1. A method for processing sending of service indication information, applied to an Access Point, AP, of a Wireless Local Area Network, WLAN, and comprising:
acquiring sending time information of grouping indication information of Stations, STAs, in the WLAN, wherein the sending time information is used for instructing the STAs to receive, according to sending moments indicated by the sending time information, service indication information corresponding to the STAs indicated by the grouping indication information;
notifying the STAs indicated by the grouping indication information of the sending time information.
2. The method according to claim 1, wherein the sending time information comprises at least one of the followings:
a sending interval of the grouping indication information, sending time offset information of service indication information in the sending interval, and a designated sending moment of the service indication information in the sending interval, wherein the sending interval is used for indicating a time interval between adjacent grouping indication information.
3. The method according to claim 2, wherein notifying the STAs indicated by the grouping indication information of the sending time information comprises:
sending a wireless frame to each of the STAs indicated by the grouping indication information, wherein the wireless frame carries the sending time information and the grouping indication information.
4. The method according to claim 3, wherein the sending time offset information comprises:
a time offset, relative to the wireless frame, of service indication information corresponding to a designated STA among the STAs indicated by the grouping indication information in a sending interval of current grouping indication information.
5. The method according to claim 4, wherein the designated STA comprises:
an STA of a first segment among STAs of a plurality of segments indicated by the grouping indication information, wherein service indication information corresponding to STAs of various segments after the STA of the first segment is arranged after service indication information corresponding to the STA of the first segment in turn.
6. The method according to claim 3, wherein the sending time offset information is carried in the wireless frame by one of the following methods:
indicating the sending time offset information by a designated field;
indicating the sending time offset information implicitly by the grouping indication information.
7. The method according to claim 6, wherein indicating the sending time offset information implicitly by the grouping indication information comprises:
performing, by the STAs indicated by the grouping indication information, calculation according to segment information in the grouping indication information, andor a sequence of the grouping indication information to obtain the sending time offset information.
8. A method for processing the receiving of service indication information, applied to a Station, STA, of a Wireless Local Area Network, WLAN, and comprising:
receiving sending time information from an Access Point, AP, in the WLAN;
receiving, according to sending moments indicated by the sending time information, service indication information corresponding to STAs indicated by grouping indication information.
9. The method according to claim 8, characterized in that the sending time information comprises at least one of the followings:
a sending interval of the grouping indication information, sending time offset information of service indication information in the sending interval, and a designated sending moment of the service indication information in the sending interval, wherein the sending interval is used for indicating a time interval between adjacent grouping indication information.
10. The method according to claim 9, characterized in that the method further comprises:
receiving the grouping indication information according to the sending interval.
11. A device for processing the sending of service indication information, applied to an Access Point, AP, of a Wireless Local Area Network, WLAN, and characterized by comprising:
an acquiring component, configured to acquire sending time information of grouping indication information of STAs in the WLAN, wherein the sending time information is used for instructing the STAs to receive, according to sending moments indicated by the sending time information, service indication information corresponding to the STAs indicated by the grouping indication information;
a notifying component, configured to notify the STAs indicated by the grouping indication information of the sending time information.
12. The device according to claim 11, characterized in that the acquiring component is configured to acquire the sending time information comprising at least one of the following content:
a sending interval of the grouping indication information, sending time offset information of service indication information in the sending interval, and a designated sending moment of the service indication information in the sending interval, wherein the sending interval is used for indicating a time interval between adjacent grouping indication information.
13. A device for processing the receiving of service indication information, applied to a Station, STA, of a Wireless Local Area Network, WLAN, characterized by comprising:
a first receiving component, configured to receive sending time information from an Access Point, AP, in the WLAN;
a second receiving component, configured to receive, according to sending moments indicated by the sending time information, service indication information corresponding to the STAs indicated by the grouping indication information.
14. The device according to claim 13, characterized in that the first receiving component is configured to receive the sending time information comprising at least one of the following content:
a sending interval of the grouping indication information, sending time offset information of service indication information in the sending interval, and a designated sending moment of the service indication information in the sending interval, wherein the sending interval is used for indicating a time interval between adjacent grouping indication information.
The claims below are in addition to those above.
All refrences to claim(s) which appear below refer to the numbering after this setence.
