim 10, wherein a plurality of unbound bodies are washed away.
17. A method of claim 11, wherein the discrete binding sites are arranged so as to inhibit a presence of more than a single body at each binding site.
18. A method of claim 11, wherein the binding sites comprise a material capable of binding to the bodies.
19. A method of claim 18, wherein the material comprises a selective affinity molecule which selectively binds to one or more particular bodies.
20. The method of claim 19, wherein the selective affinity molecule is streptavidin.
21. The method of claim 19, wherein a selective binding material is a biotinylated structure.