1. A compound of Formula (I):
or a salt, thereof:
wherein:
D is \u2014NRR1, \u2014OR, \u2014SR, \u2014S(O)R, or \u2014S(O)2R;
R is hydrogen, C1-C8 alkyl, C3-C7 cycloalkyl, aralkyl, aryl, heteroaryl, \u2014C(O)NR1R1, \u2014C(O)OR1, acyl, aroyl, or heteroaroyl;
R1 is hydrogen, C1-C8 alkyl, C3-C7 cycloalkyl, aralkyl, or aryl;
R2 is C1-C6 alkyl or C3-C7 cycloalkyl;
R3 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, aralkyl, cyanoalkyl,
\u2014(CH2)pC\u2550CH(CH2)tH, \u2014(CH2)pC\u2261C(CH2)tH, or C3-C7 cycloalkyl;
p is 1, 2, or 3;
t is 0 or 1;
R4 is hydrogen, halo, or cyano;
Q1 is hydrogen, halo, C1-C2 haloalkyl, C1-C2 alkyl, C1-C2 alkoxy, or C1-C2 haloalkoxy;
Q2 is A1 or A2;
Q3 is A1 when Q2 is A2 and Q3 is A2 when Q2 is A1;
wherein
A1 is hydrogen, halo, C1-C3 alkyl, C1-C3 haloalkyl, \u2014OR5, and
A2 is the group defined by -(Z)m-(Z1)-(Z2), wherein
Z is CH2 and m is 0, 1, 2, or 3, or
Z is NR5 and m is 0 or 1, or
Z is oxygen and m is 0 or 1, or
Z is CH2NR6 and m is 0 or 1;
Z1 is S(O)2, S(O), or C(O); and
Z2 is C1-C4 alkyl, cycloalkyl, heterocyclyl, \u2014NR8R9, aryl, arylamino, aralkyl, aralkoxy, or heteroaryl;
R5 and R6 are each independently selected from hydrogen, hydroxyl, alkoxy, aryloxy, aralkoxy, C1-C4 alkyl, C3-C7 cycloalkyl, heterocyclyl, \u2014S(O)2R7, and \u2014C(O)R7;
R7 is C1-C4 alkyl, or C3-C7 cycloalkyl;
R8 is hydrogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, aryloxy, aralkoxy, C3-C7 cycloalkyl, and C3-C7 cycloalkoxy; and
R9 is hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, aryl, acyl, carbamoyl, or heterocyclyl.
2. A compound of Formula (II):
or a salt, thereof:
wherein:
R is hydrogen, C1-C8 alkyl, C3-C7 cycloalkyl, aralkyl, aryl, heteroaryl, \u2014C(O)NR1R1, \u2014C(O)OR1, acyl, aroyl, or heteroaroyl;
R1 is hydrogen, C1-C8 alkyl, C3-C7 cycloalkyl, aralkyl, or aryl;
R2 is C1-C6 alkyl or C3-C7 cycloalkyl;
R3 is hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, aralkyl, cyanoalkyl, \u2014(CH2)pC\u2550CH(CH2)tH, \u2014(CH2)pC\u2261C(CH2)tH, or C3-C7 cycloalkyl;
p is 1, 2, or 3;
t is 0 or 1;
R4 is hydrogen, halo, or cyano;
Q1 is hydrogen, halo, C1-C2 haloalkyl, C1-C2 alkyl, C1-C2 alkoxy, or C1-C2 haloalkoxy;
Q2 is A1 or A2;
Q3 is A1 when Q2 is A2 and Q3 is A2 when Q2 is A1;
wherein
A1 is hydrogen, halo, C1-C3 alkyl, C1-C3 haloalkyl, \u2014OR5, and
A2 is the group defined by -(Z)m-(Z1)-(Z2), wherein
Z is CH2 and m is 0, 1, 2, or 3, or
Z is NR5 and m is 0 or 1, or
Z is oxygen and m is 0 or 1, or
Z is CH2NR6 and m is 0 or 1;
Z1 is S(O)2, S(O), or C(O); and
Z2 is C1-C4 alkyl, cycloalkyl, heterocyclyl, \u2014NR8R9, aryl, arylamino, aralkyl, aralkoxy, or heteroaryl;
R5 and R6 are each independently selected from hydrogen, hydroxyl, alkoxy, aryloxy, aralkoxy, C1-C4 alkyl, C3-C7 cycloalkyl, heterocyclyl, \u2014S(O)2R7, or \u2014C(O)R7;
R7 is C1-C4 alkyl, or C3-C7 cycloalkyl;
R8 is hydrogen, hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, aryloxy, aralkoxy, C3-C7 cycloalkyl, or C3-C7 cycloalkoxy; and
R9 is hydrogen, C1-C6 alkyl, C3-C7 cycloalkyl, aryl, acyl, carbamoyl, or heterocyclyl.
3. A compound as claimed in claim 1, wherein D is \u2014NRR1.
4. A compound as claimed in claim 1, wherein D is \u2014NRR1 and R is C1-C8 alkyl, aryl, or aralkyl and R1 is hydrogen.
5. A compound as claimed in claim 1, wherein D is \u2014NRR1, wherein R is methyl, isopropyl, benzyl, or phenyl and R1 is hydrogen.
6. A compound as claimed in claim 1, wherein R2 is C1-C8 alkyl.
7. A compound as claimed in claim 1, wherein R2 is methyl.
8. A compound as claimed in claim 1 or 2, wherein R3 is hydrogen, C1-C4 alkyl, cyanoalkyl, or \u2014(CH2)pC\u2261C(CH2)tH.
9. A compound as claimed in claim 1, wherein R3 is hydrogen, methyl, ethyl, isopropyl, cyanomethyl, or \u2014(CH2)pC\u2261C(CH2)tH, wherein p is 1 and t is 0.
10. A compound as claimed in claim 1, wherein R3 is methyl.
11. A compound as claimed in claim 1, wherein R4 is hydrogen or halo.
12. A compound as claimed in claim 1, wherein R4 is hydrogen.
13. A compound as claimed in claim 1, wherein Q1 is hydrogen, halo, C1-C2 alkyl or C1-C2 alkoxy.
14. A compound as claimed in claim 1, wherein Q1 is hydrogen, chloro, methyl, or methoxy.
15. A compound as claimed in claim 1, wherein Q2 is A1 and Q3 is A2.
16. A compound as claimed in claim 1, wherein Q2 is A2 and Q3 is A1.
17. A compound as claimed in claim 1, wherein Q2 is A2 and Q3 is A1, wherein A1 is hydrogen, halo, or C1-C3 haloalkyl and A2 is the group defined by -(Z)m-(Z1)-(Z2), wherein Z is CH2 and m is 0 or 1; Z1 is S(O)2; and Z2 is C1-C4 alkyl or NR8R9 and wherein R8 is hydrogen C1-C4alkyl, or alkoxy and R9 is hydrogen, C1-C4alkyl, or alkoxy.
18. A compound as claimed in claim 1, wherein Q2 is A2 and Q3 is A1, wherein A1 is hydrogen or chloro and A2 is the group defined by -(Z)m-(Z1)-(Z2), wherein Z is CH2 and m is 0 or 1; Z1 is S(O)2; and Z2 is methyl or \u2014NH2.
19. A compound as claimed in claim 1, wherein Q2 is A1 and Q3 is A2, wherein A1 is hydrogen, halo, or C1-C3 alkyl and A2 is the group defined by -(Z)m-(Z1)-(Z2), wherein Z is CH2 and m is 0 or 1; Z1 is S(O)2; and Z2 is C1-C4 alkyl or NR8R9, and wherein R8 is hydrogen C1-C4alkyl, or alkoxy and R9 is hydrogen, C1-C4alkyl, or alkoxy.
20. A compound as claimed in claim 1, wherein Q2 is A1 and Q3 is A2, wherein A1 is hydrogen, methyl, or chloro and A2 is the group defined by -(Z)m-(Z1)-(Z2), wherein Z is CH2 and m is 0 or 1; Z1 is S(O)2; and Z2 is NR8R9, wherein R8 is methoxy and R9 is hydrogen.
21. A compound as claimed in claim 1, wherein D is \u2014NRR1, where R is C1-C8 alkyl, aryl, or aralkyl and R1 is hydrogen; R2 is C1-C8 alkyl. R2 is methyl; R3 is methyl; R4 is hydrogen; Q1 is hydrogen, chloro, methyl, or methoxy; Q2 is A2 and Q3 is A1, where A1 is hydrogen or chloro and A2 is the group defined by -(Z)m-(Z1)-(Z2), where Z is CH2 and m is 0 or 1; Z1 is S(O)2; and Z2 is methyl or \u2014NH2.
22. A compound as claimed in claim 1, wherein D is \u2014NRR1, where R is C1-C8 alkyl, aryl, or aralkyl and R1 is hydrogen; R2 is C1-C8 alkyl, R2 is methyl; R3 is methyl; R4 is hydrogen; Q1 is hydrogen, chloro, methyl, or methoxy; Q2 is A1 and Q3 is A2, where A1 is hydrogen, methyl, or chloro and A2 is the group defined by -(Z)m-(Z1)-(Z2), where Z is CH2 and m is 0 or 1; Z1 is S(O)2; and Z2 is NR8R9, where R8 is methoxy and R9 is hydrogen.
23. A compound as claimed in claim 1, selected from the group consisting of:
N2-isopropyl-N5,1-dimethyl-N5-2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-yl-1H-benzimidazole-2,5-diamine;
N2-isopropyl-N5,1-dimethyl-N5-2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-yl-1H-benzimidazole-2,5-diamine;
1-{4-(4-{methyl1-methyl-2-(methylamino)-1H-benzimidazol-5-ylamino}pyrimidin-2-yl)aminophenyl}methanesulfonamide;
N2-benzyl-N5,1-dimethyl-N5-2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-yl-1H-benzimidazole-2,5-diamine;
N5,1-dimethyl-N5-2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-yl-N2-phenyl-1H-benzimidazole-2,5-diamine; and
5-({4-2-(benzylamino)-1-methyl-1H-benzimidazol-5-yl(methyl)aminopyrimidin-2-yl}amino)-N-methoxy-2-methylbenzenesulfonamide;
or a salt thereof.
24. A compound as claimed in claim 1, selected from the group:
3-{4-(2-benzylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-benzenesulfonamide;
5-{4-(2-benzylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidinylamino}-2-methyl-benzenesulfonamide;
(4-{4-(2-benzylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-phenyl)-methanesulfonamide;
2-(4-{4-(2-benzylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-phenyl)-ethanesulfonic acid methylamide;
3-(4-{2-(4-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
5-(4-{2-(4-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-2-methyl-benzenesulfonamide;
N2-(4-fluoro-benzyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
4-(4-{2-(4-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-methanesulfonamide;
2-4-(4-{2-(4-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-ethanesulfonic acid methylamide;
3-(4-{2-(4-methoxy-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
5-(4-{2-(4-methoxy-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-2-methyl-benzenesulfonamide;
N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N2-(4-methoxy-benzyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
4-(4-{2-(4-methoxy-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-methanesulfonamide;
2-4-(4-{2-(4-methoxy-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-ethanesulfonic acid methylamide;
5-(4-{2-(3-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-2-methyl-benzenesulfonamide;
3-(4-{2-(3-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
N2-(3-fluoro-benzyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
4-(4-{2-(3-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-methanesulfonamide;
2-4-(4-{2-(3-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-ethanesulfonic acid methylamide;
3-(4-{2-(4-chloro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
5-(4-{2-(4-chloro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-2-methyl-benzenesulfonamide;
2-4-(4-{2-(4-chloro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-ethanesulfonic acid methylamide;
N2-(4-chloro-benzyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
3-{4-(2-benzylamino-1-ethyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-benzenesulfonamide;
5-{4-(2-benzylamino-1-ethyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-2-methyl-benzenesulfonamide;
N2-benzyl-1-ethyl-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N5-methyl-1H-benzoimidazole-2,5-diamine;
(4-{4-(2-benzylamino-1-ethyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-phenyl)-methanesulfonamide;
3-(4-{2-(2-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylmethyl)-benzenesulfonamide;
5-(4-{2-(2-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-2-methyl-benzenesulfonamide;
4-(4-{2-(2-fluoro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-methanesulfonamide;
2-(4-{4-(2-benzylamino-1-ethyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-phenyl)-ethanesulfonic acid methylamide;
3-(4-{methyl-1-methyl-2-(1-phenyl-ethylamino)-1H-benzoimidazol-5-yl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
2-methyl-5-(4-{methyl-1-methyl-2-(1-phenyl-ethylamino)-1H-benzoimidazol-5-yl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-N2-(1-phenyl-ethyl)-1H-benzoimidazole-2,5-diamine;
4-(4-{methyl-1-methyl-2-(1-phenyl-ethylamino)-1H-benzoimidazol-5-yl-amino}-pyrimidin-2-ylamino)-phenyl-methanesulfonamide;
3-(4-{2-(3-chloro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
3-(4-{2-(3-chloro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
4-(4-{2-(4-chloro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-methanesulfonamide;
methanesulfonic acid-3-(4-{2-(4-chloro-benzylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl ester;
N5-{2-4-(2-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-N2-(4-methoxy-benzyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N5-{2-3-(2-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-N2-(4-methoxy-benzyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N5-{2-4-(1-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-N2-(4-methoxy-benzyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N5-2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N2-(4-methoxy-benzyl)-1, N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-benzyl-N5-2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N5-2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-N2-(1-phenyl-ethyl)-1H-benzoimidazole-2,5-diamine;
N5-{2-3-(2-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-1,N5-dimethyl-N2-(1-phenyl-ethyl)-1H-benzoimidazole-2,5-diamine;
N5-{2-4-(2-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-1,N5-dimethyl-N2-(1-phenyl-ethyl)-1H-benzoimidazole-2,5-diamine;
2-methyl-5-(4-{methyl-1-methyl-2-(4-methyl-benzylamino)-1H-benzoimidazol-5-yl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-N2-(4-methyl-benzyl)-1H-benzoimidazole-2,5-diamine;
N5-2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-N2-(4-methyl-benzyl)-1H-benzoimidazole-2,5-diamine;
N5-{2-4-(2-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-1,N5-dimethyl-N2-(4-methyl-benzyl)-1H-benzoimidazole-2,5-diamine;
N5-{2-3-(2-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-1,N5-dimethyl-N2-(4-methyl-benzyl)-1H-benzoimidazole-2,5-diamine; and
N5-{2-4-(1-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-1,N5-dimethyl-N2-(4-methyl-benzyl)-1H-benzoimidazole-2,5-diamine;
or a salt thereof.
25. A compound as claimed in claim 1, selected from the group:
(1-methyl-5-{methyl-2-(3-sulfamoyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-phenyl-carbamic acid tert-butyl ester;
3-{4-methyl-(1-methyl-2-phenylamino-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-benzenesulfonamide;
(1-methyl-5-{methyl-2-(4-methyl-3-sulfamoyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-phenyl-carbamic acid tert-butyl ester;
N5-2-(3-methanesulfonyl-4-methyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-N2-phenyl-1H-benzoimidazole-2,5-diamine;
N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-N2-phenyl-1H-benzoimidazole-2,5-diamine;
(4-{4-methyl-(1-methyl-2-phenylamino-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-phenyl)-methanesulfonamide;
methanesulfonic acid 4-{4-methyl-(1-methyl-2-phenylamino-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-phenyl ester;
3-(4-{2-(4-fluoro-phenylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
5-(4-{2-(4-fluoro-phenylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-2-methyl-benzenesulfonamide;
N2-(4-fluoro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
4-(4-{2-(4-fluoro-phenylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-methanesulfonamide;
methanesulfonic acid 4-(4-{2-(4-fluoro-phenylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl ester;
methanesulfonic acid 3-(4-{2-(4-fluoro-phenylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl ester;
N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-N2-p-tolyl-1H-benzoimidazole-2,5-diamine;
4-(4-{2-(4-tert-butyl-phenylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-methanesulfonamide;
3-(4-{2-(4-tert-butyl-phenylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
5-(4-{2-(4-tert-butyl-phenylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-2-methyl-benzenesulfonamide;
N2-(4-tert-butyl-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
(5-{2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-(4-methoxy-phenyl)-carbamic acid tert-butyl ester;
N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N2-(4-methoxy-phenyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
(4-methoxy-phenyl)-(1-methyl-5-{methyl-2-(4-sulfamoylmethyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-carbamic acid tert-butyl ester;
4-(4-{2-(4-methoxy-phenylamino)-1-methyl-1H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-phenyl-methanesulfonamide;
(5-{2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-(4-methoxy-phenyl)-carbamic acid tert-butyl ester;
N5-2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N2-(4-methoxy-phenyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
5-({2-4-(1-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-methyl-amino)-1-methyl-1H-benzoimidazol-2-yl-(4-methoxy-phenyl)-carbamic acid tert-butyl ester;
N5-{2-4-(1-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-N2-(4-methoxy-phenyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine; and
N5-{2-3-(1-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-N2-(4-methoxy-phenyl)-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
or a salt thereof.
26. A compound as claimed in claim 1, selected from the group:
3-{4-(2-isopropylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-benzenesulfonamide;
2-chloro-5-{4-(2-isopropylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-benzenesulfonamide;
5-{4-(2-isopropylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-2-methyl-benzenesulfonamide;
2-(4-{4-(2-isopropylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-phenyl)-ethanesulfonic acid methylamide;
methanesulfonic acid 4-{4-(2-isopropylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-phenyl ester;
methanesulfonic acid 3-{4-(2-isopropylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-phenyl ester;
N2-isopropyl-N5-2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1, N5-dimethyl-1H-benzoimidazole-2,5-diamine;
3-4-(1-methyl-2-phenethylamino-1H-benzoimidazol-5-ylamino)-pyrimidin-2-ylamino-benzenesulfonamide;
2-methyl-5-{4-methyl-(1-methyl-2-phenethylamino-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-benzenesulfonamide;
(4-{4-methyl-(1-methyl-2-phenethylamino-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-phenyl)-methanesulfonamide;
N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-N2-phenethyl-1H-benzoimidazole-2,5-diamine;
2-(4-{4-methyl-(1-methyl-2-phenethylamino-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-phenyl)-ethanesulfonic acid methylamide;
N2-tert-Butyl-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1, N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-cyclohexyl-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1, N5-dimethyl-1H-benzoimidazole-2,5-diamine;
5-{4-(2-cyclohexylamino-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-2-methyl-benzenesulfonamide;
N2-cyclohexyl-N5-{2-3-(2-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-cyclohexyl-N5-{2-4-(2-methanesulfonyl-ethyl)-phenylamino-pyridin-4-yl}-1, N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-cyclohexyl-N5-{2-4-(1-methanesulfonyl-ethyl)-phenylamino-pyrimidin-4-yl}-1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
2-methyl-5-{4-methyl-(1-methyl-2-methylamino-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-benzenesulfonamide;
(4-{4-methyl-(1-methyl-2-methylamino-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-phenyl)-methanesulfonamide;
3-{4-methyl-(1-methyl-2-methylamino-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-benzenesulfonamide;
N5-2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N2,N5-trimethyl-1H-benzoimidazole-2,5-diamine; and
(4-{4-(1-ethyl-2-methylamino-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-phenyl)-methanesulfonamide;
or a salt thereof.
27. A compound as claimed in claim 1, selected from the group:
N1-methyl-N5-2-(4-Methanesulfonymethyl-phenylamino)-pyrimidin-4-yl-N5-methyl-N2-(4-trifluoromethyl-phenyl)-1H-benzoimidazole-2,5-diamine;
N2-(3-chloro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(4-chloro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2,4-dichloro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2,5-dichloro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2-chloro-4-trifluoromethyl-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2-chloro-5-trifluoromethyl-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-N2-(4-morpholin-4-yl-phenyl)-1H-benzoimidazole-2,5-diamine;
N2-(3-fluoro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2,4-difluoro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2-chloro-4-fluoro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(4-chloro-2-fluoro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2-chloro-5-fluoro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2-fluoro-4-methyl-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2-fluoro-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
N2-(2-fluoro-5-trifluoromethyl-phenyl)-N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-1H-benzoimidazole-2,5-diamine;
4-{4-methyl-(1-methyl-2-methylsulfanyl-1H-benzoimidazol-5-yl)-amino-pyrimidin-2-ylamino}-benzene sulfonamide;
4-{4-(2-methanesulfinyl-1-methyl-1H-benzoimidazol-5-yl)-methyl-amino-pyrimidin-2-ylamino}-benzensulfonamide;
4-(4-{methyl-1-methyl-2-(4-trifluoromethyl-phenylamino)-1H-benzoimidazol-5-yl-amino}-pyrimidin-2-ylamino)-benzenesulfonamide;
(methyl-nitro-1H-benzoimidazol-2-yl)-(3-trifluoromethyl-phenyl)-amine;
(methyl-nitro-1H-benzoimidazol-2-yl)-(3-trifluoromethyl-phenyl)-carbamic acid dimethyl-ethyl ester;
(amino-methyl-1-benzoimidazol-2-yl)-(3-trifluoromethyl-phenyl)-carbamic acid dimethyl-ethyl ester;
(2-chloro-pyrimidin-4-yl)-methyl-amino-methyl-1H-benzoimidazol-2-yl}-(3-trifluoromethyl-phenyl)-carbamic acid dimethyl-ethyl ester; and
N5-2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-N1,N5-dimethyl-N2-(3-trifluoromethyl-phenyl)-1H-benzoimidazole-2,5-diamine;
or a salt thereof.
28. A compound as claimed in claim 1, selected from the group:
N2-(5-tert-butyl-isoxazol-3-yl)-N52-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-1H-methyl-amino-benzoimidazole-2,5-diamine;
N2-(5-tert-butyl-isoxazol-3-yl)-N52-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-methyl-1-1H-benzoimidazole-2,5-diamine;
N2-(5-tert-butyl-isoxazol-3-yl)-N5-2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1-methyl-1H-benzoimidazole-2,5-diamine;
N2-(5-tert-butyl-isoxazol-3-yl)-N5-2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-1,N5-dimethyl-1-H-benzoimidazole-2,5-diamine;
N2-(5-tert-butyl-isoxazol-3-yl)-N5-2-(3-methanesulfonyl-4-methyl-phenylamino)-pyrimidin-4-yl-1-methyl-1-1H-benzoimidazole-2,5-diamine;
5-(4-{2-(5-tert-butyl-isoxazol-3-ylamino)-1-methyl-1-H-benzoimidazol-5-yl-methyl-amino}-pyrimidin-2-ylamino)-2-methyl-benzenesulfonamide;
N2-(6-fluoro-4-H benzo1,3dioxin-8-ylmethyl)-N5-2-(3-methanesulfonyl-4-methyl-phenylamino)-pyrimidin-4-yl-1-methyl-1H-benzoimidazole-2,5-diamine; and
N2-(5-tert-butyl-isoxazol-3-yl)-1-methyl-N5-{2-3-(morpholine-4-sulfonyl)-phenylamino-pyrimidin-4-yl}-1H-benzoimidazole-2,5-diamine;
or a salt thereof.
29. A compound as claimed in claim 1, selected from the group:
N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)-N\u2032-phenylurea;
N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenylamino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)benzamide;
N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)indoline-1-carboxamide;
N-(5-tert-butylisoxazol-3-yl)-N\u2032-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)urea;
N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)-2-phenylacetamide;
N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)-1-phenylcyclopropanecarboxamide;
N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)isonicotinamide;
N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)cyclohexanecarboxamide;
2-(benzyloxy)-N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)acetamide;
2-(3-methylisoxazol-5-yl)-N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)acetamide; and
3-(dimethylamino)methyl-N-(1-methyl-5-{methyl2-({4-(methylsulfonyl)methylphenyl}amino)pyrimidin-4-ylamino}-1H-benzimidazol-2-yl)benzamide;
or a salt thereof.
30. A compound as claimed in claim 1, selected from the group:
N-({3-(4-methanesulfonylmethyl-phenylamino)-phenyl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-C-thiophen-2-yl-acetamide;
C-fluoro-N-({3-(3-methanesulfonylmethyl-phenylamino)-phenyl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-trifluoromethyl-benzamide;
difluoro-N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-benzamide;
N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-3,5-bis-trifluoromethyl-benzamide;
cyclohexanecarboxylic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-methyl-benzamide;
N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-4-methoxy-benzamide;
C-(chloro-trifluoromethyl-phenyl)-N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
(3,5-bis-trifluoromethyl-phenyl)-N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
N-(5-{2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-2-(3-trifluoromethylsulfanyl-phenyl)-acetamide;
(2,4-bis-trifluoromethyl-phenyl)-N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
(2-fluoro-5-trifluoromethyl-phenyl)-N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
3H-benzotriazole-5-carboxylic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
3H-benzoimidazole-5-carboxylic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
thiophene-2-carboxylic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
thiophene-3-carboxylic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-C-thiophen-2-yl-acetamide;
3-methyl-thiophene-2-carboxylic acid ({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
furan-3-carboxylic acid ({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
3-methyl-furan-2-carboxylic acid ({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-2-(3-methyl-isoxazol-5-yl)-acetamide;
C-(chloro-trifluoromethyl-phenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
N-(5-{2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-2-(3-trifluoromethylsulfanyl-phenyl)-acetamide;
C-(fluoro-trifluoromethyl-phenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-dimethyl-butyramide;
2-propyl-pentanoic acid ({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-isobutyramide;
cyclopropanecarboxylic acid ({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-4-methoxy-benzamide;
4-methoxy-N-(methyl-{methyl-2-(4-methyl-3-sulfamoyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-benzamide;
furan-2-carboxylic acid ({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
N-(methyl-{methyl-2-(4-methyl-3-sulfamoyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-C-thiophen-2-yl-acetamide;
C-(chloro-trifluoromethyl-phenyl)-N-(methyl-{methyl-2-(4-methyl-3-sulfamoyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-acetamide;
4-methoxy-N-methyl-(methyl-{2-3-(morpholine-4-sulfonyl)-phenylamino-pyrimidin-4-yl}-amino)-1H-benzoimidazol-2-yl-benzamide;
N-methyl-(methyl-{2-3-(morpholine-4-sulfonyl)-phenylamino-pyrimidin-4-yl}-amino)-1H-benzoimidazol-2-yl-C-thiophen-2-yl-acetamide;
thiophene-2-carboxylic acid methyl-(methyl-(2-3-(morpholine-4-sulfonyl)-phenylamino-pyrimidin-4-yl}-amino)-1H-benzoimidazol-2-yl-amide;
furan-2-carboxylic acid methyl-(methyl-{2-3-(morpholine-4-sulfonyl)-phenylamino-pyrimidin-4-yl}-amino)-1H-benzoimidazol-2-yl-amide;
N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-2-(3-methyl-isoxazol-5-yl)-acetamide;
furan-2-carboxylic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
2-(3-methyl-isoxazol-5-yl)-N-methyl-(methyl-{2-3-(morpholine-4-sulfonyl)-phenylamino-pyrimidin-4-yl}-amino)-1H-benzoimidazol-2-yl-acetamide;
3-methyl-furan-2-carboxylic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
N-methyl-(methyl-{2-3-(4-methyl-piperazine-1-sulfonyl)-phenylamino-pyrimidin-4-yl}-amino)-1H-benzoimidazol-2-yl-C-thiophen-2-yl-acetamide;
thiophene-2-carboxylic acid methyl-(methyl-{2-3-(4-methyl-piperazine-1-sulfonyl)-phenylamino-pyrimidin-4-yl}-amino)-1H-benzoimidazol-2-yl-amide;
furan-2-carboxylic acid methyl-(methyl-{2-3-(4-methyl-piperazine-1-sulfonyl)-phenylamino-pyrimidin-4-yl}-amino)-1H-benzoimidazol-2-yl-amide;
2-(3-methyl-isoxazol-5-yl)-N-methyl-(methyl-{2-3-(4-methyl-piperazine-1-sulfonyl)-phenylamino-pyrimidin-4-yl}-amino)-1H-benzoimidazol-2-yl-acetamide;
N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-dimethyl-butyramide;
N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-propionamide;
pentanoic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-butyramide;
phenyl-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
phenylcyclopropanecarboxylic acid ({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
1-(2,5-difluoro-phenyl)-cyclopropanecarboxylic acid ({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
1-(4-chloro-phenyl)-cyclopropanecarboxylic acid ({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
2-(4-fluoro-phenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
(3,5-bistrifluoromethyl-phenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
(3,4-dichlorophenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
1-(2,5-difluorophenyl)-cyclopropanecarboxylic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
(2,5-difluorophenyl)-N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
(3,4-dichlorophenyl)-N-({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
1-(2,5-difluorophenyl)-cyclopropanecarboxylic acid ({2-(5-ethanesulfonyl-2-methoxy-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
(2,5-difluorophenyl)-N-({2-(5-ethanesulfonyl-2-methoxy-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
1-(3,4-dichlorophenyl)-cyclopropanecarboxylic acid ({2-(5-ethanesulfonyl-2-methoxy-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
3,4-dichlorophenyl-N-({2-(5-ethanesulfoyl-2-methoxy-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
1-(2,5-difluorophenyl)-cyclopropanecarboxylic acid (methyl-{methyl-2-(4-methyl-3-sulfamoyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-amide;
1-(3,4-dichlorophenyl)-cyclopropanecarboxylic acid (methyl-{methyl-2-(4-methyl-3-sulfamoyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-amide;
(3,4-dichlorophenyl)-N-(methyl-{methyl-2-(4-methyl-3-sulfamoyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-acetamide;
2-(2,3-dimethoxyphenyl)-N-(5-{2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(2-methoxyphenyl)-N-(5-{2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(3-methoxyphenyl)-N-(5-{2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(3-methoxyphenyl)-N-(5-{2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(2-fluorophenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(3-fluorophenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
(2,5-difluorophenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
(2,3-difluorophenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(3,4-dimethoxyphenyl)-N-(5-{2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-acetamide;
(2,5-difluorophenyl)-N-(methyl-{methyl-2-(4-methyl-3-sulfamoyl-phenylamino)-pyrimidin-4-yl-amino}-1H-benzoimidazol-2-yl)-acetamide;
1-(3,4-dichloro-phenyl)-cyclopropanecarboxylic acid ({2-(3-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-amide;
2-(2-chlorophenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(3-chlorophenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(4-chlorophenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(3,5-dimethoxyphenyl)-N-(5-{2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-acetamide;
2-(2,5-dimethoxyphenyl)-N-(5-{2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-1-methyl-1H-benzoimidazol-2-yl)-acetamide;
(2,5-dichlorophenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-methyl-C-phenyl-butyramide;
(3,5-dimethylphenyl)-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-phenyl-isobutyramide; and
benzo1,3dioxol-5-yl-N-({2-(4-methanesulfonylmethyl-phenylamino)-pyrimidin-4-yl-methyl-amino}-methyl-1H-benzoimidazol-2-yl)-acetamide;
or a salt thereof.
31. A pharmaceutical composition, comprising: a therapeutically effective amount of a compound as claimed claim 1, or a salt thereof and one or more of pharmaceutically acceptable carriers, diluents and excipients.
32. The pharmaceutical composition of claim 31, further comprising at least one additional anti-neoplastic agent.
33. The pharmaceutical composition of claim 31, further comprising an additional agent which inhibits angiogenesis.